Wasf1 (WASP family member 1) - Rat Genome Database

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Gene: Wasf1 (WASP family member 1) Rattus norvegicus
Analyze
Symbol: Wasf1
Name: WASP family member 1
RGD ID: 1561954
Description: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in dendritic transport of mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium and postsynapse. Orthologous to human WASF1 (WASP family member 1); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amitrole; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin-binding protein WASF1; MGC109303; protein WAVE-1; WAS protein family, member 1; WASP family 1; WASP family protein member 1; wiskott-Aldrich syndrome protein family member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,908,458 - 45,956,118 (+)NCBIGRCr8
mRatBN7.22044,325,815 - 44,372,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2044,325,795 - 44,372,996 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2046,110,330 - 46,157,484 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,769,485 - 45,816,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02046,492,179 - 46,541,494 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,456,191 - 48,503,768 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,455,705 - 48,503,898 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,107,711 - 50,155,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2045,130,786 - 45,177,385 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Identification and characterization of a G-protein regulatory motif in WAVE1. Song KS, etal., FEBS Lett. 2006 Apr 3;580(8):1993-8. Epub 2006 Mar 6.
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6. WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Sung JY, etal., Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3112-6. doi: 10.1073/pnas.0712180105. Epub 2008 Feb 14.
Additional References at PubMed
PMID:10970852   PMID:12931191   PMID:15148305   PMID:16190876   PMID:16723544   PMID:16862120   PMID:17664349   PMID:19460862   PMID:21107423   PMID:22871113   PMID:25097019   PMID:27605705  
PMID:29961568   PMID:30053369  


Genomics

Comparative Map Data
Wasf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,908,458 - 45,956,118 (+)NCBIGRCr8
mRatBN7.22044,325,815 - 44,372,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2044,325,795 - 44,372,996 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2046,110,330 - 46,157,484 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,769,485 - 45,816,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02046,492,179 - 46,541,494 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,456,191 - 48,503,768 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,455,705 - 48,503,898 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,107,711 - 50,155,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2045,130,786 - 45,177,385 (+)NCBICelera
Cytogenetic Map20q12NCBI
WASF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386110,099,819 - 110,179,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6110,099,819 - 110,180,004 (-)EnsemblGRCh38hg38GRCh38
GRCh376110,421,022 - 110,500,873 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366110,527,715 - 110,607,900 (-)NCBINCBI36Build 36hg18NCBI36
Build 346110,527,714 - 110,606,609NCBI
Celera6111,167,684 - 111,247,873 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6107,987,658 - 108,067,845 (-)NCBIHuRef
CHM1_16110,684,246 - 110,764,410 (-)NCBICHM1_1
T2T-CHM13v2.06111,278,252 - 111,358,111 (-)NCBIT2T-CHM13v2.0
Wasf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,759,476 - 40,814,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1040,759,471 - 40,814,566 (+)EnsemblGRCm39 Ensembl
GRCm381040,883,480 - 40,938,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,883,475 - 40,938,570 (+)EnsemblGRCm38mm10GRCm38
MGSCv371040,603,340 - 40,658,375 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361040,571,988 - 40,626,982 (+)NCBIMGSCv36mm8
Celera1041,779,631 - 41,834,540 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1022.07NCBI
Wasf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,889,566 - 34,965,769 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,893,287 - 34,966,670 (-)NCBIChiLan1.0ChiLan1.0
WASF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25130,117,370 - 130,204,116 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16128,003,292 - 128,090,041 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06107,911,751 - 107,988,821 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16111,951,725 - 112,058,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6111,951,726 - 111,979,329 (-)Ensemblpanpan1.1panPan2
WASF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11266,833,776 - 66,897,500 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1266,833,995 - 66,897,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1266,653,278 - 66,717,426 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01267,717,606 - 67,781,968 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1267,717,613 - 67,781,602 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11267,069,337 - 67,133,320 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01266,915,644 - 66,979,778 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01267,187,405 - 67,251,555 (-)NCBIUU_Cfam_GSD_1.0
Wasf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946101,761,273 - 101,821,206 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365646,036,135 - 6,096,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1176,107,595 - 76,180,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,590,358 - 85,660,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WASF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11363,718,784 - 63,793,024 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1363,718,737 - 63,793,151 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604036,004,710 - 36,077,937 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wasf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249161,181,234 - 1,201,975 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249161,183,291 - 1,301,925 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wasf1
227 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000073091
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
1634  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22044,372,756 - 44,372,845 (-)MAPPERmRatBN7.2
Rnor_6.02048,456,345 - 48,456,433NCBIRnor6.0
Rnor_5.02050,107,865 - 50,107,953UniSTSRnor5.0
Celera2045,177,143 - 45,177,231UniSTS
RH134288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22044,372,644 - 44,372,854 (-)MAPPERmRatBN7.2
Rnor_6.02048,456,336 - 48,456,545NCBIRnor6.0
Rnor_5.02050,107,856 - 50,108,065UniSTSRnor5.0
Celera2045,177,031 - 45,177,240UniSTS
RH 3.4 Map20479.9UniSTS
RH144530  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22044,367,716 - 44,368,014 (-)MAPPERmRatBN7.2
Rnor_6.02048,461,175 - 48,461,472NCBIRnor6.0
Rnor_5.02050,112,695 - 50,112,992UniSTSRnor5.0
Celera2045,172,104 - 45,172,401UniSTS
RH 3.4 Map20478.4UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 45 113 91 89 59 25 59 6 213 93 93 45 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000073091   ⟹   ENSRNOP00000064342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2044,325,795 - 44,372,996 (+)Ensembl
Rnor_6.0 Ensembl2048,455,705 - 48,503,898 (-)Ensembl
RefSeq Acc Id: NM_001025114   ⟹   NP_001020285
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,908,458 - 45,955,641 (+)NCBI
mRatBN7.22044,325,815 - 44,372,999 (+)NCBI
Rnor_6.02048,456,191 - 48,503,768 (-)NCBI
Rnor_5.02050,107,711 - 50,155,913 (-)NCBI
Celera2045,130,786 - 45,177,385 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256586   ⟹   XP_006256648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,908,827 - 45,956,118 (+)NCBI
mRatBN7.22044,326,101 - 44,372,999 (+)NCBI
Rnor_6.02048,456,191 - 48,503,417 (-)NCBI
Rnor_5.02050,107,711 - 50,155,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256587   ⟹   XP_006256649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,908,827 - 45,956,118 (+)NCBI
mRatBN7.22044,326,100 - 44,372,999 (+)NCBI
Rnor_6.02048,456,191 - 48,503,417 (-)NCBI
Rnor_5.02050,107,711 - 50,155,913 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001020285   ⟸   NM_001025114
- UniProtKB: Q5BJU7 (UniProtKB/Swiss-Prot),   A6KTC6 (UniProtKB/TrEMBL),   A0A8L2QX68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256649   ⟸   XM_006256587
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QX68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256648   ⟸   XM_006256586
- Peptide Label: isoform X1
- UniProtKB: Q5BJU7 (UniProtKB/Swiss-Prot),   A6KTC6 (UniProtKB/TrEMBL),   A0A8L2QX68 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064342   ⟸   ENSRNOT00000073091
Protein Domains
WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJU7-F1-model_v2 AlphaFold Q5BJU7 1-559 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561954 AgrOrtholog
BioCyc Gene G2FUF-3411 BioCyc
Ensembl Genes ENSRNOG00000047476 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055000677 UniProtKB/Swiss-Prot
  ENSRNOG00060007026 UniProtKB/Swiss-Prot
  ENSRNOG00065008820 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073091.3 UniProtKB/TrEMBL
  ENSRNOT00055001154 UniProtKB/Swiss-Prot
  ENSRNOT00060011552 UniProtKB/Swiss-Prot
  ENSRNOT00065014075 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.280.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7313558 IMAGE-MGC_LOAD
InterPro SCAR/WAVE_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294568 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109303 IMAGE-MGC_LOAD
NCBI Gene 294568 ENTREZGENE
PANTHER PTHR12902 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wasf1 PhenoGen
PROSITE WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047476 RatGTEx
  ENSRNOG00055000677 RatGTEx
  ENSRNOG00060007026 RatGTEx
  ENSRNOG00065008820 RatGTEx
SMART WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QX68 ENTREZGENE, UniProtKB/TrEMBL
  A6KTC6 ENTREZGENE, UniProtKB/TrEMBL
  Q5BJU7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Wasf1  WASP family member 1  Wasf1  WAS protein family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Wasf1  WAS protein family, member 1  Wasf1  WASP family 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Wasf1  WASP family 1  Wasf1  WAS protein family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Wasf1  WAS protein family, member 1      Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Wasf1  WAS protein family, member 1      Symbol and Name status set to provisional 70820 PROVISIONAL