Mt4 (metallothionein 4) - Rat Genome Database

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Gene: Mt4 (metallothionein 4) Rattus norvegicus
Analyze
Symbol: Mt4
Name: metallothionein 4
RGD ID: 1565500
Description: Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cellular response to zinc ion; detoxification of copper ion; and intracellular zinc ion homeostasis. Predicted to act upstream of or within intracellular monoatomic cation homeostasis. Predicted to be active in cytoplasm and nucleus. Orthologous to human MT4 (metallothionein 4); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498911; metallothionein-4; RGD1565500
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,869,735 - 10,871,831 (-)NCBIGRCr8
mRatBN7.21910,863,813 - 10,865,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,863,813 - 10,865,909 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,831,713 - 10,833,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,598,567 - 11,600,658 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,885,565 - 10,887,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,339,767 - 11,341,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,339,767 - 11,341,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,315,073 - 11,317,169 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,300,057 - 11,302,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1910,749,778 - 10,751,874 (-)NCBICelera
Cytogenetic Map19p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function
metal ion binding  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15033980  


Genomics

Comparative Map Data
Mt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,869,735 - 10,871,831 (-)NCBIGRCr8
mRatBN7.21910,863,813 - 10,865,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,863,813 - 10,865,909 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,831,713 - 10,833,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,598,567 - 11,600,658 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,885,565 - 10,887,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,339,767 - 11,341,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,339,767 - 11,341,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,315,073 - 11,317,169 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,300,057 - 11,302,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1910,749,778 - 10,751,874 (-)NCBICelera
Cytogenetic Map19p12NCBI
MT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,565,073 - 56,568,957 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,565,073 - 56,568,957 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,598,985 - 56,602,869 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,156,462 - 55,160,370 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,156,541 - 55,160,345NCBI
Celera1641,096,796 - 41,100,689 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,469,024 - 42,472,836 (+)NCBIHuRef
CHM1_11658,005,846 - 58,009,677 (+)NCBICHM1_1
T2T-CHM13v2.01662,359,992 - 62,363,895 (+)NCBIT2T-CHM13v2.0
Mt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,863,832 - 94,865,659 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,863,825 - 94,865,659 (+)EnsemblGRCm39 Ensembl
GRCm38894,137,204 - 94,139,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,137,197 - 94,139,031 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,661,104 - 96,662,931 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,026,371 - 97,027,996 (+)NCBIMGSCv36mm8
Celera898,468,827 - 98,470,654 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.26NCBI
MT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,042,237 - 66,051,433 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,961,794 - 71,970,293 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,848,200 - 36,855,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11655,984,536 - 55,988,258 (+)NCBIpanpan1.1PanPan1.1panPan2
MT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,640,784 - 59,643,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,640,784 - 59,643,370 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,274,439 - 56,277,025 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,185,523 - 60,194,231 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,185,523 - 60,188,111 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,016,133 - 57,018,721 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,025,028 - 58,027,614 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,917,965 - 58,920,560 (-)NCBIUU_Cfam_GSD_1.0
Mt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,743,969 - 50,785,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,809,813 - 8,845,137 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,842,863 - 8,845,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,610,820 - 18,614,782 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,611,245 - 18,613,956 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Mt4
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:95
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000025694
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 7 57 19 24 4 8 4 4 31 10 51 3 23 20

Sequence


Ensembl Acc Id: ENSRNOT00000025694   ⟹   ENSRNOP00000025694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,863,813 - 10,865,909 (-)Ensembl
Rnor_6.0 Ensembl1911,339,767 - 11,341,863 (-)Ensembl
RefSeq Acc Id: NM_001126084   ⟹   NP_001119556
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,869,735 - 10,871,831 (-)NCBI
mRatBN7.21910,863,813 - 10,865,909 (-)NCBI
Rnor_6.01911,339,767 - 11,341,863 (-)NCBI
Rnor_5.01911,315,073 - 11,317,169 (-)NCBI
RGSC_v3.41911,300,057 - 11,302,153 (-)RGD
Celera1910,749,778 - 10,751,874 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001119556 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87353 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025694.3
RefSeq Acc Id: NP_001119556   ⟸   NM_001126084
- UniProtKB: D3ZTJ2 (UniProtKB/TrEMBL),   A6JY75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025694   ⟸   ENSRNOT00000025694

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTJ2-F1-model_v2 AlphaFold D3ZTJ2 1-62 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700952
Promoter ID:EPDNEW_R11476
Type:single initiation site
Name:Mt4_1
Description:metallothionein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,341,867 - 11,341,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565500 AgrOrtholog
BioCyc Gene G2FUF-6474 BioCyc
Ensembl Genes ENSRNOG00000019004 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025694.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.10.10 UniProtKB/TrEMBL
InterPro Metallothionein_dom_vert UniProtKB/TrEMBL
  Metallothionein_sfam UniProtKB/TrEMBL
  Metallothionein_vert UniProtKB/TrEMBL
  Metallothionein_vert_metal_BS UniProtKB/TrEMBL
KEGG Report rno:498911 UniProtKB/TrEMBL
NCBI Gene 498911 ENTREZGENE
PANTHER METALLOTHIONEIN-4 UniProtKB/TrEMBL
  Metallothionein_vert UniProtKB/TrEMBL
Pfam Metallothio UniProtKB/TrEMBL
PhenoGen Mt4 PhenoGen
PRINTS MTVERTEBRATE UniProtKB/TrEMBL
PROSITE METALLOTHIONEIN_VRT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019004 RatGTEx
Superfamily-SCOP Metallothionein_sfam UniProtKB/TrEMBL
UniProt A6JY75 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTJ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Mt4  metallothionein 4  RGD1565500_predicted  RGD1565500 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565500_predicted  RGD1565500 (predicted)  LOC498911  LOC498911  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498911  LOC498911      Symbol and Name status set to provisional 70820 PROVISIONAL