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Gene: Slc5a8 (solute carrier family 5 member 8) Rattus norvegicus

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Symbol:

Slc5a8

Name:

solute carrier family 5 member 8

RGD ID:

1564146

Description:

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in several processes, including monoatomic anion transport; monocarboxylic acid transport; and nitrate transmembrane transport. Predicted to act upstream of or within short-chain fatty acid transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of GINS complex. Predicted to be active in apical plasma membrane. Orthologous to human SLC5A8 (solute carrier family 5 member 8); PARTICIPATES IN nicotinamide adenine dinucleotide metabolic pathway; INTERACTS WITH 17beta-estradiol; 3-chloropropane-1,2-diol; acrolein.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC500820; RGD1564146; similar to solute carrier family 5 (iodide transporter), member 8; sodium-coupled monocarboxylate transporter 1; solute carrier family 5 (iodide transporter), member 8; solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC5A8 (solute carrier family 5 member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Slc5a8 (solute carrier family 5 (iodide transporter), member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc5a8 (solute carrier family 5 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC5A8 (solute carrier family 5 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC5A8 (solute carrier family 5 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc5a8 (solute carrier family 5 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC5A8 (solute carrier family 5 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC5A8 (solute carrier family 5 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc5a8 (solute carrier family 5 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC5A8 (solute carrier family 5 member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc5a8 (solute carrier family 5 (iodide transporter), member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc5a8l (solute carrier family 5 member 8, like)	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	slc5a8 (solute carrier family 5 member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10444	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK822.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK822.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG2187	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG2187	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	DUR3	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	DUR3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31262	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31262	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31668	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31668	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG32669	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32669	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG33124	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG33124	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG42235	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG42235	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG5687	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG5687	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6723	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6723	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG9657	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG9657	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	SLC5A11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	SLC5A11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Smvt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Smvt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	salt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	salt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	slc5a8.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc5a8.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	25,160,280 - 25,201,185 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	25,159,897 - 25,204,419 (+)	Ensembl				GRCr8
mRatBN7.2	7	23,272,891 - 23,313,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	23,272,427 - 23,314,642 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	25,267,453 - 25,308,367 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	27,429,993 - 27,470,903 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	27,207,192 - 27,248,116 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	29,434,175 - 29,476,807 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	29,435,444 - 29,477,947 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	29,534,554 - 29,578,495 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	25,585,545 - 25,626,486 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	20,428,427 - 20,468,519 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colonic Neoplasms (ISO)

hyperuricemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (EXP)

amitrole (EXP)

arsenite(3-) (ISO)

atrazine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

caffeine (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

dextran sulfate (ISO)

ethanol (ISO)

fonofos (ISO)

furan (EXP)

genistein (EXP,ISO)

hydrazine (ISO)

hydrogen peroxide (ISO)

ibuprofen (ISO)

kaempferol (ISO)

lead diacetate (ISO)

methimazole (EXP)

ozone (ISO)

parathion (ISO)

phenobarbital (EXP)

pirinixic acid (ISO)

probenecid (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

sodium atom (ISO)

sodium fluoride (EXP)

sulfadimethoxine (EXP)

terbufos (ISO)

testosterone (EXP,ISO)

titanium dioxide (ISO)

triadimefon (EXP)

triptonide (ISO)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetate transport (IEA,ISO)

chloride transport (IEA,ISO)

iodide transport (IEA,ISO)

lactate transmembrane transport (IEA)

lactate transport (IEA,ISO)

monoatomic ion transport (IEA)

monocarboxylic acid transport (IEA,ISO)

nicotinate transport (IEA,ISO)

nitrate transmembrane transport (IEA,ISO)

propanoate transmembrane transport (IBA,IEA,ISO)

pyruvate transport (IEA,ISO)

short-chain fatty acid transmembrane transport (IEA,ISO)

sodium ion transmembrane transport (IEA)

sodium ion transport (IBA,IEA)

transmembrane transport (IEA)

Cellular Component

apical plasma membrane (IEA,ISO)

GINS complex (IEA,ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

lactate transmembrane transporter activity (IEA,ISO)

monocarboxylate:sodium symporter activity (IEA,ISO)

nicotinate transmembrane transporter activity (ISO)

organic acid:sodium symporter activity (IBA,IEA,ISO)

propionate transmembrane transporter activity (IEA,ISO)

protein binding (ISO)

short-chain fatty acid transmembrane transporter activity (IEA,ISO)

symporter activity (IEA)

transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

nicotinamide adenine dinucleotide metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The human NAD metabolome: Functions, metabolism and compartmentalization.	Nikiforov A, etal., Crit Rev Biochem Mol Biol. 2015;50(4):284-97. doi: 10.3109/10409238.2015.1028612. Epub 2015 Apr 2.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15322102	PMID:19056867	PMID:20211600	PMID:20671196	PMID:22123132	PMID:23533145

Genomics

Comparative Map Data

Slc5a8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	25,160,280 - 25,201,185 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	25,159,897 - 25,204,419 (+)	Ensembl				GRCr8
mRatBN7.2	7	23,272,891 - 23,313,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	23,272,427 - 23,314,642 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	25,267,453 - 25,308,367 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	27,429,993 - 27,470,903 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	27,207,192 - 27,248,116 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	29,434,175 - 29,476,807 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	29,435,444 - 29,477,947 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	29,534,554 - 29,578,495 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	25,585,545 - 25,626,486 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	20,428,427 - 20,468,519 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

SLC5A8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	101,155,493 - 101,210,238 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	101,155,493 - 101,210,238 (-)	Ensembl			hg38	GRCh38
GRCh37	12	101,549,271 - 101,604,016 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	100,073,402 - 100,128,120 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	100,051,745 - 100,106,457	NCBI
Celera	12	101,215,310 - 101,269,325 (-)	NCBI		Celera
Cytogenetic Map	12	q23.1-q23.2	NCBI
HuRef	12	98,610,304 - 98,664,323 (-)	NCBI		HuRef
CHM1_1	12	101,515,979 - 101,569,971 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	101,117,226 - 101,171,943 (-)	NCBI		T2T-CHM13v2.0

Slc5a8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	88,721,854 - 88,765,377 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	88,721,854 - 88,765,377 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	88,885,992 - 88,929,515 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	88,885,992 - 88,929,515 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	88,348,737 - 88,392,260 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	88,315,836 - 88,365,884 (+)	NCBI		MGSCv36	mm8
MGSCv36	10	89,074,526 - 89,117,897 (+)	NCBI		MGSCv36	mm8
Celera	10	90,866,357 - 90,911,145 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	44.34	NCBI

Slc5a8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	36,725,892 - 36,769,074 (-)	Ensembl
ChiLan1.0	NW_004955405	36,717,579 - 36,769,074 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC5A8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	109,218,024 - 109,280,585 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	109,214,072 - 109,276,983 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	98,735,175 - 98,795,478 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	102,137,701 - 102,198,184 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	102,137,701 - 102,198,148 (-)	Ensembl			panPan2	panpan1.1

SLC5A8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	40,176,479 - 40,239,859 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	40,179,872 - 40,239,634 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	40,544,936 - 40,608,134 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	40,830,422 - 40,893,672 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	40,833,812 - 40,893,628 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	40,087,024 - 40,150,008 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	40,194,458 - 40,257,689 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	40,468,399 - 40,531,641 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc5a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	19,737,204 - 19,784,989 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	12,746,996 - 12,795,421 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	12,747,654 - 12,792,865 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC5A8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	82,973,284 - 83,031,157 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	82,973,179 - 83,088,542 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	87,012,757 - 87,066,769 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC5A8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	96,431,253 - 96,489,267 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	96,431,548 - 96,487,856 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	148,536,549 - 148,593,899 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc5a8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	6,681,142 - 6,729,896 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624750	6,603,668 - 6,731,219 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc5a8
309 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	46
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000008613
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	19654317	49753746	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	19654317	49753746	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	19654317	52888450	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	20555705	29891047	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	19032807	35526300	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat
70207	Niddm31	Non-insulin dependent diabetes mellitus QTL 31	3.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	18169505	26029351	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	5	11	91	47	52	21	17	21	6	159	38	80	79	72	31	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008613 ⟹ ENSRNOP00000008613

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	25,159,897 - 25,204,419 (+)	Ensembl
mRatBN7.2 Ensembl	7	23,272,849 - 23,314,642 (+)	Ensembl
Rnor_6.0 Ensembl	7	29,435,444 - 29,477,947 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106493 ⟹ ENSRNOP00000085621

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	25,159,897 - 25,198,785 (+)	Ensembl
mRatBN7.2 Ensembl	7	23,272,427 - 23,313,798 (+)	Ensembl

RefSeq Acc Id:

NM_001191987 ⟹ NP_001178916

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	25,160,280 - 25,201,185 (+)	NCBI
mRatBN7.2	7	23,272,891 - 23,313,811 (+)	NCBI
Rnor_6.0	7	29,435,832 - 29,476,807 (+)	NCBI
Rnor_5.0	7	29,534,554 - 29,578,495 (+)	NCBI
Celera	7	20,428,427 - 20,468,519 (+)	NCBI

Sequence:

show sequence

ATGGACGCTTCGCGGGACATCGGCAGCTTTGTGGTGTGGGACTACGTGGTGTTCGCAGGCATGC
TGCTCATCTCGGCGGCCATCGGCATCTATTACGCCTTCGCGGGGGGCGGCCAGCAGACCTCCAA
GGACTTTCTGATGGGCGGCCGCAGTATGAGCGCTGTGCCTGTGGCTCTGTCCCTCACCGCCAGC
TTCATGTCCGCTGTCACTGTCCTGGGCACCCCCGCCGAGGTCTACCGTTTTGGGGCGATATTCA
GCATCTTTGGCGTCACTTACTTTTTTGTAGTGGTTATCAGCGCGGAGGTCTTCCTTCCGGTGTT
CTATAGACTCGGGATCACCAGCACCTACGAGTATTTGGAGCTCAGATTTAATCGATTCATTCGT
CTCTGTGGCACAGTCCTCTTCATCGTTCAAACAATTCTGTACACTGGGATTGTGATTTATGCCC
CTGCTCTGGCTTTGAATCAAGTTACAGGATTTGATCTGTGGGGCGCAGTGGTGGCCACAGGGGT
GGTCTGCACATTCTACTGCACACTGGGTGGTCTTAAAGCAGTCGTCTGGACAGATGTTTTTCAA
GTCGGGATCATGGTGGCTGGATTTGCATCCGTGATTATACAGGCTTCCATAACTCAAGGTGGCA
TCAATACGATTTTAAGTGACGCTTCCAATGGTGGAAGATTAAACTTCTGGAATTTTAATCCTAA
CCCTTTGCAAAGACACACGTTCTGGACAATTATCGTCGGAGGGACTTTTACATGGACCACCATC
TATGGTGTCAACCAGTCCCAAGTGCAGAGATATATTTCCTGTAAAAGCAGACTCCATGCAAAAC
TGTCTCTCTATGTCAACCTTGTGGGCCTCTGGGTGATCCTCATCTGCTCCGTGTTCTGTGGGCT
TGCCCTGTACTCCAGATACCATGACTGTGATCCCTGGACATCTAAGAAAGTGTCAGAAGTTGAC
CAGCTTATGCCTTATTTGGTGCTGGACATTTTGAAAAATTATCCTGGTGTTCCCGGACTTTTTG
TGGCCTGTGCTTACAGTGGGACATTAAGCACGGTGTCTTCCAGCATCAATGCCTTGGCAGCAGT
CACTGTGGAAGATCTCATCAAACCTCGCTTCAAGTCTCTCTCAGAGAAGTCTCTGTCTTGGATT
TCTCAAGGAATGAGTGTGCTGTACGGAGCTTTGTGCATCGGGATGGCTGCTGTGGCCTCGCTGA
TGGGAGCCTTGTTACAGGCAGCACTTAGCATATTTGGCATGGTTGGTGGACCACTTCTGGGCTT
GTTTTCTTTGGGCATCTTGGTCCCCTTCGCCAACTCTGTGGGAGCCTTTGCCGGTCTGTTGGCC
GGATTTGCCGTTTCTTTATGGGTAGGAATCGGAGCCCAGCTTTATCCTCCACTTCCTGAGAGAA
CCTTACCATTGTCCCTTGAAACCCATGGCTGTAACAGCACGCACAACGGGACAGACTGGATGTC
AACCACAGAGATGCCATTTTCTACTAGCGCTTTCCAGATACACGACGTGGAAAGGAGTGCACTG
ATGGACAATTGGTATTCATTATCATATCTGTACTTCAGTACCATTGGAACCCTGACAACGTTGC
TGGTGGGGATTCTTATCAGTTTAGCAACAGGAGGAAGAAAACAGAACTTAGACCCCCGATTCTT
ACTAACCAAACAGGACTTTTTATCCAATTTTGATGTTTTTAAGAAAAAGACTCATGTTTTAAAC
TATAAAATGCATCCTGTGGAAGACGGTGGAACTGATAACCCGGCCTTCAACCACGTGGAGCTGA
ACTTCCCAGACCACAGTGGCAAGATCAATGGGACTCGCTTGTGAAGCTTCTCCAGGGCTGGATG
CTGTTGTATAATGTCTGGTTTTTTTTTATTATTAAAAAACATGTTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178916	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16992	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008613
	ENSRNOP00000008613.6
	ENSRNOP00000085621.1

RefSeq Acc Id:

NP_001178916 ⟸ NM_001191987

- UniProtKB:

D3Z9E5 (UniProtKB/TrEMBL), A0A8I6A218 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTAS
FMSAVTVLGTPAEVYRFGAIFSIFGVTYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRFIR
LCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQ
VGIMVAGFASVIIQASITQGGINTILSDASNGGRLNFWNFNPNPLQRHTFWTIIVGGTFTWTTI
YGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILICSVFCGLALYSRYHDCDPWTSKKVSEVD
QLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWI
SQGMSVLYGALCIGMAAVASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSVGAFAGLLA
GFAVSLWVGIGAQLYPPLPERTLPLSLETHGCNSTHNGTDWMSTTEMPFSTSAFQIHDVERSAL
MDNWYSLSYLYFSTIGTLTTLLVGILISLATGGRKQNLDPRFLLTKQDFLSNFDVFKKKTHVLN
YKMHPVEDGGTDNPAFNHVELNFPDHSGKINGTRL

hide sequence

Ensembl Acc Id:

ENSRNOP00000008613 ⟸ ENSRNOT00000008613

Ensembl Acc Id:

ENSRNOP00000085621 ⟸ ENSRNOT00000106493

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z9E5-F1-model_v2	AlphaFold	D3Z9E5	1-611	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695133

Promoter ID:

EPDNEW_R5658

Type:

initiation region

Name:

Slc5a8_1

Description:

solute carrier family 5 member 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	29,435,430 - 29,435,490	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564146	AgrOrtholog
BioCyc Gene	G2FUF-34497	BioCyc
Ensembl Genes	ENSRNOG00000006367	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008613	ENTREZGENE
	ENSRNOT00000008613.8	UniProtKB/TrEMBL
	ENSRNOT00000106493.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1730.10	UniProtKB/TrEMBL
InterPro	Na/Glc_symporter_sf	UniProtKB/TrEMBL
	Na/solute_symporter	UniProtKB/TrEMBL
	SLC5sbd_SMCT1	UniProtKB/TrEMBL
	Sodium:Solute_Symporter_SSF	UniProtKB/TrEMBL
KEGG Report	rno:500820	UniProtKB/TrEMBL
NCBI Gene	500820	ENTREZGENE
PANTHER	SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER	UniProtKB/TrEMBL
	SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1	UniProtKB/TrEMBL
Pfam	SSF	UniProtKB/TrEMBL
PhenoGen	Slc5a8	PhenoGen
PROSITE	NA_SOLUT_SYMP_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006367	RatGTEx
UniProt	A0A8I6A218	ENTREZGENE, UniProtKB/TrEMBL
	D3Z9E5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc5a8	solute carrier family 5 member 8	Slc5a8	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc5a8	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	Slc5a8	solute carrier family 5 (iodide transporter), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Slc5a8	solute carrier family 5 (iodide transporter), member 8	RGD1564146_predicted	similar to solute carrier family 5 (iodide transporter), member 8 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564146_predicted	similar to solute carrier family 5 (iodide transporter), member 8 (predicted)	LOC500820	similar to solute carrier family 5 (iodide transporter), member 8	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500820	similar to solute carrier family 5 (iodide transporter), member 8			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations