Tomm40l (translocase of outer mitochondrial membrane 40 like) - Rat Genome Database

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Gene: Tomm40l (translocase of outer mitochondrial membrane 40 like) Rattus norvegicus
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Symbol: Tomm40l
Name: translocase of outer mitochondrial membrane 40 like
RGD ID: 1562006
Description: Enables mitochondrion targeting sequence binding activity and preprotein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM40L (translocase of outer mitochondrial membrane 40 like); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304971; mitochondrial import receptor subunit TOM40B; protein TOMM40-like; RGD1562006; similar to hypothetical protein FLJ12770; Tomm40b; translocase of outer mitochondrial membrane 40 homolog (yeast)-like; translocase of outer mitochondrial membrane 40 homolog B; translocase of outer mitochondrial membrane 40 homolog B (yeast); translocase of outer mitochondrial membrane 40 homolog-like; translocase of outer mitochondrial membrane 40-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,169,160 - 86,174,121 (-)NCBIGRCr8
mRatBN7.21383,636,692 - 83,641,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,638,195 - 83,641,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,144,383 - 86,147,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,542,623 - 87,545,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,774,295 - 84,776,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,590,076 - 89,595,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,591,718 - 89,594,738 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,216,941 - 94,221,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,109,486 - 87,112,175 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,269,727 - 83,272,416 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Kinoshita JY, etal., J Biochem. 2007 Jun;141(6):897-906. doi: 10.1093/jb/mvm097. Epub 2007 Apr 16.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:18614015   PMID:22871113   PMID:34800366  


Genomics

Comparative Map Data
Tomm40l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,169,160 - 86,174,121 (-)NCBIGRCr8
mRatBN7.21383,636,692 - 83,641,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,638,195 - 83,641,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,144,383 - 86,147,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,542,623 - 87,545,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,774,295 - 84,776,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,590,076 - 89,595,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,591,718 - 89,594,738 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,216,941 - 94,221,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,109,486 - 87,112,175 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,269,727 - 83,272,416 (-)NCBICelera
Cytogenetic Map13q24NCBI
TOMM40L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,226,060 - 161,230,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,225,939 - 161,230,746 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,195,850 - 161,200,536 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,462,457 - 159,467,032 (+)NCBINCBI36Build 36hg18NCBI36
Celera1134,262,975 - 134,267,550 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,552,761 - 132,557,336 (+)NCBIHuRef
CHM1_11162,592,067 - 162,596,639 (+)NCBICHM1_1
T2T-CHM13v2.01160,363,506 - 160,368,192 (+)NCBIT2T-CHM13v2.0
Tomm40l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,043,579 - 171,050,020 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,043,580 - 171,050,083 (-)EnsemblGRCm39 Ensembl
GRCm381171,217,802 - 171,222,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,216,011 - 171,222,514 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,147,934 - 173,152,645 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,054,478 - 173,059,189 (-)NCBIMGSCv36mm8
Celera1173,665,942 - 173,670,655 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.22NCBI
Tomm40l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,981,024 - 12,984,999 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,981,023 - 12,984,999 (+)NCBIChiLan1.0ChiLan1.0
TOMM40L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,621,399 - 88,626,590 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,311,581 - 88,316,792 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,637,976 - 136,643,054 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,550,223 - 140,555,025 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,550,223 - 140,555,025 (+)Ensemblpanpan1.1panPan2
TOMM40L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,257,022 - 21,261,881 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,257,006 - 21,261,356 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,332,171 - 21,336,715 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,375,127 - 21,379,669 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,348,203 - 21,379,465 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,272,236 - 21,276,775 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,677,477 - 21,682,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,086,588 - 22,091,125 (-)NCBIUU_Cfam_GSD_1.0
Tomm40l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,315,440 - 7,319,991 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903524,111 - 527,765 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903524,159 - 528,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM40L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,228,554 - 89,235,347 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,230,729 - 89,235,504 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,087,411 - 97,092,101 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM40L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,752,056 - 2,756,719 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,751,114 - 2,756,658 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,800,410 - 1,805,084 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm40l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794122,136 - 162,167 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794157,139 - 162,124 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tomm40l
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:90
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000004641
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004641   ⟹   ENSRNOP00000004641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,638,195 - 83,641,654 (-)Ensembl
Rnor_6.0 Ensembl1389,591,718 - 89,594,738 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111315   ⟹   ENSRNOP00000084822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,638,195 - 83,641,654 (-)Ensembl
RefSeq Acc Id: NM_001083338   ⟹   NP_001076807
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,169,160 - 86,174,121 (-)NCBI
mRatBN7.21383,636,692 - 83,641,654 (-)NCBI
Rnor_6.01389,591,917 - 89,594,606 (-)NCBI
Rnor_5.01394,216,941 - 94,221,998 (-)NCBI
RGSC_v3.41387,109,486 - 87,112,175 (-)RGD
Celera1383,269,727 - 83,272,416 (-)RGD
Sequence:
RefSeq Acc Id: NP_001076807   ⟸   NM_001083338
- UniProtKB: A4F267 (UniProtKB/Swiss-Prot),   A6JFV2 (UniProtKB/TrEMBL),   A0A8I6A2Q4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004641   ⟸   ENSRNOT00000004641
Ensembl Acc Id: ENSRNOP00000084822   ⟸   ENSRNOT00000111315

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A4F267-F1-model_v2 AlphaFold A4F267 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562006 AgrOrtholog
BioCyc Gene G2FUF-17384 BioCyc
Ensembl Genes ENSRNOG00000003398 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022054 UniProtKB/Swiss-Prot
  ENSRNOG00060025819 UniProtKB/Swiss-Prot
  ENSRNOG00065027260 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004641.4 UniProtKB/Swiss-Prot
  ENSRNOT00000111315.1 UniProtKB/TrEMBL
  ENSRNOT00055037891 UniProtKB/Swiss-Prot
  ENSRNOT00060044676 UniProtKB/Swiss-Prot
  ENSRNOT00065047023 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.160.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Porin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Porin_Euk/Tom40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tom40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304971 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 304971 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10802 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Porin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tomm40l PhenoGen
RatGTEx ENSRNOG00000003398 RatGTEx
  ENSRNOG00055022054 RatGTEx
  ENSRNOG00060025819 RatGTEx
  ENSRNOG00065027260 RatGTEx
UniProt A0A8I6A2Q4 ENTREZGENE, UniProtKB/TrEMBL
  A4F267 ENTREZGENE
  A6JFV2 ENTREZGENE, UniProtKB/TrEMBL
  TM40L_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Tomm40l  translocase of outer mitochondrial membrane 40 like  Tomm40l  translocase of outer mitochondrial membrane 40 homolog (yeast)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Tomm40l  translocase of outer mitochondrial membrane 40 homolog (yeast)-like  Tomm40b  translocase of outer mitochondrial membrane 40 homolog B (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-12-12 Tomm40b  translocase of outer mitochondrial membrane 40 homolog B (yeast)  RGD1562006_predicted  similar to hypothetical protein FLJ12770 (predicted)  Symbol and Name updated 1299863 APPROVED
2007-12-12 RGD1562006_predicted  similar to hypothetical protein FLJ12770 (predicted)  Tomm40b  translocase of outer mitochondrial membrane 40-like  Data merged from RGD:1600937 737654 APPROVED
2007-03-31 Tomm40b  translocase of outer mitochondrial membrane 40-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1562006_predicted  similar to hypothetical protein FLJ12770 (predicted)  LOC304971  similar to hypothetical protein FLJ12770  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304971  similar to hypothetical protein FLJ12770      Symbol and Name status set to provisional 70820 PROVISIONAL