Cdc42se2 (CDC42 small effector 2)

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Gene: Cdc42se2 (CDC42 small effector 2) Rattus norvegicus

Analyze

Symbol:

Cdc42se2 (Ensembl: Cdc42se2-ps1)

Name:

CDC42 small effector 2 (Ensembl:CDC42 small effector 2, pseudogene 1)

RGD ID:

1563924

Description:

Predicted to enable signaling adaptor activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in several cellular components, including cell projection; cytoskeleton; and phagocytic cup. Predicted to be active in plasma membrane. Orthologous to human CDC42SE2 (CDC42 small effector 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; diuron.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CDC42 small effector protein 2; hypothetical protein LOC686503; hypothetical protein LOC691031; LOC100191012; LOC502327; LOC686503; LOC691031; MGC156730; MGC189425; RGD1563924; similar to CDC42 small effector 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDC42SE2 (CDC42 small effector 2)	RGD	RGD
Mus musculus (house mouse):	Cdc42se2 (CDC42 small effector 2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Cdc42se2 (CDC42 small effector 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDC42SE2 (CDC42 small effector 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDC42SE2 (CDC42 small effector 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdc42se2 (CDC42 small effector 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDC42SE2 (CDC42 small effector 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDC42SE2 (CDC42 small effector 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cdc42se2 (CDC42 small effector 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CDC42SE2 (CDC42 small effector 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdc42se2 (CDC42 small effector 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cdc42se2 (CDC42 small effector 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spec2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F09F7.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	cdc42se2l	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Related Pseudogenes:

Cdc42se2-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	38,836,549 - 38,905,056 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	38,836,555 - 38,905,059 (-)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	1	91,287,876 - 91,288,130 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	43,521,943 - 43,593,879 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	43,012,021 - 43,083,966 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	38,515,736 - 38,587,673 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	40,054,393 - 40,122,915 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	40,054,400 - 40,122,915 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	39,827,142 - 39,895,658 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	40,116,093 - 40,184,995 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	38,175,018 - 38,243,633 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

systemic primary carnitine deficiency disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzoates (ISO)

bisphenol A (EXP)

bortezomib (ISO)

caffeine (ISO)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

cycloheximide (ISO)

dicrotophos (ISO)

diuron (EXP)

entinostat (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thimerosal (ISO)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phagocytosis (IEA)

regulation of cell shape (IEA)

regulation of Rho protein signal transduction (IEA)

regulation of signal transduction (ISO,ISS)

Cellular Component

cell projection (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

phagocytic cup (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

protein binding (ISO)

signaling adaptor activity (ISO)

small GTPase binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10816584	PMID:12477932	PMID:15489334	PMID:15632090	PMID:23376485

Genomics

Comparative Map Data

Cdc42se2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	38,836,549 - 38,905,056 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	38,836,555 - 38,905,059 (-)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	1	91,287,876 - 91,288,130 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	43,521,943 - 43,593,879 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	43,012,021 - 43,083,966 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	38,515,736 - 38,587,673 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	40,054,393 - 40,122,915 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	40,054,400 - 40,122,915 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	39,827,142 - 39,895,658 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	40,116,093 - 40,184,995 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	38,175,018 - 38,243,633 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

CDC42SE2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	131,210,052 - 131,394,672 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	131,245,493 - 131,398,447 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	130,599,746 - 130,730,365 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	130,627,601 - 130,758,282 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	130,723,085 - 130,754,683	NCBI
Celera	5	126,730,097 - 126,860,712 (+)	NCBI		Celera
Cytogenetic Map	5	q31.1	NCBI
HuRef	5	125,790,800 - 125,921,594 (+)	NCBI		HuRef
CHM1_1	5	130,032,671 - 130,163,278 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	131,728,731 - 131,914,233 (+)	NCBI		T2T-CHM13v2.0

Cdc42se2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	54,608,241 - 54,678,549 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	54,608,282 - 54,678,501 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	54,717,415 - 54,787,703 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	54,717,456 - 54,787,675 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	54,530,917 - 54,601,205 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	54,560,925 - 54,631,059 (-)	NCBI		MGSCv36	mm8
Celera	11	59,304,569 - 59,374,793 (-)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	32.13	NCBI

Cdc42se2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	2,844,135 - 2,881,800 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	2,780,126 - 2,881,800 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDC42SE2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	124,724,704 - 124,862,124 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	126,689,882 - 126,827,208 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	132,860,010 - 132,989,170 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	132,954,110 - 132,989,170 (+)	Ensembl	panpan1.1		panPan2

CDC42SE2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	19,641,815 - 19,757,867 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	19,641,901 - 19,756,814 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	18,438,881 - 18,554,632 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	20,419,749 - 20,535,788 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	20,418,958 - 20,535,762 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	19,148,433 - 19,263,942 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	18,995,277 - 19,110,822 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	19,593,967 - 19,709,749 (+)	NCBI		UU_Cfam_GSD_1.0

Cdc42se2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	116,666,379 - 116,731,735 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936647	3,669,209 - 3,734,491 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936647	3,669,141 - 3,734,515 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDC42SE2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	133,638,588 - 133,683,880 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	133,564,015 - 133,683,881 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	138,884,571 - 139,002,731 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDC42SE2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	34,123,376 - 34,238,241 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	34,123,409 - 34,238,280 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	43,728,480 - 43,843,987 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdc42se2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	40,632,781 - 40,670,843 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	40,633,503 - 40,670,970 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cdc42se2
301 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1179
Count of miRNA genes:	345
Interacting mature miRNAs:	455
Transcripts:	ENSRNOT00000063891
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat

Markers in Region

RH129055

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	38,836,590 - 38,836,770 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	40,054,441 - 40,054,620	NCBI	Rnor6.0
Rnor_5.0	10	39,827,189 - 39,827,368	UniSTS	Rnor5.0
RGSC_v3.4	10	40,116,135 - 40,116,314	UniSTS	RGSC3.4
Celera	10	38,175,060 - 38,175,239	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH139144

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	91,287,897 - 91,287,929 (-)	MAPPER	mRatBN7.2
mRatBN7.2	10	38,857,698 - 38,857,948 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	40,075,513 - 40,075,808	NCBI	Rnor6.0
Rnor_5.0	10	39,848,256 - 39,848,551	UniSTS	Rnor5.0
RGSC_v3.4	10	40,137,638 - 40,137,887	UniSTS	RGSC3.4
Celera	10	38,196,147 - 38,196,396	UniSTS
RH 3.4 Map	10	404.79	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH136619

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	91,289,578 - 91,289,764 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	38,837,144 - 38,837,330 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	40,054,995 - 40,055,180	NCBI	Rnor6.0
Rnor_6.0	1	94,990,215 - 94,990,400	NCBI	Rnor6.0
Rnor_5.0	10	39,827,743 - 39,827,928	UniSTS	Rnor5.0
Rnor_5.0	1	96,082,638 - 96,082,823	UniSTS	Rnor5.0
RGSC_v3.4	1	91,099,324 - 91,099,509	UniSTS	RGSC3.4
RGSC_v3.4	10	40,116,689 - 40,116,874	UniSTS	RGSC3.4
Celera	10	38,175,614 - 38,175,799	UniSTS
Celera	1	85,618,717 - 85,618,902	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH124288

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	91,289,838 - 91,289,971 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	91,289,838 - 91,289,971 (-)	MAPPER	mRatBN7.2
Rnor_6.0	10	40,054,788 - 40,054,920	NCBI	Rnor6.0
Rnor_6.0	1	94,990,475 - 94,990,607	NCBI	Rnor6.0
Rnor_5.0	10	39,827,536 - 39,827,668	UniSTS	Rnor5.0
Rnor_5.0	1	96,082,898 - 96,083,030	UniSTS	Rnor5.0
RGSC_v3.4	1	91,099,584 - 91,099,716	UniSTS	RGSC3.4
RGSC_v3.4	10	40,116,482 - 40,116,614	UniSTS	RGSC3.4
Celera	10	38,175,407 - 38,175,539	UniSTS
Celera	1	85,618,977 - 85,619,109	UniSTS
Cytogenetic Map	10	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	45	29	19	29	8	11	74	35	41	11	8
Low			12	12		12
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001126089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC129107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC169039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_001126089 ⟹ NP_001119561

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	38,836,549 - 38,905,056 (-)	NCBI
Rnor_6.0	10	40,054,399 - 40,122,915 (-)	NCBI
Rnor_5.0	10	39,827,142 - 39,895,658 (-)	NCBI
RGSC_v3.4	10	40,116,093 - 40,184,995 (-)	RGD
Celera	10	38,175,018 - 38,243,633 (-)	RGD

Sequence:

