Dct (dopachrome tautomerase) - Rat Genome Database

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Gene: Dct (dopachrome tautomerase) Rattus norvegicus
Analyze
Symbol: Dct
Name: dopachrome tautomerase
RGD ID: 1564975
Description: Predicted to enable dopachrome isomerase activity. Predicted to be involved in melanin biosynthetic process from tyrosine and response to blue light. Predicted to act upstream of or within several processes, including melanin biosynthetic process; positive regulation of neuroblast proliferation; and ventricular zone neuroblast division. Predicted to be located in cytosol; melanosome; and plasma membrane. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH bisphenol A; Cuprizon; diuron.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); L-dopachrome tautomerase; LOC290484; RGD1564975; similar to Dopachrome tautomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   F344-Tg(Dct-lacZ)9Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,469,159 - 101,508,029 (-)NCBIGRCr8
mRatBN7.21595,062,006 - 95,100,863 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,062,003 - 95,100,836 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.015103,208,174 - 103,245,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,208,258 - 103,244,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015106,647,067 - 106,681,458 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415102,798,699 - 102,832,240 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1593,915,976 - 93,952,737 (-)NCBICelera
Cytogenetic Map15q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5,6-dihydroxyindole-2-carboxylic acid  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amentoflavone  (ISO)
arachidonic acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
cordycepin  (ISO)
Cuprizon  (EXP)
dichloroacetic acid  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
emodin  (ISO)
etoposide  (ISO)
eumelanin  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glycidol  (EXP)
isoprenaline  (ISO)
kojic acid  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nonanedioic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
scoparone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Sweroside  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1537334   PMID:2169885   PMID:7665913   PMID:15060160   PMID:16857183   PMID:21610032   PMID:26620560  


Genomics

Comparative Map Data
Dct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,469,159 - 101,508,029 (-)NCBIGRCr8
mRatBN7.21595,062,006 - 95,100,863 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,062,003 - 95,100,836 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.015103,208,174 - 103,245,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,208,258 - 103,244,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015106,647,067 - 106,681,458 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415102,798,699 - 102,832,240 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1593,915,976 - 93,952,737 (-)NCBICelera
Cytogenetic Map15q24NCBI
DCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381394,436,811 - 94,549,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1394,436,811 - 94,479,682 (-)EnsemblGRCh38hg38GRCh38
GRCh371395,089,065 - 95,201,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361393,889,836 - 93,929,924 (-)NCBINCBI36Build 36hg18NCBI36
Build 341393,889,839 - 93,929,924NCBI
Celera1375,940,079 - 75,980,144 (-)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1375,688,784 - 75,728,851 (-)NCBIHuRef
CHM1_11395,061,346 - 95,101,397 (-)NCBICHM1_1
T2T-CHM13v2.01393,640,358 - 93,752,911 (-)NCBIT2T-CHM13v2.0
Dct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914118,250,202 - 118,289,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14118,250,202 - 118,289,656 (-)EnsemblGRCm39 Ensembl
GRCm3814118,012,790 - 118,052,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14118,012,790 - 118,052,244 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714118,412,012 - 118,451,468 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614116,895,153 - 116,934,531 (-)NCBIMGSCv36mm8
Celera14116,565,242 - 116,604,520 (-)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1461.6NCBI
Dct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540415,359,402 - 15,395,535 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540415,359,402 - 15,395,556 (+)NCBIChiLan1.0ChiLan1.0
DCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21495,945,342 - 96,086,535 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11394,613,198 - 94,755,220 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01375,590,366 - 75,730,956 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11394,773,794 - 94,886,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1394,773,794 - 94,816,083 (-)Ensemblpanpan1.1panPan2
DCT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12245,271,709 - 45,305,272 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2245,271,709 - 45,305,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2245,058,426 - 45,092,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02245,702,218 - 45,736,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2245,702,218 - 45,736,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12245,356,018 - 45,389,781 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02245,396,691 - 45,430,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02245,406,488 - 45,440,246 (-)NCBIUU_Cfam_GSD_1.0
Dct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945180,841,728 - 180,877,214 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647215,074,633 - 15,110,534 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647215,074,947 - 15,110,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1163,584,869 - 63,678,344 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11163,584,865 - 63,647,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21169,660,271 - 69,730,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1373,246,161 - 73,315,574 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl373,274,621 - 73,313,905 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604629,653,840 - 29,766,858 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dct
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248791,241,910 - 1,279,444 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248791,241,593 - 1,346,765 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dct
238 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:87
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000011571
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)158885347095840528Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat

Markers in Region
DCT  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,088,641 - 95,089,156 (+)MAPPERmRatBN7.2
Rnor_6.015103,232,680 - 103,233,194NCBIRnor6.0
Rnor_5.015106,669,165 - 106,669,679UniSTSRnor5.0
RGSC_v3.415102,820,011 - 102,820,525UniSTSRGSC3.4
Celera1593,940,556 - 93,941,070UniSTS
Cytogenetic Map15q24UniSTS


Related Rat Strains
The following Strains have been annotated to Dct


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 1
Low 1 34 1 10 37 33
Below cutoff 2 9 12 1 7 1 3 3 19 22 7 10 3

Sequence


RefSeq Acc Id: ENSRNOT00000011571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl15103,208,258 - 103,244,494 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1595,062,003 - 95,100,836 (-)Ensembl
Rnor_6.0 Ensembl15103,213,968 - 103,244,494 (-)Ensembl
RefSeq Acc Id: NM_001427268   ⟹   NP_001414197
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,469,159 - 101,508,029 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414197 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02518 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086887.1
RefSeq Acc Id: NP_001414197   ⟸   NM_001427268
- Peptide Label: precursor
- UniProtKB: A0A8I6AEZ4 (UniProtKB/TrEMBL),   A6HUF5 (UniProtKB/TrEMBL)
Protein Domains
Tyrosinase copper-binding

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564975 AgrOrtholog
BioCyc Gene G2FUF-12461 BioCyc
BioCyc Pathway PWY-6498 [eumelanin biosynthesis] BioCyc
BioCyc Pathway Image PWY-6498 BioCyc
Ensembl Genes ENSRNOG00000008671 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076707.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1280.10 UniProtKB/TrEMBL
InterPro Di-copper_centre_dom_sf UniProtKB/TrEMBL
  Tyrosinase_Cu-bd UniProtKB/TrEMBL
NCBI Gene 290484 ENTREZGENE
PANTHER L-DOPACHROME TAUTOMERASE UniProtKB/TrEMBL
  TYROSINASE FAMILY MEMBER UniProtKB/TrEMBL
Pfam Tyrosinase UniProtKB/TrEMBL
PhenoGen Dct PhenoGen
PRINTS TYROSINASE UniProtKB/TrEMBL
PROSITE TYROSINASE_1 UniProtKB/TrEMBL
  TYROSINASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008671 RatGTEx
Superfamily-SCOP SSF48056 UniProtKB/TrEMBL
UniProt A0A8I6AEZ4 ENTREZGENE, UniProtKB/TrEMBL
  A6HUF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Dct  dopachrome tautomerase  Dct  dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Dct  dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)  Dct  dopachrome tautomerase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Dct  dopachrome tautomerase  RGD1564975_predicted  similar to Dopachrome tautomerase (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564975_predicted  similar to Dopachrome tautomerase (predicted)  LOC290484  similar to Dopachrome tautomerase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290484  similar to Dopachrome tautomerase      Symbol and Name status set to provisional 70820 PROVISIONAL