Lrit2 (leucine-rich repeat, Ig-like and transmembrane domains 2) - Rat Genome Database

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Gene: Lrit2 (leucine-rich repeat, Ig-like and transmembrane domains 2) Rattus norvegicus
Analyze
Symbol: Lrit2
Name: leucine-rich repeat, Ig-like and transmembrane domains 2
RGD ID: 1564668
Description: Predicted to be located in membrane. Orthologous to human LRIT2 (leucine rich repeat, Ig-like and transmembrane domains 2); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 3,3',4,4'-tetrachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine-rich repeat, immunoglobulin-like and transmembrane domains 2; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2; LOC498594; RGD1564668; similar to leucine rich repeat containing 22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21612,834,996 - 12,840,028 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1612,835,051 - 12,839,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1612,779,340 - 12,783,776 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01613,924,075 - 13,928,511 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01612,771,836 - 12,776,271 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01614,315,980 - 14,325,053 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1614,319,777 - 14,324,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01614,220,595 - 14,226,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41613,275,634 - 13,280,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1613,093,227 - 13,097,658 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lrit2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21612,834,996 - 12,840,028 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1612,835,051 - 12,839,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1612,779,340 - 12,783,776 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01613,924,075 - 13,928,511 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01612,771,836 - 12,776,271 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01614,315,980 - 14,325,053 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1614,319,777 - 14,324,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01614,220,595 - 14,226,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41613,275,634 - 13,280,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1613,093,227 - 13,097,658 (+)NCBICelera
Cytogenetic Map16p14NCBI
LRIT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381084,220,485 - 84,225,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1084,220,571 - 84,225,544 (-)EnsemblGRCh38hg38GRCh38
GRCh371085,980,241 - 85,985,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361085,970,221 - 85,975,264 (-)NCBINCBI36Build 36hg18NCBI36
Celera1079,975,750 - 79,980,793 (-)NCBICelera
Cytogenetic Map10q23.1NCBI
HuRef1079,825,720 - 79,830,763 (-)NCBIHuRef
CHM1_11086,262,008 - 86,267,051 (-)NCBICHM1_1
T2T-CHM13v2.01085,099,011 - 85,104,115 (-)NCBIT2T-CHM13v2.0
Lrit2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391436,784,923 - 36,795,700 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1436,789,886 - 36,795,700 (+)EnsemblGRCm39 Ensembl
GRCm381437,064,433 - 37,073,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1437,067,929 - 37,073,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv371437,881,235 - 37,886,921 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361435,979,290 - 35,984,976 (+)NCBIMGSCv36mm8
Celera1433,279,110 - 33,284,754 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1421.29NCBI
Lrit2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555103,732,436 - 3,736,557 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555103,732,436 - 3,736,557 (-)NCBIChiLan1.0ChiLan1.0
LRIT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11096,206,669 - 96,212,964 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01080,636,045 - 80,641,129 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11084,205,958 - 84,211,052 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1084,205,967 - 84,211,052 (-)Ensemblpanpan1.1panPan2
LRIT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1432,464,825 - 32,468,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl432,464,825 - 32,468,988 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha432,450,256 - 32,454,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0432,780,362 - 32,784,526 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl432,780,362 - 32,784,526 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1432,642,970 - 32,647,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0432,835,251 - 32,839,416 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0433,331,859 - 33,336,023 (-)NCBIUU_Cfam_GSD_1.0
Lrit2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721346,250,847 - 46,255,149 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936767833,890 - 837,647 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936767833,219 - 838,283 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRIT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1485,460,549 - 85,465,274 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11485,461,325 - 85,465,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21492,266,178 - 92,270,127 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRIT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1947,603,280 - 47,610,230 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl947,604,868 - 47,608,805 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660487,781,490 - 7,786,836 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrit2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248412,804,741 - 2,808,760 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248412,804,741 - 2,808,760 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrit2
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:57
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000038771
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system
High
Medium
Low
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038771   ⟹   ENSRNOP00000035539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1612,835,051 - 12,839,482 (+)Ensembl
Rnor_6.0 Ensembl1614,319,777 - 14,324,208 (+)Ensembl
RefSeq Acc Id: NM_001191938   ⟹   NP_001178867
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21612,834,996 - 12,840,028 (+)NCBI
Rnor_6.01614,319,777 - 14,324,208 (+)NCBI
Rnor_5.01614,220,595 - 14,226,565 (+)NCBI
Celera1613,093,227 - 13,097,658 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035539
  ENSRNOP00000035539.1
Reference Protein Sequences
RefSeq Acc Id: NP_001178867   ⟸   NM_001191938
- Peptide Label: precursor
- UniProtKB: D4A7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035539   ⟸   ENSRNOT00000038771
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7B9-F1-model_v2 AlphaFold D4A7B9 1-549 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564668 AgrOrtholog
BioCyc Gene G2FUF-11995 BioCyc
Ensembl Genes ENSRNOG00000022726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038771 ENTREZGENE
  ENSRNOT00000038771.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
KEGG Report rno:498594 UniProtKB/TrEMBL
NCBI Gene 498594 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  SYNAPTIC ADHESION-LIKE MOLECULE SALM UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PhenoGen Lrit2 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022726 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt D4A7B9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Lrit2  leucine-rich repeat, Ig-like and transmembrane domains 2  Lrit2  leucine-rich repeat, immunoglobulin-like and transmembrane domains 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Lrit2  leucine-rich repeat, immunoglobulin-like and transmembrane domains 2  RGD1564668_predicted  similar to leucine rich repeat containing 22 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564668_predicted  similar to leucine rich repeat containing 22 (predicted)  LOC498594  similar to leucine rich repeat containing 22  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498594  similar to leucine rich repeat containing 22      Symbol and Name status set to provisional 70820 PROVISIONAL