Mbd5 (methyl-CpG binding domain protein 5) - Rat Genome Database

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Gene: Mbd5 (methyl-CpG binding domain protein 5) Rattus norvegicus
Analyze
Symbol: Mbd5
Name: methyl-CpG binding domain protein 5
RGD ID: 1562961
Description: Predicted to enable chromatin binding activity. Predicted to be involved in nervous system development and regulation of behavior. Predicted to act upstream of or within glucose homeostasis; positive regulation of growth hormone receptor signaling pathway; and regulation of growth. Predicted to be located in chromocenter; midbody; and nucleoplasm. Human ortholog(s) of this gene implicated in autism spectrum disorder and autosomal dominant intellectual developmental disorder 1. Orthologous to human MBD5 (methyl-CpG binding domain protein 5); INTERACTS WITH (+)-schisandrin B; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311026; methyl-CpG-binding domain protein 5; similar to mKIAA1461 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,742,458 - 54,147,970 (+)NCBIGRCr8
mRatBN7.2333,588,854 - 33,738,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,333,554 - 33,730,156 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0333,364,812 - 33,504,144 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,440,191 - 33,504,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,600,038 - 38,663,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera331,856,644 - 31,921,520 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromocenter  (IBA,ISO)
midbody  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Extended spectrum of MBD5 mutations in neurodevelopmental disorders. Bonnet C, etal., Eur J Hum Genet. 2013 Dec;21(12):1457-61. doi: 10.1038/ejhg.2013.22. Epub 2013 Feb 20.
2. The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1. Cukier HN, etal., Autism Res. 2012 Dec;5(6):385-97. doi: 10.1002/aur.1251. Epub 2012 Oct 10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Reciprocal deletion and duplication at 2q23.1 indicates a role for MBD5 in autism spectrum disorder. Mullegama SV, etal., Eur J Hum Genet. 2014 Jan;22(1):57-63. doi: 10.1038/ejhg.2013.67. Epub 2013 May 1.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. The methyl binding domain containing protein MBD5 is a transcriptional regulator responsible for 2q23.1 deletion syndrome. Walz K and Young JI, Rare Dis. 2014 Nov 3;2(1):e967151. doi: 10.4161/2167549X.2014.967151. eCollection 2014.
Additional References at PubMed
PMID:19056867   PMID:20700456   PMID:23077600   PMID:23587880  


Genomics

Comparative Map Data
Mbd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,742,458 - 54,147,970 (+)NCBIGRCr8
mRatBN7.2333,588,854 - 33,738,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,333,554 - 33,730,156 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0333,364,812 - 33,504,144 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,440,191 - 33,504,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,600,038 - 38,663,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera331,856,644 - 31,921,520 (+)NCBICelera
Cytogenetic Map3q12NCBI
MBD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382148,020,927 - 148,516,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2148,021,011 - 148,516,971 (+)EnsemblGRCh38hg38GRCh38
GRCh372148,778,580 - 149,274,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,932,508 - 148,987,516 (+)NCBINCBI36Build 36hg18NCBI36
Build 342149,049,769 - 149,104,774NCBI
Celera2142,492,728 - 142,985,183 (+)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2140,776,638 - 141,269,422 (+)NCBIHuRef
CHM1_12148,784,226 - 149,276,488 (+)NCBICHM1_1
T2T-CHM13v2.02148,471,381 - 148,967,332 (+)NCBIT2T-CHM13v2.0
Mbd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,839,511 - 49,209,702 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,839,520 - 49,215,417 (+)EnsemblGRCm39 Ensembl
GRCm38248,949,499 - 49,319,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,949,508 - 49,325,405 (+)EnsemblGRCm38mm10GRCm38
MGSCv37248,805,028 - 49,172,589 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36249,064,365 - 49,139,005 (+)NCBIMGSCv36mm8
Celera250,621,661 - 50,990,507 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.43NCBI
Mbd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544014,270,407 - 14,413,597 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544014,267,802 - 14,412,949 (+)NCBIChiLan1.0ChiLan1.0
MBD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,428,361 - 26,924,995 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,347,218 - 11,842,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,380,363 - 152,874,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,754,368 - 152,874,042 (+)Ensemblpanpan1.1panPan2
MBD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,815,388 - 50,250,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1950,186,364 - 50,247,398 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1950,145,330 - 50,371,739 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01951,494,265 - 51,720,677 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,494,282 - 51,728,134 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11950,139,740 - 50,365,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01950,274,378 - 50,500,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,671,900 - 51,898,368 (+)NCBIUU_Cfam_GSD_1.0
Mbd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,486,058 - 112,872,593 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646928,744,814 - 28,802,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646928,748,499 - 28,889,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,659,012 - 3,725,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1153,649,859 - 4,096,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,337,836 - 3,346,811 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MBD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11033,401,903 - 33,907,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,743,166 - 33,904,508 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040165,632,515 - 166,137,209 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248661,105,616 - 1,162,288 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248661,003,279 - 1,162,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mbd5
719 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000034632
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat

Markers in Region
D3Rat98  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2333,703,347 - 33,703,538 (+)MAPPERmRatBN7.2
Rnor_6.0333,477,354 - 33,477,544NCBIRnor6.0
Rnor_5.0338,636,977 - 38,637,167UniSTSRnor5.0
RGSC_v3.4330,253,942 - 30,254,280RGDRGSC3.4
RGSC_v3.4330,253,945 - 30,254,135UniSTSRGSC3.4
RGSC_v3.1330,150,317 - 30,150,507RGD
Celera331,894,389 - 31,894,579UniSTS
RH 3.4 Map3398.9RGD
RH 3.4 Map3398.9UniSTS
SHRSP x BN Map315.1498UniSTS
SHRSP x BN Map315.1498RGD
FHH x ACI Map323.97RGD
Cytogenetic Map3q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 64 5 22 9
Low 3 43 51 41 13 41 8 11 10 30 19 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_056985410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_056985411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_056985412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_056985413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_056985414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001837441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005502930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005502931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005502932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_009624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_344906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_344907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_344909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC097988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000034632   ⟹   ENSRNOP00000031544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl333,440,191 - 33,503,685 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092907   ⟹   ENSRNOP00000075986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,333,554 - 33,730,156 (+)Ensembl
Rnor_6.0 Ensembl333,440,256 - 33,504,238 (+)Ensembl
RefSeq Acc Id: NM_001427822   ⟹   NP_001414751
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,998,098 - 54,139,389 (+)NCBI
RefSeq Acc Id: XM_056985410   ⟹   XP_056841390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
mRatBN7.2333,588,854 - 33,730,157 (+)NCBI
RefSeq Acc Id: XM_056985411   ⟹   XP_056841391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,998,101 - 54,139,394 (+)NCBI
mRatBN7.2333,588,854 - 33,730,157 (+)NCBI
RefSeq Acc Id: XM_056985412   ⟹   XP_056841392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,998,101 - 54,139,394 (+)NCBI
mRatBN7.2333,588,854 - 33,730,157 (+)NCBI
RefSeq Acc Id: XM_056985413   ⟹   XP_056841393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,126,612 (+)NCBI
mRatBN7.2333,588,854 - 33,717,386 (+)NCBI
RefSeq Acc Id: XM_056985414   ⟹   XP_056841394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,998,101 - 54,139,394 (+)NCBI
mRatBN7.2333,588,854 - 33,730,157 (+)NCBI
RefSeq Acc Id: XM_063283550   ⟹   XP_063139620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283551   ⟹   XP_063139621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283552   ⟹   XP_063139622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,742,458 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283553   ⟹   XP_063139623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,894,502 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283554   ⟹   XP_063139624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283555   ⟹   XP_063139625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283556   ⟹   XP_063139626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,742,458 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283558   ⟹   XP_063139628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,742,458 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283559   ⟹   XP_063139629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,742,458 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283560   ⟹   XP_063139630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283561   ⟹   XP_063139631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283562   ⟹   XP_063139632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283563   ⟹   XP_063139633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,998,101 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283564   ⟹   XP_063139634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XM_063283565   ⟹   XP_063139635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,139,394 (+)NCBI
RefSeq Acc Id: XR_005502930
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,143,850 (+)NCBI
mRatBN7.2333,588,854 - 33,733,478 (+)NCBI
RefSeq Acc Id: XR_005502931
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,147,970 (+)NCBI
mRatBN7.2333,588,854 - 33,738,730 (+)NCBI
RefSeq Acc Id: XR_005502932
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,138,922 (+)NCBI
mRatBN7.2333,588,854 - 33,729,809 (+)NCBI
RefSeq Acc Id: XR_010064609
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,143,850 (+)NCBI
RefSeq Acc Id: XR_010064610
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,743,062 - 54,143,850 (+)NCBI
RefSeq Acc Id: ENSRNOP00000075986   ⟸   ENSRNOT00000092907
RefSeq Acc Id: ENSRNOP00000031544   ⟸   ENSRNOT00000034632
RefSeq Acc Id: XP_056841394   ⟸   XM_056985414
- Peptide Label: isoform X3
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_056841391   ⟸   XM_056985411
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_056841390   ⟸   XM_056985410
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_056841392   ⟸   XM_056985412
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_056841393   ⟸   XM_056985413
- Peptide Label: isoform X2
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139626   ⟸   XM_063283556
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139628   ⟸   XM_063283558
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139622   ⟸   XM_063283552
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139629   ⟸   XM_063283559
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139624   ⟸   XM_063283554
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139630   ⟸   XM_063283560
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139625   ⟸   XM_063283555
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139621   ⟸   XM_063283551
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139634   ⟸   XM_063283564
- Peptide Label: isoform X5
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139635   ⟸   XM_063283565
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063139620   ⟸   XM_063283550
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139631   ⟸   XM_063283561
- Peptide Label: isoform X4
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139632   ⟸   XM_063283562
- Peptide Label: isoform X4
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139623   ⟸   XM_063283553
- Peptide Label: isoform X1
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL),   A0A1B0GWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414751   ⟸   NM_001427822
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139633   ⟸   XM_063283563
- Peptide Label: isoform X4
- UniProtKB: A6JEZ4 (UniProtKB/TrEMBL)
Protein Domains
MBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1B0GWQ8-F1-model_v2 AlphaFold A0A1B0GWQ8 1-1733 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562961 AgrOrtholog
BioCyc Gene G2FUF-49767 BioCyc
Ensembl Genes ENSRNOG00000027596 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000092907.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7445092 IMAGE-MGC_LOAD
InterPro Methyl_CpG_DNA-bd UniProtKB/TrEMBL
MGC_CLONE MGC:116128 IMAGE-MGC_LOAD
NCBI Gene Mbd5 ENTREZGENE
PANTHER METHYL-CPG-BINDING DOMAIN PROTEIN 5 UniProtKB/TrEMBL
  PTHR16112 UniProtKB/TrEMBL
PhenoGen Mbd5 PhenoGen
PROSITE MBD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027596 RatGTEx
SMART MBD UniProtKB/TrEMBL
Superfamily-SCOP Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A1B0GWQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6JEZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q4QQU4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-20 Mbd5  methyl-CpG binding domain protein 5  Mbd5  methyl-CpG binding domain protein 5  Type changed (type changed from [gene] to [protein-coding]) 629549 APPROVED
2013-08-09 Mbd5  methyl-CpG binding domain protein 5  LOC311026  similar to mKIAA1461 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC311026  similar to mKIAA1461 protein      Symbol and Name status set to provisional 70820 PROVISIONAL