Tpi1l2 (triosephosphate isomerase 1 like 2) - Rat Genome Database

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Gene: Tpi1l2 (triosephosphate isomerase 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tpi1l2
Name: triosephosphate isomerase 1 like 2
RGD ID: 1563601
Description: Predicted to enable triose-phosphate isomerase activity. Predicted to be involved in carbohydrate catabolic process; gluconeogenesis; and glyceraldehyde-3-phosphate biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1); PARTICIPATES IN fructose and mannose metabolic pathway; gluconeogenesis pathway; glycolysis pathway; INTERACTS WITH ammonium chloride; tetrachloromethane; thioacetamide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC498731; RGD1563601; similar to Tpi1 protein; Tpi1l1; triosephosphate isomerase 1 like 1; triosephosphate isomerase-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81727,307,380 - 28,230,998 (-)NCBIGRCr8
mRatBN7.21727,101,431 - 27,102,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1727,101,431 - 27,102,809 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01727,764,761 - 27,765,800 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1727,765,008 - 27,765,754 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01729,678,852 - 29,679,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41733,352,146 - 33,391,822 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1726,732,565 - 26,733,947 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Tpi1l2
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000041892
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat

Markers in Region
D17Got233  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81727,342,314 - 27,342,557 (+)Marker Load Pipeline
mRatBN7.21727,136,822 - 27,137,065 (+)MAPPERmRatBN7.2
Rnor_6.01727,800,028 - 27,800,270NCBIRnor6.0
Rnor_5.01729,713,424 - 29,713,666UniSTSRnor5.0
RGSC_v3.41733,387,180 - 33,387,422UniSTSRGSC3.4
Celera1726,767,588 - 26,767,822UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 42 101 68 66 51 9 51 6 170 66 89 38 53 15

Sequence


Ensembl Acc Id: ENSRNOT00000041892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1727,101,431 - 27,102,809 (-)Ensembl
Rnor_6.0 Ensembl1727,765,008 - 27,765,754 (-)Ensembl
RefSeq Acc Id: XM_039096247   ⟹   XP_038952175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81727,307,380 - 28,230,998 (-)NCBI
mRatBN7.21727,101,431 - 27,102,823 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038952175 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067409.2
  ENSRNOP00000082579
  ENSRNOP00000082579.1
RefSeq Acc Id: XP_038952175   ⟸   XM_039096247
- UniProtKB: A0A8I5ZVI4 (UniProtKB/TrEMBL),   A0A8L2R053 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-9667 BioCyc
Ensembl Genes ENSRNOG00000015290 UniProtKB/TrEMBL
  ENSRNOG00000031706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041892 ENTREZGENE
  ENSRNOT00000041892.3 UniProtKB/TrEMBL
  ENSRNOT00000071439.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  TIM_sf UniProtKB/TrEMBL
  TrioseP_Isoase_bac/euk UniProtKB/TrEMBL
  Triosephosphate_isomerase UniProtKB/TrEMBL
  Triosephosphate_isomerase_AS UniProtKB/TrEMBL
NCBI Gene 498731 ENTREZGENE
PANTHER PTHR21139 UniProtKB/TrEMBL
  TRIOSEPHOSPHATE ISOMERASE UniProtKB/TrEMBL
Pfam TIM UniProtKB/TrEMBL
PhenoGen Tpi1l2 PhenoGen
PROSITE TIM_1 UniProtKB/TrEMBL
  TIM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015290 RatGTEx
  ENSRNOG00000031706 RatGTEx
Superfamily-SCOP SSF51351 UniProtKB/TrEMBL
UniProt A0A8I5ZVI4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R053 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-17 Tpi1l2  triosephosphate isomerase 1 like 2  Tpi1l1  triosephosphate isomerase 1 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 Tpi1l1  triosephosphate isomerase 1 like 1  RGD1563601  similar to Tpi1 protein  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1563601  similar to Tpi1 protein   RGD1563601_predicted  similar to Tpi1 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563601_predicted  similar to Tpi1 protein (predicted)  LOC498731  similar to Tpi1 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498731  similar to Tpi1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL