Tmem212 (transmembrane protein 212)

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Gene: Tmem212 (transmembrane protein 212) Rattus norvegicus

Analyze

Symbol:

Tmem212

Name:

transmembrane protein 212

RGD ID:

1563109

Description:

Predicted to be located in membrane. Orthologous to human TMEM212 (transmembrane protein 212); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; glycidol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC499586; RGD1563109

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM212 (transmembrane protein 212)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tmem212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem212 (transmembrane protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tmem212 (transmembrane protein 212)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM212 (transmembrane protein 212)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem212	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	110,775,950 - 110,813,313 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	110,775,953 - 110,813,273 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	117,427,564 - 117,459,190 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	115,540,144 - 115,571,772 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	110,253,797 - 110,285,419 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	113,578,614 - 113,616,786 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	113,584,424 - 113,616,766 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	133,285,082 - 133,321,820 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	115,190,280 - 115,223,816 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	105,973,601 - 106,005,229 (-)	NCBI		Celera
Cytogenetic Map	2	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Fanconi syndrome (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

fipronil (ISO)

folic acid (ISO)

formaldehyde (ISO)

glycidol (EXP)

methimazole (EXP)

N,N-diethyl-m-toluamide (ISO)

titanium dioxide (ISO)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548

Genomics

Comparative Map Data

Tmem212
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	110,775,950 - 110,813,313 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	110,775,953 - 110,813,273 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	117,427,564 - 117,459,190 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	115,540,144 - 115,571,772 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	110,253,797 - 110,285,419 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	113,578,614 - 113,616,786 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	113,584,424 - 113,616,766 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	133,285,082 - 133,321,820 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	115,190,280 - 115,223,816 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	105,973,601 - 106,005,229 (-)	NCBI		Celera
Cytogenetic Map	2	q24	NCBI

TMEM212
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	171,843,349 - 171,859,318 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	171,843,349 - 171,938,715 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	171,561,139 - 171,577,108 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	171,561,139 - 171,577,108 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	169,961,011 - 169,976,978 (+)	NCBI		Celera
Cytogenetic Map	3	q26.31	NCBI
HuRef	3	168,931,203 - 168,947,168 (+)	NCBI		HuRef
CHM1_1	3	171,524,028 - 171,539,997 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	174,627,486 - 174,643,481 (+)	NCBI		T2T-CHM13v2.0

Tmem212
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	27,920,214 - 27,950,540 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	27,920,215 - 27,950,517 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	27,866,065 - 27,896,391 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	27,866,066 - 27,896,368 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	27,764,987 - 27,795,290 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	28,057,138 - 28,087,441 (-)	NCBI		MGSCv36	mm8
Celera	3	27,824,389 - 27,855,006 (-)	NCBI		Celera
Cytogenetic Map	3	A3	NCBI
cM Map	3	11.05	NCBI

Tmem212
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	1,931,859 - 1,962,791 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	1,931,855 - 1,961,957 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMEM212
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	169,731,376 - 169,744,692 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	168,851,746 - 168,867,731 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	177,034,840 - 177,050,827 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	177,034,875 - 177,048,203 (+)	Ensembl	panpan1.1		panPan2

TMEM212
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	36,149,443 - 36,159,933 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	36,148,976 - 36,197,266 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	45,162,299 - 45,186,133 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	36,233,628 - 36,257,398 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	36,233,451 - 36,243,866 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	36,173,891 - 36,197,704 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	36,137,489 - 36,158,488 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	36,399,103 - 36,409,800 (+)	NCBI		UU_Cfam_GSD_1.0

Tmem212
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	102,807,198 - 102,831,798 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936593	790,311 - 814,739 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936593	654,721 - 814,739 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM212
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	110,414,367 - 110,423,699 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	110,414,389 - 110,434,357 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	119,400,408 - 119,420,121 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM212
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	17,622,134 - 17,634,095 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666063	26,377,967 - 26,392,451 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem212
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	49,917,533 - 49,929,068 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmem212
181 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	400
Count of miRNA genes:	228
Interacting mature miRNAs:	256
Transcripts:	ENSRNOT00000016858, ENSRNOT00000074723
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
7411551	Bw131	Body weight QTL 131	29.6	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	67942638	112942638	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	88862519	133862519	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	88862519	133862519	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1598862	Glom9	Glomerulus QTL 9	3.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	2	92337601	137337601	Rat
1598863	Cm65	Cardiac mass QTL 65	2.3		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	92337601	137337601	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	102803808	147803808	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	104559726	149559726	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	appendage
High
Medium						3	3
Low					39	7	8
Below cutoff	3	7	2	2	9	10		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001164438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001164439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BE108013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO384351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000016858 ⟹ ENSRNOP00000016858

