Isca2 (iron-sulfur cluster assembly 2) - Rat Genome Database

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Gene: Isca2 (iron-sulfur cluster assembly 2) Rattus norvegicus
Analyze
Symbol: Isca2
Name: iron-sulfur cluster assembly 2
RGD ID: 1563216
Description: Predicted to enable identical protein binding activity; iron ion binding activity; and iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Predicted to be part of mitochondrial [4Fe-4S] assembly complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hbld1; HESB like domain containing 1; hypothetical protein LOC500694; iron-sulfur cluster assembly 2 homolog; iron-sulfur cluster assembly 2 homolog (S. cerevisiae); iron-sulfur cluster assembly 2 homolog, mitochondrial; LOC500694; RGD1563216; similar to HESB like domain containing 1; uncharacterized protein LOC500694
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Isca2-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,149,593 - 110,151,103 (+)NCBIGRCr8
mRatBN7.26104,418,509 - 104,420,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,418,454 - 104,420,045 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,587,949 - 104,589,458 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,887,108 - 104,888,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,256,458 - 104,257,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,488,678 - 108,490,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,488,678 - 108,490,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,059,002 - 117,060,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,815,061 - 108,816,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6102,243,383 - 102,244,893 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:22323289   PMID:34800366  


Genomics

Comparative Map Data
Isca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,149,593 - 110,151,103 (+)NCBIGRCr8
mRatBN7.26104,418,509 - 104,420,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,418,454 - 104,420,045 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,587,949 - 104,589,458 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,887,108 - 104,888,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,256,458 - 104,257,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,488,678 - 108,490,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,488,678 - 108,490,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,059,002 - 117,060,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,815,061 - 108,816,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6102,243,383 - 102,244,893 (+)NCBICelera
Cytogenetic Map6q31NCBI
ISCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,493,765 - 74,497,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,493,756 - 74,497,106 (+)EnsemblGRCh38hg38GRCh38
GRCh371474,960,468 - 74,963,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,030,221 - 74,031,923 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,030,220 - 74,031,922NCBI
Celera1454,998,835 - 55,000,656 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,128,867 - 55,130,715 (+)NCBIHuRef
CHM1_11474,899,959 - 74,901,807 (+)NCBICHM1_1
T2T-CHM13v2.01468,702,736 - 68,706,077 (+)NCBIT2T-CHM13v2.0
Isca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,820,007 - 84,821,863 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,820,025 - 84,821,862 (+)EnsemblGRCm39 Ensembl
GRCm381284,773,230 - 84,775,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,773,251 - 84,775,088 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,114,220 - 86,116,039 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,663,018 - 85,664,836 (+)NCBIMGSCv36mm8
Celera1286,229,524 - 86,231,343 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.38NCBI
Isca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,008,246 - 1,010,041 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,008,246 - 1,010,030 (-)NCBIChiLan1.0ChiLan1.0
ISCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,577,491 - 75,580,448 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,794,022 - 74,795,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,046,821 - 55,048,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,894,694 - 73,896,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,894,694 - 73,896,444 (+)Ensemblpanpan1.1panPan2
ISCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,650,864 - 47,657,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,650,938 - 47,652,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,334,798 - 47,342,174 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,877,829 - 47,885,208 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,877,883 - 47,884,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,548,997 - 47,556,348 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,570,242 - 47,577,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,968,246 - 47,975,623 (+)NCBIUU_Cfam_GSD_1.0
Isca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,390,176 - 28,392,252 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,676,677 - 3,678,949 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,676,752 - 3,678,741 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISCA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,740,491 - 97,743,911 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,740,479 - 97,746,491 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,582,734 - 103,584,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ISCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,700,941 - 51,702,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2451,700,991 - 51,702,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605339,935,914 - 39,937,682 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473427,165,007 - 27,166,595 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473427,165,000 - 27,166,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Isca2
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:49
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000016089
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
RH143366  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,418,809 - 104,419,046 (+)MAPPERmRatBN7.2
mRatBN7.21467,719,188 - 67,719,310 (+)MAPPERmRatBN7.2
Rnor_6.01472,259,518 - 72,259,639NCBIRnor6.0
Rnor_6.06108,488,979 - 108,489,215NCBIRnor6.0
Rnor_5.01472,287,979 - 72,288,100UniSTSRnor5.0
Rnor_5.06117,059,975 - 117,060,211UniSTSRnor5.0
RGSC_v3.46108,815,417 - 108,815,653UniSTSRGSC3.4
RGSC_v3.41472,887,023 - 72,887,144UniSTSRGSC3.4
Celera1466,671,454 - 66,671,575UniSTS
Celera6102,243,684 - 102,243,920UniSTS
RH 3.4 Map14486.07UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016089   ⟹   ENSRNOP00000016089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,418,454 - 104,420,045 (+)Ensembl
Rnor_6.0 Ensembl6108,488,678 - 108,490,188 (+)Ensembl
RefSeq Acc Id: NM_001109278   ⟹   NP_001102748
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,149,593 - 110,151,103 (+)NCBI
mRatBN7.26104,418,509 - 104,420,019 (+)NCBI
Rnor_6.06108,488,678 - 108,490,188 (+)NCBI
Rnor_5.06117,059,002 - 117,060,512 (-)NCBI
RGSC_v3.46108,815,061 - 108,816,650 (+)RGD
Celera6102,243,383 - 102,244,893 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102748 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81531 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016089.3
  ENSRNOP00000081697.1
RefSeq Acc Id: NP_001102748   ⟸   NM_001109278
- Peptide Label: precursor
- UniProtKB: D4A4L5 (UniProtKB/TrEMBL),   A6JDY3 (UniProtKB/TrEMBL),   A0A8I5ZSL2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016089   ⟸   ENSRNOT00000016089
Protein Domains
FeS cluster biogenesis

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4L5-F1-model_v2 AlphaFold D4A4L5 1-154 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694731
Promoter ID:EPDNEW_R5255
Type:multiple initiation site
Name:Isca2_1
Description:iron-sulfur cluster assembly 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06108,488,659 - 108,488,719EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563216 AgrOrtholog
BioCyc Gene G2FUF-36807 BioCyc
Ensembl Genes ENSRNOG00000005077 UniProtKB/TrEMBL
  ENSRNOG00000012085 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006734.6 UniProtKB/TrEMBL
  ENSRNOT00000016089.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.300.12 UniProtKB/TrEMBL
InterPro FeS_biogenesis UniProtKB/TrEMBL
  FeS_cluster_insertion UniProtKB/TrEMBL
  FeS_cluster_insertion_CS UniProtKB/TrEMBL
  HesB-like_dom UniProtKB/TrEMBL
KEGG Report rno:500694 UniProtKB/TrEMBL
NCBI Gene 500694 ENTREZGENE
PANTHER IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
  IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Fe-S_biosyn UniProtKB/TrEMBL
PhenoGen Isca2 PhenoGen
PROSITE HESB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005077 RatGTEx
  ENSRNOG00000012085 RatGTEx
Superfamily-SCOP HesB_yadR_yfhF-like UniProtKB/TrEMBL
UniProt A0A8I5ZSL2 ENTREZGENE, UniProtKB/TrEMBL
  A6JDY3 ENTREZGENE, UniProtKB/TrEMBL
  D4A4L5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Isca2  iron-sulfur cluster assembly 2  Isca2  iron-sulfur cluster assembly 2 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-03 Isca2  iron-sulfur cluster assembly 2 homolog (S. cerevisiae)  RGD1563216  similar to HESB like domain containing 1  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1563216  similar to HESB like domain containing 1   RGD1563216_predicted  similar to HESB like domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563216_predicted  similar to HESB like domain containing 1 (predicted)  LOC500694  similar to HESB like domain containing 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500694  similar to HESB like domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL