Eif5-ps1 (eukaryotic translation initiation factor 5, pseudogene 1) - Rat Genome Database

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Gene: Eif5-ps1 (eukaryotic translation initiation factor 5, pseudogene 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Eif5-ps1
Name: eukaryotic translation initiation factor 5, pseudogene 1
RGD ID: 1564400
Description: Predicted to enable GTP binding activity and translation initiation factor activity. Predicted to be involved in translational initiation; INTERACTS WITH (+)-schisandrin B; ammonium chloride; paraquat.
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: INFERRED
Previously known as: eukaryotic translation initiation factor 5-like; LOC295660; RGD1564400; similar to Eukaryotic translation initiation factor 5 (eIF-5)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Functional Gene: Eif5  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8373,974,260 - 73,977,621 (+)NCBIGRCr8
mRatBN7.2353,566,365 - 53,569,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,566,757 - 53,568,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx356,962,021 - 56,965,393 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,545,608 - 65,548,980 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0355,021,248 - 55,022,439 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0361,636,597 - 61,638,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,912,744 - 50,914,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera353,130,164 - 53,132,754 (+)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Eif5-ps1
71 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000119951   ⟹   ENSRNOP00000096885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl353,566,757 - 53,568,645 (+)Ensembl
RefSeq Acc Id: XM_039106359   ⟹   XP_038962287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2353,566,531 - 53,569,302 (+)NCBI
Protein Sequences
Ensembl Protein ENSRNOP00000096885.1
RefSeq Acc Id: XP_038962287   ⟸   XM_039106359
RefSeq Acc Id: ENSRNOP00000096885   ⟸   ENSRNOT00000119951
Protein Domains
W2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-49519 BioCyc
Ensembl Genes ENSRNOG00000065729 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000119951.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.180 UniProtKB/TrEMBL
  2.20.25.350 UniProtKB/TrEMBL
  3.30.30.170 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  IF2/IF5 UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5_dom UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5_N UniProtKB/TrEMBL
  W2_domain UniProtKB/TrEMBL
NCBI Gene 295660 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 5 UniProtKB/TrEMBL
  PTHR23001 UniProtKB/TrEMBL
Pfam eIF-5_eIF-2B UniProtKB/TrEMBL
  PF02020 UniProtKB/TrEMBL
PhenoGen Eif5-ps1 PhenoGen
PROSITE PS51363 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065729 RatGTEx
SMART eIF2B_5 UniProtKB/TrEMBL
  eIF5C UniProtKB/TrEMBL
Superfamily-SCOP SSF100966 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
UniProt A0A8I6AVQ3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-10 Eif5-ps1  eukaryotic translation initiation factor 5, pseudogene 1  Eif5-ps1  eukaryotic translation initiation factor 5, pseudogene 1  Type changed (type changed from [protein-coding] to [pseudo]) 629549 APPROVED
2022-03-10 Eif5-ps1  eukaryotic translation initiation factor 5, pseudogene 1  RGD1564400  similar to Eukaryotic translation initiation factor 5 (eIF-5)  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1564400  similar to Eukaryotic translation initiation factor 5 (eIF-5)   RGD1564400_predicted  similar to Eukaryotic translation initiation factor 5 (eIF-5) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564400_predicted  similar to Eukaryotic translation initiation factor 5 (eIF-5) (predicted)  LOC295660  similar to Eukaryotic translation initiation factor 5 (eIF-5)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC295660  similar to Eukaryotic translation initiation factor 5 (eIF-5)      Symbol and Name status set to provisional 70820 PROVISIONAL