Dhrs2l1 (dehydrogenase/reductase member 2 like 1) - Rat Genome Database

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Gene: Dhrs2l1 (dehydrogenase/reductase member 2 like 1) Rattus norvegicus
Analyze
Symbol: Dhrs2l1
Name: dehydrogenase/reductase member 2 like 1
RGD ID: 1564324
Description: Predicted to enable carbonyl reductase (NADPH) activity; INTERACTS WITH acrylamide; bisphenol A; cefaloridine.
Type: protein-coding
RefSeq Status: PREDICTED
Previously known as: hypothetical protein LOC290217; LOC290217; RGD1564324; similar to dehydrogenase/reductase member 2; uncharacterized protein LOC290217
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,605,149 - 32,608,039 (+)NCBIGRCr8
mRatBN7.21528,635,197 - 28,638,087 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,635,197 - 28,638,087 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,480,911 - 30,483,801 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,628,107 - 31,630,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,870,763 - 29,873,653 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,821,095 - 33,841,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,822,730 - 33,825,620 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,702,181 - 37,726,342 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,270,015 - 33,272,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1528,213,007 - 28,215,897 (+)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Dhrs2l1
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:119
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000067607
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
BF389513  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,637,900 - 28,638,020 (+)MAPPERmRatBN7.2
Rnor_6.01533,825,434 - 33,825,553NCBIRnor6.0
Rnor_5.01537,711,295 - 37,711,414UniSTSRnor5.0
RGSC_v3.41533,272,476 - 33,272,595UniSTSRGSC3.4
Celera1528,215,711 - 28,215,830UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
1 36 7 1 1 1 43 2 34 39 28

Sequence


Ensembl Acc Id: ENSRNOT00000067607   ⟹   ENSRNOP00000060750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,635,197 - 28,638,087 (+)Ensembl
Rnor_6.0 Ensembl1533,822,730 - 33,825,620 (+)Ensembl
RefSeq Acc Id: NM_001106035   ⟹   NP_001099505
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,605,149 - 32,608,039 (+)NCBI
mRatBN7.21528,635,197 - 28,638,087 (+)NCBI
Rnor_6.01533,822,730 - 33,825,620 (+)NCBI
Rnor_5.01537,702,181 - 37,726,342 (+)NCBI
RGSC_v3.41533,270,015 - 33,272,662 (+)RGD
Celera1528,213,007 - 28,215,897 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099505 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14221 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060750.1
RefSeq Acc Id: NP_001099505   ⟸   NM_001106035
- UniProtKB: D3ZP23 (UniProtKB/TrEMBL),   A6KGZ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060750   ⟸   ENSRNOT00000067607

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZP23-F1-model_v2 AlphaFold D3ZP23 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-13739 BioCyc
Ensembl Genes ENSRNOG00000042267 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067607.4 UniProtKB/TrEMBL
KEGG Report rno:290217 UniProtKB/TrEMBL
NCBI Gene 290217 ENTREZGENE
PhenoGen Dhrs2l1 PhenoGen
RatGTEx ENSRNOG00000042267 RatGTEx
UniProt A6KGZ2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZP23 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Dhrs2l1  dehydrogenase/reductase member 2 like 1  RGD1564324  similar to dehydrogenase/reductase member 2  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1564324  similar to dehydrogenase/reductase member 2   RGD1564324_predicted  similar to dehydrogenase/reductase member 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564324_predicted  similar to dehydrogenase/reductase member 2 (predicted)  LOC290217  similar to dehydrogenase/reductase member 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290217  similar to dehydrogenase/reductase member 2      Symbol and Name status set to provisional 70820 PROVISIONAL