Gpr143 (G protein-coupled receptor 143) - Rat Genome Database

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Gene: Gpr143 (G protein-coupled receptor 143) Rattus norvegicus
Analyze
Symbol: Gpr143
Name: G protein-coupled receptor 143
RGD ID: 1565799
Description: Predicted to enable L-DOPA receptor activity; carboxylic acid binding activity; and dopamine binding activity. Predicted to be involved in several processes, including melanosome organization; melanosome transport; and regulation of melanosome organization. Predicted to be located in several cellular components, including apical plasma membrane; lysosomal membrane; and melanosome. Predicted to be active in melanosome membrane and plasma membrane. Human ortholog(s) of this gene implicated in congenital nystagmus 6 and ocular albinism 1. Orthologous to human GPR143 (G protein-coupled receptor 143); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G-protein coupled receptor 143; LOC302619; RGD1565799; similar to Oa1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X25,498,601 - 25,523,408 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX25,498,601 - 25,523,400 (+)EnsemblGRCr8
mRatBN7.2X22,002,914 - 22,027,720 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX22,002,914 - 22,027,715 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX22,908,314 - 22,933,122 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X26,329,287 - 26,354,095 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X22,584,854 - 22,609,647 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X23,668,363 - 23,693,162 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX23,668,363 - 23,693,162 (+)Ensemblrn6Rnor6.0
Rnor_5.0X24,084,931 - 24,109,730 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X42,481,440 - 42,506,239 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX22,403,114 - 22,427,887 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10471510   PMID:16524428   PMID:16621890   PMID:18697795   PMID:18828673   PMID:19717472   PMID:24117106   PMID:25108060   PMID:35063136  


Genomics

Comparative Map Data
Gpr143
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X25,498,601 - 25,523,408 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX25,498,601 - 25,523,400 (+)EnsemblGRCr8
mRatBN7.2X22,002,914 - 22,027,720 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX22,002,914 - 22,027,715 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX22,908,314 - 22,933,122 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X26,329,287 - 26,354,095 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X22,584,854 - 22,609,647 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X23,668,363 - 23,693,162 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX23,668,363 - 23,693,162 (+)Ensemblrn6Rnor6.0
Rnor_5.0X24,084,931 - 24,109,730 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X42,481,440 - 42,506,239 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX22,403,114 - 22,427,887 (+)NCBICelera
Cytogenetic MapXq13NCBI
GPR143
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X9,725,346 - 9,778,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX9,725,346 - 9,786,297 (-)Ensemblhg38GRCh38
GRCh37X9,693,386 - 9,733,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X9,653,454 - 9,693,917 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X9,503,189 - 9,543,653NCBI
CeleraX13,865,374 - 13,905,925 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX7,525,733 - 7,566,160 (-)NCBIHuRef
CHM1_1X9,723,929 - 9,764,313 (-)NCBICHM1_1
T2T-CHM13v2.0X9,307,982 - 9,361,208 (-)NCBIT2T-CHM13v2.0
Gpr143
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,564,917 - 151,591,647 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,564,917 - 151,591,642 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X152,781,921 - 152,808,651 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,781,921 - 152,808,646 (+)Ensemblmm10GRCm38
MGSCv37X149,216,464 - 149,243,189 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X148,122,702 - 148,149,362 (+)NCBIMGSCv36mm8
CeleraX136,442,756 - 136,469,491 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Gpr143
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554997,909,019 - 7,928,431 (-)Ensembl
ChiLan1.0NW_0049554997,900,276 - 7,953,847 (-)NCBIChiLan1.0ChiLan1.0
GPR143
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X11,528,918 - 11,569,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X11,532,585 - 11,573,122 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X2,357,835 - 2,398,389 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X9,609,597 - 9,650,069 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX9,609,598 - 9,650,075 (-)EnsemblpanPan2panpan1.1
GPR143
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X6,438,068 - 6,479,731 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX6,437,660 - 6,474,447 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX6,385,711 - 6,433,423 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X6,374,640 - 6,424,234 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX6,357,768 - 6,445,621 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X6,367,596 - 6,415,264 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X6,402,457 - 6,450,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X6,395,377 - 6,440,848 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpr143
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049534,141,453 - 4,180,471 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936644196,263 - 235,305 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936644196,344 - 236,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR143
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X6,242,296 - 6,276,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1Y4,669,764 - 4,704,304 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X6,541,506 - 6,575,924 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR143
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X8,178,818 - 8,223,291 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX8,179,154 - 8,222,603 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660569,855,363 - 9,896,337 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr143
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248347,295,069 - 7,308,920 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248347,281,962 - 7,329,484 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr143
49 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:53
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000004758
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
RH134759  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X22,027,470 - 22,027,688 (+)MAPPERmRatBN7.2
Rnor_6.0X23,692,918 - 23,693,135NCBIRnor6.0
Rnor_5.0X24,109,486 - 24,109,703UniSTSRnor5.0
RGSC_v3.4X42,505,995 - 42,506,212UniSTSRGSC3.4
CeleraX22,427,643 - 22,427,860UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 31 124 54 53 27 12 27 5 170 60 2 105 73 79 26 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000004758   ⟹   ENSRNOP00000004758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX25,498,601 - 25,523,400 (+)Ensembl
mRatBN7.2 EnsemblX22,002,914 - 22,027,715 (+)Ensembl
Rnor_6.0 EnsemblX23,668,363 - 23,693,162 (+)Ensembl
RefSeq Acc Id: NM_001106958   ⟹   NP_001100428
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X25,498,601 - 25,523,400 (+)NCBI
mRatBN7.2X22,002,914 - 22,027,715 (+)NCBI
Rnor_6.0X23,668,363 - 23,693,162 (+)NCBI
Rnor_5.0X24,084,931 - 24,109,730 (+)NCBI
RGSC_v3.4X42,481,440 - 42,506,239 (+)RGD
CeleraX22,403,114 - 22,427,887 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099643   ⟹   XP_038955571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X25,498,861 - 25,523,408 (+)NCBI
mRatBN7.2X22,003,093 - 22,027,720 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100428 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955571 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90600 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004758
  ENSRNOP00000004758.4
RefSeq Acc Id: NP_001100428   ⟸   NM_001106958
- UniProtKB: D4A082 (UniProtKB/TrEMBL),   A6K2D0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004758   ⟸   ENSRNOT00000004758
RefSeq Acc Id: XP_038955571   ⟸   XM_039099643
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A082-F1-model_v2 AlphaFold D4A082 1-405 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565799 AgrOrtholog
BioCyc Gene G2FUF-2706 BioCyc
Ensembl Genes ENSRNOG00000003543 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004758 ENTREZGENE
  ENSRNOT00000004758.6 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Ocular_alb1 UniProtKB/TrEMBL
KEGG Report rno:302619 UniProtKB/TrEMBL
NCBI Gene 302619 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 143 UniProtKB/TrEMBL
  PTHR15177 UniProtKB/TrEMBL
Pfam Ocular_alb UniProtKB/TrEMBL
PhenoGen Gpr143 PhenoGen
PRINTS OCULARALBNSM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003543 RatGTEx
UniProt A6K2D0 ENTREZGENE, UniProtKB/TrEMBL
  D4A082 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Gpr143  G protein-coupled receptor 143   Gpr143_predicted  G protein-coupled receptor 143 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Gpr143_predicted  G protein-coupled receptor 143 (predicted)  RGD1565799_predicted  similar to Oa1 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1565799_predicted  similar to Oa1 (predicted)  LOC302619  similar to Oa1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302619  similar to Oa1      Symbol and Name status set to provisional 70820 PROVISIONAL