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	110,781,829 - 110,813,273 (-)	Ensembl
Rnor_6.0 Ensembl	2	113,584,424 - 113,616,766 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000074723 ⟹ ENSRNOP00000067020

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	110,795,514 - 110,813,273 (-)	Ensembl
Rnor_6.0 Ensembl	2	113,598,991 - 113,616,766 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110191 ⟹ ENSRNOP00000089499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	110,795,260 - 110,813,273 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111448 ⟹ ENSRNOP00000096381

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	110,775,953 - 110,813,273 (-)	Ensembl

RefSeq Acc Id:

NM_001164438 ⟹ NP_001157910

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	110,795,514 - 110,813,273 (-)	NCBI
Rnor_6.0	2	113,598,991 - 113,616,766 (-)	NCBI
Rnor_5.0	2	133,285,082 - 133,321,820 (-)	NCBI
RGSC_v3.4	2	115,190,280 - 115,223,816 (-)	RGD
Celera	2	105,987,094 - 106,005,229 (-)	NCBI

Sequence:

show sequence

TCACAGAGCAAAGAGTCAGGCCGCAGAGGAAAATGAAGGGCCTCTACCAGGCTGCTGGCAGGAC
CCTGGTCACTCTGGGGAGCCTGAGCATCTTCTCTGGATCCATCGCCTTCTTCCCTGTCTTTTCC
TGCAAGCTTTGGTACACAGGATGGAGCGTTTGGATTGCCTGTCCCATCTGGAACGGGGCTTTGG
CTGTCACAGCTGGATCACTCGTGCTGCTGGCTCATCGAGAGTGGACTCAGAGACACTTGTGGGA
AGCTGTTTTCACCTTTGTAGTTCTGAGCATTCTGGGATGTCCCCTTCATTTCGCAGTAGCCTTG
CAGTCTGCCCTCCTTGGTCCATATTGCTTCTACTCCTTTTCAGGGGTCTCGGGGACCAATTACC
TCGGTTATGCAGTTGCCTTCCCTTTTCCGTACACGAAGTTCCCATCGGTCTGTGTAGACCCACT
GCACTATGAAGAGTATCACCTGACCCTTCAGGCCCTGGACCTGGGCCTGAGCCTCACCCTGTTC
TGTGTGTCTGTAGCTGTGTTCATCAAGCTTTCTGCAAGACTGATGCAGACCGGACACGTAAATG
GGCCATGTGCCAAGGACTGCAAAAATAGGATGGCCCAGCAGCCCCACGCAGCAGCCTGGCGCAG
CAGCCCCGCGTAGCCCTGCGTGGCCCCCGCGCGGCCCACATCACACACAACTTACATTGGACAA
CTGATCCAGAAACACAGCAATTATCAGCATTCTCGGTCCAATCAGTAATGCAGCTATGGGAAAA
TAAGGATCAGGATTTCTGACACCTTGCAGCCATTCCCTCAACTGCGCCCTCCGCCAGCCATCCA
GATGGGGTGTCTCCTTTTATTTTCCTTTCATTATTTTTTGTTATGCTTTGTGGCTTTTTTTAAT
GAAAAGGGGAGGGAAAACATTTCCCCCTCTTGTCGTGTGAGGTGATGGTTTTACTTTTTCTAAT
GAATGGAGATGCTTGCCTCACAGAAAAGATGCCGGTAAACCCTTCAGGTGTAATTTAAAGACAC
TTGAGCAAAACATTTATTAACCCGCAGTTCTTTCCCGTAGCAGGAGACAGATGAGCTGGCATGT
AATGGCGCATGTCTTGAGCATCATTAATTCTCTGCAACAGTACAAATATTAGGGAGGTATTTTG
AGACAGGCTCTCATAATGTAGATGGGGCTGGCAAATCCCCCTGCCTCTGCCTCTGATGTGCTGG
GATGACAGATATGGTTCACCACGCCCAGCTTCTGTAAGTGTACTTTGAAATGGAATATATTGTT
TTTGAAACAGACAGAATATATTGTTTTTGAAAATGACACTT

hide sequence

RefSeq Acc Id:

NM_001164439 ⟹ NP_001157911

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	110,781,827 - 110,813,273 (-)	NCBI
Rnor_6.0	2	113,584,422 - 113,616,766 (-)	NCBI
Rnor_5.0	2	133,285,082 - 133,321,820 (-)	NCBI
RGSC_v3.4	2	115,190,280 - 115,223,816 (-)	RGD
Celera	2	105,973,601 - 106,005,229 (-)	RGD

Sequence:

show sequence

TCACAGAGCAAAGAGTCAGGCCGCAGAGGAAAATGAAGGGCCTCTACCAGGCTGCTGGCAGGAC
CCTGGTCACTCTGGGGAGCCTGAGCATCTTCTCTGGATCCATCGCCTTCTTCCCTGTCTTTTCC
TGCAAGCTTTGGTACACAGGATGGAGCGTTTGGATTGCCTGTCCCATCTGGAACGGGGCTTTGG
CTGTCACAGCTGGATCACTCGTGCTGCTGGCTCATCGAGAGTGGACTCAGAGACACTTGTGGGA
AGCTGTTTTCACCTTTGTAGTTCTGAGCATTCTGGGATGTCCCCTTCATTTCGCAGTAGCCTTG
CAGTCTGCCCTCCTTGGTCCATATTGCTTCTACTCCTTTTCAGGGGTCTCGGGGACCAATTACC
TCGGTTATGCAGTTGCCTTCCCTTTTCCGTACACGAAGTTCCCATCGGTCTGTGTAGACCCACT
GCACTATGAAGAGTATCACCTGACCCTTCAGGCCCTGGACCTGGGCCTGAGCCTCACCCTGTTC
TGTGTGTCTGTAGCTGTGTTCATCAAGCTTTCTGCAAGACTGATGCAGACCGGACACGTAAATG
GTCCAAGGAATGCACAATAAAGTTGAAGCTGCGTTCCCCTTCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006232219 ⟹ XP_006232281

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	110,775,950 - 110,813,303 (-)	NCBI
Rnor_6.0	2	113,578,614 - 113,616,786 (-)	NCBI
Rnor_5.0	2	133,285,082 - 133,321,820 (-)	NCBI

Sequence:

show sequence

TTGTGTTTTGGTAACAGATATCACAGAGCAAAGAGTCAGGCCGCAGAGGAAAATGAAGGGCCTC
TACCAGGCTGCTGGCAGGACCCTGGTCACTCTGGGGAGCCTGAGCATCTTCTCTGGATCCATCG
CCTTCTTCCCTGTCTTTTCCTGCAAGCTTTGGTACACAGGATGGAGCGTTTGGATTGCCTGTCC
CATCTGGAACGGGGCTTTGGCTGTCACAGCTGGATCACTCGTGCTGCTGGCTCATCGAGAGTGG
ACTCAGAGACACTTGTGGGAAGCTGTTTTCACCTTTGTAGTTCTGAGCATTCTGGGATGTCCCC
TTCATTTCGCAGTAGCCTTGCAGTCTGCCCTCCTTGGTCCATATTGCTTCTACTCCTTTTCAGG
GGTCTCGGGGACCAATTACCTCGGTTATGCAGTTGCCTTCCCTTTTCCGTACACGAAGTTCCCA
TCGGTCTGTGTAGACCCACTGCACTATGAAGAGTATCACCTGACCCTTCAGGCCCTGGACCTGG
GCCTGAGCCTCACCCTGTTCTGTGTGTCTGTAGCTGTGTTCATCAAGCTTTCTGCAAGACTGAT
GCAGACCGGACACGTAAATACAGGGGGCCCTCGCCACGCTCCGGATGTGACACCCAGATCCTCC
TGGAAGTTAACAGAAGCCACCAACACTGACTACAGCTAAGCTAGACTATCATAGCTCCTTGACA
CTTTAATATATATTTCAAAAAAATTGACAATAAATCATTTTTACAACATCA

hide sequence

RefSeq Acc Id:

XM_039102862 ⟹ XP_038958790

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	110,775,950 - 110,813,305 (-)	NCBI

RefSeq Acc Id:

XM_039102863 ⟹ XP_038958791

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	110,775,950 - 110,813,302 (-)	NCBI

RefSeq Acc Id:

XM_039102864 ⟹ XP_038958792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	110,775,950 - 110,813,313 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001157910	(Get FASTA)	NCBI Sequence Viewer
	NP_001157911	(Get FASTA)	NCBI Sequence Viewer
	XP_006232281	(Get FASTA)	NCBI Sequence Viewer
	XP_038958790	(Get FASTA)	NCBI Sequence Viewer
	XP_038958791	(Get FASTA)	NCBI Sequence Viewer
	XP_038958792	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01124	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001157911 ⟸ NM_001164439
- Peptide Label:	isoform 2
- UniProtKB:	D3ZW63 (UniProtKB/TrEMBL), A6IHH6 (UniProtKB/TrEMBL), A0A8I6A9Z3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKGLYQAAGRTLVTLGSLSIFSGSIAFFPVFSCKLWYTGWSVWIACPIWNGALAVTAGSLVLLA HREWTQRHLWEAVFTFVVLSILGCPLHFAVALQSALLGPYCFYSFSGVSGTNYLGYAVAFPFPY TKFPSVCVDPLHYEEYHLTLQALDLGLSLTLFCVSVAVFIKLSARLMQTGHVNGPRNAQ hide sequence

RefSeq Acc Id:	NP_001157910 ⟸ NM_001164438
- Peptide Label:	isoform 1
- UniProtKB:	M0RBS4 (UniProtKB/TrEMBL), A0A8I6A9Z3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKGLYQAAGRTLVTLGSLSIFSGSIAFFPVFSCKLWYTGWSVWIACPIWNGALAVTAGSLVLLA HREWTQRHLWEAVFTFVVLSILGCPLHFAVALQSALLGPYCFYSFSGVSGTNYLGYAVAFPFPY TKFPSVCVDPLHYEEYHLTLQALDLGLSLTLFCVSVAVFIKLSARLMQTGHVNGPCAKDCKNRM AQQPHAAAWRSSPA hide sequence

RefSeq Acc Id:	XP_006232281 ⟸ XM_006232219
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AQP5 (UniProtKB/TrEMBL), A0A8I6A9Z3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKGLYQAAGRTLVTLGSLSIFSGSIAFFPVFSCKLWYTGWSVWIACPIWNGALAVTAGSLVLLA HREWTQRHLWEAVFTFVVLSILGCPLHFAVALQSALLGPYCFYSFSGVSGTNYLGYAVAFPFPY TKFPSVCVDPLHYEEYHLTLQALDLGLSLTLFCVSVAVFIKLSARLMQTGHVNTGGPRHAPDVT PRSSWKLTEATNTDYS hide sequence

RefSeq Acc Id:

ENSRNOP00000016858 ⟸ ENSRNOT00000016858

RefSeq Acc Id:

ENSRNOP00000067020 ⟸ ENSRNOT00000074723

RefSeq Acc Id:	XP_038958792 ⟸ XM_039102864
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038958790 ⟸ XM_039102862
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A9Z3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958791 ⟸ XM_039102863
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6A9Z3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000089499 ⟸ ENSRNOT00000110191

RefSeq Acc Id:

ENSRNOP00000096381 ⟸ ENSRNOT00000111448

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0RBS4-F1-model_v2	AlphaFold	M0RBS4	1-206	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563109	AgrOrtholog
BioCyc Gene	G2FUF-53500	BioCyc
Ensembl Genes	ENSRNOG00000012608	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000016858	ENTREZGENE
	ENSRNOP00000016858.6	UniProtKB/TrEMBL
	ENSRNOP00000067020	ENTREZGENE
	ENSRNOP00000067020.1	UniProtKB/TrEMBL
	ENSRNOP00000089499.1	UniProtKB/TrEMBL
	ENSRNOP00000096381	ENTREZGENE
	ENSRNOP00000096381.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016858	ENTREZGENE
	ENSRNOT00000016858.9	UniProtKB/TrEMBL
	ENSRNOT00000074723	ENTREZGENE
	ENSRNOT00000074723.2	UniProtKB/TrEMBL
	ENSRNOT00000110191.1	UniProtKB/TrEMBL
	ENSRNOT00000111448	ENTREZGENE
	ENSRNOT00000111448.1	UniProtKB/TrEMBL
KEGG Report	rno:499586	UniProtKB/TrEMBL
NCBI Gene	499586	ENTREZGENE
PhenoGen	Tmem212	PhenoGen
UniProt	A0A8I6A9Z3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AQP5	ENTREZGENE, UniProtKB/TrEMBL
	A6IHH6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZW63	ENTREZGENE, UniProtKB/TrEMBL
	M0RBS4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-05-21	Tmem212	transmembrane protein 212	RGD1563109	RGD1563109	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1563109	RGD1563109	RGD1563109_predicted	RGD1563109 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1563109_predicted	RGD1563109 (predicted)	LOC499586	LOC499586	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC499586	LOC499586			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar