Edem1 (ER degradation enhancing alpha-mannosidase like protein 1) - Rat Genome Database

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Gene: Edem1 (ER degradation enhancing alpha-mannosidase like protein 1) Rattus norvegicus
Analyze
Symbol: Edem1
Name: ER degradation enhancing alpha-mannosidase like protein 1
RGD ID: 1563633
Description: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Predicted to be involved in several processes, including positive regulation of retrograde protein transport, ER to cytosol; proteolysis involved in protein catabolic process; and trimming of terminal mannose on C branch. Predicted to act upstream of or within ERAD pathway. Predicted to be located in aggresome; endoplasmic reticulum membrane; and endoplasmic reticulum quality control compartment. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1; ER degradation-enhancing alpha-mannosidase-like protein 1; LOC297504; RGD1563633; similar to mKIAA0212 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,350,989 - 143,385,693 (+)NCBIGRCr8
GRCr8 Ensembl4143,353,624 - 143,388,060 (+)EnsemblGRCr8 Ensembl
mRatBN7.24141,797,631 - 141,829,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,797,701 - 141,829,717 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4147,219,703 - 147,251,737 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04143,000,435 - 143,032,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,644,436 - 141,676,471 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,886,644 - 140,918,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,886,545 - 140,915,779 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04217,499,472 - 217,532,312 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,349,966 - 144,379,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4130,450,129 - 130,482,057 (+)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
doxorubicin  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-serine  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
nilotinib  (ISO)
nitrates  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenformin  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
rimonabant  (ISO)
salubrinal  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
Additional References at PubMed
PMID:11375934   PMID:12610306   PMID:14643017   PMID:17360537   PMID:19524542   PMID:20065073   PMID:21062743   PMID:24200403   PMID:25092655  


Genomics

Comparative Map Data
Edem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,350,989 - 143,385,693 (+)NCBIGRCr8
GRCr8 Ensembl4143,353,624 - 143,388,060 (+)EnsemblGRCr8 Ensembl
mRatBN7.24141,797,631 - 141,829,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,797,701 - 141,829,717 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4147,219,703 - 147,251,737 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04143,000,435 - 143,032,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,644,436 - 141,676,471 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,886,644 - 140,918,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,886,545 - 140,915,779 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04217,499,472 - 217,532,312 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,349,966 - 144,379,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4130,450,129 - 130,482,057 (+)NCBICelera
Cytogenetic Map4q41NCBI
EDEM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3835,187,707 - 5,219,958 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl35,187,646 - 5,219,958 (+)EnsemblGRCh38hg38GRCh38
GRCh3735,229,392 - 5,261,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3635,204,433 - 5,236,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 3435,204,432 - 5,236,642NCBI
Celera35,167,241 - 5,199,525 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef35,161,963 - 5,194,537 (+)NCBIHuRef
CHM1_135,179,737 - 5,212,027 (+)NCBICHM1_1
T2T-CHM13v2.035,181,638 - 5,213,889 (+)NCBIT2T-CHM13v2.0
Edem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,800,984 - 108,836,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,805,602 - 108,836,317 (+)EnsemblGRCm39 Ensembl
GRCm386108,824,045 - 108,859,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,828,641 - 108,859,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,778,635 - 108,809,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366108,794,429 - 108,825,128 (+)NCBIMGSCv36mm8
Celera6110,630,730 - 110,662,933 (+)NCBICelera
Cytogenetic Map6E2NCBI
cM Map649.87NCBI
Edem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554218,196,557 - 8,225,561 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554218,196,631 - 8,225,561 (-)NCBIChiLan1.0ChiLan1.0
EDEM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v225,192,405 - 5,224,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan135,197,163 - 5,229,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v035,133,927 - 5,162,485 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.135,234,108 - 5,266,057 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl35,234,123 - 5,262,003 (+)Ensemblpanpan1.1panPan2
EDEM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,444,013 - 12,473,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,452,730 - 12,472,069 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2012,418,401 - 12,446,815 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02012,487,485 - 12,515,859 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2012,487,377 - 12,515,849 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12012,193,009 - 12,221,286 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02012,534,428 - 12,562,719 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02012,520,467 - 12,548,815 (-)NCBIUU_Cfam_GSD_1.0
Edem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494211,531,211 - 11,558,394 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365774,486,885 - 4,513,555 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365774,486,617 - 4,516,379 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDEM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,703,621 - 61,732,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11361,703,601 - 61,732,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21368,054,514 - 68,138,465 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EDEM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12241,253,861 - 41,286,185 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2241,253,989 - 41,282,140 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041125,336,058 - 125,368,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477315,846,553 - 15,878,803 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477315,846,347 - 15,878,312 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Edem1
253 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:140
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000010810, ENSRNOT00000075308
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat

Markers in Region
RH129325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,829,491 - 141,829,671 (+)MAPPERmRatBN7.2
Rnor_6.04140,918,429 - 140,918,608NCBIRnor6.0
Rnor_5.04217,532,087 - 217,532,266UniSTSRnor5.0
RGSC_v3.44144,382,453 - 144,382,632UniSTSRGSC3.4
Celera4130,481,832 - 130,482,011UniSTS
Cytogenetic Map4q41UniSTS
RH132662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,827,303 - 141,827,521 (+)MAPPERmRatBN7.2
Rnor_6.04140,916,241 - 140,916,458NCBIRnor6.0
Rnor_5.04217,529,899 - 217,530,116UniSTSRnor5.0
RGSC_v3.44144,380,265 - 144,380,482UniSTSRGSC3.4
Celera4130,479,644 - 130,479,861UniSTS
RH 3.4 Map4897.8UniSTS
Cytogenetic Map4q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000088273   ⟹   ENSRNOP00000069931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4143,353,624 - 143,388,060 (+)Ensembl
mRatBN7.2 Ensembl4141,797,701 - 141,829,717 (+)Ensembl
Rnor_6.0 Ensembl4140,886,545 - 140,915,779 (+)Ensembl
RefSeq Acc Id: NM_001305279   ⟹   NP_001292208
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84143,353,675 - 143,385,693 (+)NCBI
mRatBN7.24141,797,701 - 141,829,717 (+)NCBI
Rnor_6.04140,886,644 - 140,918,654 (+)NCBI
Celera4130,450,129 - 130,482,057 (+)NCBI
Sequence:
RefSeq Acc Id: XR_010065628
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84143,350,989 - 143,380,841 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001292208 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91484 (Get FASTA)   NCBI Sequence Viewer  
  EDL91485 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069931
  ENSRNOP00000069931.1
RefSeq Acc Id: NP_001292208   ⟸   NM_001305279
- UniProtKB: D3ZJE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069931   ⟸   ENSRNOT00000088273

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJE0-F1-model_v2 AlphaFold D3ZJE0 1-650 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693300
Promoter ID:EPDNEW_R3810
Type:initiation region
Name:Edem1_1
Description:ER degradation enhancing alpha-mannosidase like protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04140,886,659 - 140,886,719EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563633 AgrOrtholog
BioCyc Gene G2FUF-43444 BioCyc
BioCyc Pathway PWY-7919 [protein N-glycosylation processing phase (plants and animals)] BioCyc
BioCyc Pathway Image PWY-7919 BioCyc
Ensembl Genes ENSRNOG00000055365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088273 ENTREZGENE
  ENSRNOT00000088273.2 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  EDEM1/2/3 UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/TrEMBL
KEGG Report rno:297504 UniProtKB/TrEMBL
NCBI Gene 297504 ENTREZGENE
PANTHER ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR45679 UniProtKB/TrEMBL
Pfam Glyco_hydro_47 UniProtKB/TrEMBL
PhenoGen Edem1 PhenoGen
PRINTS GLYHDRLASE47 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055365 RatGTEx
Superfamily-SCOP Glyco_hydro_47 UniProtKB/TrEMBL
UniProt D3ZJE0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Edem1  ER degradation enhancing alpha-mannosidase like protein 1  Edem1  ER degradation enhancer, mannosidase alpha-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Edem1  ER degradation enhancer, mannosidase alpha-like 1  RGD1563633_predicted  similar to mKIAA0212 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563633_predicted  similar to mKIAA0212 protein (predicted)  LOC297504  similar to mKIAA0212 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC297504  similar to mKIAA0212 protein      Symbol and Name status set to provisional 70820 PROVISIONAL