C16h10orf71 (similar to human chromosome 10 open reading frame 71) - Rat Genome Database

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Gene: C16h10orf71 (similar to human chromosome 10 open reading frame 71) Rattus norvegicus
Analyze
Symbol: C16h10orf71 (Ensembl: RGD1564899)
Name: similar to human chromosome 10 open reading frame 71 (Ensembl:similar to chromosome 10 open reading frame 71)
RGD ID: 1564899
Description: Involved in positive regulation of calcineurin-NFAT signaling cascade. Located in Z disc. Orthologous to human C10orf71 (chromosome 10 open reading frame 71); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CEFIP; LOC498579; RGD1564899; similar to chromosome 10 open reading frame 71; uncharacterized protein C10orf71 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,916,901 - 7,968,280 (-)NCBIGRCr8
mRatBN7.2167,910,597 - 7,961,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,910,433 - 7,961,958 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0168,879,907 - 8,907,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,881,138 - 8,885,797 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,846,768 - 10,856,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,167,813 - 8,172,721 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,263,241 - 7,290,797 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Z disc  (IBA,IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling. Dierck F, etal., J Biol Chem. 2017 Sep 15;292(37):15180-15191. doi: 10.1074/jbc.M117.786764. Epub 2017 Jul 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
C16h10orf71
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,916,901 - 7,968,280 (-)NCBIGRCr8
mRatBN7.2167,910,597 - 7,961,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,910,433 - 7,961,958 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0168,879,907 - 8,907,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,881,138 - 8,885,797 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,846,768 - 10,856,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,167,813 - 8,172,721 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,263,241 - 7,290,797 (+)NCBICelera
Cytogenetic Map16p16NCBI
C10orf71
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381049,297,050 - 49,327,492 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1049,299,170 - 49,327,492 (+)EnsemblGRCh38hg38GRCh38
GRCh371050,507,215 - 50,535,537 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361050,177,193 - 50,205,538 (+)NCBINCBI36Build 36hg18NCBI36
Build 341050,177,192 - 50,205,538NCBI
Celera1044,093,353 - 44,121,712 (+)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1044,771,705 - 44,800,063 (+)NCBIHuRef
CHM1_11050,789,482 - 50,817,794 (+)NCBICHM1_1
T2T-CHM13v2.01050,145,795 - 50,176,288 (+)NCBIT2T-CHM13v2.0
3425401B19Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,381,075 - 32,429,787 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,381,076 - 32,407,250 (-)EnsemblGRCm39 Ensembl
GRCm381432,659,118 - 32,707,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,659,119 - 32,685,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv371433,472,308 - 33,498,458 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361433,472,305 - 33,498,458 (-)NCBIMGSCv36mm8
Celera1428,915,536 - 28,941,706 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
CUNH10orf71
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556895,279 - 899,835 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955556894,707 - 917,196 (-)NCBIChiLan1.0ChiLan1.0
C8H10orf71
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2861,565,940 - 61,594,246 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11061,571,259 - 61,599,565 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01044,916,625 - 44,945,094 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C28H10orf71
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,221,423 - 1,250,122 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,245,117 - 1,249,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,457,002 - 1,485,375 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,397,998 - 1,427,515 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,400,115 - 1,427,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,196,258 - 1,225,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,233,558 - 1,261,932 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,365,178 - 1,393,560 (+)NCBIUU_Cfam_GSD_1.0
CUNH10orf71
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,755,625 - 79,780,373 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728959,147 - 963,448 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936728958,481 - 982,624 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C14H10orf71
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1489,913,142 - 89,917,696 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11489,892,435 - 89,918,364 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21497,797,356 - 97,827,580 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH10orf71
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1942,483,873 - 42,510,826 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl942,484,882 - 42,489,189 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660482,244,474 - 2,249,472 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH10orf71
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624928614,610 - 618,845 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624928614,036 - 636,557 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C16h10orf71
378 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:17
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000073370
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
RH137487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,911,685 - 7,911,875 (+)MAPPERmRatBN7.2
Rnor_6.0168,880,713 - 8,880,902NCBIRnor6.0
Rnor_5.01610,846,785 - 10,846,974UniSTSRnor5.0
RGSC_v3.4168,167,830 - 8,168,019UniSTSRGSC3.4
Celera167,289,802 - 7,289,991UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 8 11 8
Low 14 7 9 7 4 2 15 8
Below cutoff 3 22 13 9 13 21 23 17 2

Sequence


RefSeq Acc Id: ENSRNOT00000073370   ⟹   ENSRNOP00000067550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,910,433 - 7,961,958 (-)Ensembl
Rnor_6.0 Ensembl168,881,138 - 8,885,797 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098917   ⟹   ENSRNOP00000081405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,910,433 - 7,938,579 (-)Ensembl
RefSeq Acc Id: NM_001419656   ⟹   NP_001406585
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,917,973 - 7,944,556 (-)NCBI
mRatBN7.2167,911,669 - 7,938,252 (-)NCBI
RefSeq Acc Id: XM_006252757   ⟹   XP_006252819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,916,901 - 7,944,791 (-)NCBI
mRatBN7.2167,910,597 - 7,938,433 (-)NCBI
Rnor_6.0168,879,907 - 8,907,462 (-)NCBI
Rnor_5.01610,846,768 - 10,856,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600296   ⟹   XP_017455785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,916,901 - 7,944,653 (-)NCBI
mRatBN7.2167,910,597 - 7,938,433 (-)NCBI
Rnor_6.0168,879,907 - 8,907,462 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094889   ⟹   XP_038950817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,916,901 - 7,968,239 (-)NCBI
mRatBN7.2167,910,597 - 7,961,900 (-)NCBI
RefSeq Acc Id: XM_063275629   ⟹   XP_063131699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,916,901 - 7,968,280 (-)NCBI
RefSeq Acc Id: XM_573855   ⟹   XP_573855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,916,901 - 7,944,781 (-)NCBI
mRatBN7.2167,910,597 - 7,938,433 (-)NCBI
Rnor_6.0168,879,907 - 8,907,462 (-)NCBI
Rnor_5.01610,846,768 - 10,856,696 (-)NCBI
RGSC_v3.4168,167,813 - 8,172,721 (-)RGD
Sequence:
RefSeq Acc Id: XP_573855   ⟸   XM_573855
- Peptide Label: isoform X1
- UniProtKB: M0RD54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252819   ⟸   XM_006252757
- Peptide Label: isoform X1
- UniProtKB: M0RD54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455785   ⟸   XM_017600296
- Peptide Label: isoform X1
- UniProtKB: M0RD54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067550   ⟸   ENSRNOT00000073370
RefSeq Acc Id: XP_038950817   ⟸   XM_039094889
- Peptide Label: isoform X1
- UniProtKB: M0RD54 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000081405   ⟸   ENSRNOT00000098917
RefSeq Acc Id: NP_001406585   ⟸   NM_001419656
- UniProtKB: M0RD54 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131699   ⟸   XM_063275629
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RD54-F1-model_v2 AlphaFold M0RD54 1-1422 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564899 AgrOrtholog
BioCyc Gene G2FUF-12102 BioCyc
Ensembl Genes ENSRNOG00000049942 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021143 UniProtKB/Swiss-Prot
  ENSRNOG00060013008 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073370.3 UniProtKB/Swiss-Prot
  ENSRNOT00000098917.1 UniProtKB/Swiss-Prot
  ENSRNOT00055036119 UniProtKB/Swiss-Prot
  ENSRNOT00055036125 UniProtKB/Swiss-Prot
  ENSRNOT00060022151 UniProtKB/Swiss-Prot
  ENSRNOT00060022157 UniProtKB/Swiss-Prot
InterPro DUF4585 UniProtKB/Swiss-Prot
KEGG Report rno:498579 UniProtKB/Swiss-Prot
NCBI Gene 498579 ENTREZGENE
PANTHER CARDIAC-ENRICHED FHL2-INTERACTING PROTEIN UniProtKB/Swiss-Prot
  CARDIAC-ENRICHED FHL2-INTERACTING PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam DUF4585 UniProtKB/Swiss-Prot
PhenoGen C16h10orf71 PhenoGen
RatGTEx ENSRNOG00000049942 RatGTEx
  ENSRNOG00055021143 RatGTEx
  ENSRNOG00060013008 RatGTEx
UniProt CEFIP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-09 C16h10orf71  similar to human chromosome 10 open reading frame 71  RGD1564899  similar to chromosome 10 open reading frame 71  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564899  similar to chromosome 10 open reading frame 71   RGD1564899_predicted  similar to chromosome 10 open reading frame 71 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564899_predicted  similar to chromosome 10 open reading frame 71 (predicted)  LOC498579  similar to chromosome 10 open reading frame 71  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498579  similar to chromosome 10 open reading frame 71      Symbol and Name status set to provisional 70820 PROVISIONAL