Apoo (apolipoprotein O) - Rat Genome Database

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Gene: Apoo (apolipoprotein O) Rattus norvegicus
Analyze
Symbol: Apoo
Name: apolipoprotein O
RGD ID: 1565289
Description: Predicted to be involved in cristae formation. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human APOO (apolipoprotein O); PARTICIPATES IN mitochondrial protein import pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363474; MICOS complex subunit MIC26; RGD1565289; similar to RIKEN cDNA 0610008C08
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X63,151,736 - 63,256,696 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX63,151,814 - 63,256,690 (+)EnsemblGRCr8
mRatBN7.2X59,157,971 - 59,262,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX59,158,049 - 59,262,940 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX60,611,279 - 60,714,042 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X64,112,402 - 64,215,169 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X61,657,121 - 61,768,684 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X63,521,033 - 63,625,134 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX63,520,991 - 63,625,134 (+)Ensemblrn6Rnor6.0
Rnor_5.0X64,430,860 - 64,534,961 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X81,784,706 - 81,889,551 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX59,587,672 - 59,692,328 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Zerbes RM, etal., Biol Chem. 2012 Nov;393(11):1247-61. doi: 10.1515/hsz-2012-0239.
Additional References at PubMed
PMID:20833797   PMID:21700703   PMID:24743151   PMID:25764979   PMID:25781180   PMID:25997101  


Genomics

Comparative Map Data
Apoo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X63,151,736 - 63,256,696 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX63,151,814 - 63,256,690 (+)EnsemblGRCr8
mRatBN7.2X59,157,971 - 59,262,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX59,158,049 - 59,262,940 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX60,611,279 - 60,714,042 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X64,112,402 - 64,215,169 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X61,657,121 - 61,768,684 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X63,521,033 - 63,625,134 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX63,520,991 - 63,625,134 (+)Ensemblrn6Rnor6.0
Rnor_5.0X64,430,860 - 64,534,961 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X81,784,706 - 81,889,551 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX59,587,672 - 59,692,328 (+)NCBICelera
Cytogenetic MapXq22NCBI
APOO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X23,833,353 - 23,907,938 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX23,833,353 - 23,908,070 (-)Ensemblhg38GRCh38
GRCh37X23,851,470 - 23,926,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,761,391 - 23,835,958 (-)NCBIBuild 36Build 36hg18NCBI36
CeleraX27,970,217 - 28,043,546 (-)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX21,597,250 - 21,670,104 (-)NCBIHuRef
CHM1_1X23,882,370 - 23,957,282 (-)NCBICHM1_1
T2T-CHM13v2.0X23,417,034 - 23,491,615 (-)NCBIT2T-CHM13v2.0
Apoo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X93,410,615 - 93,460,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX93,410,723 - 93,460,699 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X94,367,010 - 94,417,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX94,367,117 - 94,417,093 (+)Ensemblmm10GRCm38
MGSCv37X91,612,449 - 91,662,429 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X90,619,873 - 90,669,806 (+)NCBIMGSCv36mm8
CeleraX81,307,125 - 81,343,955 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.56NCBI
Apoo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,255,030 - 4,325,568 (-)Ensembl
ChiLan1.0NW_0049555094,256,834 - 4,325,086 (-)NCBIChiLan1.0ChiLan1.0
APOO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X25,634,548 - 25,708,412 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X25,637,937 - 25,711,738 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X16,432,822 - 16,506,668 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X23,807,998 - 23,879,906 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX23,806,477 - 23,880,518 (-)EnsemblpanPan2panpan1.1
APOO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X19,501,849 - 19,555,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X19,456,861 - 19,510,690 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX19,456,893 - 19,510,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X19,496,013 - 19,549,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X19,529,419 - 19,583,232 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X19,585,588 - 19,639,345 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apoo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X12,401,975 - 12,490,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936624667,297 - 721,464 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936624667,659 - 754,944 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX19,953,158 - 20,017,727 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X19,953,147 - 20,017,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X21,323,359 - 21,366,041 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X22,295,822 - 22,377,670 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX22,295,037 - 22,377,668 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605624,181,041 - 24,254,590 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624897228,049 - 299,069 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624897228,324 - 299,017 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoo
376 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000071590, ENSRNOT00000073955
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X6103585667175160Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
RH133416  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X63,169,115 - 63,169,310 (+)Marker Load Pipeline
mRatBN7.2X59,175,352 - 59,175,547 (+)MAPPERmRatBN7.2
Rnor_6.0X63,538,288 - 63,538,482NCBIRnor6.0
Rnor_5.0X64,448,115 - 64,448,309UniSTSRnor5.0
RGSC_v3.4X81,802,060 - 81,802,254UniSTSRGSC3.4
CeleraX59,604,914 - 59,605,108UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map16q11UniSTS
BE104365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X59,182,749 - 59,182,938 (+)MAPPERmRatBN7.2
Rnor_6.0X63,545,835 - 63,546,023NCBIRnor6.0
Rnor_5.0X64,455,662 - 64,455,850UniSTSRnor5.0
RGSC_v3.4X81,809,457 - 81,809,645UniSTSRGSC3.4
CeleraX59,612,311 - 59,612,499UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071590   ⟹   ENSRNOP00000065539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX63,151,814 - 63,256,690 (+)Ensembl
mRatBN7.2 EnsemblX59,158,049 - 59,262,934 (+)Ensembl
Rnor_6.0 EnsemblX63,520,991 - 63,625,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073955   ⟹   ENSRNOP00000065393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX63,172,875 - 63,235,051 (+)Ensembl
mRatBN7.2 EnsemblX59,178,973 - 59,241,290 (+)Ensembl
Rnor_6.0 EnsemblX63,542,191 - 63,625,128 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098632   ⟹   ENSRNOP00000089406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX63,151,841 - 63,256,690 (+)Ensembl
mRatBN7.2 EnsemblX59,178,785 - 59,262,940 (+)Ensembl
RefSeq Acc Id: NM_001199178   ⟹   NP_001186107
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X63,151,856 - 63,256,696 (+)NCBI
mRatBN7.2X59,158,091 - 59,262,940 (+)NCBI
Rnor_6.0X63,521,033 - 63,625,134 (+)NCBI
Rnor_5.0X64,430,860 - 64,534,961 (+)NCBI
CeleraX59,587,672 - 59,692,328 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099893   ⟹   XP_038955821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X63,151,862 - 63,256,696 (+)NCBI
mRatBN7.2X59,158,060 - 59,262,940 (+)NCBI
RefSeq Acc Id: XM_039099894   ⟹   XP_038955822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X63,151,736 - 63,180,168 (+)NCBI
mRatBN7.2X59,157,971 - 59,183,849 (+)NCBI
RefSeq Acc Id: XM_039099895   ⟹   XP_038955823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X63,151,737 - 63,223,909 (+)NCBI
mRatBN7.2X59,157,972 - 59,230,146 (+)NCBI
RefSeq Acc Id: NP_001186107   ⟸   NM_001199178
- UniProtKB: M0R7V3 (UniProtKB/TrEMBL),   A0A8I6A768 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065393   ⟸   ENSRNOT00000073955
Ensembl Acc Id: ENSRNOP00000065539   ⟸   ENSRNOT00000071590
RefSeq Acc Id: XP_038955822   ⟸   XM_039099894
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955823   ⟸   XM_039099895
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038955821   ⟸   XM_039099893
- Peptide Label: isoform X1
- UniProtKB: A6IQ10 (UniProtKB/TrEMBL),   A0A8I6A768 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089406   ⟸   ENSRNOT00000098632

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7V3-F1-model_v2 AlphaFold M0R7V3 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701841
Promoter ID:EPDNEW_R12365
Type:multiple initiation site
Name:Apoo_1
Description:apolipoprotein O
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X63,521,017 - 63,521,077EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565289 AgrOrtholog
BioCyc Gene G2FUF-2240 BioCyc
Ensembl Genes ENSRNOG00000046918 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071590 ENTREZGENE
  ENSRNOT00000071590.5 UniProtKB/TrEMBL
  ENSRNOT00000073955.5 UniProtKB/TrEMBL
  ENSRNOT00000098632 ENTREZGENE
  ENSRNOT00000098632.2 UniProtKB/TrEMBL
InterPro Apolipoprotein_O UniProtKB/TrEMBL
  MIC26/MIC27_animal UniProtKB/TrEMBL
KEGG Report rno:363474 UniProtKB/TrEMBL
NCBI Gene 363474 ENTREZGENE
PANTHER PTHR14564 UniProtKB/TrEMBL
Pfam ApoO UniProtKB/TrEMBL
PhenoGen Apoo PhenoGen
RatGTEx ENSRNOG00000046918 RatGTEx
UniProt A0A8I6A768 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ10 ENTREZGENE, UniProtKB/TrEMBL
  M0R7G4_RAT UniProtKB/TrEMBL
  M0R7V3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Apoo  apolipoprotein O  RGD1565289  similar to RIKEN cDNA 0610008C08  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565289  similar to RIKEN cDNA 0610008C08   RGD1565289_predicted  similar to RIKEN cDNA 0610008C08 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 RGD1565289_predicted  similar to RIKEN cDNA 0610008C08 (predicted)  LOC683412  hypothetical protein LOC683412  Data merged from RGD:1586878 1643240 APPROVED
2006-11-19 LOC683412  hypothetical protein LOC683412      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1565289_predicted  similar to RIKEN cDNA 0610008C08 (predicted)  LOC363474  similar to RIKEN cDNA 0610008C08  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363474  similar to RIKEN cDNA 0610008C08      Symbol and Name status set to provisional 70820 PROVISIONAL