C11h21orf91 (similar to human chromosome 21 open reading frame 91) - Rat Genome Database

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Gene: C11h21orf91 (similar to human chromosome 21 open reading frame 91) Rattus norvegicus
Analyze
Symbol: C11h21orf91 (Ensembl: RGD1563888)
Name: similar to human chromosome 21 open reading frame 91 (Ensembl:similar to DNA segment, Chr 16, ERATO Doi 472, expressed)
RGD ID: 1563888
Description: Predicted to be involved in cerebral cortex neuron differentiation and positive regulation of dendritic spine development. Orthologous to human C21orf91 (chromosome 21 open reading frame 91); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC360692; LOC100909817; LOC102549227; LOC360692; RGD1563888; similar to DNA segment, Chr 16, ERATO Doi 472, expressed; uncharacterized LOC100909817; uncharacterized LOC102549227; uncharacterized protein LOC102549227; uncharacterized protein LOC360692
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,716,034 - 30,749,292 (-)NCBIGRCr8
mRatBN7.21117,229,129 - 17,262,307 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1117,229,138 - 17,262,483 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1125,878,233 - 25,911,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01118,610,326 - 18,643,400 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01117,769,043 - 17,802,121 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01117,073,296 - 17,120,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1117,076,980 - 17,130,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01120,732,095 - 20,735,084 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41117,446,314 - 17,476,625 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1117,221,974 - 17,249,856 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27404227  


Genomics

Comparative Map Data
C11h21orf91
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,716,034 - 30,749,292 (-)NCBIGRCr8
mRatBN7.21117,229,129 - 17,262,307 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1117,229,138 - 17,262,483 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1125,878,233 - 25,911,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01118,610,326 - 18,643,400 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01117,769,043 - 17,802,121 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01117,073,296 - 17,120,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1117,076,980 - 17,130,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01120,732,095 - 20,735,084 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41117,446,314 - 17,476,625 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1117,221,974 - 17,249,856 (-)NCBICelera
Cytogenetic Map11q11NCBI
C21orf91
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382117,788,974 - 17,819,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2117,788,974 - 17,819,386 (-)EnsemblGRCh38hg38GRCh38
GRCh372119,161,291 - 19,191,673 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362118,083,155 - 18,113,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 342118,086,994 - 18,112,513NCBI
Celera214,339,748 - 4,370,167 (-)NCBICelera
Cytogenetic Map21q21.1NCBI
HuRef214,550,222 - 4,580,642 (-)NCBIHuRef
CHM1_12118,722,458 - 18,752,865 (-)NCBICHM1_1
T2T-CHM13v2.02116,148,342 - 16,178,714 (-)NCBIT2T-CHM13v2.0
D16Ertd472e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391678,337,224 - 78,373,576 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1678,337,226 - 78,373,596 (-)EnsemblGRCm39 Ensembl
GRCm381678,540,336 - 78,576,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1678,540,338 - 78,576,708 (-)EnsemblGRCm38mm10GRCm38
MGSCv371678,540,583 - 78,576,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361678,426,122 - 78,459,239 (-)NCBIMGSCv36mm8
Celera1678,762,071 - 78,791,896 (-)NCBICelera
Cytogenetic Map16C3.1NCBI
cM Map1645.36NCBI
LOC102013799
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540719,094,101 - 19,124,370 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540719,093,931 - 19,124,997 (-)NCBIChiLan1.0ChiLan1.0
C22H21orf91
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22214,283,766 - 14,314,161 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1219,111,542 - 9,141,925 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0214,524,103 - 4,554,496 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12117,877,448 - 17,918,985 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2117,888,992 - 17,918,985 (-)Ensemblpanpan1.1panPan2
C31H21orf91
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13114,225,807 - 14,254,801 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3114,230,000 - 14,254,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3114,239,257 - 14,267,958 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03114,253,948 - 14,282,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3114,253,990 - 14,282,587 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13114,256,210 - 14,284,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03114,261,717 - 14,290,398 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03114,666,956 - 14,695,648 (-)NCBIUU_Cfam_GSD_1.0
CUNH21orf91
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497115,271,247 - 15,299,794 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650510,194,961 - 10,219,126 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650510,190,248 - 10,219,502 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C13H21orf91
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13182,374,587 - 182,409,289 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113182,374,587 - 182,409,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213192,507,038 - 192,540,595 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH21orf91
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1274,773,057 - 74,802,684 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl274,773,356 - 74,807,405 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605079,188,089 - 79,218,635 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH21orf91
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247456,185,226 - 6,201,376 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247456,180,514 - 6,213,299 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C11h21orf91
248 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:138
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000002119
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat

Markers in Region
AW536354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21117,236,529 - 17,236,618 (+)MAPPERmRatBN7.2
Rnor_6.01117,079,872 - 17,079,960NCBIRnor6.0
Rnor_5.01120,734,788 - 20,734,876UniSTSRnor5.0
RGSC_v3.41117,450,574 - 17,450,662UniSTSRGSC3.4
Celera1117,224,656 - 17,224,744UniSTS
Cytogenetic Map11q11UniSTS
RH143077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21117,233,749 - 17,233,863 (+)MAPPERmRatBN7.2
Rnor_6.01117,077,094 - 17,077,207NCBIRnor6.0
Rnor_5.01120,732,010 - 20,732,123UniSTSRnor5.0
RGSC_v3.41117,447,796 - 17,447,909UniSTSRGSC3.4
Celera1117,221,889 - 17,222,002UniSTS
RH 3.4 Map1167.8UniSTS
Cytogenetic Map11q11UniSTS
RH135316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21117,261,201 - 17,261,393 (+)MAPPERmRatBN7.2
Rnor_6.01117,129,109 - 17,129,300NCBIRnor6.0
Rnor_6.01117,119,191 - 17,119,382NCBIRnor6.0
Rnor_5.01120,782,295 - 20,782,486UniSTSRnor5.0
Rnor_5.01120,772,377 - 20,772,568UniSTSRnor5.0
RGSC_v3.41117,475,574 - 17,475,765UniSTSRGSC3.4
Celera1117,249,465 - 17,249,656UniSTS
RH 3.4 Map1167.8UniSTS
Cytogenetic Map11q11UniSTS
AW530763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21117,245,755 - 17,245,910 (+)MAPPERmRatBN7.2
Rnor_6.01117,104,710 - 17,104,864NCBIRnor6.0
Rnor_6.01117,089,097 - 17,089,251NCBIRnor6.0
Rnor_5.01120,757,896 - 20,758,050UniSTSRnor5.0
Rnor_5.01120,744,013 - 20,744,167UniSTSRnor5.0
RGSC_v3.41117,459,799 - 17,459,953UniSTSRGSC3.4
Celera1117,233,867 - 17,234,021UniSTS
RH 3.4 Map1190.3UniSTS
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 15 4 19 4 23 12 38 11
Low 1 43 42 37 37 8 10 51 23 3 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000002119   ⟹   ENSRNOP00000002119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1117,076,980 - 17,130,120 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087665   ⟹   ENSRNOP00000075597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1117,234,000 - 17,262,228 (-)Ensembl
Rnor_6.0 Ensembl1117,077,179 - 17,119,582 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094529   ⟹   ENSRNOP00000095898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1117,229,138 - 17,262,483 (-)Ensembl
RefSeq Acc Id: NM_001108312   ⟹   NP_001101782
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,716,034 - 30,749,122 (-)NCBI
mRatBN7.21117,229,129 - 17,262,223 (-)NCBI
Rnor_6.01117,077,179 - 17,119,582 (-)NCBI
Rnor_5.01120,732,095 - 20,735,084 (-)NCBI
RGSC_v3.41117,446,314 - 17,476,625 (-)RGD
Celera1117,221,974 - 17,249,856 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768531   ⟹   XP_008766753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,720,578 - 30,749,204 (-)NCBI
mRatBN7.21117,229,129 - 17,262,143 (-)NCBI
Rnor_6.01117,073,296 - 17,120,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598023   ⟹   XP_017453512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,720,578 - 30,749,292 (-)NCBI
mRatBN7.21117,229,129 - 17,262,307 (-)NCBI
Rnor_6.01117,073,296 - 17,120,235 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088457   ⟹   XP_038944385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,716,041 - 30,748,921 (-)NCBI
mRatBN7.21117,229,129 - 17,262,149 (-)NCBI
RefSeq Acc Id: NP_001101782   ⟸   NM_001108312
- UniProtKB: A6JL42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766753   ⟸   XM_008768531
- Peptide Label: isoform X1
- UniProtKB: A6JL42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453512   ⟸   XM_017598023
- Peptide Label: isoform X1
- UniProtKB: A6JL42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075597   ⟸   ENSRNOT00000087665
RefSeq Acc Id: ENSRNOP00000002119   ⟸   ENSRNOT00000002119
RefSeq Acc Id: XP_038944385   ⟸   XM_039088457
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000095898   ⟸   ENSRNOT00000094529

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACQ8-F1-model_v2 AlphaFold D4ACQ8 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698013
Promoter ID:EPDNEW_R8534
Type:multiple initiation site
Name:RGD1563888_1
Description:similar to DNA segment, Chr 16, ERATO Doi 472, expressed
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01117,130,127 - 17,130,187EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563888 AgrOrtholog
BioCyc Gene G2FUF-22129 BioCyc
Ensembl Genes ENSRNOG00000001554 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087665.2 UniProtKB/TrEMBL
  ENSRNOT00000094529.1 UniProtKB/TrEMBL
InterPro EURL_prot UniProtKB/TrEMBL
KEGG Report rno:360692 UniProtKB/TrEMBL
NCBI Gene 360692 ENTREZGENE
PANTHER PROTEIN EURL HOMOLOG UniProtKB/TrEMBL
  PTHR15961 UniProtKB/TrEMBL
Pfam EURL UniProtKB/TrEMBL
PhenoGen C11h21orf91 PhenoGen
RatGTEx ENSRNOG00000001554 RatGTEx
UniProt A0A0G2KB02_RAT UniProtKB/TrEMBL
  A0A8I6ARB3_RAT UniProtKB/TrEMBL
  A6JL42 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C11h21orf91  similar to human chromosome 21 open reading frame 91  RGD1563888  similar to DNA segment, Chr 16, ERATO Doi 472, expressed  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1563888  similar to DNA segment, Chr 16, ERATO Doi 472, expressed  LOC102549227  uncharacterized LOC102549227  Data merged from RGD:7577751 737654 PROVISIONAL
2015-07-29 RGD1563888  similar to DNA segment, Chr 16, ERATO Doi 472, expressed  LOC100909817  uncharacterized LOC100909817  Data merged from RGD:6501639 737654 PROVISIONAL
2013-12-18 LOC102549227  uncharacterized LOC102549227      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100909817  uncharacterized LOC100909817      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1563888  similar to DNA segment, Chr 16, ERATO Doi 472, expressed   RGD1563888_predicted  similar to DNA segment, Chr 16, ERATO Doi 472, expressed (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563888_predicted  similar to DNA segment, Chr 16, ERATO Doi 472, expressed (predicted)  LOC360692  similar to DNA segment, Chr 16, ERATO Doi 472, expressed  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360692  similar to DNA segment, Chr 16, ERATO Doi 472, expressed      Symbol and Name status set to provisional 70820 PROVISIONAL