Itgb1bp2 (integrin subunit beta 1 binding protein 2) - Rat Genome Database

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Gene: Itgb1bp2 (integrin subunit beta 1 binding protein 2) Rattus norvegicus
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Symbol: Itgb1bp2
Name: integrin subunit beta 1 binding protein 2
RGD ID: 1565015
Description: Enables integrin binding activity. Predicted to be involved in centrosome duplication. Predicted to be active in Z disc. Orthologous to human ITGB1BP2 (integrin subunit beta 1 binding protein 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: integrin beta 1 binding protein 2; integrin beta-1-binding protein 2; LOC317258; melusin; RGD1565015; similar to melusin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,612,118 - 70,617,158 (+)NCBIGRCr8
mRatBN7.2X66,572,537 - 66,577,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,572,537 - 66,577,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,055,878 - 68,060,519 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,556,287 - 71,560,932 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,117,186 - 69,121,831 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,342,770 - 71,347,623 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,342,775 - 71,347,619 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,193,462 - 72,198,315 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,520,700 - 89,525,600 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX66,928,207 - 66,932,844 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Z disc  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. Brancaccio M, etal., J Biol Chem. 1999 Oct 8;274(41):29282-8.
2. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Brancaccio M, etal., Nat Med. 2003 Jan;9(1):68-75. Epub 2002 Dec 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12965203   PMID:21757757   PMID:23198998   PMID:30904475  


Genomics

Comparative Map Data
Itgb1bp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,612,118 - 70,617,158 (+)NCBIGRCr8
mRatBN7.2X66,572,537 - 66,577,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,572,537 - 66,577,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,055,878 - 68,060,519 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,556,287 - 71,560,932 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,117,186 - 69,121,831 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,342,770 - 71,347,623 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,342,775 - 71,347,619 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,193,462 - 72,198,315 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,520,700 - 89,525,600 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX66,928,207 - 66,932,844 (+)NCBICelera
Cytogenetic MapXq22NCBI
ITGB1BP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,301,750 - 71,305,371 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,301,750 - 71,305,371 (+)EnsemblGRCh38hg38GRCh38
GRCh37X70,521,600 - 70,525,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,438,353 - 70,441,929 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X70,304,648 - 70,308,225NCBI
CeleraX70,875,506 - 70,879,082 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,337,919 - 64,341,495 (+)NCBIHuRef
CHM1_1X70,414,681 - 70,418,257 (+)NCBICHM1_1
T2T-CHM13v2.0X69,735,860 - 69,739,481 (+)NCBIT2T-CHM13v2.0
Itgb1bp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,492,694 - 100,520,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,492,694 - 100,497,147 (+)EnsemblGRCm39 Ensembl
GRCm38X101,449,088 - 101,466,122 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,449,088 - 101,453,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X98,644,448 - 98,648,880 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,651,884 - 97,656,498 (+)NCBIMGSCv36mm8
CeleraX88,366,894 - 88,371,326 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.17NCBI
Itgb1bp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,854,270 - 10,858,636 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547510,854,148 - 10,858,802 (+)NCBIChiLan1.0ChiLan1.0
ITGB1BP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,974,360 - 70,978,179 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,977,720 - 70,981,782 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,564,946 - 60,569,045 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,620,027 - 70,624,138 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,620,025 - 70,624,138 (+)Ensemblpanpan1.1panPan2
ITGB1BP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,632,566 - 55,652,801 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,633,060 - 55,636,868 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,459,421 - 46,479,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,601,297 - 56,621,805 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,601,734 - 56,605,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,568,927 - 54,589,320 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,900,649 - 55,921,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,828,059 - 55,848,566 (+)NCBIUU_Cfam_GSD_1.0
Itgb1bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,555,881 - 46,560,183 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762318,055 - 321,843 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936762318,055 - 322,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB1BP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,316,471 - 57,325,096 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,316,490 - 57,321,614 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ITGB1BP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,112,400 - 61,117,566 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX61,113,673 - 61,118,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,963,649 - 2,968,066 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb1bp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,584,519 - 1,588,617 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,583,796 - 1,588,778 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgb1bp2
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:43
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000004888
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000004888   ⟹   ENSRNOP00000004888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,572,537 - 66,577,174 (+)Ensembl
Rnor_6.0 EnsemblX71,342,775 - 71,347,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110786   ⟹   ENSRNOP00000087908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,572,585 - 66,577,170 (+)Ensembl
RefSeq Acc Id: NM_001108245   ⟹   NP_001101715
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,612,521 - 70,617,158 (+)NCBI
mRatBN7.2X66,572,537 - 66,577,174 (+)NCBI
Rnor_6.0X71,342,770 - 71,347,623 (+)NCBI
Rnor_5.0X72,193,462 - 72,198,315 (+)NCBI
RGSC_v3.4X89,520,700 - 89,525,600 (+)RGD
CeleraX66,928,207 - 66,932,844 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063280031   ⟹   XP_063136101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,612,118 - 70,617,154 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101715 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136101 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95891 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004888.4
  ENSRNOP00000087908.1
RefSeq Acc Id: NP_001101715   ⟸   NM_001108245
- UniProtKB: D3ZW59 (UniProtKB/TrEMBL),   A6IQC2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004888   ⟸   ENSRNOT00000004888
Ensembl Acc Id: ENSRNOP00000087908   ⟸   ENSRNOT00000110786
RefSeq Acc Id: XP_063136101   ⟸   XM_063280031
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A523 (UniProtKB/TrEMBL)
Protein Domains
CHORD   CS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZW59-F1-model_v2 AlphaFold D3ZW59 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701878
Promoter ID:EPDNEW_R12402
Type:single initiation site
Name:Itgb1bp2_1
Description:integrin subunit beta 1 binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,342,773 - 71,342,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565015 AgrOrtholog
BioCyc Gene G2FUF-2098 BioCyc
Ensembl Genes ENSRNOG00000003596 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004888.8 UniProtKB/TrEMBL
  ENSRNOT00000110786.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.790 UniProtKB/TrEMBL
  4.10.1130.20 UniProtKB/TrEMBL
InterPro CHORD UniProtKB/TrEMBL
  CS-like_domain UniProtKB/TrEMBL
  HSP20-like_chaperone UniProtKB/TrEMBL
KEGG Report rno:317258 UniProtKB/TrEMBL
NCBI Gene 317258 ENTREZGENE
PANTHER CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  ZGC:92429 UniProtKB/TrEMBL
Pfam CHORD UniProtKB/TrEMBL
  PF04969 UniProtKB/TrEMBL
PhenoGen Itgb1bp2 PhenoGen
PROSITE CHORD UniProtKB/TrEMBL
  PS51203 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003596 RatGTEx
Superfamily-SCOP HSP20_chap UniProtKB/TrEMBL
UniProt A0A8I6A523 ENTREZGENE, UniProtKB/TrEMBL
  A6IQC2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgb1bp2  integrin subunit beta 1 binding protein 2  Itgb1bp2  integrin beta 1 binding protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Itgb1bp2  integrin beta 1 binding protein 2   Itgb1bp2_predicted  integrin beta 1 binding protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Itgb1bp2_predicted  integrin beta 1 binding protein 2 (predicted)  RGD1565015_predicted  similar to melusin (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1565015_predicted  similar to melusin (predicted)  LOC317258  similar to melusin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317258  similar to melusin      Symbol and Name status set to provisional 70820 PROVISIONAL