Skp2 (S-phase kinase associated protein 2) - Rat Genome Database

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Gene: Skp2 (S-phase kinase associated protein 2) Rattus norvegicus
Analyze
Symbol: Skp2
Name: S-phase kinase associated protein 2
RGD ID: 1562456
Description: Predicted to enable identical protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in cellular response to cell-matrix adhesion and positive regulation of smooth muscle cell proliferation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2); PARTICIPATES IN Notch signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17beta-estradiol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC294790; RGD1562456; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1); similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (F-box/WD-40 protein 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,888,406 - 59,916,471 (-)NCBIGRCr8
mRatBN7.2258,161,226 - 58,189,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,161,229 - 58,189,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx265,259,097 - 65,287,393 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,371,360 - 63,399,422 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,372,679 - 58,400,741 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0258,506,146 - 58,534,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,506,151 - 58,534,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0277,593,574 - 77,621,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,769,164 - 58,797,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera253,770,002 - 53,798,066 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-nitrophenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
escitalopram  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fraxetin  (ISO)
gamma-linolenic acid  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
irinotecan  (ISO)
isosilybin A  (ISO)
lactacystin  (ISO)
leflunomide  (ISO)
maneb  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
orlistat  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium tungstate  (ISO)
stattic  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
triacsin C  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells. Bellet MM, etal., Cell Cycle. 2014;13(12):1902-11. doi: 10.4161/cc.28760. Epub 2014 Apr 17.
2. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
3. Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. Carrano AC and Pagano M, J Cell Biol. 2001 Jun 25;153(7):1381-90.
4. An in vivo study of Cdh1/APC in breast cancer formation. Fujita T, etal., Int J Cancer. 2009 Aug 15;125(4):826-36.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma. Kamata Y, etal., J Cancer Res Clin Oncol. 2005 Sep;131(9):591-6. Epub 2005 Oct 20.
7. Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium. Lahav-Baratz S, etal., Mol Hum Reprod. 2004 Aug;10(8):567-72. Epub 2004 Jun 25.
8. Expression of p27 and its ubiquitin ligase subunit Skp2 in upper urinary tract transitional cell carcinoma. Langner C, etal., Urology. 2004 Sep;64(3):611-6.
9. A relationship between p27kip1 and Skp2 following adult brain injury: implications for glial proliferation. Liu Y, etal., J Neurotrauma. 2009 Oct 23.
10. Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study. Liu Z, etal., J Exp Clin Cancer Res. 2008 Oct 15;27:51.
11. The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy. Nguyen PL, etal., Urol Oncol. 2009 May 16.
12. [Expression of Skp2 in cervical squamous cell carcinoma and precancerous lesions and its correlation with HPV16/18 infection] Pan BJ and Chen JW, Zhonghua Bing Li Xue Za Zhi. 2008 Sep;37(9):589-93.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. Ren S, etal., Int J Biochem Cell Biol. 2020 Aug;125:105777. doi: 10.1016/j.biocel.2020.105777. Epub 2020 Jun 3.
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha. Scotto L, etal., Mol Cancer. 2008 Jun 17;7:58.
18. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Shim EH, etal., Cancer Res. 2003 Apr 1;63(7):1583-8.
19. Clinical significance of Skp2 expression, alone and combined with Jab1 and p27 in epithelial ovarian tumors. Sui L, etal., Oncol Rep. 2006 Apr;15(4):765-71.
20. S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo. Wu YJ, etal., J Vasc Surg. 2009 Nov;50(5):1135-42.
21. A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. Yokoi S, etal., Am J Pathol. 2002 Jul;161(1):207-16. doi: 10.1016/S0002-9440(10)64172-7.
