Adamts2 (ADAM metallopeptidase with thrombospondin type 1 motif, 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Adamts2 (ADAM metallopeptidase with thrombospondin type 1 motif, 2) Rattus norvegicus
Analyze
Symbol: Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 2
RGD ID: 1565950
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within several processes, including collagen fibril organization; protein processing; and spermatogenesis. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome dermatosparaxis type. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 2; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; LOC287899; RGD1565950; similar to A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,422,030 - 35,627,483 (+)NCBIGRCr8
mRatBN7.21034,920,992 - 35,126,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,921,049 - 35,123,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,593,339 - 39,808,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,132,574 - 8,348,184 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,587,008 - 34,802,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,098,051 - 36,304,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,098,051 - 36,304,409 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,868,666 - 36,075,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,168,655 - 36,377,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1034,268,635 - 34,483,095 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
N-nitrosodiethylamine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke. Arning A, etal., Blood. 2012 Dec 20;120(26):5231-6. doi: 10.1182/blood-2012-07-442038. Epub 2012 Sep 18.
2. Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene. Colige A, etal., J Invest Dermatol. 2004 Oct;123(4):656-63.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11284712   PMID:16556917   PMID:24006456  


Genomics

Comparative Map Data
Adamts2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,422,030 - 35,627,483 (+)NCBIGRCr8
mRatBN7.21034,920,992 - 35,126,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,921,049 - 35,123,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,593,339 - 39,808,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,132,574 - 8,348,184 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,587,008 - 34,802,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,098,051 - 36,304,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,098,051 - 36,304,409 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,868,666 - 36,075,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,168,655 - 36,377,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1034,268,635 - 34,483,095 (+)NCBICelera
Cytogenetic Map10q22NCBI
ADAMTS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,110,853 - 179,345,461 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,110,853 - 179,345,461 (-)EnsemblGRCh38hg38GRCh38
GRCh375178,537,854 - 178,772,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365178,473,456 - 178,704,935 (-)NCBINCBI36Build 36hg18NCBI36
Build 345178,510,735 - 178,704,935NCBI
Celera5174,165,082 - 174,399,060 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,265,383 - 173,499,085 (-)NCBIHuRef
CHM1_15177,971,059 - 178,205,092 (-)NCBICHM1_1
T2T-CHM13v2.05179,664,045 - 179,898,855 (-)NCBIT2T-CHM13v2.0
Adamts2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,492,912 - 50,698,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,492,911 - 50,698,400 (+)EnsemblGRCm39 Ensembl
GRCm381150,602,085 - 50,807,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,602,084 - 50,807,573 (+)EnsemblGRCm38mm10GRCm38
MGSCv371150,415,587 - 50,617,551 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,445,508 - 50,647,472 (+)NCBIMGSCv36mm8
Celera1155,162,823 - 55,366,156 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.78NCBI
Adamts2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554081,157,740 - 1,367,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554081,157,826 - 1,367,146 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,047,680 - 174,289,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,182,352 - 172,428,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,264,811 - 174,502,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,554,934 - 181,785,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,557,928 - 181,786,175 (-)Ensemblpanpan1.1panPan2
ADAMTS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,279,983 - 2,504,630 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,280,108 - 2,502,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,405,139 - 2,628,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,257,166 - 2,480,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,256,096 - 2,478,201 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,228,645 - 2,452,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,306,958 - 2,530,502 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,547,778 - 2,771,332 (+)NCBIUU_Cfam_GSD_1.0
Adamts2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213120,182,091 - 120,431,360 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,394,119 - 1,641,130 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,394,119 - 1,643,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl279,182,943 - 79,406,875 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1279,182,901 - 79,406,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,866,167 - 81,010,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12380,852,588 - 81,081,593 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2380,852,331 - 81,080,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,207,935 - 12,439,252 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,070,087 - 42,264,849 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,070,069 - 42,264,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts2
1379 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:111
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000065477
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
D10Mgh10  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01036,185,929 - 36,186,066NCBIRnor6.0
Rnor_5.01035,954,931 - 35,955,068UniSTSRnor5.0
RGSC_v3.41036,254,742 - 36,254,879UniSTSRGSC3.4
RGSC_v3.41036,254,741 - 36,254,879RGDRGSC3.4
RGSC_v3.11036,255,791 - 36,255,928RGD
Celera1034,362,292 - 34,362,429UniSTS
RH 3.4 Map10374.6UniSTS
RH 3.4 Map10374.6RGD
RH 2.0 Map10401.0RGD
SHRSP x BN Map1034.04RGD
FHH x ACI Map1033.0199RGD
Cytogenetic Map10q22UniSTS
RH130935  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21035,123,419 - 35,123,610 (+)MAPPERmRatBN7.2
Rnor_6.01036,301,374 - 36,301,564NCBIRnor6.0
Rnor_5.01036,072,046 - 36,072,236UniSTSRnor5.0
RGSC_v3.41036,377,239 - 36,377,429UniSTSRGSC3.4
Celera1034,482,694 - 34,482,884UniSTS
RH 3.4 Map10363.7UniSTS
Cytogenetic Map10q22UniSTS
Adamts2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,922,276 - 34,922,574 (+)MAPPERmRatBN7.2
Rnor_6.01036,099,279 - 36,099,576NCBIRnor6.0
Rnor_5.01035,869,962 - 35,870,259UniSTSRnor5.0
Celera1034,269,863 - 34,270,160UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 8 4 3 4 2 2 2 25 10 2
Low 3 20 49 37 16 37 6 9 62 35 16 1 6
Below cutoff 8

Sequence


RefSeq Acc Id: ENSRNOT00000083568   ⟹   ENSRNOP00000072563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1036,099,263 - 36,304,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083971   ⟹   ENSRNOP00000075206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,921,049 - 35,123,821 (+)Ensembl
Rnor_6.0 Ensembl1036,098,051 - 36,301,775 (+)Ensembl
RefSeq Acc Id: NM_001395424   ⟹   NP_001382353
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,422,030 - 35,627,483 (+)NCBI
mRatBN7.21034,920,992 - 35,126,465 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382353 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04279 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075206
  ENSRNOP00000075206.2
RefSeq Acc Id: ENSRNOP00000075206   ⟸   ENSRNOT00000083971
RefSeq Acc Id: ENSRNOP00000072563   ⟸   ENSRNOT00000083568
RefSeq Acc Id: NP_001382353   ⟸   NM_001395424
- Peptide Label: precursor
- UniProtKB: D3ZTE7 (UniProtKB/TrEMBL),   A6HE24 (UniProtKB/TrEMBL)
Protein Domains
Peptidase M12B   PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTE7-F1-model_v2 AlphaFold D3ZTE7 1-1170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697157
Promoter ID:EPDNEW_R7681
Type:initiation region
Name:Adamts2_1
Description:ADAM metallopeptidase with thrombospondin type 1 motif, 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01036,097,994 - 36,098,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565950 AgrOrtholog
BioCyc Gene G2FUF-25230 BioCyc
Ensembl Genes ENSRNOG00000061484 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083971 ENTREZGENE
  ENSRNOT00000083971.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS2 UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report rno:287899 UniProtKB/TrEMBL
NCBI Gene 287899 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 2 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts2 PhenoGen
PRINTS ADAMTS2 UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061484 RatGTEx
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt A6HE24 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTE7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts2  ADAM metallopeptidase with thrombospondin type 1 motif, 2  Adamts2  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Adamts2  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2  RGD1565950_predicted  similar to A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565950_predicted  similar to A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 (predicted)  LOC287899  similar to A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC287899  similar to A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2      Symbol and Name status set to provisional 70820 PROVISIONAL