Pdcd5l1 (programmed cell death 5 like 1) - Rat Genome Database

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Gene: Pdcd5l1 (programmed cell death 5 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Pdcd5l1
Name: programmed cell death 5 like 1
RGD ID: 1564319
Description: Predicted to enable DNA binding activity. Predicted to be active in cytosol and nucleus. Orthologous to human PDCD5 (programmed cell death 5); INTERACTS WITH bisphenol A; Cuprizon; indole-3-methanol.
Type: protein-coding
RefSeq Status: PREDICTED
Previously known as: hypothetical protein LOC366089; LOC366089; RGD1564319; similar to TF-1 apoptosis related protein 19; uncharacterized protein LOC366089
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,051,611 - 84,053,009 (+)NCBIGRCr8
mRatBN7.2363,644,615 - 63,646,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl363,644,581 - 63,664,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx366,982,390 - 66,983,784 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0375,565,987 - 75,567,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0373,335,563 - 73,336,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0365,672,058 - 65,673,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl365,672,058 - 65,673,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0372,235,317 - 72,236,715 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4361,403,851 - 61,405,249 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera363,111,021 - 63,112,419 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
nucleus  (IBA)

Molecular Function
DNA binding  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Pdcd5l1
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:120
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000057901
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 10 9 29 26 31 14 9 14 4 56 31 20 2 35 17

Sequence


Ensembl Acc Id: ENSRNOT00000057901   ⟹   ENSRNOP00000054709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl365,672,058 - 65,673,454 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110264   ⟹   ENSRNOP00000086126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl363,644,581 - 63,664,425 (+)Ensembl
RefSeq Acc Id: NM_001126290   ⟹   NP_001119762
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8384,051,611 - 84,053,009 (+)NCBI
mRatBN7.2363,644,615 - 63,646,013 (+)NCBI
Rnor_6.0365,672,058 - 65,673,456 (+)NCBI
Rnor_5.0372,235,317 - 72,236,715 (+)NCBI
RGSC_v3.4361,403,851 - 61,405,249 (+)RGD
Celera363,111,021 - 63,112,419 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001119762 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI60905 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086126.1
RefSeq Acc Id: NP_001119762   ⟸   NM_001126290
- UniProtKB: B1H286 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054709   ⟸   ENSRNOT00000057901
Ensembl Acc Id: ENSRNOP00000086126   ⟸   ENSRNOT00000110264

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1H286-F1-model_v2 AlphaFold B1H286 1-126 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692164
Promoter ID:EPDNEW_R2689
Type:multiple initiation site
Name:RGD1564319_1
Description:similar to TF-1 apoptosis related protein 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0365,672,051 - 65,672,111EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564319 AgrOrtholog
BioCyc Gene G2FUF-49254 BioCyc
Ensembl Genes ENSRNOG00000038050 Ensembl
  ENSRNOG00000067541 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000110264.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.140 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455398 IMAGE-MGC_LOAD
InterPro PDCD5-like_sf UniProtKB/TrEMBL
  TFAR19_DNA_bd UniProtKB/TrEMBL
KEGG Report rno:366089 UniProtKB/TrEMBL
MGC_CLONE MGC:188637 IMAGE-MGC_LOAD
NCBI Gene 366089 ENTREZGENE
PANTHER PROGRAMMED CELL DEATH PROTEIN 5 UniProtKB/TrEMBL
  TFAR19_DNA_bd UniProtKB/TrEMBL
Pfam dsDNA_bind UniProtKB/TrEMBL
PhenoGen Pdcd5l1 PhenoGen
PIRSF TFAR19 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038050 RatGTEx
  ENSRNOG00000067541 RatGTEx
Superfamily-SCOP TFAR19-related UniProtKB/TrEMBL
UniProt B1H286 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Pdcd5l1  programmed cell death 5 like 1  RGD1564319  similar to TF-1 apoptosis related protein 19  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1564319  similar to TF-1 apoptosis related protein 19   RGD1564319_predicted  similar to TF-1 apoptosis related protein 19 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564319_predicted  similar to TF-1 apoptosis related protein 19 (predicted)  LOC366089  similar to TF-1 apoptosis related protein 19  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366089  similar to TF-1 apoptosis related protein 19      Symbol and Name status set to provisional 70820 PROVISIONAL