Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sestd1 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SESTD1 mRNA] | CTD | PMID:31150632 | Sestd1 | Rat | (-)-demecolcine | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of SESTD1 mRNA | CTD | PMID:23649840 | Sestd1 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SESTD1 mRNA | CTD | PMID:22079256 | Sestd1 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SESTD1 mRNA | CTD | PMID:36331819 | Sestd1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SESTD1 mRNA | CTD | PMID:22206623 | Sestd1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Sestd1 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of SESTD1 mRNA | CTD | PMID:22206623 | Sestd1 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of SESTD1 mRNA | CTD | PMID:29097150 | Sestd1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SESTD1 promoter] | CTD | PMID:19654925 | Sestd1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SESTD1 mRNA | CTD | PMID:33387578 | Sestd1 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Sestd1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of SESTD1 mRNA | CTD | PMID:28973697 | Sestd1 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Sestd1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of SESTD1 mRNA | CTD | PMID:28973697 | Sestd1 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of SESTD1 mRNA | CTD | PMID:28959563 | Sestd1 | Rat | aflatoxin B1 | decreases methylation | ISO | SESTD1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SESTD1 gene | CTD | PMID:27153756 | Sestd1 | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of SESTD1 mRNA | CTD | PMID:30779732 | Sestd1 | Rat | antirheumatic drug | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SESTD1 mRNA | CTD | PMID:24449571 | Sestd1 | Rat | aristolochic acid A | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SESTD1 mRNA | CTD | PMID:33212167 | Sestd1 | Rat | Aroclor 1254 | decreases expression | ISO | Sestd1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of SESTD1 mRNA | CTD | PMID:23650126 | Sestd1 | Rat | benzo[e]pyrene | increases methylation | ISO | SESTD1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of SESTD1 intron | CTD | PMID:30157460 | Sestd1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SESTD1 mRNA | CTD | PMID:25181051|PMID:29097150 | Sestd1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SESTD1 mRNA | CTD | PMID:30816183|PMID:34947998 | Sestd1 | Rat | butanal | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of SESTD1 mRNA | CTD | PMID:26079696 | Sestd1 | Rat | cadmium atom | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SESTD1 more ... | CTD | PMID:35301059 | Sestd1 | Rat | cadmium atom | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SESTD1 more ... | CTD | PMID:37236586 | Sestd1 | Rat | cadmium dichloride | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of SESTD1 mRNA | CTD | PMID:38382870 | Sestd1 | Rat | cadmium dichloride | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SESTD1 more ... | CTD | PMID:37236586 | Sestd1 | Rat | cadmium dichloride | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SESTD1 more ... | CTD | PMID:35301059 | Sestd1 | Rat | cadmium dichloride | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SESTD1 mRNA | CTD | PMID:38568856 | Sestd1 | Rat | CGP 52608 | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SESTD1 gene] | CTD | PMID:28238834 | Sestd1 | Rat | choline | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Sestd1 | Rat | copper(II) sulfate | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SESTD1 mRNA | CTD | PMID:19549813 | Sestd1 | Rat | cyclosporin A | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SESTD1 mRNA | CTD | PMID:20106945|PMID:21632981|PMID:25562108 | Sestd1 | Rat | Dibutyl phosphate | affects expression | ISO | SESTD1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SESTD1 mRNA | CTD | PMID:37042841 | Sestd1 | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of SESTD1 mRNA | CTD | PMID:21266533 | Sestd1 | Rat | dioxygen | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [sulforaphane affects the susceptibility to Oxygen] which affects the expression of SESTD1 mRNA | CTD | PMID:30529165 | Sestd1 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of SESTD1 mRNA | CTD | PMID:21551480|PMID:25152437 | Sestd1 | Rat | dorsomorphin | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Sestd1 | Rat | entinostat | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | entinostat results in decreased expression of SESTD1 mRNA | CTD | PMID:26272509 | Sestd1 | Rat | entinostat | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Sestd1 | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of SESTD1 mRNA | CTD | PMID:34044035 | Sestd1 | Rat | folic acid | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SESTD1 mRNA; [Methionine deficiency co-treated more ... | CTD | PMID:20938992|PMID:22206623 | Sestd1 | Rat | folic acid | decreases expression | ISO | Sestd1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SESTD1 mRNA | CTD | PMID:25629700 | Sestd1 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of SESTD1 mRNA | CTD | PMID:27387713 | Sestd1 | Rat | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of SESTD1 gene | CTD | PMID:35440735 | Sestd1 | Rat | GSK-J4 | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | GSK-J4 results in increased expression of SESTD1 mRNA | CTD | PMID:29301935 | Sestd1 | Rat | ketoconazole | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Ketoconazole results in increased expression of SESTD1 mRNA | CTD | PMID:36621641 | Sestd1 | Rat | L-methionine | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Sestd1 | Rat | methapyrilene | increases methylation | ISO | SESTD1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of SESTD1 intron | CTD | PMID:30157460 | Sestd1 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of SESTD1 gene | CTD | PMID:35440735 | Sestd1 | Rat | methyl methanesulfonate | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SESTD1 mRNA | CTD | PMID:23649840 | Sestd1 | Rat | methylmercury chloride | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SESTD1 mRNA | CTD | PMID:28001369 | Sestd1 | Rat | nickel atom | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Nickel results in decreased expression of SESTD1 mRNA | CTD | PMID:25583101 | Sestd1 | Rat | nickel sulfate | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of SESTD1 mRNA | CTD | PMID:22714537 | Sestd1 | Rat | niclosamide | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Niclosamide results in decreased expression of SESTD1 mRNA | CTD | PMID:36318118 | Sestd1 | Rat | panobinostat | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Sestd1 | Rat | panobinostat | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | panobinostat results in decreased expression of SESTD1 mRNA | CTD | PMID:26272509 | Sestd1 | Rat | paracetamol | affects expression | ISO | Sestd1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SESTD1 mRNA | CTD | PMID:17562736 | Sestd1 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SESTD1 mRNA | CTD | PMID:33387578 | Sestd1 | Rat | pentanal | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | pentanal results in decreased expression of SESTD1 mRNA | CTD | PMID:26079696 | Sestd1 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SESTD1 mRNA | CTD | PMID:36331819 | Sestd1 | Rat | pirinixic acid | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Sestd1 | Rat | pirinixic acid | increases expression | ISO | Sestd1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SESTD1 mRNA | CTD | PMID:20813756 | Sestd1 | Rat | potassium chromate | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SESTD1 mRNA | CTD | PMID:22079256 | Sestd1 | Rat | potassium chromate | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SESTD1 mRNA | CTD | PMID:22079256 | Sestd1 | Rat | progesterone | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Progesterone results in increased expression of SESTD1 mRNA | CTD | PMID:20864642 | Sestd1 | Rat | rimonabant | affects expression | ISO | Sestd1 (Mus musculus) | 6480464 | Rimonabant affects the expression of SESTD1 mRNA | CTD | PMID:19030233 | Sestd1 | Rat | rimonabant | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SESTD1 mRNA] | CTD | PMID:19030233 | Sestd1 | Rat | SB 431542 | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Sestd1 | Rat | sevoflurane | decreases expression | ISO | Sestd1 (Mus musculus) | 6480464 | Sevoflurane results in decreased expression of SESTD1 protein | CTD | PMID:35249202 | Sestd1 | Rat | sodium arsenate | increases expression | ISO | Sestd1 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of SESTD1 mRNA | CTD | PMID:21795629 | Sestd1 | Rat | sodium arsenite | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SESTD1 mRNA | CTD | PMID:22714537 | Sestd1 | Rat | sulforaphane | multiple interactions | ISO | Sestd1 (Mus musculus) | 6480464 | [sulforaphane affects the susceptibility to Oxygen] which affects the expression of SESTD1 mRNA | CTD | PMID:30529165 | Sestd1 | Rat | sunitinib | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SESTD1 mRNA | CTD | PMID:31533062 | Sestd1 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SESTD1 mRNA] | CTD | PMID:31150632 | Sestd1 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SESTD1 mRNA | CTD | PMID:31150632 | Sestd1 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SESTD1 mRNA | CTD | PMID:34492290 | Sestd1 | Rat | thiram | increases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Thiram results in increased expression of SESTD1 mRNA | CTD | PMID:38568856 | Sestd1 | Rat | trichostatin A | multiple interactions | ISO | SESTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Sestd1 | Rat | valproic acid | decreases expression | ISO | SESTD1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SESTD1 mRNA | CTD | PMID:23179753|PMID:25192806|PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















