Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tln2 | Rat | 1,1-dichloroethene | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of TLN2 mRNA | CTD | PMID:26682919 | Tln2 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Tln2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of TLN2 mRNA | CTD | PMID:22206623 | Tln2 | Rat | 17beta-estradiol | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of TLN2 mRNA | CTD | PMID:20404318 | Tln2 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of TLN2 mRNA | CTD | PMID:32741896 | Tln2 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of TLN2 mRNA | CTD | PMID:32741896 | Tln2 | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Tln2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Tln2 | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Tln2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Tln2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TLN2 mRNA | CTD | PMID:32109520 and PMID:33387578 | Tln2 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Tln2 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Tln2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Tln2 | Rat | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of TLN2 mRNA | CTD | PMID:21061450 | Tln2 | Rat | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in increased expression of TLN2 protein | CTD | PMID:31675489 | Tln2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of TLN2 protein | CTD | PMID:34186270 | Tln2 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of TLN2 mRNA | CTD | PMID:28973697 | Tln2 | Rat | 7,12-dimethyltetraphene | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | 9 more ... | CTD | PMID:32553695 | Tln2 | Rat | acrolein | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of TLN2 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Tln2 | Rat | aflatoxin B1 | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of TLN2 mRNA | CTD | PMID:21641981 | Tln2 | Rat | aflatoxin B1 | increases methylation | ISO | TLN2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TLN2 gene and Aflatoxin B1 results in increased methylation of TLN2 intron | CTD | PMID:27153756 and PMID:30157460 | Tln2 | Rat | all-trans-retinoic acid | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TLN2 mRNA | CTD | PMID:23724009 | Tln2 | Rat | alpha-pinene | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of TLN2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of TLN2 mRNA | CTD | PMID:32699268 | Tln2 | Rat | Aroclor 1254 | increases expression | ISO | Tln2 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of TLN2 mRNA | CTD | PMID:23650126 | Tln2 | Rat | arsenic trichloride | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | arsenic trichloride results in increased expression of TLN2 mRNA and arsenic trichloride results in increased expression of TLN2 protein | CTD | PMID:21750348 | Tln2 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of TLN2 gene | CTD | PMID:28931070 and PMID:35440735 | Tln2 | Rat | benzatropine | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Benztropine results in decreased expression of TLN2 protein | CTD | PMID:34122009 | Tln2 | Rat | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of TLN2 mRNA | CTD | PMID:21839799 | Tln2 | Rat | benzo[a]pyrene | affects methylation | ISO | TLN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TLN2 3' UTR and Benzo(a)pyrene affects the methylation of TLN2 intron | CTD | PMID:27901495 and PMID:30157460 | Tln2 | Rat | benzo[a]pyrene | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TLN2 mRNA | CTD | PMID:20064835 more ... | Tln2 | Rat | benzo[a]pyrene | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of TLN2 mRNA | CTD | PMID:19770486 more ... | Tln2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | Tln2 | Rat | benzo[e]pyrene | increases methylation | ISO | TLN2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of TLN2 intron | CTD | PMID:30157460 | Tln2 | Rat | Benzo[k]fluoranthene | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | benzo(k)fluoranthene results in decreased expression of TLN2 mRNA | CTD | PMID:21635667 | Tln2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TLN2 mRNA | CTD | PMID:25181051 | Tln2 | Rat | bisphenol A | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of TLN2 protein | CTD | PMID:37567409 | Tln2 | Rat | bisphenol A | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of TLN2 gene | CTD | PMID:31601247 | Tln2 | Rat | bisphenol A | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of TLN2 protein | CTD | PMID:31675489 | Tln2 | Rat | bisphenol A | affects methylation | ISO | TLN2 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of TLN2 gene | CTD | PMID:31601247 | Tln2 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of TLN2 mRNA | CTD | PMID:30816183 | Tln2 | Rat | Bisphenol B | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of TLN2 protein | CTD | PMID:34186270 | Tln2 | Rat | caffeine | decreases phosphorylation | ISO | TLN2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of TLN2 protein | CTD | PMID:35688186 | Tln2 | Rat | cannabidiol | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Cannabidiol results in decreased expression of TLN2 protein | CTD | PMID:34122009 | Tln2 | Rat | carbon nanotube | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Tln2 | Rat | CGP 52608 | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TLN2 gene] | CTD | PMID:28238834 | Tln2 | Rat | chlordecone | increases expression | ISO | Tln2 (Mus musculus) | 6480464 | Chlordecone results in increased expression of TLN2 mRNA | CTD | PMID:33711761 | Tln2 | Rat | chlorpyrifos | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of TLN2 mRNA | CTD | PMID:37019170 | Tln2 | Rat | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of TLN2 mRNA | CTD | PMID:22023808 | Tln2 | Rat | cisplatin | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of TLN2 mRNA | CTD | PMID:27392435 | Tln2 | Rat | cisplatin | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of TLN2 mRNA | CTD | PMID:27392435 | Tln2 | Rat | clozapine | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Clozapine results in decreased expression of TLN2 protein | CTD | PMID:34122009 | Tln2 | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of TLN2 mRNA | CTD | PMID:24386269 | Tln2 | Rat | copper(II) sulfate | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of TLN2 mRNA | CTD | PMID:19549813 | Tln2 | Rat | cyclosporin A | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TLN2 mRNA | CTD | PMID:25562108 | Tln2 | Rat | cytarabine | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of TLN2 mRNA | CTD | PMID:21198554 | Tln2 | Rat | decabromodiphenyl ether | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of TLN2 protein | CTD | PMID:31675489 | Tln2 | Rat | dicrotophos | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of TLN2 mRNA | CTD | PMID:28302478 | Tln2 | Rat | dorsomorphin | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLN2 mRNA | CTD | PMID:27188386 | Tln2 | Rat | doxorubicin | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of TLN2 mRNA | CTD | PMID:29803840 | Tln2 | Rat | ethanol | multiple interactions | ISO | Tln2 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of TLN2 mRNA | CTD | PMID:30319688 | Tln2 | Rat | folic acid | increases expression | ISO | Tln2 (Mus musculus) | 6480464 | Folic Acid results in increased expression of TLN2 mRNA | CTD | PMID:25629700 | Tln2 | Rat | FR900359 | affects phosphorylation | ISO | TLN2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of TLN2 protein | CTD | PMID:37730182 | Tln2 | Rat | fulvestrant | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of TLN2 gene | CTD | PMID:31601247 | Tln2 | Rat | haloperidol | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Haloperidol results in decreased expression of TLN2 protein | CTD | PMID:34122009 | Tln2 | Rat | Indeno[1,2,3-cd]pyrene | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | indeno(1 more ... | CTD | PMID:21635667 | Tln2 | Rat | ivermectin | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of TLN2 protein | CTD | PMID:32959892 | Tln2 | Rat | lead diacetate | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | lead acetate results in decreased expression of TLN2 mRNA | CTD | PMID:21829687 | Tln2 | Rat | methapyrilene | increases methylation | ISO | TLN2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of TLN2 intron | CTD | PMID:30157460 | Tln2 | Rat | methotrexate | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of TLN2 mRNA | CTD | PMID:21678067 | Tln2 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of TLN2 gene | CTD | PMID:35440735 | Tln2 | Rat | nickel atom | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of TLN2 mRNA | CTD | PMID:25583101 | Tln2 | Rat | nickel sulfate | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of TLN2 mRNA | CTD | PMID:16780908 | Tln2 | Rat | nickel sulfate | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of TLN2 mRNA | CTD | PMID:16780908 | Tln2 | Rat | O-methyleugenol | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of TLN2 mRNA | CTD | PMID:32234424 | Tln2 | Rat | ouabain | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Ouabain results in decreased expression of TLN2 mRNA | CTD | PMID:28795476 | Tln2 | Rat | ozone | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of TLN2 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Tln2 | Rat | ozone | decreases phosphorylation | EXP | | 6480464 | Ozone results in decreased phosphorylation of TLN2 protein | CTD | PMID:33146391 | Tln2 | Rat | paracetamol | affects expression | ISO | Tln2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of TLN2 mRNA | CTD | PMID:17562736 | Tln2 | Rat | paracetamol | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of TLN2 mRNA | CTD | PMID:29067470 | Tln2 | Rat | paracetamol | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TLN2 mRNA | CTD | PMID:26690555 | Tln2 | Rat | PCB138 | multiple interactions | ISO | Tln2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Tln2 | Rat | pirinixic acid | increases expression | ISO | Tln2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of TLN2 mRNA | CTD | PMID:18301758 more ... | Tln2 | Rat | SB 431542 | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLN2 mRNA | CTD | PMID:27188386 | Tln2 | Rat | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of TLN2 protein | CTD | PMID:29459688 | Tln2 | Rat | sodium arsenite | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TLN2 mRNA | CTD | PMID:38568856 | Tln2 | Rat | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of TLN2 mRNA | CTD | PMID:19281266 | Tln2 | Rat | sunitinib | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of TLN2 mRNA | CTD | PMID:31533062 | Tln2 | Rat | testosterone | affects expression | ISO | Tln2 (Mus musculus) | 6480464 | Testosterone affects the expression of TLN2 mRNA | CTD | PMID:20403060 | Tln2 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of TLN2 mRNA | CTD | PMID:32741896 | Tln2 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TLN2 mRNA | CTD | PMID:31150632 | Tln2 | Rat | tetraphene | decreases expression | ISO | TLN2 (Homo sapiens) | 6480464 | benz(a)anthracene results in decreased expression of TLN2 mRNA | CTD | PMID:21635667 | Tln2 | Rat | triptonide | increases expression | ISO | Tln2 (Mus musculus) | 6480464 | triptonide results in increased expression of TLN2 mRNA | CTD | PMID:33045310 | Tln2 | Rat | trovafloxacin | decreases expression | ISO | Tln2 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of TLN2 mRNA | CTD | PMID:35537566 | Tln2 | Rat | valproic acid | increases methylation | ISO | TLN2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of TLN2 gene | CTD | PMID:29154799 | Tln2 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of TLN2 mRNA | CTD | PMID:29427782 | Tln2 | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of TLN2 mRNA | CTD | PMID:29427782 | Tln2 | Rat | valproic acid | multiple interactions | ISO | TLN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLN2 mRNA | CTD | PMID:27188386 | Tln2 | Rat | valproic acid | increases expression | ISO | TLN2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TLN2 mRNA | CTD | PMID:23179753 and PMID:28001369 | Tln2 | Rat | vancomycin | increases expression | ISO | Tln2 (Mus musculus) | 6480464 | Vancomycin results in increased expression of TLN2 mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||
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