Frmpd2 (FERM and PDZ domain containing 2) - Rat Genome Database

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Gene: Frmpd2 (FERM and PDZ domain containing 2) Rattus norvegicus
Analyze
Symbol: Frmpd2
Name: FERM and PDZ domain containing 2
RGD ID: 1565652
Description: Predicted to enable 1-phosphatidylinositol binding activity. Predicted to be involved in bicellular tight junction assembly. Predicted to be located in basolateral plasma membrane and bicellular tight junction. Orthologous to human FRMPD2 (FERM and PDZ domain containing 2); INTERACTS WITH Cuprizon; methoxychlor; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07024637.1; FERM and PDZ domain-containing protein 2; LOC100910975; LOC108353074; LOC498583; RGD1565652; similar to FERM and PDZ domain containing 2; uncharacterized LOC100910975; uncharacterized LOC108353074
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,763,889 - 8,883,558 (+)NCBIGRCr8
mRatBN7.2168,757,642 - 8,877,307 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,757,705 - 8,877,303 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0169,745,171 - 9,879,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,772,688 - 9,847,444 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01611,793,571 - 11,832,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01611,698,696 - 11,750,655 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,068,307 - 9,141,670 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera166,330,578 - 6,450,050 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19706687  


Genomics

Comparative Map Data
Frmpd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,763,889 - 8,883,558 (+)NCBIGRCr8
mRatBN7.2168,757,642 - 8,877,307 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,757,705 - 8,877,303 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0169,745,171 - 9,879,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,772,688 - 9,847,444 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01611,793,571 - 11,832,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01611,698,696 - 11,750,655 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,068,307 - 9,141,670 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera166,330,578 - 6,450,050 (-)NCBICelera
Cytogenetic Map16p16NCBI
FRMPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381048,156,559 - 48,274,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1048,153,088 - 48,274,696 (-)EnsemblGRCh38hg38GRCh38
GRCh371049,364,602 - 49,482,739 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,034,611 - 49,152,723 (-)NCBINCBI36Build 36hg18NCBI36
Build 341049,034,607 - 49,129,806NCBI
Celera1042,962,487 - 43,068,811 (-)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1043,635,981 - 43,747,566 (-)NCBIHuRef
HuRef1043,629,288 - 43,630,117 (-)NCBIHuRef
CHM1_11049,646,437 - 49,764,818 (-)NCBICHM1_1
T2T-CHM13v2.01048,998,450 - 49,123,638 (-)NCBIT2T-CHM13v2.0
Frmpd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,193,475 - 33,297,226 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,193,653 - 33,297,226 (+)EnsemblGRCm39 Ensembl
GRCm381433,483,501 - 33,575,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,471,696 - 33,575,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv371434,284,882 - 34,384,044 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,300,788 - 32,404,360 (+)NCBIMGSCv36mm8
Celera1429,752,836 - 29,825,439 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.46NCBI
Frmpd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,732,134 - 1,837,060 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,732,140 - 1,847,956 (+)NCBIChiLan1.0ChiLan1.0
FRMPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2860,415,130 - 60,542,431 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11060,423,765 - 60,547,732 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,968,125 - 46,094,690 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FRMPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128196,839 - 309,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28421,044 - 539,662 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028365,830 - 485,905 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.128172,901 - 285,653 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028214,130 - 326,655 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028300,201 - 420,038 (-)NCBIUU_Cfam_GSD_1.0
Frmpd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,716,359 - 80,851,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,919,128 - 2,050,930 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,919,161 - 2,053,794 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRMPD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,864,884 - 88,966,188 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,847,972 - 88,966,206 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,575,803 - 96,625,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FRMPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1943,520,355 - 43,650,045 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl943,544,323 - 43,644,831 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660483,290,194 - 3,421,723 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Frmpd2
1095 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000048001   ⟹   ENSRNOP00000048385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,757,705 - 8,877,303 (+)Ensembl
RefSeq Acc Id: XM_039094910   ⟹   XP_038950838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,763,889 - 8,883,558 (+)NCBI
mRatBN7.2168,757,642 - 8,877,307 (+)NCBI
RefSeq Acc Id: XM_039094911   ⟹   XP_038950839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,763,889 - 8,883,558 (+)NCBI
mRatBN7.2168,757,642 - 8,877,307 (+)NCBI
RefSeq Acc Id: XM_039094912   ⟹   XP_038950840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,825,797 - 8,883,558 (+)NCBI
mRatBN7.2168,819,880 - 8,877,307 (+)NCBI
RefSeq Acc Id: XM_063275920   ⟹   XP_063131990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,826,665 - 8,883,558 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038950838 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950839 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950840 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131990 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048385
  ENSRNOP00000048385.6
RefSeq Acc Id: XP_038950838   ⟸   XM_039094910
- Peptide Label: isoform X1
- UniProtKB: F1LVM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950839   ⟸   XM_039094911
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950840   ⟸   XM_039094912
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000048385   ⟸   ENSRNOT00000048001
RefSeq Acc Id: XP_063131990   ⟸   XM_063275920
- Peptide Label: isoform X3
Protein Domains
FERM   KIND   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVM9-F1-model_v2 AlphaFold F1LVM9 1-623 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565652 AgrOrtholog
BioCyc Gene G2FUF-12091 BioCyc
Ensembl Genes ENSRNOG00000029131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048001.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  KIND_dom UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene 498583 ENTREZGENE
PANTHER NON-SPECIFIC PROTEIN-TYROSINE KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13 UniProtKB/TrEMBL
Pfam FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PhenoGen Frmpd2 PhenoGen
PRINTS BAND41 UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  KIND UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029131 RatGTEx
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  KIND UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt F1LVM9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Frmpd2  FERM and PDZ domain containing 2  AABR07024637.1    Data merged from RGD:15003728 737654 PROVISIONAL
2021-03-09 Frmpd2  FERM and PDZ domain containing 2  LOC108353074  uncharacterized LOC108353074  Data merged from RGD:11421049 737654 PROVISIONAL
2019-11-08 AABR07024637.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-08-02 LOC108353074  uncharacterized LOC108353074      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-07-29 Frmpd2  FERM and PDZ domain containing 2  LOC100910975  uncharacterized LOC100910975  Data merged from RGD:6495585 737654 PROVISIONAL
2014-07-28 Frmpd2  FERM and PDZ domain containing 2  RGD1565652  similar to FERM and PDZ domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910975  uncharacterized LOC100910975      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1565652  similar to FERM and PDZ domain containing 2   RGD1565652_predicted  similar to FERM and PDZ domain containing 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565652_predicted  similar to FERM and PDZ domain containing 2 (predicted)  LOC498583  similar to FERM and PDZ domain containing 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498583  similar to FERM and PDZ domain containing 2      Symbol and Name status set to provisional 70820 PROVISIONAL