Vav3 (vav guanine nucleotide exchange factor 3) - Rat Genome Database

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Gene: Vav3 (vav guanine nucleotide exchange factor 3) Rattus norvegicus
Analyze
Symbol: Vav3
Name: vav guanine nucleotide exchange factor 3
RGD ID: 1565941
Description: Predicted to enable epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and regulation of cell size. Predicted to act upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in immunological synapse. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; Fc epsilon receptor mediated signaling pathway; B cell receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanine nucleotide exchange factor VAV3; LOC295378; RGD1565941; similar to Vav 3 oncogene; vav 3 guanine nucleotide exchange factor; vav 3 oncogene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82199,699,861 - 200,042,344 (+)NCBIGRCr8
mRatBN7.22197,011,901 - 197,354,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2204,649,909 - 204,985,041 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02202,536,978 - 202,872,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02197,354,079 - 197,689,388 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02212,247,061 - 212,585,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2212,247,451 - 212,585,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02231,716,228 - 232,053,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42204,982,222 - 205,326,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2189,650,820 - 189,990,562 (+)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
fipronil  (EXP)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
leflunomide  (ISO)
luteolin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8990121   PMID:15249579   PMID:15708849   PMID:15728722   PMID:17875758   PMID:19969623   PMID:21178006   PMID:22467863   PMID:23376485   PMID:37591108  


Genomics

Comparative Map Data
Vav3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82199,699,861 - 200,042,344 (+)NCBIGRCr8
mRatBN7.22197,011,901 - 197,354,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2204,649,909 - 204,985,041 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02202,536,978 - 202,872,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02197,354,079 - 197,689,388 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02212,247,061 - 212,585,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2212,247,451 - 212,585,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02231,716,228 - 232,053,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42204,982,222 - 205,326,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2189,650,820 - 189,990,562 (+)NCBICelera
Cytogenetic Map2q41NCBI
VAV3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381107,571,161 - 107,965,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1107,571,161 - 107,965,180 (-)EnsemblGRCh38hg38GRCh38
GRCh371108,113,783 - 108,507,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361107,915,305 - 108,309,068 (-)NCBINCBI36Build 36hg18NCBI36
Build 341107,825,831 - 108,219,580NCBI
Celera1106,288,518 - 106,682,258 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1106,059,691 - 106,453,322 (-)NCBIHuRef
CHM1_11108,228,649 - 108,622,362 (-)NCBICHM1_1
T2T-CHM13v2.01107,608,692 - 108,002,653 (-)NCBIT2T-CHM13v2.0
Vav3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393109,247,757 - 109,593,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3109,247,969 - 109,593,014 (+)EnsemblGRCm39 Ensembl
GRCm383109,340,465 - 109,685,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3109,340,653 - 109,685,698 (+)EnsemblGRCm38mm10GRCm38
MGSCv373109,143,601 - 109,488,612 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363109,468,739 - 109,813,750 (+)NCBIMGSCv36mm8
Celera3111,676,271 - 112,018,586 (+)NCBICelera
Cytogenetic Map3F3NCBI
cM Map348.13NCBI
Vav3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543511,326,910 - 11,599,043 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543511,326,910 - 11,599,043 (-)NCBIChiLan1.0ChiLan1.0
VAV3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21119,178,596 - 119,579,566 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11118,341,662 - 118,742,435 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,101,651 - 110,531,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11109,216,867 - 109,617,658 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1109,210,813 - 109,617,658 (-)Ensemblpanpan1.1panPan2
VAV3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1643,663,787 - 44,002,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl643,559,985 - 44,000,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha646,430,623 - 46,782,296 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0643,923,858 - 44,276,352 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl643,923,610 - 44,276,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1643,658,033 - 44,009,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0643,628,551 - 43,981,239 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0644,059,178 - 44,411,293 (+)NCBIUU_Cfam_GSD_1.0
Vav3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058116,810,838 - 117,160,637 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936731417,322 - 767,429 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936731417,610 - 767,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAV3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4111,824,896 - 112,202,825 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14111,825,071 - 112,202,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24122,945,014 - 122,967,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VAV3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12025,631,104 - 26,023,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2025,631,171 - 26,023,849 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603832,217,599 - 32,613,494 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vav3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247723,604,165 - 4,022,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247723,604,553 - 4,022,986 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vav3
2060 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:172
Interacting mature miRNAs:233
Transcripts:ENSRNOT00000027813
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat

Markers in Region
AI145306  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22197,353,911 - 197,354,092 (+)MAPPERmRatBN7.2
Rnor_6.02212,585,409 - 212,585,589NCBIRnor6.0
Rnor_5.02232,053,556 - 232,053,736UniSTSRnor5.0
RGSC_v3.42205,326,096 - 205,326,276UniSTSRGSC3.4
Celera2189,990,153 - 189,990,333UniSTS
RH 3.4 Map21418.01UniSTS
Cytogenetic Map2q34-q41UniSTS
BF403608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22197,273,440 - 197,273,561 (+)MAPPERmRatBN7.2
Rnor_6.02212,504,940 - 212,505,060NCBIRnor6.0
Rnor_5.02231,973,087 - 231,973,207UniSTSRnor5.0
RGSC_v3.42205,245,636 - 205,245,756UniSTSRGSC3.4
Celera2189,909,872 - 189,909,992UniSTS
RH 3.4 Map21417.71UniSTS
Cytogenetic Map2q34-q41UniSTS
AU048068  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22197,057,882 - 197,058,211 (+)MAPPERmRatBN7.2
mRatBN7.26112,690,410 - 112,690,443 (+)MAPPERmRatBN7.2
Rnor_6.02212,292,139 - 212,292,467NCBIRnor6.0
Rnor_6.02212,292,139 - 212,292,729NCBIRnor6.0
Rnor_5.02231,760,456 - 231,761,046UniSTSRnor5.0
Rnor_5.02231,760,456 - 231,760,784UniSTSRnor5.0
RGSC_v3.42205,027,960 - 205,028,288UniSTSRGSC3.4
Celera2189,695,853 - 189,696,159UniSTS
Cytogenetic Map2q34-q41UniSTS
AI102699  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22197,336,060 - 197,336,253 (+)MAPPERmRatBN7.2
Rnor_6.02212,567,562 - 212,567,754NCBIRnor6.0
Rnor_5.02232,035,709 - 232,035,901UniSTSRnor5.0
RGSC_v3.42205,308,248 - 205,308,440UniSTSRGSC3.4
Celera2189,972,481 - 189,972,673UniSTS
RH 3.4 Map21418.01UniSTS
Cytogenetic Map2q34-q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 8 19 40 33 9 11
Low 2 43 49 41 41 8 10 34 2 27 8
Below cutoff 1 5

Sequence


RefSeq Acc Id: ENSRNOT00000027813   ⟹   ENSRNOP00000027813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2197,012,735 - 197,354,321 (+)Ensembl
Rnor_6.0 Ensembl2212,247,451 - 212,585,818 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077883   ⟹   ENSRNOP00000073138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2197,091,794 - 197,354,321 (+)Ensembl
Rnor_6.0 Ensembl2212,257,225 - 212,585,818 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098387   ⟹   ENSRNOP00000080097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106503   ⟹   ENSRNOP00000088576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)Ensembl
RefSeq Acc Id: NM_001191714   ⟹   NP_001178643
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82199,700,778 - 200,042,344 (+)NCBI
mRatBN7.22197,012,735 - 197,354,321 (+)NCBI
Rnor_6.02212,247,451 - 212,585,818 (+)NCBI
Rnor_5.02231,716,228 - 232,053,965 (+)NCBI
Celera2189,650,820 - 189,990,562 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590775   ⟹   XP_017446264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82199,699,861 - 200,042,344 (+)NCBI
mRatBN7.22197,011,901 - 197,354,321 (+)NCBI
Rnor_6.02212,247,061 - 212,585,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281659   ⟹   XP_063137729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82199,699,861 - 200,014,574 (+)NCBI
RefSeq Acc Id: NP_001178643   ⟸   NM_001191714
- UniProtKB: A0A8I5ZPB5 (UniProtKB/TrEMBL),   A0A8I6A8C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446264   ⟸   XM_017590775
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073138   ⟸   ENSRNOT00000077883
RefSeq Acc Id: ENSRNOP00000027813   ⟸   ENSRNOT00000027813
RefSeq Acc Id: ENSRNOP00000088576   ⟸   ENSRNOT00000106503
RefSeq Acc Id: ENSRNOP00000080097   ⟸   ENSRNOT00000098387
RefSeq Acc Id: XP_063137729   ⟸   XM_063281659
- Peptide Label: isoform X2
Protein Domains
Calponin-homology (CH)   DH   PH   Phorbol-ester/DAG-type   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWB1-F1-model_v2 AlphaFold F1LWB1 1-847 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565941 AgrOrtholog
BioCyc Gene G2FUF-51577 BioCyc
Ensembl Genes ENSRNOG00000020485 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027813.7 UniProtKB/TrEMBL
  ENSRNOT00000077883.2 UniProtKB/TrEMBL
  ENSRNOT00000098387 ENTREZGENE
  ENSRNOT00000098387.1 UniProtKB/TrEMBL
  ENSRNOT00000106503.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Calponin-like_dom_sf UniProtKB/TrEMBL
  CAMSAP_CH UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  PH_Vav UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SM22_calponin UniProtKB/TrEMBL
  VAV3_SH2 UniProtKB/TrEMBL
  VAV3_SH3_1 UniProtKB/TrEMBL
  VAV3_SH3_2 UniProtKB/TrEMBL
KEGG Report rno:295378 UniProtKB/TrEMBL
NCBI Gene 295378 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3 UniProtKB/TrEMBL
  PROTEIN VAV UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  CAMSAP_CH UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Vav3 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  SM22CALPONIN UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  FILAMIN_REPEAT UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020485 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2K4R0_RAT UniProtKB/TrEMBL
  A0A8I5ZPB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8C8 ENTREZGENE, UniProtKB/TrEMBL
  A6HV41_RAT UniProtKB/TrEMBL
  F1LWB1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Vav3  vav guanine nucleotide exchange factor 3  Vav3  vav 3 guanine nucleotide exchange factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Vav3  vav 3 guanine nucleotide exchange factor  Vav3  vav 3 oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Vav3  vav 3 oncogene  RGD1565941_predicted  similar to Vav 3 oncogene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565941_predicted  similar to Vav 3 oncogene (predicted)  LOC295378  similar to Vav 3 oncogene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC295378  similar to Vav 3 oncogene      Symbol and Name status set to provisional 70820 PROVISIONAL