Gsta3l1 (glutathione S-transferase alpha 3 like 1) - Rat Genome Database

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Gene: Gsta3l1 (glutathione S-transferase alpha 3 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gsta3l1 (Ensembl: RGD1562107)
Name: glutathione S-transferase alpha 3 like 1 (Ensembl:similar to class-alpha glutathione S-transferase)
RGD ID: 1562107
Description: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process; PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutathione S-transferase; LOC363205; RGD1562107; similar to class-alpha glutathione S-transferase
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,115,727 - 31,128,997 (+)NCBIGRCr8
mRatBN7.2923,619,691 - 23,628,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,620,010 - 23,632,333 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0927,311,229 - 27,324,452 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,311,886 - 27,324,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,166,518 - 26,179,481 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,965,797 - 19,978,363 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera921,193,581 - 21,206,752 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Gsta3l1
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000038486
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat

Markers in Region
RH138131  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2923,632,257 - 23,632,501 (+)MAPPERmRatBN7.2
Rnor_6.0927,324,134 - 27,324,377NCBIRnor6.0
Rnor_5.0926,179,351 - 26,179,594UniSTSRnor5.0
RGSC_v3.4919,978,045 - 19,978,288UniSTSRGSC3.4
Celera921,206,434 - 21,206,677UniSTS
RH 3.4 Map9229.39UniSTS
Cytogenetic Map9q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 6 6 5
Low 2 9 1 6 1 6 22 10 2
Below cutoff 8 3 2 3 3 5 37 6 16 3

Sequence


RefSeq Acc Id: ENSRNOT00000038486   ⟹   ENSRNOP00000029347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,620,010 - 23,632,333 (+)Ensembl
Rnor_6.0 Ensembl927,311,886 - 27,324,158 (+)Ensembl
RefSeq Acc Id: XM_343545   ⟹   XP_343546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,115,727 - 31,128,997 (+)NCBI
mRatBN7.2923,619,691 - 23,628,517 (+)NCBI
Rnor_6.0927,311,233 - 27,324,452 (+)NCBI
Rnor_5.0926,166,518 - 26,179,481 (+)NCBI
RGSC_v3.4919,965,797 - 19,978,363 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_343546 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18641 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029347.6
RefSeq Acc Id: XP_343546   ⟸   XM_343545
- Sequence:
RefSeq Acc Id: ENSRNOP00000029347   ⟸   ENSRNOT00000038486
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD94-F1-model_v2 AlphaFold D3ZD94 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562107 AgrOrtholog
BioCyc Gene G2FUF-28010 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000024755 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038486.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  GST_alpha UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene 363205 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
  GLUTATHIONE TRANSFERASE UniProtKB/TrEMBL
Pfam GST_C_3 UniProtKB/TrEMBL
  GST_N UniProtKB/TrEMBL
PhenoGen Gsta3l1 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024755 RatGTEx
Superfamily-SCOP GST_C_like UniProtKB/TrEMBL
  Thiordxn-like_fd UniProtKB/TrEMBL
UniProt D3ZD94_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Gsta3l1  glutathione S-transferase alpha 3 like 1  RGD1562107  similar to class-alpha glutathione S-transferase  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1562107  similar to class-alpha glutathione S-transferase   RGD1562107_predicted  similar to class-alpha glutathione S-transferase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562107_predicted  similar to class-alpha glutathione S-transferase (predicted)  LOC363205  similar to class-alpha glutathione S-transferase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363205  similar to class-alpha glutathione S-transferase      Symbol and Name status set to provisional 70820 PROVISIONAL