Emx2 (empty spiracles homeobox 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Emx2 (empty spiracles homeobox 2) Rattus norvegicus
Analyze
Symbol: Emx2
Name: empty spiracles homeobox 2
RGD ID: 1564797
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in nervous system development; regulation of transcription by RNA polymerase II; and stereocilium bundle organization. Predicted to act upstream of or within several processes, including forebrain development; neuron migration; and ureter morphogenesis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to human EMX2 (empty spiracles homeobox 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: empty spiracles homolog 2; homeobox protein EMX2; LOC499380; RGD1564797; similar to empty spiracles-like protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,612,663 - 268,619,671 (+)NCBIGRCr8
mRatBN7.21258,626,584 - 258,633,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,626,584 - 258,633,594 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,832,393 - 266,839,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,538,418 - 273,545,420 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01266,179,101 - 266,186,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,633,938 - 280,640,946 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,633,938 - 280,640,946 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,993,648 - 288,000,656 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41266,004,257 - 266,011,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1254,275,943 - 254,282,950 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
15-acetyldeoxynivalenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
CHIR 99021  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. EMX2 gene expression predicts liver metastasis and survival in colorectal cancer. Aykut B, etal., BMC Cancer. 2017 Aug 22;17(1):555. doi: 10.1186/s12885-017-3556-2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma. Giroux Leprieur E, etal., Lung Cancer. 2014 Sep;85(3):465-71. doi: 10.1016/j.lungcan.2014.06.018. Epub 2014 Jun 30.
4. Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer. Li J, etal., PLoS One. 2012;7(9):e45970. doi: 10.1371/journal.pone.0045970. Epub 2012 Sep 21.
5. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients. Okamoto J, etal., Clin Lung Cancer. 2011 Jul;12(4):237-44. doi: 10.1016/j.cllc.2011.03.025. Epub 2011 Apr 24.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Wang L, etal., Oncol Rep. 2019 Nov;42(5):2169-2178. doi: 10.3892/or.2019.7284. Epub 2019 Aug 20.
10. EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas. Yue D, etal., PLoS One. 2015 Jul 1;10(7):e0132134. doi: 10.1371/journal.pone.0132134. eCollection 2015.
11. Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells. Zhang Y, etal., Oncol Res. 2017 Apr 14;25(4):537-544. doi: 10.3727/096504016X14756640150695. Epub 2016 Oct 5.
Additional References at PubMed
PMID:9098922   PMID:10729342   PMID:12091317   PMID:12196586   PMID:12209834   PMID:12561075   PMID:12764040   PMID:15147765   PMID:15294144   PMID:15917450   PMID:16919471   PMID:21731775  


Genomics

Comparative Map Data
Emx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,612,663 - 268,619,671 (+)NCBIGRCr8
mRatBN7.21258,626,584 - 258,633,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,626,584 - 258,633,594 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,832,393 - 266,839,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,538,418 - 273,545,420 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01266,179,101 - 266,186,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,633,938 - 280,640,946 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,633,938 - 280,640,946 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,993,648 - 288,000,656 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41266,004,257 - 266,011,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1254,275,943 - 254,282,950 (+)NCBICelera
Cytogenetic Map1q55NCBI
EMX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810117,542,746 - 117,549,546 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10117,542,445 - 117,549,546 (+)EnsemblGRCh38hg38GRCh38
GRCh3710119,302,257 - 119,309,057 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610119,291,946 - 119,299,043 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410119,291,945 - 119,299,043NCBI
Celera10113,031,949 - 113,039,046 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10112,930,193 - 112,937,289 (+)NCBIHuRef
CHM1_110119,586,078 - 119,593,194 (+)NCBICHM1_1
T2T-CHM13v2.010118,437,136 - 118,443,925 (+)NCBIT2T-CHM13v2.0
Emx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391959,447,122 - 59,453,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1959,446,804 - 59,453,789 (+)EnsemblGRCm39 Ensembl
GRCm381959,458,690 - 59,465,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1959,458,372 - 59,465,357 (+)EnsemblGRCm38mm10GRCm38
MGSCv371959,533,180 - 59,539,847 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361959,511,622 - 59,518,607 (+)NCBIMGSCv36mm8
Celera1961,658,178 - 61,664,837 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.28NCBI
Emx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543122,192,446 - 22,199,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543122,192,446 - 22,199,141 (+)NCBIChiLan1.0ChiLan1.0
EMX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28129,405,618 - 129,419,620 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110129,417,530 - 129,424,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010114,124,759 - 114,132,109 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110117,551,451 - 117,557,972 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10117,551,451 - 117,557,972 (+)Ensemblpanpan1.1panPan2
EMX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12828,002,966 - 28,009,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2828,003,710 - 28,009,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2828,146,341 - 28,153,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02828,532,618 - 28,539,604 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2828,532,897 - 28,538,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12828,094,345 - 28,101,342 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02828,108,855 - 28,115,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02828,303,055 - 28,310,050 (+)NCBIUU_Cfam_GSD_1.0
Emx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721318,241,303 - 18,247,914 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364867,313,190 - 7,319,995 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364867,313,689 - 7,319,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14127,650,688 - 127,655,706 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114127,649,675 - 127,656,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214139,052,130 - 139,055,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EMX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19110,347,043 - 110,353,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9110,347,379 - 110,353,643 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604871,602,815 - 71,610,687 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473729,103,279 - 29,110,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473729,103,378 - 29,110,356 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Emx2
28 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:449
Count of miRNA genes:242
Interacting mature miRNAs:287
Transcripts:ENSRNOT00000012564
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1223262787260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat

Markers in Region
D1Mit14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21258,625,162 - 258,625,266 (+)MAPPERmRatBN7.2
Rnor_6.01280,632,517 - 280,632,620NCBIRnor6.0
Rnor_5.01287,992,227 - 287,992,330UniSTSRnor5.0
RGSC_v3.41266,002,835 - 266,002,939RGDRGSC3.4
RGSC_v3.41266,002,836 - 266,002,939UniSTSRGSC3.4
RGSC_v3.11266,213,881 - 266,213,984RGD
Celera1254,274,522 - 254,274,625UniSTS
RH 3.4 Map11706.6UniSTS
RH 3.4 Map11706.6RGD
RH 2.0 Map11324.4999RGD
FHH x ACI Map1132.1799RGD
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 39 109 65 64 33 24 33 6 180 86 89 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012564   ⟹   ENSRNOP00000012564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1258,626,584 - 258,633,594 (+)Ensembl
Rnor_6.0 Ensembl1280,633,938 - 280,640,946 (+)Ensembl
RefSeq Acc Id: NM_001109169   ⟹   NP_001102639
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81268,612,663 - 268,619,671 (+)NCBI
mRatBN7.21258,626,584 - 258,633,594 (+)NCBI
Rnor_6.01280,633,938 - 280,640,946 (+)NCBI
Rnor_5.01287,993,648 - 288,000,656 (+)NCBI
RGSC_v3.41266,004,257 - 266,011,265 (+)RGD
Celera1254,275,943 - 254,282,950 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271792   ⟹   XP_063127862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81268,613,298 - 268,618,267 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102639 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127862 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94560 (Get FASTA)   NCBI Sequence Viewer  
  EDL94561 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012564
  ENSRNOP00000012564.3
RefSeq Acc Id: NP_001102639   ⟸   NM_001109169
- UniProtKB: D3ZCK7 (UniProtKB/TrEMBL),   A6JI86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012564   ⟸   ENSRNOT00000012564
RefSeq Acc Id: XP_063127862   ⟸   XM_063271792
- Peptide Label: isoform X1
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCK7-F1-model_v2 AlphaFold D3ZCK7 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691015
Promoter ID:EPDNEW_R1540
Type:single initiation site
Name:Emx2_1
Description:empty spiracles homeobox 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01280,633,971 - 280,634,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564797 AgrOrtholog
BioCyc Gene G2FUF-55248 BioCyc
Ensembl Genes ENSRNOG00000009482 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012564 ENTREZGENE
  ENSRNOT00000012564.4 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro EMX-VAX-Noto_Homeobox_TFs UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_region UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  HTH_lambrepressr UniProtKB/TrEMBL
KEGG Report rno:499380 UniProtKB/TrEMBL
NCBI Gene 499380 ENTREZGENE
PANTHER HOMEOBOX PROTEIN EMX-RELATED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN EMX2 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Emx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/TrEMBL
  HTHREPRESSR UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009482 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6JI86 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCK7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Emx2  empty spiracles homeobox 2  RGD1564797_predicted  similar to empty spiracles-like protein 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564797_predicted  similar to empty spiracles-like protein 2 (predicted)  LOC499380  similar to empty spiracles-like protein 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499380  similar to empty spiracles-like protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL