Pik3r5 (phosphoinositide-3-kinase, regulatory subunit 5) - Rat Genome Database

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Gene: Pik3r5 (phosphoinositide-3-kinase, regulatory subunit 5) Rattus norvegicus
Analyze
Symbol: Pik3r5
Name: phosphoinositide-3-kinase, regulatory subunit 5
RGD ID: 1563261
Description: Enables 1-phosphatidylinositol-3-kinase regulator activity. Involved in phosphatidylinositol metabolic process. Part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC497931; phosphoinositide 3-kinase regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5, p101; RGD1563261; similar to novel protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81053,631,469 - 53,699,550 (+)NCBIGRCr8
mRatBN7.21053,132,585 - 53,200,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,132,603 - 53,199,374 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1057,838,940 - 57,859,341 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,327,976 - 57,348,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01052,836,777 - 52,857,177 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,013,686 - 55,078,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,013,703 - 55,080,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01054,757,809 - 54,822,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,227,872 - 55,248,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1052,347,081 - 52,367,505 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
anthracene-1,8,9-triol  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cholic acid  (ISO)
choline  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
Mezerein  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
ozone  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propionic acid  (ISO)
saccharin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sulfadimethoxine  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway  (IEA)
eicosanoid signaling pathway   (ISO)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway   (IEA)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
type 2 diabetes mellitus pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
3. Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Kondo Y, etal., Proc Natl Acad Sci U S A. 2004 May 11;101(19):7398-403. Epub 2004 May 3.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12507995   PMID:15611065  


Genomics

Comparative Map Data
Pik3r5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81053,631,469 - 53,699,550 (+)NCBIGRCr8
mRatBN7.21053,132,585 - 53,200,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,132,603 - 53,199,374 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1057,838,940 - 57,859,341 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,327,976 - 57,348,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01052,836,777 - 52,857,177 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,013,686 - 55,078,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,013,703 - 55,080,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01054,757,809 - 54,822,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,227,872 - 55,248,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1052,347,081 - 52,367,505 (+)NCBICelera
Cytogenetic Map10q24NCBI
PIK3R5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,878,916 - 8,965,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,878,911 - 8,965,712 (-)EnsemblGRCh38hg38GRCh38
GRCh37178,782,233 - 8,869,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,724,138 - 8,756,559 (-)NCBINCBI36Build 36hg18NCBI36
Build 34178,724,137 - 8,756,559NCBI
Celera178,814,067 - 8,900,857 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,681,483 - 8,768,185 (-)NCBIHuRef
CHM1_1178,791,349 - 8,878,194 (-)NCBICHM1_1
T2T-CHM13v2.0178,786,072 - 8,872,872 (-)NCBIT2T-CHM13v2.0
Pik3r5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,322,951 - 68,388,675 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,322,947 - 68,388,675 (+)EnsemblGRCm39 Ensembl
GRCm381168,432,125 - 68,497,849 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,432,121 - 68,497,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv371168,245,627 - 68,311,348 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,248,320 - 68,314,041 (+)NCBIMGSCv36mm8
Celera1175,369,339 - 75,435,134 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1141.69NCBI
Pik3r5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,065,857 - 8,091,486 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,025,231 - 8,091,406 (+)NCBIChiLan1.0ChiLan1.0
PIK3R5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21964,780,309 - 64,868,388 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11769,590,055 - 69,677,728 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01742,686,483 - 42,773,668 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11747,421,204 - 47,507,282 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1747,475,201 - 47,507,282 (+)Ensemblpanpan1.1panPan2
PIK3R5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,538,354 - 33,604,984 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,532,708 - 33,604,984 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,674,664 - 33,741,285 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0533,641,537 - 33,708,256 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,635,875 - 33,708,207 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,609,183 - 33,675,765 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,566,733 - 33,633,509 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,743,236 - 33,809,805 (-)NCBIUU_Cfam_GSD_1.0
Pik3r5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560248,554,342 - 48,581,804 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365952,029,814 - 2,055,976 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365952,029,074 - 2,053,954 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,979,207 - 54,054,490 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,979,206 - 54,046,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21256,731,153 - 56,799,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,235,891 - 8,322,347 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl168,234,962 - 8,322,320 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,059,577 - 13,147,349 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3r5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478611,408,279 - 11,472,472 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3r5
367 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:165
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000032785
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 6 15 5
Low 2 21 29 19 4 19 2 2 54 35 37 6 2
Below cutoff 22 22 22 22 6 9 20 4 6

Sequence


RefSeq Acc Id: ENSRNOT00000032785   ⟹   ENSRNOP00000030578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,132,603 - 53,199,374 (+)Ensembl
Rnor_6.0 Ensembl1055,013,703 - 55,080,421 (+)Ensembl
RefSeq Acc Id: NM_001191923   ⟹   NP_001178852
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,677,832 - 53,698,261 (+)NCBI
mRatBN7.21053,178,944 - 53,199,374 (+)NCBI
Rnor_6.01055,058,434 - 55,078,863 (+)NCBI
Rnor_5.01054,757,809 - 54,822,968 (+)NCBI
Celera1052,347,081 - 52,367,505 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246770   ⟹   XP_006246832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,631,469 - 53,699,550 (+)NCBI
mRatBN7.21053,132,585 - 53,200,663 (+)NCBI
Rnor_6.01055,013,686 - 55,078,986 (+)NCBI
Rnor_5.01054,757,809 - 54,822,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597454   ⟹   XP_017452943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,631,469 - 53,699,550 (+)NCBI
mRatBN7.21053,132,585 - 53,200,663 (+)NCBI
Rnor_6.01055,013,686 - 55,078,986 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086573   ⟹   XP_038942501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,631,555 - 53,699,550 (+)NCBI
mRatBN7.21053,132,612 - 53,200,663 (+)NCBI
RefSeq Acc Id: XM_063269618   ⟹   XP_063125688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,670,884 - 53,699,550 (+)NCBI
RefSeq Acc Id: XM_063269619   ⟹   XP_063125689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,637,672 - 53,699,550 (+)NCBI
RefSeq Acc Id: NP_001178852   ⟸   NM_001191923
- UniProtKB: D4A4I3 (UniProtKB/TrEMBL),   A6HFK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246832   ⟸   XM_006246770
- Peptide Label: isoform X1
- UniProtKB: D4A4I3 (UniProtKB/TrEMBL),   A6HFK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452943   ⟸   XM_017597454
- Peptide Label: isoform X2
- UniProtKB: A6HFK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030578   ⟸   ENSRNOT00000032785
RefSeq Acc Id: XP_038942501   ⟸   XM_039086573
- Peptide Label: isoform X1
- UniProtKB: D4A4I3 (UniProtKB/TrEMBL),   A6HFK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125689   ⟸   XM_063269619
- Peptide Label: isoform X1
- UniProtKB: A6HFK4 (UniProtKB/TrEMBL),   D4A4I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125688   ⟸   XM_063269618
- Peptide Label: isoform X1
- UniProtKB: A6HFK4 (UniProtKB/TrEMBL),   D4A4I3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4I3-F1-model_v2 AlphaFold D4A4I3 1-872 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697297
Promoter ID:EPDNEW_R7820
Type:multiple initiation site
Name:Pik3r5_1
Description:phosphoinositide-3-kinase, regulatory subunit 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01055,013,702 - 55,013,762EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563261 AgrOrtholog
BioCyc Gene G2FUF-24635 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000023428 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032785.6 UniProtKB/TrEMBL
InterPro PI3K_1B_gamma_p101_su UniProtKB/TrEMBL
KEGG Report rno:497931 UniProtKB/TrEMBL
NCBI Gene 497931 ENTREZGENE
PANTHER PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5 UniProtKB/TrEMBL
  PTHR15593 UniProtKB/TrEMBL
Pfam PI3K_1B_p101 UniProtKB/TrEMBL
PhenoGen Pik3r5 PhenoGen
RatGTEx ENSRNOG00000023428 RatGTEx
UniProt A6HFK4 ENTREZGENE, UniProtKB/TrEMBL
  D4A4I3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Pik3r5  phosphoinositide-3-kinase, regulatory subunit 5  Pik3r5  phosphoinositide-3-kinase, regulatory subunit 5, p101  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Pik3r5  phosphoinositide-3-kinase, regulatory subunit 5, p101  RGD1563261_predicted  similar to novel protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563261_predicted  similar to novel protein (predicted)  LOC497931  similar to novel protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC497931  similar to novel protein      Symbol and Name status set to provisional 70820 PROVISIONAL