Additional References at PubMed
PMID:10790373   PMID:12477932   PMID:16880511   PMID:17647103   PMID:17785450   PMID:17873289   PMID:18599477   PMID:18604603   PMID:19028597   PMID:19047054   PMID:19056892   PMID:20924167  
PMID:22017545   PMID:22344541   PMID:22770219   PMID:23277542   PMID:24441545   PMID:25651564   PMID:27011052   PMID:27194766   PMID:30629029   PMID:32313103   PMID:33837090  


Genomics

Comparative Map Data
Skp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,888,406 - 59,916,471 (-)NCBIGRCr8
mRatBN7.2258,161,226 - 58,189,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,161,229 - 58,189,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx265,259,097 - 65,287,393 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,371,360 - 63,399,422 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,372,679 - 58,400,741 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0258,506,146 - 58,534,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,506,151 - 58,534,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0277,593,574 - 77,621,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,769,164 - 58,797,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera253,770,002 - 53,798,066 (-)NCBICelera
Cytogenetic Map2q16NCBI
SKP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38536,152,111 - 36,193,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl536,151,989 - 36,196,849 (+)EnsemblGRCh38hg38GRCh38
GRCh37536,152,213 - 36,184,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36536,187,946 - 36,219,904 (+)NCBINCBI36Build 36hg18NCBI36
Celera536,037,882 - 36,069,833 (+)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef536,103,294 - 36,135,146 (+)NCBIHuRef
CHM1_1536,154,887 - 36,186,889 (+)NCBICHM1_1
T2T-CHM13v2.0536,400,405 - 36,441,818 (+)NCBIT2T-CHM13v2.0
Skp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,112,070 - 9,155,512 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,112,073 - 9,155,512 (-)EnsemblGRCm39 Ensembl
GRCm38159,111,982 - 9,155,425 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,111,985 - 9,155,425 (-)EnsemblGRCm38mm10GRCm38
MGSCv37159,041,742 - 9,070,207 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,038,867 - 9,067,333 (-)NCBIMGSCv36mm8
Celera158,929,103 - 8,957,934 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.84NCBI
Skp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542620,972,663 - 20,999,769 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542620,972,663 - 20,999,769 (+)NCBIChiLan1.0ChiLan1.0
SKP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2474,145,802 - 74,177,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1572,299,431 - 72,331,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0574,179,608 - 74,211,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1579,460,989 - 79,493,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl579,461,018 - 79,492,311 (-)Ensemblpanpan1.1panPan2
SKP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1472,352,966 - 72,386,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl472,352,986 - 72,386,307 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha471,962,697 - 71,996,249 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0472,860,285 - 72,892,402 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl472,861,375 - 72,892,173 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1472,606,024 - 72,639,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0472,729,654 - 72,763,206 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0473,263,074 - 73,296,649 (-)NCBIUU_Cfam_GSD_1.0
Skp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213225,707,776 - 225,735,425 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365185,637,331 - 5,664,778 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365185,635,856 - 5,664,057 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1621,463,012 - 21,509,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11621,463,270 - 21,500,925 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21622,480,017 - 22,517,706 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SKP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1435,009,114 - 35,040,518 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl435,009,076 - 35,042,632 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607125,339,782 - 25,375,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Skp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475918,830,323 - 18,858,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475918,796,055 - 18,858,692 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Skp2
141 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:734
Count of miRNA genes:310
Interacting mature miRNAs:400
Transcripts:ENSRNOT00000023099
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)25653191259324719Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH128818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2258,161,312 - 58,161,496 (+)MAPPERmRatBN7.2
mRatBN7.21162,064,085 - 162,064,276 (+)MAPPERmRatBN7.2
Rnor_6.01172,378,776 - 172,378,966NCBIRnor6.0
Rnor_6.0258,506,233 - 58,506,416NCBIRnor6.0
Rnor_5.01179,374,519 - 179,374,709UniSTSRnor5.0
Rnor_5.0277,593,661 - 77,593,844UniSTSRnor5.0
RGSC_v3.41165,573,459 - 165,573,649UniSTSRGSC3.4
RGSC_v3.4258,769,251 - 58,769,434UniSTSRGSC3.4
Celera253,770,089 - 53,770,272UniSTS
Celera1159,987,473 - 159,987,663UniSTS
Cytogenetic Map1q33UniSTS
Cytogenetic Map2q16UniSTS
RH143607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2258,161,723 - 58,161,986 (+)MAPPERmRatBN7.2
Rnor_6.0258,506,644 - 58,506,906NCBIRnor6.0
Rnor_5.0277,594,072 - 77,594,334UniSTSRnor5.0
RGSC_v3.4258,769,662 - 58,769,924UniSTSRGSC3.4
Celera253,770,500 - 53,770,762UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000089178   ⟹   ENSRNOP00000074788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl258,161,229 - 58,189,338 (-)Ensembl
Rnor_6.0 Ensembl258,506,151 - 58,534,211 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115243   ⟹   ENSRNOP00000095009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl258,161,229 - 58,189,338 (-)Ensembl
RefSeq Acc Id: NM_001106416   ⟹   NP_001099886
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,888,406 - 59,916,471 (-)NCBI
mRatBN7.2258,161,226 - 58,189,293 (-)NCBI
Rnor_6.0258,506,146 - 58,534,211 (-)NCBI
Rnor_5.0277,593,574 - 77,621,639 (-)NCBI
RGSC_v3.4258,769,164 - 58,797,229 (-)RGD
Celera253,770,002 - 53,798,066 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099886 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66459 (Get FASTA)   NCBI Sequence Viewer  
  EDL75673 (Get FASTA)   NCBI Sequence Viewer  
  EDL75674 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074788.1
  ENSRNOP00000095009.1
RefSeq Acc Id: NP_001099886   ⟸   NM_001106416
- UniProtKB: A6KGJ1 (UniProtKB/TrEMBL),   A0A8I6AMP0 (UniProtKB/TrEMBL),   A0A0G2K8Y9 (UniProtKB/TrEMBL),   B2GUZ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074788   ⟸   ENSRNOT00000089178
Ensembl Acc Id: ENSRNOP00000095009   ⟸   ENSRNOT00000115243
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUZ0-F1-model_v2 AlphaFold B2GUZ0 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691179
Promoter ID:EPDNEW_R1703
Type:multiple initiation site
Name:Skp2_1
Description:S-phase kinase associated protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0258,534,285 - 58,534,345EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562456 AgrOrtholog
BioCyc Gene G2FUF-54103 BioCyc
Ensembl Genes ENSRNOG00000059059 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089178.2 UniProtKB/TrEMBL
  ENSRNOT00000115243.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9027296 IMAGE-MGC_LOAD
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt_Cys-con_subtyp UniProtKB/TrEMBL
KEGG Report rno:294790 UniProtKB/TrEMBL
MGC_CLONE MGC:187758 IMAGE-MGC_LOAD
NCBI Gene 294790 ENTREZGENE
PANTHER PROTEIN ARABIDILLO 1 UniProtKB/TrEMBL
  PROTEIN ARABIDILLO 1 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Skp2 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059059 RatGTEx
SMART FBOX UniProtKB/TrEMBL
  LRR_CC UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
UniProt A0A0G2K8Y9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMP0 ENTREZGENE, UniProtKB/TrEMBL
  A6KGJ1 ENTREZGENE, UniProtKB/TrEMBL
  B2GUZ0 ENTREZGENE
UniProt Secondary B2GUZ0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-21 Skp2  S-phase kinase associated protein 2  Skp2  S-phase kinase-associated protein 2, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Skp2  S-phase kinase-associated protein 2, E3 ubiquitin protein ligase  Skp2  S-phase kinase-associated protein 2 (p45)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Skp2  S-phase kinase-associated protein 2 (p45)  RGD1562456_predicted  similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (F-box/WD-40 protein 1) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-10 RGD1562456_predicted  similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (F-box/WD-40 protein 1) (predicted)    similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1562456_predicted  similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1) (predicted)  LOC294790  similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294790  similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1)      Symbol and Name status set to provisional 70820 PROVISIONAL