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Gene: Dact1 (dishevelled-binding antagonist of beta-catenin 1) Rattus norvegicus

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Symbol:

Dact1

Name:

dishevelled-binding antagonist of beta-catenin 1

RGD ID:

1564008

Description:

Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and enzyme binding activity. Predicted to be involved in several processes, including negative regulation of JNK cascade; negative regulation of beta-catenin-TCF complex assembly; and regulation of Wnt signaling pathway. Predicted to act upstream of or within several processes, including dendrite morphogenesis; negative regulation of Wnt signaling pathway; and positive regulation of fat cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dapper homolog 1; dapper homolog 1, antagonist of beta-catenin; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin, homolog 1; dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis); LOC500666; RGD1564008; similar to dapper 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	95,526,645 - 95,538,625 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	95,526,690 - 95,551,053 (+)	Ensembl				GRCr8
mRatBN7.2	6	89,790,676 - 89,818,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	89,790,644 - 89,817,906 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	90,174,745 - 90,185,345 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	90,474,205 - 90,484,805 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	89,913,716 - 89,924,316 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	93,740,440 - 93,751,003 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	93,740,586 - 93,749,809 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	103,201,826 - 103,212,384 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	93,402,304 - 93,411,668 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	88,272,055 - 88,282,541 (+)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Axenfeld-Rieger syndrome (ISO)

Colorectal Neoplasms (ISO)

Townes-Brocks syndrome (ISO)

Townes-Brocks Syndrome 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (EXP,ISO)

amiodarone (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

calciol (ISO)

cantharidin (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

choline (ISO)

cisplatin (ISO)

clothianidin (ISO)

cobalt dichloride (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

diquat (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

entinostat (ISO)

ethanol (ISO)

fenvalerate (EXP)

flusilazole (ISO)

folic acid (ISO)

gentamycin (EXP)

glucose (ISO)

hydrogen cyanide (ISO)

indometacin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (EXP,ISO)

nickel atom (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium cyanide (ISO)

potassium dichromate (ISO)

progesterone (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

toluene 2,4-diisocyanate (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (ISO)

dendrite morphogenesis (ISO)

embryonic hindgut morphogenesis (ISO)

embryonic morphogenesis (ISO)

gastrulation with mouth forming second (ISO)

negative regulation of beta-catenin-TCF complex assembly (ISO)

negative regulation of canonical Wnt signaling pathway (IBA,ISO)

negative regulation of G1/S transition of mitotic cell cycle (ISO)

negative regulation of JNK cascade (IBA,ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of Wnt signaling pathway (ISO)

neural tube development (ISO)

positive regulation of canonical Wnt signaling pathway (ISO)

positive regulation of fat cell differentiation (ISO)

positive regulation of protein catabolic process (ISO)

positive regulation of Wnt signaling pathway (ISO)

regulation of canonical Wnt signaling pathway (ISO)

regulation of nodal signaling pathway (ISO)

regulation of postsynapse organization (ISO)

regulation of protein stability (ISO)

regulation of Wnt signaling pathway, planar cell polarity pathway (IBA,ISO)

synapse organization (ISO)

Wnt signaling pathway (IEA)

Cellular Component

beta-catenin destruction complex (ISO)

cytoplasm (IBA,IEA,ISO)

glutamatergic synapse (ISO)

nucleoplasm (ISO)

nucleus (ISO)

postsynapse (ISO)

Molecular Function

beta-catenin binding (ISO)

delta-catenin binding (ISO)

histone deacetylase binding (ISO)

protein binding (ISO)

protein kinase A binding (ISO)

protein kinase C binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

transcription regulator inhibitor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15580286	PMID:16446366	PMID:17197390	PMID:18936100	PMID:19073771	PMID:19701191	PMID:20145239	PMID:20335472	PMID:21262972	PMID:21718540	PMID:22470507	PMID:22610794
PMID:24879894	PMID:25825496	PMID:27714812	PMID:35802196

Genomics

Comparative Map Data

Dact1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	95,526,645 - 95,538,625 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	95,526,690 - 95,551,053 (+)	Ensembl				GRCr8
mRatBN7.2	6	89,790,676 - 89,818,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	89,790,644 - 89,817,906 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	90,174,745 - 90,185,345 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	90,474,205 - 90,484,805 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	89,913,716 - 89,924,316 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	93,740,440 - 93,751,003 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	93,740,586 - 93,749,809 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	103,201,826 - 103,212,384 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	93,402,304 - 93,411,668 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	88,272,055 - 88,282,541 (+)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

DACT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	58,634,061 - 58,648,321 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	58,633,967 - 58,648,321 (+)	Ensembl			hg38	GRCh38
GRCh37	14	59,100,779 - 59,115,039 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	58,174,510 - 58,184,792 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	58,174,611 - 58,184,789	NCBI
Celera	14	39,154,745 - 39,165,027 (+)	NCBI		Celera
Cytogenetic Map	14	q23.1	NCBI
HuRef	14	39,264,994 - 39,279,247 (+)	NCBI		HuRef
CHM1_1	14	59,039,260 - 59,053,513 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	52,841,138 - 52,855,396 (+)	NCBI		T2T-CHM13v2.0

Dact1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	71,356,658 - 71,366,881 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	71,356,658 - 71,366,881 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	71,309,884 - 71,320,107 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	71,309,884 - 71,320,107 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	72,410,871 - 72,421,094 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	72,228,589 - 72,237,499 (+)	NCBI		MGSCv36	mm8
Celera	12	72,410,534 - 72,420,756 (+)	NCBI		Celera
Cytogenetic Map	12	C3	NCBI
cM Map	12	29.39	NCBI

Dact1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955466	12,367,775 - 12,373,036 (+)	Ensembl
ChiLan1.0	NW_004955466	12,367,760 - 12,374,141 (+)	NCBI	ChiLan1.0	ChiLan1.0

DACT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	59,761,876 - 59,772,346 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	58,978,423 - 58,988,860 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	39,231,910 - 39,242,353 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	57,498,901 - 57,510,019 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	57,499,906 - 57,510,019 (+)	Ensembl			panPan2	panpan1.1

DACT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	33,950,016 - 33,959,671 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	33,949,926 - 33,958,449 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	33,710,858 - 33,719,128 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	34,191,432 - 34,199,711 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	34,191,432 - 34,199,675 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	33,803,264 - 33,811,542 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	33,871,726 - 33,879,997 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	34,246,058 - 34,254,343 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dact1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	71,165,976 - 71,174,693 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	3,017,150 - 3,025,684 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	3,017,029 - 3,026,759 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DACT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	187,719,290 - 187,729,422 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	187,719,391 - 187,729,568 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DACT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	35,821,518 - 35,832,486 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	35,821,990 - 35,832,712 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	24,088,036 - 24,098,815 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dact1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624884	3,739,334 - 3,948,621 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624884	3,733,648 - 3,750,207 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Dact1
203 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	107
Count of miRNA genes:	88
Interacting mature miRNAs:	96
Transcripts:	ENSRNOT00000011466
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	89762877	106752806	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	58632962	103632962	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	85140138	130140138	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	73463459	109394713	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	82523650	110548006	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
4889848	Pur25	Proteinuria QTL 25	14	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	56728562	90198260	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	85140138	130140138	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	83190345	106747639	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
738034	Anxrr5	Anxiety related response QTL 5	5.9		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	6	84130881	129130881	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat
1300076	Glom8	Glomerulus QTL 8	7	9e-09	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat

Markers in Region

RH135896

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	89,800,961 - 89,801,144 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	93,750,637 - 93,750,819	NCBI	Rnor6.0
Rnor_5.0	6	103,212,018 - 103,212,200	UniSTS	Rnor5.0
RGSC_v3.4	6	93,412,445 - 93,412,627	UniSTS	RGSC3.4
Celera	6	88,282,175 - 88,282,357	UniSTS
Cytogenetic Map	6	q24	UniSTS

UniSTS:498289

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	89,794,805 - 89,794,871 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	93,744,571 - 93,744,636	NCBI	Rnor6.0
Rnor_6.0	6	93,738,191 - 93,738,256	NCBI	Rnor6.0
Rnor_5.0	6	103,199,572 - 103,199,637	UniSTS	Rnor5.0
Rnor_5.0	6	103,205,952 - 103,206,017	UniSTS	Rnor5.0
RGSC_v3.4	6	93,406,289 - 93,406,354	UniSTS	RGSC3.4
Celera	6	88,276,186 - 88,276,251	UniSTS
Cytogenetic Map	6	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	153	91	90	59	77	59	6	335	177	11	132	75	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001077448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002726752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_576044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010052134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011466 ⟹ ENSRNOP00000011466

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	95,526,690 - 95,551,053 (+)	Ensembl
mRatBN7.2 Ensembl	6	89,790,644 - 89,817,906 (+)	Ensembl
Rnor_6.0 Ensembl	6	93,740,586 - 93,749,809 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000124549 ⟹ ENSRNOP00000109069

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	95,526,690 - 95,537,296 (+)	Ensembl

RefSeq Acc Id:

NM_001399171 ⟹ NP_001386100

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	95,526,690 - 95,537,296 (+)	NCBI
mRatBN7.2	6	89,790,722 - 89,801,328 (+)	NCBI

RefSeq Acc Id:

XM_576044 ⟹ XP_576044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	95,526,645 - 95,537,296 (+)	NCBI
mRatBN7.2	6	89,790,676 - 89,801,328 (+)	NCBI
Rnor_6.0	6	93,740,440 - 93,751,003 (+)	NCBI
Rnor_5.0	6	103,201,826 - 103,212,384 (+)	NCBI
RGSC_v3.4	6	93,402,304 - 93,411,668 (+)	RGD

Sequence:

show sequence

CCGGGAGTGACGTAGCGTGGCCAGGGCGTTATCAGCTGCGGGGCCGCAGACTGGAGCAGCGCGG
GATGCGAGTGCGGGCGGCATGAGCTCCCGGCCGGGACCCTAGCGCGTGCTGCTGCTCTCGGGCT
GGCCGGGCCTCGGGGGTCATGAAGCCCGACTCAGCGCGCGAGCCCGAGCCGCTGAGCCCCGGCA
GGGGCGCAGAGGCCGAGGGGCGCTGGCGCGAGAGGGGCGAGGCGGACACGGAGCGGCAGCGCAC
CCGCGAGCGCCAGGAGGCCACGCTGGCGGGGCTGGCGGAGCTGGGGTACCTGCGGCAACGCCAG
GAGCTGCTGGTGCGCGGTGCGCTGCGCTGCTCCGGGGCCGTGGGGACCGTCGCGCCGCGCGCCG
GGGAGCTGCGGGGGGACGCGGCGCAGCGCAGCCGCCTGGAGGAGAAGTTCCTGGAGGAGAACAT
CTTGCTGCTGCGGAGGCAGTTGAATTGTTTGAGGAGAAGAGATGCCGGTTTGTTGAATCAGTTG
CAAGAACTTGACAAGCAGATAAGTGACCTGAGACTGGATGTTGAGAAGACATCTGAGGAGCACC
TGGAGACGGACAGCCGGCCTAGCTCAGGGTTTTATGAGCTGAGTGATGGGGCTTCCGGGTCCCT
TTCTAACTCCTCTAACTCCGTGTTCAGTGAATGTTTGTCCAGTTGCCATTCCAGCACCTGCTTC
TGCAGCCCCTTGGAGGCAGCCTTGACCATCTCGGACGGTTGCCCCAAATCTGCAGATCTCATAG
GATGGTTGGAATGTAAAGGCGGCCACTGTGAAGACCAGGCCTCAGGGACAATGTGCAGTTCCCC
CTCCACACCACAATTTAACCCCCTTGATGTCATTGCAGATGTGAATCCTAAATACCAGTGTGAC
CTTGTGTCTAAAAACGGGAATGACGTATATCGGTATCCCAGTCCACTTCACGCTGTGGCTGTGC
AGAGCCCAATGTTTCTCCTTTGTCTGACGGGCAACTCTCTGAGGGAAGAGGAGGGGCTTGGGAA
CCACGCCAGCGACATTTGCATTGGATCTGAACTGAATGCCACCAAAATGGATAATTCCTTGCCA
TCTCCAAGCAGTTTGTGGCCGGCTTCTCAGCCTGCATCCAGTAAGAAAATGGATGGGTATATTC
TGAGCCTGGTCCAGAAGAAAACACACCCTGTAAGGACCAATAAACCTAGAACCAGTGTGAACGC
TGACCCTACCAAGGGGCTTCTGAGGAATGGAAGTGTGTGTGTCAGGGCCCCTAGTAGTGTCCCA
CAGGGCAGCAATGTGAACCTTAAGAATACGAAACAGATGTGTTTGCCCTGTGGGGGAATACCCT
CTTTGGAAAATGGGCCATTCTCTCCTCCTAAGCAGAGGTCAAAAGACTCGAAGACAGACCAGTC
AGAAAGTAAGAGGTTGGCTCTGCAGGAGGGCTGCTCGGTAGGCACTGCCATGGAACCCCAAAGC
AAGCATCTGCCCAAAATCGCCAAGGCAGCCTCTCAAGAGCTTGTAAGGTGTCAAGCTGGGCTGG
GAGAATCTATGAAGGAAAGCAATCAGGTTTCAGCCGTTTCTCCTAAAACAAGTCCGGGCGGAGG
CCCTGTCGCTTCCACAGAGAGCAAAGCTCTGCAGCTCCAGAAAAAGATGCCACAGAAGAGCAGT
CTACAGGCCTTGCCTGCGGTGGACAGGCCATCCTTGGACTTCAAAAGCGAGGGCTCTTCTCAAA
GCCTCGAAGAAGGGCATCTGGTAAAAGCTCAGTTCATCCCAGGGCAGCAGGCGGGCGCCAGGCC
TCACCGTGCACACAGGAACCCGGGTGTCGCAAGGAGCGCCACCTTGAAGGCCCGTGGCCAGGCA
GCCACAGAACATGGCCTTCCCACCGTCAGGGAGAAACCGCGGGCGGTGGGCAAGAAGTGCCGTT
TCCCAGACGACTTGGATACAAATAAGAAACTCAGGAAGGCCTCCTCCAAGGGCCGGCGCAGCAG
CGGGCTGCCCGACGCGAGCCTTCCTGGCAGGCCACTGGGCACCGGCGGCCATAGGGCAGGCAGC
AGGGCGCACGCGCACGGACGGGAGCCGGTGGTGGCCAAACCTAAACACAAGCGAACCGACTACC
GGAGGTGGAAGTCGTCGGCCGAGGTCTCCTACGAAGAGGCCCTGCGGAGGGCACGGAGGGCTCG
CAGGGAGCACGGGGGCGCCTACCCAGTGGCCGTGGCCGTGCCCTACCCCAGCCCCTACGCCTAC
GTGGCCAGCGACTCTGAGTACTCGGCCGAGTGTGAGTCGCTCTTCCACTCCACGGTGGTGGACA
CCAGCGAGGACGATCAGAGCAACTACACCACCAACTGCTTTGGCGACAGTGAGTCCAGCGTGAG
CGAGGGCGACTTCGTGGGTGAGAGCACCACCACCAGCGACTCTGAGGAGAGCGGGGGTTTAATC
TGGTCCCAGTTTGTCCAGACTCTCCCTATTCAAACGGTTACGGCCCCAGACCTTCACACCCGCC
CCACAAAAACCTTTGTCAAAATTAAGGCCTCGCACAACCTCAAGAAGAAGATCCTCCGCTTCCG
GTCAGGCTCTTTGAAACTGATGACTACTGTTTGAGTAGCTGATGTAGCGAGTGTCTTCCCCTCC
CCCAGTCTCTGGAAAAGAAAAGAAAGAAAGAAAAAAGGTGGTGTCTTAATATTTGTGTCATACT
TAAATGATACTTTCCTTCTACTAGGATAAACCCAAGATAAATTATGTCTCGCCATCATGTATGG
ACGCTAGTGCCTTTAATGGAAGGTGAAGGATGTATCGCTAGTTAGAAGTGAATATTGAGGTCTT
AGTGGTGGTGATAATGAATGAATTTTGATTATCAGATGTTTTGTCCGAGTGTCTGGCAAAGTAC
AGGTCTGTGATGTTTCAAGTTTTATTTGGATGAGACCTTTTGTTTCCGAGGTCTGTGGATAAAA
TTTTTAAGTCGTGAACTCGCGCCTTGATGTTTTAGGGCTGTGTCCCTGAAAAGACTTTCCGGTT
GAGGGGCATTGCATACAATTGTGTAGAATAGGTAGAAAAAAAAATGGTCATTGCTTTCTGTAAA
CTTTTTTAATATAGTCAACATTTCTCAGATGTCTCTCCATCCTATTTTCTTCTTAGAAGTACAC
TTTTTACTGGATTTAGAACCTAGTAGACCAGACTGTAAATCTGGAGGTGGTAAACTGGATAGGA
AGACTGACAGGACCTTAGAAGGATTCACAAAAACCTTTGCCACGTGTAGTGCCTCAGCCTTCGT
TACAGTAACTCTTTCTGGGCCAGGTATCCAGCAGTTTTTGATGCCTTTCTCTCTGCTCCTAACT
TGTATCCAATACAACTGTTTGTCCCTTAGACAGCTTGCCTTTGGGATAAAATGTTGGTCCTATG
GTGCAAAGAAATTCACCCTTACTGGGCATGACTCCAAGCCCAGAATTGCTCTCACCTAAGCACT
GGCCTAAACAGTAGTGCAGTTCACTCCCCACTGGACCACTGACTTGTCTGGAAGGGCTTTACAT
TTTTTAAAAAAGTTTTTGGTAAACAGTATTGTGTAAAATAGAATTTTTTAAATACTGATATATG
CATGTTTTGTGCATGAGTAGTAGTTATTTGGATTCCTGTTTTGATATTCCTGTTGTTGAATTAC
TGTATAATATAAACAGTATGTGTTTTATATATATCATTGTGTAAATTTAATATAACACATTATA
TGCTGTACTAAATGATTTGTTTTATTGCTGTTAACTTTGTTATTTGTTATAAAAACCAGATGTT
TACACTTATAAA

hide sequence

RefSeq Acc Id:

XR_010052134

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	95,526,645 - 95,538,625 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386100	(Get FASTA)	NCBI Sequence Viewer
	XP_576044	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03574	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011466
	ENSRNOP00000011466.3
	ENSRNOP00000109069

RefSeq Acc Id:	XP_576044 ⟸ XM_576044
- Peptide Label:	isoform X1
- UniProtKB:	D4A3W8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPDSAREPEPLSPGRGAEAEGRWRERGEADTERQRTRERQEATLAGLAELGYLRQRQELLVRG ALRCSGAVGTVAPRAGELRGDAAQRSRLEEKFLEENILLLRRQLNCLRRRDAGLLNQLQELDKQ ISDLRLDVEKTSEEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSSTCFCSPLEA ALTISDGCPKSADLIGWLECKGGHCEDQASGTMCSSPSTPQFNPLDVIADVNPKYQCDLVSKNG NDVYRYPSPLHAVAVQSPMFLLCLTGNSLREEEGLGNHASDICIGSELNATKMDNSLPSPSSLW PASQPASSKKMDGYILSLVQKKTHPVRTNKPRTSVNADPTKGLLRNGSVCVRAPSSVPQGSNVN LKNTKQMCLPCGGIPSLENGPFSPPKQRSKDSKTDQSESKRLALQEGCSVGTAMEPQSKHLPKI AKAASQELVRCQAGLGESMKESNQVSAVSPKTSPGGGPVASTESKALQLQKKMPQKSSLQALPA VDRPSLDFKSEGSSQSLEEGHLVKAQFIPGQQAGARPHRAHRNPGVARSATLKARGQAATEHGL PTVREKPRAVGKKCRFPDDLDTNKKLRKASSKGRRSSGLPDASLPGRPLGTGGHRAGSRAHAHG REPVVAKPKHKRTDYRRWKSSAEVSYEEALRRARRARREHGGAYPVAVAVPYPSPYAYVASDSE YSAECESLFHSTVVDTSEDDQSNYTTNCFGDSESSVSEGDFVGESTTTSDSEESGGLIWSQFVQ TLPIQTVTAPDLHTRPTKTFVKIKASHNLKKKILRFRSGSLKLMTTV hide sequence

Ensembl Acc Id:

ENSRNOP00000011466 ⟸ ENSRNOT00000011466

RefSeq Acc Id:	NP_001386100 ⟸ NM_001399171
- UniProtKB:	D4A3W8 (UniProtKB/TrEMBL), A6HC19 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109069 ⟸ ENSRNOT00000124549

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3W8-F1-model_v2	AlphaFold	D4A3W8	1-815	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694656

Promoter ID:

EPDNEW_R5174

Type:

multiple initiation site

Name:

Dact1_1

Description:

dishevelled-binding antagonist of beta-catenin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	93,740,497 - 93,740,557	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564008	AgrOrtholog
BioCyc Gene	G2FUF-37181	BioCyc
Ensembl Genes	ENSRNOG00000008445	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011466	ENTREZGENE
	ENSRNOT00000011466.4	UniProtKB/TrEMBL
	ENSRNOT00000124549	ENTREZGENE
InterPro	Dapper	UniProtKB/TrEMBL
NCBI Gene	500666	ENTREZGENE
PANTHER	PTHR15919	UniProtKB/TrEMBL
	PTHR15919:SF12	UniProtKB/TrEMBL
Pfam	Dapper	UniProtKB/TrEMBL
PhenoGen	Dact1	PhenoGen
RatGTEx	ENSRNOG00000008445	RatGTEx
UniProt	A6HC19	ENTREZGENE, UniProtKB/TrEMBL
	D4A3W8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-05-22	Dact1	dishevelled-binding antagonist of beta-catenin 1	Dact1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Dact1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	RGD1564008_predicted	similar to dapper 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564008_predicted	similar to dapper 1 (predicted)	LOC500666	similar to dapper 1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500666	similar to dapper 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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