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Gene: Apip (APAF1 interacting protein) Rattus norvegicus

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Symbol:

Apip

Name:

APAF1 interacting protein

RGD ID:

1564562

Description:

Predicted to enable identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Predicted to be involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and pyroptotic inflammatory response. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm. Orthologous to human APIP (APAF1 interacting protein); PARTICIPATES IN cysteine and methionine metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC295961; methylthioribulose-1-phosphate dehydratase; probable methylthioribulose-1-phosphate dehydratase; RGD1564562; similar to MMRP19

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	APIP (APAF1 interacting protein)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Apip (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Apip (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	APIP (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	APIP (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Apip (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	APIP (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	APIP (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Apip (APAF1 interacting protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif 19)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Apip (APAF1 interacting protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	APIP (APAF1 interacting protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	apip (APAF1 interacting protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11134	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MDE1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC373.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	apip	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	109,886,919 - 109,913,295 (+)	NCBI		GRCr8
mRatBN7.2	3	89,431,964 - 89,458,000 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	89,432,037 - 89,458,340 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	92,931,217 - 92,957,295 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	101,530,251 - 101,556,331 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	99,359,187 - 99,385,302 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	92,969,128 - 92,998,104 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	92,969,141 - 92,995,483 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	99,612,110 - 99,640,878 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	88,306,123 - 88,332,800 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	88,509,653 - 88,535,688 (+)	NCBI		Celera
Cytogenetic Map	3	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Pyruvate Dehydrogenase E3-Binding Protein Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cobalt dichloride (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

glyphosate (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

methimazole (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

propiconazole (EXP)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

thalidomide (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid biosynthetic process (IEA)

apoptotic process (IEA,ISO)

L-methionine salvage from methylthioadenosine (IBA,IEA,ISO)

methionine biosynthetic process (IEA)

negative regulation of apoptotic process (IEA,ISO)

protein homotetramerization (IEA,ISO)

pyroptotic inflammatory response (IEA,ISO)

regulation of ERK1 and ERK2 cascade (IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

endomembrane system (IEA)

Molecular Function

identical protein binding (IEA,ISO)

lyase activity (IEA)

metal ion binding (IEA)

methylthioribulose 1-phosphate dehydratase activity (IBA,IEA,ISO)

protein binding (ISO)

zinc ion binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cysteine and methionine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15262985	PMID:16189514	PMID:17086211	PMID:19060904	PMID:22837397	PMID:23285211	PMID:24367089	PMID:25416956	PMID:31515488

Genomics

Comparative Map Data

Apip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	109,886,919 - 109,913,295 (+)	NCBI		GRCr8
mRatBN7.2	3	89,431,964 - 89,458,000 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	89,432,037 - 89,458,340 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	92,931,217 - 92,957,295 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	101,530,251 - 101,556,331 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	99,359,187 - 99,385,302 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	92,969,128 - 92,998,104 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	92,969,141 - 92,995,483 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	99,612,110 - 99,640,878 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	88,306,123 - 88,332,800 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	88,509,653 - 88,535,688 (+)	NCBI		Celera
Cytogenetic Map	3	q32	NCBI

APIP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	34,882,295 - 34,916,379 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	34,853,094 - 34,916,379 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	34,903,842 - 34,937,926 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	34,860,421 - 34,894,484 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	35,051,185 - 35,085,276 (-)	NCBI		Celera
Cytogenetic Map	11	p13	NCBI
HuRef	11	34,602,325 - 34,636,417 (-)	NCBI		HuRef
CHM1_1	11	34,902,113 - 34,936,196 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	35,020,271 - 35,054,314 (-)	NCBI		T2T-CHM13v2.0

Apip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	102,904,020 - 102,922,994 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	102,904,020 - 102,922,989 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	103,073,675 - 103,092,649 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	103,073,675 - 103,092,644 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	102,913,832 - 102,932,806 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	102,874,514 - 102,893,460 (+)	NCBI		MGSCv36	mm8
Celera	2	104,317,769 - 104,336,727 (+)	NCBI		Celera
Cytogenetic Map	2	E2	NCBI
cM Map	2	54.29	NCBI

Apip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	11,405,721 - 11,429,146 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	11,405,721 - 11,426,700 (+)	NCBI	ChiLan1.0	ChiLan1.0

APIP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	37,103,066 - 37,137,097 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	37,107,771 - 37,141,802 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	34,855,437 - 34,889,486 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	34,730,671 - 34,764,732 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	34,730,671 - 34,764,732 (-)	Ensembl	panpan1.1		panPan2

APIP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	33,012,049 - 33,033,453 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	33,011,121 - 33,033,435 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	32,617,866 - 32,639,261 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	33,623,160 - 33,644,563 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	33,183,124 - 33,204,482 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	32,774,401 - 32,795,973 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	33,409,813 - 33,431,215 (+)	NCBI		UU_Cfam_GSD_1.0

Apip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	30,091,219 - 30,114,204 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936533	3,216,187 - 3,238,776 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936533	3,216,020 - 3,238,999 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APIP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	26,095,038 - 26,115,462 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	26,095,020 - 26,115,462 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	28,461,921 - 28,482,434 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APIP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	30,344,658 - 30,374,741 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	30,344,690 - 30,374,737 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	127,458,535 - 127,492,516 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Apip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	12,257,597 - 12,280,154 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	12,257,591 - 12,285,968 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Apip
230 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	8
Count of miRNA genes:	8
Interacting mature miRNAs:	8
Transcripts:	ENSRNOT00000009797
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	51490129	111359995	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	73592611	110333156	Rat
1358293	Bw38	Body weight QTL 38	6	0.0000031	body mass (VT:0001259)	body weight (CMO:0000012)	3	74364268	119364268	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	101255536	134750886	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	70311536	115311536	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	81541464	126563126	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	36721849	110333156	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	42158111	124558371	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	42158111	124558371	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat

Markers in Region

AU047000

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	89,442,844 - 89,442,958 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	92,980,075 - 92,980,188	NCBI	Rnor6.0
Rnor_5.0	3	99,622,849 - 99,622,962	UniSTS	Rnor5.0
RGSC_v3.4	3	88,317,646 - 88,317,759	UniSTS	RGSC3.4
Celera	3	88,520,536 - 88,520,649	UniSTS
Cytogenetic Map	3	q32	UniSTS

RH135014

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	89,445,012 - 89,445,226 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	92,982,243 - 92,982,456	NCBI	Rnor6.0
Rnor_5.0	3	99,625,017 - 99,625,230	UniSTS	Rnor5.0
RGSC_v3.4	3	88,319,814 - 88,320,027	UniSTS	RGSC3.4
Celera	3	88,522,704 - 88,522,917	UniSTS
RH 3.4 Map	3	670.3	UniSTS
Cytogenetic Map	3	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009797 ⟹ ENSRNOP00000009797

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	89,432,037 - 89,458,340 (+)	Ensembl
Rnor_6.0 Ensembl	3	92,969,141 - 92,995,483 (+)	Ensembl

RefSeq Acc Id:

NM_001106492 ⟹ NP_001099962

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	109,886,919 - 109,912,955 (+)	NCBI
mRatBN7.2	3	89,431,964 - 89,458,000 (+)	NCBI
Rnor_6.0	3	92,969,178 - 92,995,229 (+)	NCBI
Rnor_5.0	3	99,612,110 - 99,640,878 (+)	NCBI
RGSC_v3.4	3	88,306,123 - 88,332,800 (+)	RGD
Celera	3	88,509,653 - 88,535,688 (+)	RGD

Sequence:

show sequence

TGCTTCTCGCTCTTGCTCCGCCCCCAGACTGCCCGCTTTGCAGACTAATAGCGTTCTTGTGGAC
CACTTAGACGTAGAACGTGCTCGGGGTGGCTAACTGAGCGGAGTTAGAACCATGTCTGGCTGTC
AAGCGCAAGGAGACTGTTGCTCGCGGCCGTATGGCGCGCAGGACAAGGAACATCCCAGATTCCT
GATCCCAGAACTTTGCAAACAGTTTTACCATCTGGGCTGGGTCACTGGCACTGGAGGAGGAATC
AGCTTGAAGCATGGCAATGAAATCTACATTGCTCCCTCAGGCGTGCAAAAGGAGCGCATTCAGC
CAGAAGACATGTTTGTTTGTGACATCAATGAGCAGGACATAAGTGGGCCTCCAGCATCTAAGAA
TCTTAAGAAAAGCCAGTGTACGCCTCTTTTCATGAACGCTTACACCATGAGAGGAGCAGGCGCA
GTGATTCATACCCACTCTAAAGCTGCTGTGATGGCTACCCTTCTGTTTCCAGGACAGGAGTTTA
AAATTACACATCAAGAGATGATCAAAGGAATAAGGAAATGTACCTCTGGAGGGTATTACAGATA
CGATGATATATTAGTGGTACCCATTATTGAGAACACTCCTGAAGAGAAGGACCTCAAAGAACGG
ATGGCTCGTGCCATGAATGAATACCCAGACTCCTGTGCAGTTCTAGTCAGGCGTCACGGGGTGT
ACGTGTGGGGAGAAACATGGGAGAAAGCAAAAACCATGTGTGAGTGTTATGATTACCTGTTTGA
CATTGCTGTCTCCATGAAGAAGATGGGGCTGGATCCAACGCAGTTCCCAGTTGGAGAACATGGA
ATCGTATAAGCCAAGTGGACGCCTAAGAATCTCCAAAAATAAAACAAACTCAATTACGCCTTAA
ATAAAACTCTGCTACTTTTAAATG

hide sequence

RefSeq Acc Id:

XM_039104529 ⟹ XP_038960457

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	109,904,152 - 109,913,295 (+)	NCBI
mRatBN7.2	3	89,449,197 - 89,457,997 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099962	(Get FASTA)	NCBI Sequence Viewer
	XP_038960457	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL79656	(Get FASTA)	NCBI Sequence Viewer
	EDL79657	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009797
	ENSRNOP00000009797.6

RefSeq Acc Id:	NP_001099962 ⟸ NM_001106492
- UniProtKB:	D3ZUI1 (UniProtKB/TrEMBL), A6HNQ5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFVCDINEQDISGPPASKNLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGQEFKIT HQEMIKGIRKCTSGGYYRYDDILVVPIIENTPEEKDLKERMARAMNEYPDSCAVLVRRHGVYVW GETWEKAKTMCECYDYLFDIAVSMKKMGLDPTQFPVGEHGIV hide sequence

Ensembl Acc Id:

ENSRNOP00000009797 ⟸ ENSRNOT00000009797

RefSeq Acc Id:	XP_038960457 ⟸ XM_039104529
- Peptide Label:	isoform X1
- UniProtKB:	A6HNQ6 (UniProtKB/TrEMBL)

Protein Domains

Class II aldolase/adducin N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZUI1-F1-model_v2	AlphaFold	D3ZUI1	1-241	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692251

Promoter ID:

EPDNEW_R2776

Type:

initiation region

Name:

Apip_1

Description:

APAF1 interacting protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	92,969,189 - 92,969,249	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564562	AgrOrtholog
BioCyc Gene	G2FUF-48586	BioCyc
Ensembl Genes	ENSRNOG00000007446	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009797	ENTREZGENE
	ENSRNOT00000009797.7	UniProtKB/TrEMBL
Gene3D-CATH	3.40.225.10	UniProtKB/TrEMBL
InterPro	Aldolase_II/adducin_N	UniProtKB/TrEMBL
	Aldolase_II/adducin_N_sf	UniProtKB/TrEMBL
	MethylthioRu-1-P_deHdtase_MtnB	UniProtKB/TrEMBL
	Salvage_MtnB_euk	UniProtKB/TrEMBL
KEGG Report	rno:295961	UniProtKB/TrEMBL
NCBI Gene	295961	ENTREZGENE
PANTHER	METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE	UniProtKB/TrEMBL
	PTHR10640	UniProtKB/TrEMBL
Pfam	Aldolase_II	UniProtKB/TrEMBL
PhenoGen	Apip	PhenoGen
RatGTEx	ENSRNOG00000007446	RatGTEx
SMART	Aldolase_II	UniProtKB/TrEMBL
Superfamily-SCOP	Aldolase_II_N	UniProtKB/TrEMBL
UniProt	A6HNQ5	ENTREZGENE, UniProtKB/TrEMBL
	A6HNQ6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZUI1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Apip	APAF1 interacting protein	Apip_predicted	APAF1 interacting protein (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Apip_predicted	APAF1 interacting protein (predicted)	RGD1564562_predicted	similar to MMRP19 (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1564562_predicted	similar to MMRP19 (predicted)	LOC295961	similar to MMRP19	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC295961	similar to MMRP19			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)