Arhgef26 (Rho guanine nucleotide exchange factor 26) - Rat Genome Database

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Gene: Arhgef26 (Rho guanine nucleotide exchange factor 26) Rattus norvegicus
Analyze
Symbol: Arhgef26
Name: Rho guanine nucleotide exchange factor 26
RGD ID: 1562559
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within endothelial cell morphogenesis and ruffle assembly. Orthologous to human ARHGEF26 (Rho guanine nucleotide exchange factor 26); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC310460; RGD1562559; Rho guanine nucleotide exchange factor (GEF) 26; Sgef; similar to SH3-containing guanine nucleotide exchange factor; Src homology 3 domain-containing guanine nucleotide exchange factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22146,740,336 - 146,850,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2146,739,631 - 146,850,819 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0227,107,263 - 27,236,336 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,107,318 - 27,236,672 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,226,201 - 46,351,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42151,998,907 - 152,114,966 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2141,079,334 - 141,189,916 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dibenz[a,h]anthracene  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glycerol  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propane-1,2-diol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23372835  


Genomics

Comparative Map Data
Arhgef26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22146,740,336 - 146,850,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2146,739,631 - 146,850,819 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0227,107,263 - 27,236,336 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,107,318 - 27,236,672 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,226,201 - 46,351,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42151,998,907 - 152,114,966 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2141,079,334 - 141,189,916 (+)NCBICelera
Cytogenetic Map2q12NCBI
ARHGEF26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383154,121,003 - 154,257,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3154,121,003 - 154,257,827 (+)EnsemblGRCh38hg38GRCh38
GRCh373153,838,792 - 153,975,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363155,321,884 - 155,457,031 (+)NCBINCBI36Build 36hg18NCBI36
Celera3152,256,672 - 152,396,290 (+)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3151,230,419 - 151,370,369 (+)NCBIHuRef
CHM1_13153,801,970 - 153,938,825 (+)NCBICHM1_1
T2T-CHM13v2.03156,892,016 - 157,032,100 (+)NCBIT2T-CHM13v2.0
Arhgef26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39362,244,946 - 62,369,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl362,245,765 - 62,369,642 (+)EnsemblGRCm39 Ensembl
GRCm38362,338,777 - 62,462,221 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl362,338,344 - 62,462,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv37362,142,699 - 62,266,143 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36362,426,706 - 62,550,150 (+)NCBIMGSCv36mm8
Celera362,018,356 - 62,139,695 (+)NCBICelera
Cytogenetic Map3E1NCBI
Arhgef26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554485,494,571 - 5,627,107 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554485,494,571 - 5,627,107 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan13152,037,453 - 152,176,712 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03151,174,223 - 151,313,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13158,728,629 - 158,865,631 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3158,728,681 - 158,866,019 (+)Ensemblpanpan1.1panPan2
ARHGEF26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12348,290,105 - 48,400,879 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2348,290,104 - 48,399,096 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2348,155,624 - 48,268,098 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02348,918,456 - 49,031,214 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2348,918,746 - 49,031,202 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12348,500,657 - 48,612,000 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02348,556,219 - 48,668,057 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02348,838,156 - 48,950,583 (+)NCBIUU_Cfam_GSD_1.0
Arhgef26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560287,799,054 - 87,892,403 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365191,840,970 - 1,934,905 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365191,841,549 - 1,934,898 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1394,155,872 - 94,289,782 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11394,155,632 - 94,296,699 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213102,204,629 - 102,324,347 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11536,455,968 - 36,595,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1536,455,962 - 36,594,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660419,118,545 - 9,263,011 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473031,716,182 - 31,847,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef26
500 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:516
Count of miRNA genes:265
Interacting mature miRNAs:323
Transcripts:ENSRNOT00000019553
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2142323368146786035Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2142323368146786035Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2142323368146786035Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2142323368146786035Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat

Markers in Region
D2Chm46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22146,785,831 - 146,786,035 (+)MAPPERmRatBN7.2
Rnor_6.0227,161,158 - 27,161,361NCBIRnor6.0
Rnor_5.0246,277,209 - 46,277,412UniSTSRnor5.0
RGSC_v3.42152,050,347 - 152,050,550UniSTSRGSC3.4
Celera2141,125,225 - 141,125,402UniSTS
Cytogenetic Map2q31UniSTS
BQ206062  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22146,738,594 - 146,738,812 (+)MAPPERmRatBN7.2
Rnor_6.0227,106,081 - 27,106,298NCBIRnor6.0
Rnor_5.0246,225,009 - 46,225,226UniSTSRnor5.0
RGSC_v3.42151,997,166 - 151,997,383UniSTSRGSC3.4
Celera2141,078,151 - 141,078,368UniSTS
RH 3.4 Map2958.0UniSTS
Cytogenetic Map2q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 21 13 13 42 16 28 11
Low 1 40 36 28 19 28 8 11 32 19 13 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019553   ⟹   ENSRNOP00000019554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2146,739,631 - 146,850,819 (+)Ensembl
Rnor_6.0 Ensembl227,107,318 - 27,236,672 (+)Ensembl
RefSeq Acc Id: XM_227201   ⟹   XP_227201
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22146,740,336 - 146,850,918 (+)NCBI
Rnor_6.0227,107,263 - 27,236,336 (+)NCBI
Rnor_5.0246,226,201 - 46,351,854 (+)NCBI
RGSC_v3.42151,998,907 - 152,114,966 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_227201 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14822 (Get FASTA)   NCBI Sequence Viewer  
  EDM14823 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_227201   ⟸   XM_227201
- UniProtKB: D4A1D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019554   ⟸   ENSRNOT00000019553
Protein Domains
DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1D2-F1-model_v2 AlphaFold D4A1D2 1-869 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691085
Promoter ID:EPDNEW_R1606
Type:single initiation site
Name:Arhgef26_1
Description:Rho guanine nucleotide exchange factor 26
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0227,107,322 - 27,107,382EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562559 AgrOrtholog
BioCyc Gene G2FUF-52944 BioCyc
Ensembl Genes ENSRNOG00000014549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019554 ENTREZGENE
  ENSRNOP00000019554.7 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019553 ENTREZGENE
  ENSRNOT00000019553.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARHGEF16/ARHGEF26_SH3 UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Ephexin-like UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_ephexin UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:310460 UniProtKB/TrEMBL
NCBI Gene 310460 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Arhgef26 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt D4A1D2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef26  Rho guanine nucleotide exchange factor 26  Arhgef26  Rho guanine nucleotide exchange factor (GEF) 26  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Arhgef26  Rho guanine nucleotide exchange factor (GEF) 26  Sgef  Src homology 3 domain-containing guanine nucleotide exchange factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Sgef  Src homology 3 domain-containing guanine nucleotide exchange factor  RGD1562559_predicted  similar to SH3-containing guanine nucleotide exchange factor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562559_predicted  similar to SH3-containing guanine nucleotide exchange factor (predicted)  LOC310460  similar to SH3-containing guanine nucleotide exchange factor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC310460  similar to SH3-containing guanine nucleotide exchange factor      Symbol and Name status set to provisional 70820 PROVISIONAL