Scrib (scribble planar cell polarity protein) - Rat Genome Database

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Gene: Scrib (scribble planar cell polarity protein) Rattus norvegicus
Analyze
Symbol: Scrib
Name: scribble planar cell polarity protein
RGD ID: 1565055
Description: Predicted to enable protein kinase binding activity and signaling adaptor activity. Involved in several processes, including astrocyte cell migration; neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of postsynaptic neurotransmitter receptor internalization. Located in cell-cell junction. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Orthologous to human SCRIB (scribble planar cell polarity protein); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362938; LOC362939; protein scribble homolog; RGD1565055; scribbled homolog; scribbled homolog (Drosophila); scribbled planar cell polarity protein; similar to PDZ-domain protein scribble
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,640,034 - 109,663,354 (-)NCBIGRCr8
mRatBN7.27107,759,343 - 107,782,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,759,343 - 107,782,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,499,717 - 109,522,737 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,723,394 - 111,746,414 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,680,128 - 111,703,152 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,105,810 - 117,128,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,105,810 - 117,128,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,091,481 - 117,114,469 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,077,733 - 114,100,721 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,116,077 - 104,138,929 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
apoptotic process involved in morphogenesis  (ISO)
astrocyte cell migration  (IMP)
auditory receptor cell morphogenesis  (ISO)
auditory receptor cell stereocilium organization  (ISO)
cell migration  (IBA,ISO)
cell population proliferation  (ISO)
cell-cell adhesion  (IBA,ISO)
cochlear nucleus development  (ISO)
epithelial structure maintenance  (ISO)
establishment of apical/basal cell polarity  (ISO)
establishment of T cell polarity  (ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (IBA)
inner ear receptor cell stereocilium organization  (ISO)
mammary gland duct morphogenesis  (ISO)
morphogenesis of embryonic epithelium  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of translational initiation  (ISO)
neural tube closure  (ISO)
neurotransmitter receptor transport postsynaptic membrane to endosome  (IBA)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (IBA,IDA,IMP)
polarized epithelial cell differentiation  (ISO)
positive chemotaxis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of type II interferon production  (ISO)
post-anal tail morphogenesis  (ISO)
protein localization  (ISO)
protein localization to adherens junction  (ISO)
receptor clustering  (IBA)
regulation of postsynaptic neurotransmitter receptor internalization  (IDA,IMP)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle targeting  (ISO)
vesicle-mediated transport in synapse  (IDA,IMP)
wound healing  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Planar cell polarity signaling in vertebrates. Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
3. Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration. Osmani N, etal., Curr Biol. 2006 Dec 19;16(24):2395-405. Epub 2006 Nov 2.
4. Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling. Piguel NH, etal., Cell Rep. 2014 Oct 23;9(2):712-27. doi: 10.1016/j.celrep.2014.09.017. Epub 2014 Oct 9.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12499390   PMID:15182672   PMID:15458844   PMID:15649318   PMID:15775968   PMID:16344308   PMID:16611247   PMID:16687519   PMID:16965391   PMID:18329370   PMID:18716323   PMID:19041750  
PMID:19458197   PMID:20215345   PMID:20237282   PMID:20357130   PMID:20363326   PMID:20458337   PMID:20643356   PMID:21515572   PMID:22095531   PMID:22114281   PMID:22333836   PMID:23038739  
PMID:23973368   PMID:25468996   PMID:27380321   PMID:28169360  


Genomics

Comparative Map Data
Scrib
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,640,034 - 109,663,354 (-)NCBIGRCr8
mRatBN7.27107,759,343 - 107,782,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,759,343 - 107,782,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,499,717 - 109,522,737 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,723,394 - 111,746,414 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,680,128 - 111,703,152 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,105,810 - 117,128,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,105,810 - 117,128,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,091,481 - 117,114,469 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,077,733 - 114,100,721 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,116,077 - 104,138,929 (-)NCBICelera
Cytogenetic Map7q34NCBI
SCRIB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,790,925 - 143,815,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,790,920 - 143,815,773 (-)EnsemblGRCh38hg38GRCh38
GRCh378144,873,095 - 144,897,943 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,945,078 - 144,969,537 (-)NCBINCBI36Build 36hg18NCBI36
Celera8141,185,992 - 141,210,452 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,126,075 - 140,150,540 (-)NCBIHuRef
CHM1_18144,913,332 - 144,937,791 (-)NCBICHM1_1
T2T-CHM13v2.08144,947,418 - 144,972,471 (-)NCBIT2T-CHM13v2.0
Scrib
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,919,011 - 75,941,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,919,007 - 75,941,633 (-)EnsemblGRCm39 Ensembl
GRCm381576,047,162 - 76,069,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,047,158 - 76,069,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371575,877,616 - 75,900,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361575,874,441 - 75,896,985 (-)NCBIMGSCv36mm8
Celera1577,548,113 - 77,570,657 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.29NCBI
Scrib
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,461,760 - 2,482,098 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,461,526 - 2,482,734 (-)NCBIChiLan1.0ChiLan1.0
SCRIB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,275,637 - 161,301,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18136,792,596 - 136,819,011 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08140,544,797 - 140,571,078 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18143,557,479 - 143,582,409 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,557,722 - 143,582,353 (-)Ensemblpanpan1.1panPan2
SCRIB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,356,405 - 37,374,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,356,405 - 37,374,681 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,312,750 - 37,331,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,828,183 - 37,846,535 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,828,186 - 37,846,509 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,502,286 - 37,520,617 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,619,233 - 37,637,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,100,565 - 38,118,912 (-)NCBIUU_Cfam_GSD_1.0
Scrib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303923,076 - 943,996 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364708,349,188 - 8,369,864 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364708,349,175 - 8,370,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCRIB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4825,062 - 852,664 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14824,925 - 852,360 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SCRIB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,008,722 - 138,033,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,008,579 - 138,033,843 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,843,884 - 1,869,060 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scrib
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,997,408 - 13,018,533 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,997,358 - 13,018,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scrib
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000045280
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH141209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27107,782,970 - 107,783,185 (+)MAPPERmRatBN7.2
Rnor_6.07117,129,438 - 117,129,652NCBIRnor6.0
Rnor_5.07117,115,109 - 117,115,323UniSTSRnor5.0
RGSC_v3.47114,101,361 - 114,101,575UniSTSRGSC3.4
Celera7104,139,569 - 104,139,783UniSTS
Cytogenetic Map7q34UniSTS
BE119987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27107,766,848 - 107,767,009 (+)MAPPERmRatBN7.2
Rnor_6.07117,113,316 - 117,113,476NCBIRnor6.0
Rnor_5.07117,098,987 - 117,099,147UniSTSRnor5.0
RGSC_v3.47114,085,239 - 114,085,399UniSTSRGSC3.4
Celera7104,123,583 - 104,123,743UniSTS
RH 3.4 Map7785.2UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000045280   ⟹   ENSRNOP00000044022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,759,343 - 107,782,331 (-)Ensembl
Rnor_6.0 Ensembl7117,105,810 - 117,128,798 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097559   ⟹   ENSRNOP00000095752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,759,343 - 107,782,331 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101717   ⟹   ENSRNOP00000090189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,759,343 - 107,782,331 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102170   ⟹   ENSRNOP00000095517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,759,343 - 107,782,331 (-)Ensembl
RefSeq Acc Id: NM_001191879   ⟹   NP_001178808
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,022 (-)NCBI
mRatBN7.27107,759,343 - 107,782,331 (-)NCBI
Rnor_6.07117,105,810 - 117,128,798 (-)NCBI
Rnor_5.07117,091,481 - 117,114,469 (-)NCBI
Celera7104,116,077 - 104,138,929 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241818   ⟹   XP_006241880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
mRatBN7.27107,759,343 - 107,782,360 (-)NCBI
Rnor_6.07117,105,810 - 117,128,800 (-)NCBI
Rnor_5.07117,091,481 - 117,114,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241819   ⟹   XP_006241881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
mRatBN7.27107,759,343 - 107,782,360 (-)NCBI
Rnor_6.07117,105,810 - 117,128,800 (-)NCBI
Rnor_5.07117,091,481 - 117,114,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765578   ⟹   XP_008763800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
mRatBN7.27107,759,343 - 107,782,361 (-)NCBI
Rnor_6.07117,105,810 - 117,128,800 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594968   ⟹   XP_017450457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
mRatBN7.27107,759,343 - 107,782,361 (-)NCBI
Rnor_6.07117,106,336 - 117,128,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079543   ⟹   XP_038935471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
mRatBN7.27107,759,343 - 107,782,361 (-)NCBI
RefSeq Acc Id: XM_039079544   ⟹   XP_038935472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
mRatBN7.27107,759,343 - 107,782,361 (-)NCBI
RefSeq Acc Id: XM_039079545   ⟹   XP_038935473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
mRatBN7.27107,759,343 - 107,782,361 (-)NCBI
RefSeq Acc Id: XM_063263870   ⟹   XP_063119940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
RefSeq Acc Id: XM_063263871   ⟹   XP_063119941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
RefSeq Acc Id: XM_063263872   ⟹   XP_063119942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
RefSeq Acc Id: XM_063263873   ⟹   XP_063119943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,640,034 - 109,663,354 (-)NCBI
RefSeq Acc Id: XR_005486672
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,644,690 - 109,663,354 (-)NCBI
mRatBN7.27107,764,000 - 107,782,364 (-)NCBI
RefSeq Acc Id: XR_010053008
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,641,937 - 109,663,354 (-)NCBI
RefSeq Acc Id: NP_001178808   ⟸   NM_001191879
- UniProtKB: A6HS53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241881   ⟸   XM_006241819
- Peptide Label: isoform X8
- UniProtKB: A0A8I6APB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241880   ⟸   XM_006241818
- Peptide Label: isoform X4
- UniProtKB: D3ZWS0 (UniProtKB/TrEMBL),   A6HS52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763800   ⟸   XM_008765578
- Peptide Label: isoform X5
- UniProtKB: A6HS51 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450457   ⟸   XM_017594968
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000044022   ⟸   ENSRNOT00000045280
RefSeq Acc Id: XP_038935471   ⟸   XM_039079543
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935473   ⟸   XM_039079545
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038935472   ⟸   XM_039079544
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000090189   ⟸   ENSRNOT00000101717
Ensembl Acc Id: ENSRNOP00000095517   ⟸   ENSRNOT00000102170
Ensembl Acc Id: ENSRNOP00000095752   ⟸   ENSRNOT00000097559
RefSeq Acc Id: XP_063119943   ⟸   XM_063263873
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063119942   ⟸   XM_063263872
- Peptide Label: isoform X10
- UniProtKB: A0A8I6ANK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119941   ⟸   XM_063263871
- Peptide Label: isoform X9
- UniProtKB: A0A8I6ABB5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119940   ⟸   XM_063263870
- Peptide Label: isoform X6
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWS0-F1-model_v2 AlphaFold D3ZWS0 1-1663 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695401
Promoter ID:EPDNEW_R5924
Type:initiation region
Name:Scrib_1
Description:scribbled planar cell polarity protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07117,128,817 - 117,128,877EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565055 AgrOrtholog
BioCyc Gene G2FUF-32962 BioCyc
Ensembl Genes ENSRNOG00000032574 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045280.5 UniProtKB/TrEMBL
  ENSRNOT00000097559.1 UniProtKB/TrEMBL
  ENSRNOT00000101717.1 UniProtKB/TrEMBL
  ENSRNOT00000102170.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Synaptic_Scaffolding_LAP-MAGUK UniProtKB/TrEMBL
KEGG Report rno:362938 UniProtKB/TrEMBL
NCBI Gene 362938 ENTREZGENE
PANTHER DISCS LARGE UniProtKB/TrEMBL
  PROTEIN SCRIBBLE HOMOLOG UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PhenoGen Scrib PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032574 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
UniProt A0A8I6ABB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANK4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APB3 ENTREZGENE, UniProtKB/TrEMBL
  A6HS51 ENTREZGENE, UniProtKB/TrEMBL
  A6HS52 ENTREZGENE, UniProtKB/TrEMBL
  A6HS53 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWS0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Scrib  scribble planar cell polarity protein  Scrib  scribbled planar cell polarity protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-20 Scrib  scribbled planar cell polarity protein  Scrib  scribbled homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Scrib  scribbled homolog (Drosophila)  Scrib_predicted  scribbled homolog (Drosophila) (predicted)  Data merged from RGD:1310522 1643240 APPROVED
2008-03-06 Scrib  scribbled homolog (Drosophila)  RGD1565055_predicted  similar to PDZ-domain protein scribble (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565055_predicted  similar to PDZ-domain protein scribble (predicted)  LOC362938  similar to PDZ-domain protein scribble  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362938  similar to PDZ-domain protein scribble      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Scrib_predicted  scribbled homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED