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Gene: Tlr11 (toll-like receptor 11) Rattus norvegicus

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Symbol:

Tlr11

Name:

toll-like receptor 11

RGD ID:

1564460

Description:

Predicted to enable signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Predicted to act upstream of or within response to bacterium. Predicted to be located in membrane. Predicted to be active in plasma membrane; PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH bisphenol A; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC498491; RGD1564460; similar to toll-like receptor 11

RGD Orthologs

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Tlr11 (toll-like receptor 11)	RGD	RGD
Alliance orthologs ³
Mus musculus (house mouse):	Tlr11 (toll-like receptor 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tlr20.4 (toll-like receptor 20, tandem duplicate 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|PhylomeDB)
Danio rerio (zebrafish):	tlr20f (toll-like receptor 20f)	Alliance	DIOPT (Hieranoid\|InParanoid\|PhylomeDB)
Danio rerio (zebrafish):	tlr20.2 (toll-like receptor 20, tandem duplicate 2)	Alliance	DIOPT (OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Tehao	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	LOC100498493	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	26,018,987 - 26,023,426 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	26,018,987 - 26,024,110 (+)	Ensembl				GRCr8
mRatBN7.2	15	23,545,408 - 23,549,849 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	23,545,408 - 23,549,849 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	26,316,647 - 26,321,080 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	27,277,986 - 27,282,425 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	25,525,198 - 25,529,637 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	27,177,900 - 27,182,339 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	27,177,900 - 27,182,339 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	31,114,731 - 31,119,170 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	26,073,335 - 26,076,214 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	23,877,213 - 23,881,652 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

membranoproliferative glomerulonephritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

bisphenol A (EXP)

methamphetamine (ISO)

PCB138 (ISO)

pioglitazone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

immune system process (IEA)

inflammatory response (IBA,IEA)

innate immune response (IEA)

response to bacterium (ISO)

response to other organism (IEA)

signal transduction (IEA)

toll-like receptor signaling pathway (IBA)

Cellular Component

membrane (IEA)

plasma membrane (IBA)

Molecular Function

protein binding (ISO)

signaling receptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

toxoplasmosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	TLR4 links podocytes with the innate immune system to mediate glomerular injury.	Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15001781	PMID:17314314	PMID:19703144

Genomics

Comparative Map Data

Tlr11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	26,018,987 - 26,023,426 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	26,018,987 - 26,024,110 (+)	Ensembl				GRCr8
mRatBN7.2	15	23,545,408 - 23,549,849 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	23,545,408 - 23,549,849 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	26,316,647 - 26,321,080 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	27,277,986 - 27,282,425 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	25,525,198 - 25,529,637 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	27,177,900 - 27,182,339 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	27,177,900 - 27,182,339 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	31,114,731 - 31,119,170 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	26,073,335 - 26,076,214 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	23,877,213 - 23,881,652 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

Tlr11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	50,595,371 - 50,601,120 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	50,595,371 - 50,601,120 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	50,357,914 - 50,363,663 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	50,357,914 - 50,363,663 (+)	Ensembl			mm10	GRCm38
MGSCv37	14	50,980,177 - 50,983,338 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	49,282,453 - 49,285,445 (+)	NCBI		MGSCv36	mm8
Celera	14	46,598,260 - 46,601,421 (+)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	26.07	NCBI

Variants

Variants in Tlr11
4 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	24
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000039925
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	20248600	37896129	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	14481165	28469888	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	19856566	34924750	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	11	22	67	71	74	43	50	43	6	209	100	11	42	47	69	31	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001144779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC122990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ539013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000039925 ⟹ ENSRNOP00000051449

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	26,018,987 - 26,024,110 (+)	Ensembl
mRatBN7.2 Ensembl	15	23,545,408 - 23,549,849 (+)	Ensembl
Rnor_6.0 Ensembl	15	27,177,900 - 27,182,339 (+)	Ensembl

RefSeq Acc Id:

NM_001144779 ⟹ NP_001138251

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,018,987 - 26,023,426 (+)	NCBI
mRatBN7.2	15	23,545,408 - 23,549,849 (+)	NCBI
Rnor_6.0	15	27,177,900 - 27,182,339 (+)	NCBI
Rnor_5.0	15	31,114,731 - 31,119,170 (+)	NCBI
RGSC_v3.4	15	26,073,335 - 26,076,214 (+)	RGD
Celera	15	23,877,213 - 23,881,652 (+)	NCBI

Sequence:

show sequence

ACATATCACCAATAACATAGTTCTGTGCAGCAGAGCAGGTGGAGGGAAGAGAAAGGTTTTCCTC
TCTGGCTATGGGTGATGAAAGAGAACTCTCTTGAGAACGTGAATATCTCCACCACCTCATGCTC
AAAGAATCAATGCCAAAGATGGAAAGACATCTGTTCCACTCTGTTCTCCTCATTCTGATACTAC
TGACTTTGGTGAGCCTTAACTTGACCGGCTTGGCATGGACTATCCCTGATTGCATCATAGCAGA
CAGCTTGTTATTTCCTAACCTTTCCTCCTACATCCCATTCTGTACCTTGGCCCCAAGGCTGCAT
CTTTTGGCATCTTGTTCCAATGTTAAAAACATAAATCAAACCCTAGAAAAAGTGCCCAGAAATA
CAGAGGTGCTTTGCCTCCAGGGCATGGTTCCTACTCTGCCAGCAAATGCCTTTGATGGCTTCTA
CTCCCTACAGCTTCTAAGGCTTCAATTGGGTACAACCAACATCACATCTAGGACTTTCCAAGGC
CTGGACCAGCTACAGTACCTTTTTTTTGAGCATCACGCTCCCTGTTGCCTAAGTCTGTTCCTCC
CTCCAGATAGTTTAGAGTCTCTCAGATCCCTTAGTAGTCTTTCCTTTCAAGGATACTGCCTGAC
TTATAGCCACAGCATCTACTTGCCAACCACTCTCAGGCATCTAACCATGAGGAACAGCTGCCTG
ACAAAGTTGCAGGAACTTCAAAGACTCTTCCCAGATCTTCTGCTGGGTGCCTCTTCTACACCCA
ATACCAAACCAAGGACACCCTTTCTAGAGGTGCTGGATTTATCTTACAACCTTCAGCTGAAGCA
GGCAGGTATCAGAGACTTGTATGGCCTCACACTCCATTCCCTAATATTGGATGGCACCCCACTA
AGAGCACTTGATCTCACAAGCTCAGGACTGCTCCACTTGCACTTCCTCTCCCTCGTGGGTACGG
GTATAGAAAAACTGCCTGCAAGTGTGACCGGCTTCTCTGAGCTTTGTGCACTTGATCTTGGGAA
GAATCAAATCCAAAACATCTTAGGAAATGGAGATATCCTAGGTTTGAAAGCCCTGAAATTCCTC
AGCCTTCATGATAACCATCTGCAATCACTTCCCGTCAGGTTTCTGCGTACTCTACCCCAGCTTC
AGAAGCTCAACCTATCTATGAATAAGCTTGGCCCAATCTTGGAGCTTCCAGAAGGACTCTTTAG
CACAAATCTAACAGTGCTAGATCTGTCCCACAATCAACTCTGTGAAATACCCCGTGGGAATTTC
TCCTTCCTTTCACAGCTCCAGGAGCTCTGGCTGAGTGGCAATAACATCTCTAGTTTATCCAATG
AGAGCCTGCAGGGACTGAGGTGGCTGAGGACACTAGACTTGAGTTGGAATCAAATTAAAGTACT
CAAACCAGGATGGCTCTCTCATCTTCCTGCGCTGACTACCTTGAACCTTCTGGGCACTTACTTA
GAGCATATCTCAGGCACACAACTTCAGGGTCCCAAGATGCTAAGACATCTACAACTGGGTTCTT
TTCCAACGCTGGAAATATATCGTCTCTGGTTCCCAATGCTCCTCAGCTTAGAAATACAAGCAGA
AACATATATCCAGTTTATGGTTCCAAGCGGAGAGCCATTCTTATTCTTGGAGAACCTTACCTTA
GAGACTTCCAATCTGTTACTGGAACCAAAAACCACCACAATTCATTTTCCCTCCCTACGTCGCC
TCACCTTGCGTGGCTACAGTATCTTCTTGTCAACCAGTCAACTCCAGAGTTTCTTCCCACCACA
GCTTCCCCTCCTGGAGTACTTCTTTGTATGGTGTAGAAATGACGATGCAGTAGACCTCCATCTA
TTCGAGATGCCCAGGCTGCGTGTGCTAGAGCTGGGCAACCTTAATTTTTTCTACGAGTCAAGTA
CGGTGAAGCTAGAGATGCTGCTCAACGAGGTGCCTCAGTTACAGGTACTGGCATTGAGTCACCT
AAATCTCAAGAACCTCTCTGTGTCCAGCTTTAAGGGTTTGCAGAGCCTCAAACTGCTGCTGCTC
AACTCCGAAAGAGCCCTGGAGATGAACAGCAACCTTCAGGAGTTAATTCCTCAGATTCCTCAGT
ATGTTTATTTCTCAGATGTCACCTTTGCCTGCCAGTGTGAAACTTCCTGGCTGGAGTCTTGGGC
TACACGGGCCCCAAACACTTTCGTTTATGGGCTGGAAAAACCCATCTGCATGGCTAATGCCTCC
GACTACTCCAAAACTCTACTGTTCTCCTTCCTTGCTACCAATTGCCCACATGGCACTGAGTTTT
GGGGCTTCCTCACCAGTTTCTCCCTGCTGCTTCTGCTGATAATCCTTCCTCTAATTAGCTGTCA
TAAATGGTCCTGGCTCCATCACCTCTGGACACTCTTTCACACCTGTTGGTGGAAATTAGGCGGA
CATAGACTCAGAGGGCAATTCAACTACGATGTCTTTATATCCTATTGTGAAGAGGACCAAGATT
GGGTGCTGGAAGAACTGGTTCCGGTTTTGGAGAAAGCCCCTCCTGAAGGTGAGGGCTTGAGGCT
CTGCTTGCCTGCCAGGGACTTTGGGATTGGAAATGACAGGATGGAATCCATGATTGCCAGCATG
GGCAAAAGCAGAGCCATCCTCTGTGTGCTCACAGGTCAGGCCTTAGCAAGTCCCTGGTGCAATC
TAGAGTTAAGACTGGCCACTTACCATTTGATAGCCAGGCCCGGGACCACTTGCCTTCTGCTGCT
GTTTCTGGAGCCCCTTGATAGGCAGAAGCTCCATAGTTACCACCGCCTCTCCCGATGGCTCCAG
AAGGAGGACTATTTTGATTTGTCCCAAGGGAAAATGGAGTGGAACACTTTCTGTGAGCAACTGA
AGCAACGGCTCAGAAAAGCTAGAAAAGAAAGAGAAGATTAAGGGCTGTCTGGGATGTTGCTGTG
CAGAAAATCCTTTCAGCAGCAGCAAGAATGCTCTCTCATCACTAGAGCACGGACTCAAAAGTGG
GGCAAAAATAGTATATTTTTAAATGCTATATTAAATGCTACTGGTTGGGAAGTCTTTTAAAACA
CTGGAAAATATTCATTTAGAAAACAATTCTTTTACGTGCTAGTGCATTCCAGCACGAGATATTG
CTCAGCACACAAGGCAAAGAGGTTTGTGCAATCCTGTGTATGTTTTTTACAAAACTTTTCAAAA
TAAATCCATCCTGCTACTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001138251	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACL80330	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000051449
	ENSRNOP00000051449.4

RefSeq Acc Id:

NP_001138251 ⟸ NM_001144779

- UniProtKB:

F7EMB9 (UniProtKB/TrEMBL), B8YJH0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLKESMPKMERHLFHSVLLILILLTLVSLNLTGLAWTIPDCIIADSLLFPNLSSYIPFCTLAPR
LHLLASCSNVKNINQTLEKVPRNTEVLCLQGMVPTLPANAFDGFYSLQLLRLQLGTTNITSRTF
QGLDQLQYLFFEHHAPCCLSLFLPPDSLESLRSLSSLSFQGYCLTYSHSIYLPTTLRHLTMRNS
CLTKLQELQRLFPDLLLGASSTPNTKPRTPFLEVLDLSYNLQLKQAGIRDLYGLTLHSLILDGT
PLRALDLTSSGLLHLHFLSLVGTGIEKLPASVTGFSELCALDLGKNQIQNILGNGDILGLKALK
FLSLHDNHLQSLPVRFLRTLPQLQKLNLSMNKLGPILELPEGLFSTNLTVLDLSHNQLCEIPRG
NFSFLSQLQELWLSGNNISSLSNESLQGLRWLRTLDLSWNQIKVLKPGWLSHLPALTTLNLLGT
YLEHISGTQLQGPKMLRHLQLGSFPTLEIYRLWFPMLLSLEIQAETYIQFMVPSGEPFLFLENL
TLETSNLLLEPKTTTIHFPSLRRLTLRGYSIFLSTSQLQSFFPPQLPLLEYFFVWCRNDDAVDL
HLFEMPRLRVLELGNLNFFYESSTVKLEMLLNEVPQLQVLALSHLNLKNLSVSSFKGLQSLKLL
LLNSERALEMNSNLQELIPQIPQYVYFSDVTFACQCETSWLESWATRAPNTFVYGLEKPICMAN
ASDYSKTLLFSFLATNCPHGTEFWGFLTSFSLLLLLIILPLISCHKWSWLHHLWTLFHTCWWKL
GGHRLRGQFNYDVFISYCEEDQDWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGNDRMESMIA
SMGKSRAILCVLTGQALASPWCNLELRLATYHLIARPGTTCLLLLFLEPLDRQKLHSYHRLSRW
LQKEDYFDLSQGKMEWNTFCEQLKQRLRKARKERED

hide sequence

Ensembl Acc Id:

ENSRNOP00000051449 ⟸ ENSRNOT00000039925

Protein Domains

TIR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7EMB9-F1-model_v2	AlphaFold	F7EMB9	1-932	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564460	AgrOrtholog
BioCyc Gene	G2FUF-14083	BioCyc
Ensembl Genes	ENSRNOG00000032368	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039925	ENTREZGENE
	ENSRNOT00000039925.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10140	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
InterPro	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	Toll-Interleukin_rcpt	UniProtKB/TrEMBL
	Toll_tir_struct_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:498491	UniProtKB/TrEMBL
NCBI Gene	498491	ENTREZGENE
PANTHER	PTHR24365	UniProtKB/TrEMBL
	TOLL-LIKE RECEPTOR 11	UniProtKB/TrEMBL
Pfam	LRR_8	UniProtKB/TrEMBL
	TIR_2	UniProtKB/TrEMBL
PhenoGen	Tlr11	PhenoGen
PROSITE	LRR	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000032368	RatGTEx
SMART	LRR_SD22	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
UniProt	B8YJH0	ENTREZGENE, UniProtKB/TrEMBL
	F7EMB9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Tlr11	toll-like receptor 11	RGD1564460_predicted	similar to toll-like receptor 11 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564460_predicted	similar to toll-like receptor 11 (predicted)	LOC498491	similar to toll-like receptor 11	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498491	similar to toll-like receptor 11			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)