Frem2 (FRAS1 related extracellular matrix 2) - Rat Genome Database

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Gene: Frem2 (FRAS1 related extracellular matrix 2) Rattus norvegicus
Analyze
Symbol: Frem2
Name: FRAS1 related extracellular matrix 2
RGD ID: 1566012
Description: Predicted to be involved in anatomical structure morphogenesis and cell adhesion. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; eye development; and inner ear development. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Used to study Fraser syndrome 2. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fras1 related extracellular matrix protein 2; FRAS1-related extracellular matrix protein 2; LOC310418; RGD1566012; similar to OTTHUMP00000018288
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Frem2fpl  
Genetic Models: FPL/Iet
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22137,602,784 - 137,740,785 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2137,602,784 - 137,740,785 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2144,186,132 - 144,324,110 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02142,298,198 - 142,436,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02136,929,969 - 137,067,935 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02142,747,501 - 142,885,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2142,747,501 - 142,885,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02162,430,795 - 162,568,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42142,464,169 - 142,604,059 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2132,100,362 - 132,238,927 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Fused pulmonary lobes is a rat model of human Fraser syndrome. Kiyozumi D, etal., Biochem Biophys Res Commun. 2011 Jul 29;411(2):440-4. doi: 10.1016/j.bbrc.2011.06.174. Epub 2011 Jul 2.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury. Seibert FS, etal., Acta Physiol (Oxf). 2013 Apr;207(4):700-8. doi: 10.1111/apha.12064. Epub 2013 Feb 14.
Additional References at PubMed
PMID:15838507   PMID:16880404   PMID:17251066   PMID:17596926   PMID:21795542   PMID:23376485   PMID:23533145   PMID:25807483   PMID:26234751   PMID:29688405   PMID:30802441  


Genomics

Comparative Map Data
Frem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22137,602,784 - 137,740,785 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2137,602,784 - 137,740,785 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2144,186,132 - 144,324,110 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02142,298,198 - 142,436,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02136,929,969 - 137,067,935 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02142,747,501 - 142,885,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2142,747,501 - 142,885,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02162,430,795 - 162,568,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42142,464,169 - 142,604,059 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2132,100,362 - 132,238,927 (-)NCBICelera
Cytogenetic Map2q26NCBI
FREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381338,687,077 - 38,887,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1338,687,077 - 38,887,131 (+)EnsemblGRCh38hg38GRCh38
GRCh371339,261,214 - 39,461,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361338,159,173 - 38,359,268 (+)NCBINCBI36Build 36hg18NCBI36
Build 341338,255,292 - 38,358,072NCBI
Celera1320,314,868 - 20,515,290 (+)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1320,059,603 - 20,259,887 (+)NCBIHuRef
CHM1_11339,228,938 - 39,428,968 (+)NCBICHM1_1
T2T-CHM13v2.01337,903,789 - 38,103,862 (+)NCBIT2T-CHM13v2.0
Frem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39353,421,359 - 53,566,014 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl353,421,359 - 53,564,776 (-)EnsemblGRCm39 Ensembl
GRCm38353,513,938 - 53,658,593 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl353,513,938 - 53,657,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv37353,317,860 - 53,461,277 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36353,601,867 - 53,745,013 (-)NCBIMGSCv36mm8
Celera353,238,829 - 53,381,524 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.24NCBI
Frem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554317,364,937 - 7,541,648 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554317,364,937 - 7,541,419 (-)NCBIChiLan1.0ChiLan1.0
FREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11329,319,867 - 29,523,385 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01319,900,324 - 20,103,303 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11338,490,750 - 38,692,200 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1338,490,750 - 38,687,048 (+)Ensemblpanpan1.1panPan2
FREM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1252,097,264 - 2,264,049 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl252,102,849 - 2,264,456 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha252,193,436 - 2,359,496 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0252,194,254 - 2,360,131 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl252,198,985 - 2,359,379 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,095,553 - 2,261,726 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,089,594 - 2,255,805 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0252,159,315 - 2,325,419 (-)NCBIUU_Cfam_GSD_1.0
Frem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945163,183,741 - 163,353,464 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365656,671,737 - 6,837,514 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365656,671,578 - 6,837,514 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,959,666 - 14,113,230 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,775,267 - 14,116,377 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1317,121,063 - 17,310,149 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl317,129,126 - 17,300,363 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605726,957,763 - 27,140,436 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249201,683,351 - 1,904,557 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249201,683,342 - 1,908,602 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Frem2
611 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:59
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000031487
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
12879830Bw178Body weight QTL 1780.001body mass (VT:0001259)body weight (CMO:0000012)2137219876142323610Rat
12879831Cm82Cardiac mass QTL 820.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2137219876142323610Rat
12879832Cm83Cardiac mass QTL 830.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2137219876142323610Rat
12879833Cm84Cardiac mass QTL 840.001heart right ventricle mass (VT:0007033)heart weight to body weight ratio (CMO:0000074)2137219876142323610Rat
12879834Am1Aortic mass QTL 10.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2137219876142323610Rat
12879835Kidm60Kidney mass QTL 600.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2137219876142323610Rat
1549841Bp256Blood pressure QTL 2560.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2137219876142323610Rat

Markers in Region
RH141524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22137,602,299 - 137,602,514 (+)MAPPERmRatBN7.2
Rnor_6.02142,747,017 - 142,747,231NCBIRnor6.0
Rnor_5.02162,430,311 - 162,430,525UniSTSRnor5.0
RGSC_v3.42142,464,256 - 142,464,470UniSTSRGSC3.4
Celera2132,099,878 - 132,100,092UniSTS
RH 3.4 Map2858.5UniSTS
Cytogenetic Map2q26UniSTS


Genetic Models
This gene Frem2 is modified in the following models/strains:
FPL/Iet    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 2 2 2 2 2 4 22 21 8 2
Low 1 20 39 23 19 23 6 9 68 13 19 3 6
Below cutoff 2 1 13 13 13 2 1

Sequence


RefSeq Acc Id: ENSRNOT00000031487   ⟹   ENSRNOP00000031592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2137,602,784 - 137,740,785 (-)Ensembl
Rnor_6.0 Ensembl2142,747,501 - 142,885,604 (-)Ensembl
RefSeq Acc Id: NM_001245978   ⟹   NP_001232907
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22137,602,784 - 137,740,785 (-)NCBI
Rnor_6.02142,747,501 - 142,885,604 (-)NCBI
Rnor_5.02162,430,795 - 162,568,910 (-)NCBI
Celera2132,100,362 - 132,238,927 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001232907 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAK14372 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031592
  ENSRNOP00000031592.6
RefSeq Acc Id: NP_001232907   ⟸   NM_001245978
- Peptide Label: precursor
- UniProtKB: F1T1U1 (UniProtKB/TrEMBL),   D3ZG74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031592   ⟸   ENSRNOT00000031487
Protein Domains
Calx-beta

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566012 AgrOrtholog
BioCyc Gene G2FUF-53093 BioCyc
Ensembl Genes ENSRNOG00000021670 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031487 ENTREZGENE
  ENSRNOT00000031487.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2030 UniProtKB/TrEMBL
InterPro CalX-like_sf UniProtKB/TrEMBL
  Calx_beta UniProtKB/TrEMBL
  CSPG_rpt UniProtKB/TrEMBL
  FRAS1-rel_N UniProtKB/TrEMBL
KEGG Report rno:310418 UniProtKB/TrEMBL
NCBI Gene 310418 ENTREZGENE
PANTHER FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2 UniProtKB/TrEMBL
  MATRIX PROTEIN, PUTATIVE-RELATED UniProtKB/TrEMBL
Pfam Cadherin_3 UniProtKB/TrEMBL
  Calx-beta UniProtKB/TrEMBL
  Frem_N UniProtKB/TrEMBL
PhenoGen Frem2 PhenoGen
PROSITE CSPG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021670 RatGTEx
SMART Calx_beta UniProtKB/TrEMBL
Superfamily-SCOP SSF141072 UniProtKB/TrEMBL
UniProt D3ZG74 ENTREZGENE, UniProtKB/TrEMBL
  F1T1U1 ENTREZGENE
UniProt Secondary F1T1U1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-29 Frem2  FRAS1 related extracellular matrix 2  Frem2  Fras1 related extracellular matrix protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Frem2  Fras1 related extracellular matrix protein 2   Frem2_predicted  Fras1 related extracellular matrix protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Frem2_predicted  Fras1 related extracellular matrix protein 2 (predicted)  RGD1566012_predicted  similar to OTTHUMP00000018288 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1566012_predicted  similar to OTTHUMP00000018288 (predicted)  LOC310418  similar to OTTHUMP00000018288  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC310418  similar to OTTHUMP00000018288      Symbol and Name status set to provisional 70820 PROVISIONAL