show sequence

AGCTGCTGGCGTGTGGAGATCCTAGGAGCTTCGGAGCCGGCGCTCGGAGCCGCGCGACTGGAGC
AGGCGGCGGAGACAAAGGCGACGATAGCGCCAGTGTTGAGTGAAACACAGAAACCAAATGAGAA
GATGTCTTCAAGGAACAACTGCTAATGAGTCTGCAGAGTCGCCTGTGTGTCTTTCAGCGTAGTC
TCCACTCAGAGCTGAGTGAGTGGCCCCATTGATGAGTGACCTGCTGCCGGCTCTGGACCAAAGC
TGTTCTGTCCTTCCCACTGACTTGGAACCAGTCTGTAGAACCGGAAGCAGAGAAAAGAAGCAAT
CAGACTTCCCTTTCAATCAACTCGTGACATTTGACTCCAGAGACAGAGGCACAGTGAAATAGTT
ATCTGACGACCATCCTCACTTTGAGGGCGCACATCGTGGAGCTTCCTGTGTGAAGATTTGGAGC
CTTCGTGGTGCTTGCTCAGGCCTTGGACTGAGCATGAGTGAATTCTGGCTGTGCTTCAACTGCT
GTATTGCAGAGCAGCCTCAGCCTAAGAGGCGACGACGGATTGACCGAAGTATGATTGGGGAACC
AACCAACTTTGTGCACACAGCTCACGTAGGATCCGGAGACCTATTTAGTGGGATGAACTCGGTC
AGCTCCATTCAGAACCAGATGCAGTCCAAGGGAGGTTATGGAGGAGGAATGCCTGCCAATGTGC
AGATGCAGCTTGTGGACACAAAGGCAGGATAGCCCTGGTCCCTTCATCTGTCATTGTGAACTCC
CGTATTTTCTCTGTCCACAGTTCTATAATATTTTTGTCTTGTGATTGGATTTCTTTTATTTTAA
TTATAAAAAAGAAGTGTGGCGGCAATCTGTTCACCCTGTGATCTCCAGCAAAGATGTTCCTGCT
CCAGGGAAGGCAGTGTCAGGCCGACCTGCCTTGCCGTTAGCGGCATGCATGCCTGGGACTCTGA
CAGAGTTCTTTGGATCGTAGCTGAATTTTCAATGTTTAATTGACATGGATCGGATCTTAGCATG
GTCTTCTTTGTGACTGCTAGCACTGTATTGTAATTTTCCATTTTAAACCTTTTCGTTGCACCTC
CAGCCCCTCTGCCGTATGATTTACTGGTAAACAAAGAGCTGTAATTACTGCCATCGTTTATGTA
TATTTGGAAGGTATGAGACCCACAGCACAATAGTCCTTTGCAGCTGTGGAACGTGCGTGGAGTG
CGTCTGCACACTCCATGGTGCTGCTCAGAGGGGACCCCATGGGACACCAGACCTCCATCCTGAG
CTGCTGCAGCCTGAGGTGGCTCCCCTCTCAGAGGAGGCTCTTTACACATATTCCGAGTGGGTTC
TGGTCTGACAAGAGCCGTGACAGGAAAGCCTGCGTTGCAGAGGCAGTGGCTTGGCTGTAAATGT
TGAGTGTATTTATTTGAGAGTAAGGACCTGTGATTGTGAGCAGATGCAGTCTGGATCTGAGTGT
GTGAAGCCCATTCAGTCTCTCAGCATCTCCGTCCTGTTAGCTCTTTGTGTTTCTAAGACTTTTG
GGGTCAGATTGCTCCCCCTGTCTGTGAGTTCAGATTCCGGCCTCTGCCACCAGCTGTGACTCGC
AGGGTCCTTGGCCTTCCAGTGTTCACTTACCATGGACGCTGTGGCAGCTTCCAACAGCAGCCTG
CTGCCTGGCTGCCTCAGTGACCAGCCCTCAGTAACATTCTGAGGGTAGTAAGAGGCCTTTGCTC
AGGTCCCGTTCTGTCCTCTTCCCTGCTGAGTGTAAGTAGCTGGGCCCTGTGGTCCACAGTACTT
TCTATCTGCCTTTGACTGATCGATTAGCATTTGTGCAGAAGATGGGTCTTAACTCAGATTAGAG
CACTGAAGGCACGTAGGTCCTCGGCTAGAGAAGCTGTGATCTTTTCTTTTCTGCCTTCACCTGT
CCCCGTCCTGAGAATGCTGACTGAAGAGCCACTAGGCTGAGGCAGGCAAAGCCAAAAGCATTTC
CCTCTGTTTCTTCAGAGCGTAACTTACACAGGGTGGAACACTGGGTGACCTGATTCTTACCATT
CTTAGGTGTCAGTCCTGAGCACAGAGGATTTCTCTGTCTAGGAGAAACGTTTTCTTCACTGGAT
GGACACTGCACTCTAGAGTCTGCCATTCTGCTTAGCCAGGGTGAGGTTCCTGCCAGGGCACTGC
TGTGTGCAGACTTTCTGTATAACAGACAGGGAATTCTTGGCATCGTCGGCACTGATGGATGGGA
CAGCACAGGGAGCCATTGTCCCCTCCCCCATCACTGTTTGCTGCTCCAAGGCCAGTCATTAATA
AGCCAAAGGCTCCTGAAGCCCATGATGGTCCTGGCAGCCTCTGACCTCTCGGCACAGTGAGACA
CTGTCCCCAGCACAGCGCCTGGTGCCCTGGAGGGTTCCAGTAAGGTCGAGAGAGTGTACAGCGT
GACCTGGTACATGCTGGTTATGGAGGCCTGAGGATGCCGGCAAAGGTGCAGGGACATGTCCCAC
CTCCTCCAATGGGATCGTAAACCTTGGGAACTCCTCTGTTCCCCTAGTCACACATCTCATTTTT
AAATTGGAGCTAATAGGATTTTGTACCCAGAATTTATTATATTGTTAATATTTCTCTGAAATAC
ATGGTAACAACTAGTAAGCAGGAGAAACAGCAGATCGCAGCGGTGTGCTGGGCGCAGCTTCTCC
AGTGGGCCTGGAAAGTGTTTGGTCATGAAACGGAGCTGTTGGTGAGAGCAGCTGCTTGATCTGC
TCGGTGACTCGTGCTCAGCCCCAGAAGACAAGATGGACGTATTTTTATAATCTAAGCATACTTT
TTTTGTACATTGTGTTCATTCTTGAATAAAGTGAGCTCACTGTTGGCTTGTAGATATTAAAAAA
GAAAGTATTGATTTTGATTCAATAAATGTTTTCTTTTAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001119561	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A1L1K4	(Get FASTA)	NCBI Sequence Viewer
	AAI69039	(Get FASTA)	NCBI Sequence Viewer
	EDM04437	(Get FASTA)	NCBI Sequence Viewer
	EDM04438	(Get FASTA)	NCBI Sequence Viewer
	EDM04439	(Get FASTA)	NCBI Sequence Viewer
	EDM04440	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001119561 ⟸ NM_001126089
- UniProtKB:	B5DFF3 (UniProtKB/Swiss-Prot), A1L1K4 (UniProtKB/Swiss-Prot), V9GZ87 (UniProtKB/TrEMBL), A6HEI3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEFWLCFNCCIAEQPQPKRRRRIDRSMIGEPTNFVHTAHVGSGDLFSGMNSVSSIQNQMQSKG GYGGGMPANVQMQLVDTKAG hide sequence

Protein Domains

CRIB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A1L1K4-F1-model_v2	AlphaFold	A1L1K4	1-83	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563924	AgrOrtholog
BioCyc Gene	G2FUF-25104	BioCyc
Ensembl Genes	ENSRNOG00000037364	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000042449	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000061001	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOP00000088149	ENTREZGENE
	ENSRNOP00000088149.1	UniProtKB/TrEMBL
	ENSRNOP00000097546.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000056539.3	UniProtKB/TrEMBL
	ENSRNOT00000063891	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOT00000103241	ENTREZGENE
	ENSRNOT00000103241.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.810.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7103559	IMAGE-MGC_LOAD
InterPro	CRIB_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CRIB_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SPEC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:100362023	UniProtKB/TrEMBL
	rno:691031	UniProtKB/TrEMBL
MGC_CLONE	MGC:156730	IMAGE-MGC_LOAD
NCBI Gene	691031	ENTREZGENE
PANTHER	CDC42 SMALL EFFECTOR PROTEIN 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13502	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cdc42se2	PhenoGen
PROSITE	CRIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A1L1K4	ENTREZGENE
	A6HEI3	ENTREZGENE, UniProtKB/TrEMBL
	B5DFF3	ENTREZGENE
	C42S2_RAT	UniProtKB/Swiss-Prot
	V9GZ87	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	B5DFF3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-06-15	Cdc42se2	CDC42 small effector 2	Cdc42se2	CDC42 small effector 2	Data Merged	1643240	APPROVED
2009-01-20	Cdc42se2	CDC42 small effector 2	LOC686503	hypothetical protein LOC686503	Data Merged	737654	APPROVED
2008-12-01	Cdc42se2	CDC42 small effector 2	LOC691031	hypothetical protein LOC691031	Data Merged	737654	APPROVED
2008-12-01	Cdc42se2	CDC42 small effector 2	LOC691031	hypothetical protein LOC691031	Data Merged	737654	APPROVED
2008-03-06	Cdc42se2	CDC42 small effector 2	RGD1563924_predicted	similar to CDC42 small effector 2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Cdc42se2	CDC42 small effector 2	RGD1563924_predicted	similar to CDC42 small effector 2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC686503	hypothetical protein LOC686503			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC686503	hypothetical protein LOC686503			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC691031	hypothetical protein LOC691031			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC691031	hypothetical protein LOC691031			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-07	RGD1563924_predicted	similar to CDC42 small effector 2 (predicted)	LOC502327	similar to CDC42 small effector 2	Symbol and Name status set to approved	1299863	APPROVED
2006-03-07	RGD1563924_predicted	similar to CDC42 small effector 2 (predicted)	LOC502327	similar to CDC42 small effector 2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC502327	similar to CDC42 small effector 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-02-09	LOC502327	similar to CDC42 small effector 2			Symbol and Name status set to provisional	70820	PROVISIONAL

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar