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Gene: Tnfrsf11a (TNF receptor superfamily member 11A) Rattus norvegicus

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Symbol:

Tnfrsf11a

Name:

TNF receptor superfamily member 11A

RGD ID:

1563614

Description:

Predicted to enable cytokine binding activity and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to zinc ion starvation; osteoclast differentiation; and response to insulin. Predicted to be located in several cellular components, including cell surface; cytosol; and membrane raft. Predicted to be active in external side of plasma membrane. Biomarker of myocarditis. Human ortholog(s) of this gene implicated in bone development disease and bone remodeling disease (multiple). Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a); PARTICIPATES IN cytokine mediated signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC498206; RANK; RGD1563614; similar to Tumor necrosis factor receptor superfamily, member 11a; tumor necrosis factor receptor superfamily member 11a; Tumor necrosis factor receptor superfamily, member 11a; tumor necrosis factor receptor superfamily, member 11a, NFKB activator

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	22,442,930 - 22,501,257 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	22,442,665 - 22,501,257 (+)	Ensembl				GRCr8
mRatBN7.2	13	21,928,370 - 21,986,719 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	21,928,408 - 21,986,695 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	22,247,466 - 22,306,553 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	23,532,261 - 23,591,345 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	22,216,155 - 22,275,239 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	25,778,306 - 25,835,802 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	25,778,317 - 25,835,957 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	30,966,261 - 30,997,692 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	11,958,002 - 12,014,371 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	21,798,588 - 21,856,355 (+)	NCBI		Celera
Cytogenetic Map	13	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alveolar Bone Loss (IEP)

autosomal recessive osteopetrosis 7 (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

bone development disease (ISO)

chromosome 18q deletion syndrome (ISO)

familial expansile osteolysis (ISO)

genetic disease (ISO)

Inflammation (ISO)

multiple congenital anomalies-hypotonia-seizures syndrome 1 (ISO)

myocarditis (IEP)

Neoplasm Metastasis (ISO)

osteopetrosis (ISO)

osteoporosis (ISO)

osteosclerosis (ISO)

Paget's disease of bone (ISO,ISS)

Paget's disease of bone 2 (ISO)

Prostatic Neoplasms (ISO)

stomach cancer (ISO)

Tibial Fractures (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (EXP,ISO)

azadirachtin A (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroquine (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

desferrioxamine B (ISO)

dextran sulfate (ISO)

diarsenic trioxide (EXP,ISO)

diquat (ISO)

dorsomorphin (ISO)

ellagic acid (ISO)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

furosemide (EXP)

gentamycin (EXP)

glycidol (EXP)

indole-3-methanol (EXP)

isoflurane (EXP)

kaempferol (ISO)

L-methionine (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

mangiferin (ISO)

methotrexate (EXP)

modafinil (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (EXP)

naringin (ISO)

nitrates (EXP)

o-anisidine (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (EXP,ISO)

p-menthan-3-ol (ISO)

paracetamol (ISO)

paraquat (EXP)

pentobarbital (EXP)

perfluorooctanoic acid (EXP)

pinostrobin (EXP)

pirinixic acid (ISO)

progesterone (ISO)

quercetin (ISO)

raloxifene (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

Salidroside (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium fluoride (ISO)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

thymol (ISO)

thymol sulfate(1-) (ISO)

titanium atom (ISO)

titanium dioxide (EXP,ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA,ISO)

cellular response to zinc ion starvation (IEP)

circadian temperature homeostasis (IEA,ISO)

lymph node development (IBA,IEA,ISO)

mammary gland alveolus development (IEA,ISO)

multinuclear osteoclast differentiation (IBA,IEA,ISO)

ossification (IBA,IEA,ISO)

osteoclast differentiation (IEA,IEP,ISO)

positive regulation of bone resorption (IBA,IEA,ISO)

positive regulation of canonical NF-kappaB signal transduction (IEA,ISO)

positive regulation of ERK1 and ERK2 cascade (IEA,ISO)

positive regulation of fever generation by positive regulation of prostaglandin secretion (IEA,ISO)

positive regulation of JNK cascade (IEA,ISO)

positive regulation of non-canonical NF-kappaB signal transduction (IEA,ISO)

positive regulation of osteoclast differentiation (IEA,ISO)

response to ethanol (IEP)

response to insulin (IEP)

response to interleukin-1 (IEA,ISO)

response to lipopolysaccharide (IEA,ISO)

response to mechanical stimulus (IEP)

response to tumor necrosis factor (IEA,ISO)

tumor necrosis factor-mediated signaling pathway (IBA,IEA,ISO)

Cellular Component

cell surface (IEA,ISO)

cytosol (IEA,ISO)

external side of plasma membrane (IBA,IEA,ISO)

membrane (IEA)

membrane raft (IEA,ISO)

plasma membrane (IEA,ISO)

Molecular Function

cytokine binding (IBA,IEA,ISO)

protein binding (ISO)

transmembrane signaling receptor activity (IEA,ISO)

tumor necrosis factor receptor activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cytokine mediated signaling pathway (IEA)

rheumatoid arthritis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease.	Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2.	Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation.	Chen G, etal., Cancer. 2006 Jul 15;107(2):289-98.
3.	Imbalance of RANK, RANKL and OPG expression during tibial fracture repair in diabetic rats.	de Amorim FP, etal., J Mol Histol. 2008 Aug;39(4):401-8. Epub 2008 Jul 1.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes.	Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
6.	Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK.	Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
7.	Identification of a prognostic 5-Gene expression signature for gastric cancer.	Hou JY, etal., J Cancer Res Clin Oncol. 2017 Apr;143(4):619-629. doi: 10.1007/s00432-016-2324-z. Epub 2016 Dec 29.
8.	Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis.	Hughes AE, etal., Nat Genet. 2000 Jan;24(1):45-8.
9.	Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo.	Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
10.	NF-kappa B genes have a major role in inflammatory breast cancer.	Lerebours F, etal., BMC Cancer. 2008 Feb 4;8:41.
11.	Osteoprotegerin/RANK/RANKL axis in cardiac remodeling due to immuno-inflammatory myocardial disease.	Liu W, etal., Exp Mol Pathol. 2008 Jun;84(3):213-7. Epub 2008 Mar 7.
12.	Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae in rat molar by heavy orthodontic force.	Nakano Y, etal., Eur J Orthod. 2011 Aug;33(4):335-43. doi: 10.1093/ejo/cjq068. Epub 2010 Sep 10.
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
15.	GOA pipeline	RGD automated data pipeline
16.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Comprehensive gene review and curation	RGD comprehensive gene curation
19.	Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model.	Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.

Additional References at PubMed

PMID:9367155	PMID:10500098	PMID:11051546	PMID:11805147	PMID:12296995	PMID:18606301	PMID:19325147	PMID:19940926	PMID:20074454	PMID:21327437	PMID:21844205	PMID:22848465
PMID:23443487	PMID:25406873	PMID:29211121	PMID:29297549	PMID:29529595	PMID:38923421

Genomics

Comparative Map Data

Tnfrsf11a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	22,442,930 - 22,501,257 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	22,442,665 - 22,501,257 (+)	Ensembl				GRCr8
mRatBN7.2	13	21,928,370 - 21,986,719 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	21,928,408 - 21,986,695 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	22,247,466 - 22,306,553 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	23,532,261 - 23,591,345 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	22,216,155 - 22,275,239 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	25,778,306 - 25,835,802 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	25,778,317 - 25,835,957 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	30,966,261 - 30,997,692 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	11,958,002 - 12,014,371 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	21,798,588 - 21,856,355 (+)	NCBI		Celera
Cytogenetic Map	13	p11	NCBI

TNFRSF11A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	62,325,310 - 62,391,288 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	62,325,287 - 62,391,288 (+)	Ensembl			hg38	GRCh38
GRCh37	18	59,992,543 - 60,058,521 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	58,143,528 - 58,204,484 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	58,143,527 - 58,204,482	NCBI
Celera	18	56,711,789 - 56,772,745 (+)	NCBI		Celera
Cytogenetic Map	18	q21.33	NCBI
HuRef	18	56,726,294 - 56,766,005 (+)	NCBI		HuRef
CHM1_1	18	59,988,087 - 60,050,490 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	62,528,176 - 62,594,158 (+)	NCBI		T2T-CHM13v2.0

Tnfrsf11a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	105,708,443 - 105,777,172 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	105,708,443 - 105,775,709 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	105,780,673 - 105,849,444 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	105,780,718 - 105,847,981 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	107,677,300 - 107,744,558 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	107,608,270 - 107,672,989 (+)	NCBI		MGSCv36	mm8
Celera	1	108,658,349 - 108,696,865 (+)	NCBI		Celera
Cytogenetic Map	1	E2.1	NCBI
cM Map	1	49.7	NCBI

Tnfrsf11a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	46,264,164 - 46,296,368 (+)	Ensembl
ChiLan1.0	NW_004955402	46,242,329 - 46,298,157 (+)	NCBI	ChiLan1.0	ChiLan1.0

TNFRSF11A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	79,846,412 - 79,912,279 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	65,539,023 - 65,604,890 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	55,695,394 - 55,761,307 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	59,032,727 - 59,075,044 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	59,034,770 - 59,075,044 (+)	Ensembl			panPan2	panpan1.1

TNFRSF11A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	14,504,595 - 14,555,956 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	14,503,033 - 14,556,041 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	15,469,086 - 15,523,233 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	14,362,189 - 14,416,396 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	14,362,936 - 14,416,396 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	14,398,162 - 14,452,574 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	14,331,546 - 14,385,610 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	14,578,257 - 14,632,411 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tnfrsf11a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	27,705,806 - 27,756,172 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	2,945,010 - 2,995,207 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	2,944,841 - 2,986,113 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TNFRSF11A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	159,128,038 - 159,187,481 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	159,128,039 - 159,187,476 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	176,590,571 - 176,650,002 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TNFRSF11A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	17,385,251 - 17,446,442 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666060	8,239,048 - 8,304,073 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tnfrsf11a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624792	8,029,364 - 8,084,424 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624792	8,029,383 - 8,087,824 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Tnfrsf11a
435 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	116
Count of miRNA genes:	97
Interacting mature miRNAs:	104
Transcripts:	ENSRNOT00000021129
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34785618	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12285517	34884386	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	6002008	37088115	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
2303031	Bp326	Blood pressure QTL 326			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	12285517	23516549	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	12285517	34884386	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	34785618	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	85	59	6	347	185	11	144	79	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021129 ⟹ ENSRNOP00000021129

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	22,442,665 - 22,501,257 (+)	Ensembl
mRatBN7.2 Ensembl	13	21,928,408 - 21,986,695 (+)	Ensembl
Rnor_6.0 Ensembl	13	25,778,317 - 25,835,957 (+)	Ensembl

RefSeq Acc Id:

NM_001271235 ⟹ NP_001258164

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	22,442,971 - 22,501,257 (+)	NCBI
mRatBN7.2	13	21,928,408 - 21,986,695 (+)	NCBI
Rnor_6.0	13	25,778,306 - 25,835,802 (+)	NCBI
Rnor_5.0	13	30,966,261 - 30,997,692 (+)	NCBI
Celera	13	21,798,588 - 21,856,355 (+)	NCBI

Sequence:

show sequence

GCCCGCCCGCACCGCGCCATGGCCCCGCGCGCCCGGCGGCGCCGCCAGTTTCCCGCGCCTCTGC
TGGCGCTCTGCGTGCTGCTCCTCCCATTGCAGGTGACCCTCCAAGTCACTCTGCCGTGCACCCA
GGAGAGGCACTATGAGCATCTTGGACGGTGTTGCAGCAGATGCGAACCAGGAAAGTACCTGTCT
TCTAAATGCACTCCCACCTCCGACAGTGTGTGTCTGCCCTGTGGCCCAGATGAATACTTGGATA
CCTGGAATGAAGAAGATAAATGCTTGCTGCATAAAGTCTGTGATGCAGGCAAGGCCCTGGTGGC
GGTGGACCCTGGCAACCACACGGCCCCGCGTCGCTGTGCCTGCACGGCGGGCTACCACTGGAAC
GCAGACTGCGAGTGCTGCCGTCGGAACACGGAGTGCGCACCGGGCTTCGGAGCTCAACATCCCT
TGCAGCTCAACGTGGATACCGTGTGCACACCCTGCCTCCTGGGCTTCTTCTCAGATGTCTTTTC
GTCAACAGACAAATGCAAACCCTGGACCAACTGCACCGTCCTTGGGAAGATGGAAGCACACCAA
GGGACGACGGAATCAGATGTGGTCTGCAGCTCTTCCCTGACACTCATAAAACCACCCAAGGAGG
CCCAGGTTTACTTGCCCAGTCTCATCGTCCTGCTCCTCTTCATCTCTGTGGTAGTGGTGGCTGC
CATCGTCTTCAGCATTTACTACAGGAAGGGAGGGAAAACGCTGACAGCTAATCTGTGGAATTGG
GTCAATGATGCTTGCAGTAGTCTCAGTGGAAATAAGGAGTCCTCAGGGGACCATTGTGTTGGTT
CCCACTCGGCAAACTCCAGCCAGCAAGAAGTGTGTGAAGGTATCTTACTAATGACTCGGGAGGA
GAAGATGGTTCCAGAAGACTGTGCTGGAGTCTGTGGACCTGTGCGTGCGGCAAGTGGGCCCTGG
GCAGAAGGCAGAGATGCTAGGACGTTCACCTTAGTCAGCGAGGTTGAGACGCAGGGGAACCTCT
CAAGGAAGATCCCCACAGAAGATGAGTACACGGACCGGCCCTCACAGCCTCCGAATGGTTCACT
GTTCCTAATCCAGCCTGGAAGCAGATCGACACCCCCGTTCCAGGAGCCCCTGGAAGTGGGGGAG
AACGACAGTTTAAGCCAGTGTTTCACGGGGACGGAAAGCATGGTGGATTCCGAAGGCTGCGACT
TCACCGAGCCTCCAAGCAGAACTGACTATATGCCTGCATCCCCTGAAAAGCTCCTGACAAAAGA
AATAGAGGATGACAGTTGCCTACCCTGGGTGGCCAACTCCAACTCAACGGATGGCTACACAGGC
AGTGGGAACACTCCTGGGGAGGACCATGAACCCCTTCCGGGGTCCCTGAAATGTGGACCGTTGC
CCCAGTGTGCCTACAGCATAGGCCTTCCCAGTGAAGCAGCAGCCAGCTTGGCAGAGGTCGGAGC
GCAGCCCCAGGACAGGGCTGATGCAAAGCTTCCGAGCTCAGAGAGGGGAGCCTCGGGGTCTGGG
AGTTCGCCCAGTGAACAGCCACCTGCCTCTGGAAACGTGACAGGAAACAGTAACTCCACGTTCA
TCTCCAGCGGGCAGGTGATGAACTTCAAGGGTGACATCATCGTGGTGTACGTCAGTCAGACCTC
ACAGGAGGGCCCGGGGCCTGCAGAGCCAGAGCCAGAGCCGGAGCCCGTGGGCCGCCCAGTGCAG
GAGGAGACACTGGCACACAGAGACTCCTTTGCGGGCACCGCACCGCGCTTCCCCGACGCATGCA
CCACCGGGGCTGGGTTACAGGAGAAGGGGGCATCTCGGCCGAAGGACTGGGCATCACGGCCGGT
GCAGGAGCAGGGTGGGGCGCAGGCTTCACTCAATACCCAGGGGTCCGGACAATGTGCAGAATGA
CCGCACCTTCTCTGCCTGCCCTGGGTGCAGGGCACCAATGGCTTTCCATAAACATGTGGTTAGC
CACTGCGCACCTCCTCACAGGTGCAGGCTGCTGGCATGGTGGTGGAGCCCACCTCTCATTTCCT
CCAGTATCCCTCTCCTCTGCCTCCTACCACCTGGCATCATTCAGTTTGGCCTTTTTTGCAACGT
CGGTGTCCTGCATTATTGCGATCTATAGCACCCCGCCCCCCATATTTATTATTCACTTGCTCCA
GTAGTGATATTCCCCCCCTCTCGATATATATAATCTCCTGACAATTCTGAAGGTGCTGTCCCCT
TTACATTATTTGGCACTCCTCTCACCGGCCTTTGCCAGTGTCCTCTAAGCAGAAAAGGCCAGAT
GTAGAGAGCTGGGGAGTGAAGTGCAAGAAATGAGTAGAGGGGCTCATATTTTCTGAAAACAGTC
TGTGTCTCAGTTTTTCTCCAAAGAGTGAAAGGGACACACGGCCACCACCACTAAAGCTTTTAGT
TTGTATAGATCCTTGAGAGCTAAGTTCCGGTGGCCTTGTCCCCTACCTGGTTTTAATTTTGTTT
GTTTTTTTGTTTGTTTTGTTTTGTTTTGTTTTTTCCACGGTGGCAGGTACTTGGCCACTAAATC
TCAAAAAAAAAAAAATCCTATCTTTTGTGGTTTGGGCATTCTTATTTTTAAACAATTAGCTGTC
TAGAAAGAGGGAGAAGTAAATAGGACATAAGGCCAAAGGGAAAATGAAGATGCCAGGGAAATTA
AAGAAAGAATGAATAAAGTTGACACGCTAA

hide sequence

RefSeq Acc Id:

XM_008769487 ⟹ XP_008767709

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	22,442,930 - 22,501,257 (+)	NCBI
mRatBN7.2	13	21,928,370 - 21,986,719 (+)	NCBI
Rnor_6.0	13	25,778,329 - 25,835,802 (+)	NCBI

Sequence:

show sequence

CCCGCGCGCCCGGCGGCGCCGCCAGTTTCCCGCGCCTCTGCTGGCGCTCTGCGTGCTGCTCCTC
CCATTGCAGGTGACCCTCCAAGTCACTCTGCCGTGCACCCAGGAGAGGCACTATGAGCATCTTG
GACGGTGTTGCAGCAGATGCGAACCAGGAAAGTACCTGTCTTCTAAATGCACTCCCACCTCCGA
CAGTGTGTGTCTGCCCTGTGGCCCAGATGAATACTTGGATACCTGGAATGAAGAAGATAAATGC
TTGCTGCATAAAGTCTGTGATGCAGGCAAGGCCCTGGTGGCGGTGGACCCTGGCAACCACACGG
CCCCGCGTCGCTGTGCCTGCACGGCGGGCTACCACTGGAACGCAGACTGCGAGTGCTGCCGTCG
GAACACGGAGTGCGCACCGGGCTTCGGAGCTCAACATCCCTCTCAACGTGGATACCGTGTGCAC
ACCCTGCCTCCTGGGCTTCTTCTCAGATGTCTTTTCGTCAACAGACAAATGCAAACCCTGGACC
AACTGCACCGTCCTTGGGAAGATGGAAGCACACCAAGGGACGACGGAATCAGATGTGGTCTGCA
GCTCTTCCCTGACACTCATAAAACCACCCAAGGAGGCCCAGGTTTACTTGCCCAGTCTCATCGT
CCTGCTCCTCTTCATCTCTGTGGTAGTGGTGGCTGCCATCGTCTTCAGCATTTACTACAGGAAG
GGAGGGAAAACGCTGACAGCTAATCTGTGGAATTGGGTCAATGATGCTTGCAGTAGTCTCAGTG
GAAATAAGGAGTCCTCAGGGGACCATTGTGTTGGTTCCCACTCGGCAAACTCCAGCCAGCAAGA
AGTGTGTGAAGGTATCTTACTAATGACTCGGGAGGAGAAGATGGTTCCAGAAGACTGTGCTGGA
GTCTGTGGACCTGTGCGTGCGGCAAGTGGGCCCTGGGCAGAAGGCAGAGATGCTAGGACGTTCA
CCTTAGTCAGCGAGGTTGAGACGCAGGGGAACCTCTCAAGGAAGATCCCCACAGAAGATGAGTA
CACGGACCGGCCCTCACAGCCTCCGAATGGTTCACTGTTCCTAATCCAGCCTGGAAGCAGATCG
ACACCCCCGTTCCAGGAGCCCCTGGAAGTGGGGGAGAACGACAGTTTAAGCCAGTGTTTCACGG
GGACGGAAAGCATGGTGGATTCCGAAGGCTGCGACTTCACCGAGCCTCCAAGCAGAACTGACTA
TATGCCTGCATCCCCTGAAAAGCTCCTGACAAAAGAAATAGAGGATGACAGTTGCCTACCCTGG
GTGGCCAACTCCAACTCAACGGATGGCTACACAGGCAGTGGGAACACTCCTGGGGAGGACCATG
AACCCCTTCCGGGGTCCCTGAAATGTGGACCGTTGCCCCAGTGTGCCTACAGCATAGGCCTTCC
CAGTGAAGCAGCAGCCAGCTTGGCAGAGGTCGGAGCGCAGCCCCAGGACAGGGCTGATGCAAAG
CTTCCGAGCTCAGAGAGGGGAGCCTCGGGGTCTGGGAGTTCGCCCAGTGAACAGCCACCTGCCT
CTGGAAACGTGACAGGAAACAGTAACTCCACGTTCATCTCCAGCGGGCAGGTGATGAACTTCAA
GGGTGACATCATCGTGGTGTACGTCAGTCAGACCTCACAGGAGGGCCCGGGGCCTGCAGAGCCA
GAGCCAGAGCCGGAGCCCGTGGGCCGCCCAGTGCAGGAGGAGACACTGGCACACAGAGACTCCT
TTGCGGGCACCGCACCGCGCTTCCCCGACGCATGCACCACCGGGGCTGGGTTACAGGAGAAGGG
GGCATCTCGGCCGAAGGACTGGGCATCACGGCCGGTGCAGGAGCAGGGTGGGGCGCAGGCTTCA
CTCAATACCCAGGGGTCCGGACAATGTGCAGAATGACCGCACCTTCTCTGCCTGCCCTGGGTGC
AGGGCACCAATGGCTTTCCATAAACATGTGGTTAGCCACTGCGCACCTCCTCACAGGTGCAGGC
TGCTGGCATGGTGGTGGAGCCCACCTCTCATTTCCTCCAGTATCCCTCTCCTCTGCCTCCTACC
ACCTGGCATCATTCAGTTTGGCCTTTTTTGCAACGTCGGTGTCCTGCATTATTGCGATCTATAG
CACCCCGCCCCCCATATTTATTATTCACTTGCTCCAGTAGTGATATTCCCCCCCTCTCGATATA
TATAATCTCCTGACAATTCTGAAGGTGCTGTCCCCTTTACATTATTTGGCACTCCTCTCACCGG
CCTTTGCCAGTGTCCTCTAAGCAGAAAAGGCCAGATGTAGAGAGCTGGGGAGTGAAGTGCAAGA
AATGAGTAGAGGGGCTCATATTTTCTGAAAACAGTCTGTGTCTCAGTTTTTCTCCAAAGAGTGA
AAGGGACACACGGCCACCACCACTAAAGCTTTTAGTTTGTATAGATCCTTGAGAGCTAAGTTCC
GGTGGCCTTGTCCCCTACCTGGTTTTAATTTTGTTTGTTTTTTTGTTTGTTTTGTTTTGTTTTG
TTTTTTCCACGGTGGCAGGTACTTGGCCACTAAATCTCAAAAAAAAAAAAATCCTATCTTTTGT
GGTTTGGGCATTCTTATTTTTAAACAATTAGCTGTCTAGAAAGAGGGAGAAGTAAATAGGACAT
AAGGCCAAAGGGAAAATGAAGATGCCAGGGAAATTAAAGAAAGAATGAATAAAGTTGACACGCT
AA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258164	(Get FASTA)	NCBI Sequence Viewer
	XP_008767709	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL91736	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021129
	ENSRNOP00000021129.4

RefSeq Acc Id:	NP_001258164 ⟸ NM_001271235
- Peptide Label:	precursor
- UniProtKB:	F1M8Z6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPRARRRRQFPAPLLALCVLLLPLQVTLQVTLPCTQERHYEHLGRCCSRCEPGKYLSSKCTPT SDSVCLPCGPDEYLDTWNEEDKCLLHKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNADCECC RRNTECAPGFGAQHPLQLNVDTVCTPCLLGFFSDVFSSTDKCKPWTNCTVLGKMEAHQGTTESD VVCSSSLTLIKPPKEAQVYLPSLIVLLLFISVVVVAAIVFSIYYRKGGKTLTANLWNWVNDACS SLSGNKESSGDHCVGSHSANSSQQEVCEGILLMTREEKMVPEDCAGVCGPVRAASGPWAEGRDA RTFTLVSEVETQGNLSRKIPTEDEYTDRPSQPPNGSLFLIQPGSRSTPPFQEPLEVGENDSLSQ CFTGTESMVDSEGCDFTEPPSRTDYMPASPEKLLTKEIEDDSCLPWVANSNSTDGYTGSGNTPG EDHEPLPGSLKCGPLPQCAYSIGLPSEAAASLAEVGAQPQDRADAKLPSSERGASGSGSSPSEQ PPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGPGPAEPEPEPEPVGRPVQEETLAH RDSFAGTAPRFPDACTTGAGLQEKGASRPKDWASRPVQEQGGAQASLNTQGSGQCAE hide sequence

RefSeq Acc Id:

XP_008767709 ⟸ XM_008769487

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSILDGVAADANQESTCLLNALPPPTVCVCPVAQMNTWIPGMKKINACCIKSVMQARPWWRWTL
ATTRPRVAVPARRATTGTQTASAAVGTRSAHRASELNIPLNVDTVCTPCLLGFFSDVFSSTDKC
KPWTNCTVLGKMEAHQGTTESDVVCSSSLTLIKPPKEAQVYLPSLIVLLLFISVVVVAAIVFSI
YYRKGGKTLTANLWNWVNDACSSLSGNKESSGDHCVGSHSANSSQQEVCEGILLMTREEKMVPE
DCAGVCGPVRAASGPWAEGRDARTFTLVSEVETQGNLSRKIPTEDEYTDRPSQPPNGSLFLIQP
GSRSTPPFQEPLEVGENDSLSQCFTGTESMVDSEGCDFTEPPSRTDYMPASPEKLLTKEIEDDS
CLPWVANSNSTDGYTGSGNTPGEDHEPLPGSLKCGPLPQCAYSIGLPSEAAASLAEVGAQPQDR
ADAKLPSSERGASGSGSSPSEQPPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGPG
PAEPEPEPEPVGRPVQEETLAHRDSFAGTAPRFPDACTTGAGLQEKGASRPKDWASRPVQEQGG
AQASLNTQGSGQCAE

hide sequence

Ensembl Acc Id:

ENSRNOP00000021129 ⟸ ENSRNOT00000021129

Protein Domains

TNFR-Cys

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M8Z6-F1-model_v2	AlphaFold	F1M8Z6	1-633	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698746

Promoter ID:

EPDNEW_R9271

Type:

initiation region

Name:

Tnfrsf11a_1

Description:

TNF receptor superfamily member 11A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	25,778,305 - 25,778,365	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563614	AgrOrtholog
BioCyc Gene	G2FUF-18630	BioCyc
Ensembl Genes	ENSRNOG00000015615	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021129	ENTREZGENE
	ENSRNOT00000021129.5	UniProtKB/TrEMBL
Gene3D-CATH	Tumor Necrosis Factor Receptor, subunit A, domain 2	UniProtKB/TrEMBL
InterPro	RANK_CRD_2	UniProtKB/TrEMBL
	TNFR_11	UniProtKB/TrEMBL
	TNFR_11A	UniProtKB/TrEMBL
	TNFR_Cys_rich_reg	UniProtKB/TrEMBL
	TNFRSF11A	UniProtKB/TrEMBL
	TNFRSF11A_N	UniProtKB/TrEMBL
KEGG Report	rno:498206	UniProtKB/TrEMBL
NCBI Gene	498206	ENTREZGENE
PANTHER	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A	UniProtKB/TrEMBL
	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A	UniProtKB/TrEMBL
Pfam	RANK_CRD_2	UniProtKB/TrEMBL
	TNFR_c6	UniProtKB/TrEMBL
PhenoGen	Tnfrsf11a	PhenoGen
PRINTS	TNFACTORR11	UniProtKB/TrEMBL
	TNFACTORR11A	UniProtKB/TrEMBL
PROSITE	TNFR_NGFR_1	UniProtKB/TrEMBL
	TNFR_NGFR_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015615	RatGTEx
SMART	TNFR	UniProtKB/TrEMBL
Superfamily-SCOP	TNF receptor-like	UniProtKB/TrEMBL
UniProt	F1M8Z6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-05	Tnfrsf11a	TNF receptor superfamily member 11A	Tnfrsf11a	tumor necrosis factor receptor superfamily member 11a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-25	Tnfrsf11a	tumor necrosis factor receptor superfamily member 11a	Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-02-02	Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a	Tnfrsf11a_predicted	Tumor necrosis factor receptor superfamily, member 11a (predicted)	'predicted' is removed	2292626	APPROVED
2007-02-05	Tnfrsf11a_predicted	Tumor necrosis factor receptor superfamily, member 11a (predicted)	RGD1563614_predicted	similar to Tumor necrosis factor receptor superfamily, member 11a (predicted)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1563614_predicted	similar to Tumor necrosis factor receptor superfamily, member 11a (predicted)	LOC498206	similar to Tumor necrosis factor receptor superfamily, member 11a	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498206	similar to Tumor necrosis factor receptor superfamily, member 11a			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)