Zfp341 (zinc finger protein 341) - Rat Genome Database

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Gene: Zfp341 (zinc finger protein 341) Rattus norvegicus
Analyze
Symbol: Zfp341
Name: zinc finger protein 341
RGD ID: 1564726
Description: Predicted to enable DNA binding activity and DNA-binding transcription activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in hyper IgE recurrent infection syndrome 3. Orthologous to human ZNF341 (zinc finger protein 341); INTERACTS WITH bisphenol A; 1,2-dichloroethane (ortholog); 2,2',4,4'-Tetrabromodiphenyl ether (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07054367.1; LOC296300; LRRGT00145; similar to zinc finger protein 341; Zfp966; zinc finger protein 966; Znf341
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,582,937 - 163,616,448 (+)NCBIGRCr8
mRatBN7.23143,122,699 - 143,156,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,119,093 - 143,156,249 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03150,114,853 - 150,172,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,135,821 - 150,153,775 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.03156,511,320 - 156,544,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,086,839 - 145,105,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3141,855,266 - 141,888,862 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:29907690  


Genomics

Comparative Map Data
Zfp341
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,582,937 - 163,616,448 (+)NCBIGRCr8
mRatBN7.23143,122,699 - 143,156,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,119,093 - 143,156,249 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03150,114,853 - 150,172,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,135,821 - 150,153,775 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.03156,511,320 - 156,544,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,086,839 - 145,105,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3141,855,266 - 141,888,862 (+)NCBICelera
Cytogenetic Map3q41NCBI
ZNF341
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,731,996 - 33,792,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,731,657 - 33,792,269 (+)EnsemblGRCh38hg38GRCh38
GRCh372032,319,802 - 32,380,075 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,783,469 - 31,843,736 (+)NCBINCBI36Build 36hg18NCBI36
Build 342031,783,468 - 31,843,736NCBI
Celera2029,072,525 - 29,132,795 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,105,231 - 29,164,875 (+)NCBIHuRef
CHM1_12032,221,188 - 32,281,398 (+)NCBICHM1_1
T2T-CHM13v2.02035,458,351 - 35,518,627 (+)NCBIT2T-CHM13v2.0
Zfp341
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,453,736 - 154,488,741 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,455,217 - 154,488,741 (+)EnsemblGRCm39 Ensembl
GRCm382154,611,816 - 154,646,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,613,297 - 154,646,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv372154,439,104 - 154,472,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,304,809 - 154,338,258 (+)NCBIMGSCv36mm8
MGSCv362155,440,850 - 155,474,283 (+)NCBIMGSCv36mm8
Celera2160,541,217 - 160,566,229 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
Znf341
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,537,917 - 27,583,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542227,537,293 - 27,583,713 (-)NCBIChiLan1.0ChiLan1.0
ZNF341
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,418,445 - 39,483,467 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,411,547 - 39,476,569 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02030,018,348 - 30,079,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,166,374 - 31,218,282 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,164,597 - 31,218,282 (+)Ensemblpanpan1.1panPan2
ZNF341
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,937,990 - 22,984,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,938,093 - 22,982,367 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2422,583,240 - 22,629,894 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,624,867 - 23,671,552 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,624,950 - 23,670,551 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,917,225 - 22,963,979 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,010,745 - 23,057,362 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,488,954 - 23,494,847 (+)NCBIUU_Cfam_GSD_1.0
UU_Cfam_GSD_1.02423,441,838 - 23,462,455 (+)NCBIUU_Cfam_GSD_1.0
Znf341
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,894,730 - 171,933,200 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,816,328 - 6,851,452 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,816,349 - 6,851,609 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF341
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,224,048 - 37,280,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,223,959 - 37,272,263 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,186,197 - 42,200,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF341
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1238,020,915 - 38,081,559 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl238,028,765 - 38,080,814 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605088,799,998 - 88,860,135 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf341
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,519,035 - 5,565,613 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,518,327 - 5,565,661 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp341
153 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:52
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000047286
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat

Markers in Region
RH130998  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,155,893 - 143,156,110 (+)MAPPERmRatBN7.2
Rnor_6.03150,172,069 - 150,172,285NCBIRnor6.0
Rnor_5.03156,543,895 - 156,544,111UniSTSRnor5.0
RGSC_v3.43145,123,667 - 145,123,883UniSTSRGSC3.4
Celera3141,888,506 - 141,888,722UniSTS
RH 3.4 Map31266.2UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000047286   ⟹   ENSRNOP00000043308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,119,093 - 143,156,249 (+)Ensembl
RefSeq Acc Id: XM_008762405   ⟹   XP_008760627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,582,937 - 163,616,448 (+)NCBI
mRatBN7.23143,122,708 - 143,156,250 (+)NCBI
Rnor_6.03150,114,853 - 150,172,425 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106691   ⟹   XP_038962619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,582,937 - 163,616,448 (+)NCBI
mRatBN7.23143,122,704 - 143,156,250 (+)NCBI
RefSeq Acc Id: XM_039106692   ⟹   XP_038962620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,582,937 - 163,616,448 (+)NCBI
mRatBN7.23143,122,701 - 143,156,250 (+)NCBI
RefSeq Acc Id: XM_039106694   ⟹   XP_038962622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,595,421 - 163,616,448 (+)NCBI
mRatBN7.23143,135,221 - 143,156,250 (+)NCBI
RefSeq Acc Id: XM_063285100   ⟹   XP_063141170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,592,985 - 163,616,448 (+)NCBI
RefSeq Acc Id: XP_008760627   ⟸   XM_008762405
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038962620   ⟸   XM_039106692
- Peptide Label: isoform X3
- UniProtKB: A6KI01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962619   ⟸   XM_039106691
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962622   ⟸   XM_039106694
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000043308   ⟸   ENSRNOT00000047286
RefSeq Acc Id: XP_063141170   ⟸   XM_063285100
- Peptide Label: isoform X4
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7ETL6-F1-model_v2 AlphaFold F7ETL6 1-428 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564726 AgrOrtholog
BioCyc Gene G2FUF-47166 BioCyc
Ensembl Genes ENSRNOG00000017086 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047286.4 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125614 IMAGE-MGC_LOAD
InterPro Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
MGC_CLONE MGC:105872 IMAGE-MGC_LOAD
NCBI Gene 296300 ENTREZGENE
PANTHER FI03704P-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Zfp341 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017086 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A6KI01 ENTREZGENE, UniProtKB/TrEMBL
  F7ETL6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Zfp341  zinc finger protein 341  AABR07054367.1    Data merged from RGD:15003446 737654 PROVISIONAL
2019-11-08 AABR07054367.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2012-11-27 Znf341  zinc finger protein 341  Zfp966  zinc finger protein 966  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-27 Zfp341  zinc finger protein 341  Znf341  zinc finger protein 341  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-17 Zfp966  zinc finger protein 966  LOC296300  similar to zinc finger protein 341  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC296300  similar to zinc finger protein 341      Symbol and Name status set to provisional 70820 PROVISIONAL