Ptges3 (prostaglandin E synthase 3) - Rat Genome Database

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Gene: Ptges3 (prostaglandin E synthase 3) Rattus norvegicus
Analyze
Symbol: Ptges3
Name: prostaglandin E synthase 3
RGD ID: 1561913
Description: Enables several functions, including Hsp90 protein binding activity; p53 binding activity; and prostaglandin-E synthase activity. Involved in neuron apoptotic process; positive regulation of gene expression; and prostaglandin biosynthetic process. Located in actin filament; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human PTGES3 (prostaglandin E synthase 3); PARTICIPATES IN aldosterone signaling pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cPGES; cytosolic prostaglandin E2 synthase; hsp90 co-chaperone; LOC362809; MGC188278; progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); prostaglandin-E synthase 3; RGD1561913; similar to Sid3177p; telomerase-binding protein p23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,075,230 - 1,092,363 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,075,227 - 1,092,695 (+)EnsemblGRCr8
mRatBN7.27490,698 - 507,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7490,656 - 508,084 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,248,927 - 3,266,205 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,124,939 - 5,142,219 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,426,505 - 5,443,663 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,479,267 - 2,497,024 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,479,311 - 2,497,013 (+)Ensemblrn6Rnor6.0
Rnor_5.072,459,082 - 2,476,400 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,351,206 - 1,368,857 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7370,050 - 386,953 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
albendazole  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
chelerythrine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
disulfiram  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel subsulfide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (EXP)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
trichloroethene  (ISO)
uranium atom  (ISO)
valdecoxib  (EXP)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. Chinta SJ, etal., J Mol Neurosci. 2009 Sep;39(1-2):157-68. Epub 2009 Jan 15.
2. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. Claveau D, etal., J Immunol. 2003 May 1;170(9):4738-44.
3. Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton. Czar MJ, etal., Eur J Cell Biol. 1996 Aug;70(4):322-30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
6. Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats. Hofacker A, etal., J Neurosci. 2005 Sep 28;25(39):9005-9.
7. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
8. Cytosolic prostaglandin E2 synthase/p23 but not apoptosis-linked gene 2 is downregulated in human atherosclerotic plaques. Martinet W, etal., Cardiovasc Res. 2004 Feb 1;61(2):360-1.
9. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. Mattila S, etal., Neuropathology. 2009 Apr;29(2):156-65.
10. Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH. Nakatani Y, etal., Prostaglandins Other Lipid Mediat. 2011 Apr;94(3-4):112-7. Epub 2011 Feb 17.
11. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
12. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. Quinta HR, etal., J Neurochem. 2010 Nov;115(3):716-34. doi: 10.1111/j.1471-4159.2010.06970.x. Epub 2010 Sep 28.
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Simpson NE, etal., Cancer Res. 2010 Nov 1;70(21):8446-56. Epub 2010 Sep 16.
16. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
17. Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein. Tanioka T, etal., Biochem Biophys Res Commun. 2003 Apr 18;303(4):1018-23.
18. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. Tanioka T, etal., J Biol Chem. 2000 Oct 20;275(42):32775-82.
19. Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain. Vazquez-Tello A, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Nov;287(5):R1155-63. Epub 2004 Jul 29.
20. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Whitesell L, etal., Mol Cell Biol. 1998 Mar;18(3):1517-24.
21. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:10197982   PMID:10543959   PMID:10811660   PMID:12077419   PMID:12135483   PMID:12477932   PMID:12853476   PMID:17438133   PMID:19740745   PMID:19751963   PMID:21630459   PMID:22871113  
PMID:23376485   PMID:29093345   PMID:29127155  


Genomics

Comparative Map Data
Ptges3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,075,230 - 1,092,363 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,075,227 - 1,092,695 (+)EnsemblGRCr8
mRatBN7.27490,698 - 507,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7490,656 - 508,084 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,248,927 - 3,266,205 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,124,939 - 5,142,219 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,426,505 - 5,443,663 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,479,267 - 2,497,024 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,479,311 - 2,497,013 (+)Ensemblrn6Rnor6.0
Rnor_5.072,459,082 - 2,476,400 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,351,206 - 1,368,857 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7370,050 - 386,953 (+)NCBICelera
Cytogenetic Map7q11NCBI
PTGES3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,663,349 - 56,688,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,663,341 - 56,688,408 (-)Ensemblhg38GRCh38
GRCh371257,057,133 - 57,082,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,343,649 - 55,368,156 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1256,709,596 - 56,735,126 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,096,410 - 54,121,394 (-)NCBIHuRef
CHM1_11257,024,664 - 57,049,890 (-)NCBICHM1_1
T2T-CHM13v2.01256,631,338 - 56,658,334 (-)NCBIT2T-CHM13v2.0
Ptges3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,894,851 - 127,913,123 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,894,823 - 127,913,141 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810128,058,982 - 128,077,254 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,058,954 - 128,077,272 (+)Ensemblmm10GRCm38
MGSCv3710127,496,038 - 127,514,310 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610127,461,931 - 127,480,203 (+)NCBIMGSCv36mm8
Celera10130,453,617 - 130,471,989 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
Ptges3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,203,076 - 4,209,910 (-)Ensembl
ChiLan1.0NW_0049554584,203,075 - 4,209,967 (-)NCBIChiLan1.0ChiLan1.0
PTGES3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,634,948 - 37,663,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,634,392 - 37,660,421 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,221,908 - 32,247,228 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,475,989 - 32,503,181 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,476,835 - 32,503,181 (+)EnsemblpanPan2panpan1.1
PTGES3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110885,744 - 903,814 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10870,392 - 909,161 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha10948,938 - 967,016 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.010895,074 - 912,966 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10879,724 - 919,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110871,924 - 889,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,115,085 - 1,132,100 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,238,847 - 1,256,742 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptges3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,879,818 - 57,900,555 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936646969,674 - 990,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGES3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,000,341 - 22,021,660 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1522,000,335 - 22,022,830 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,674,707 - 23,696,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGES3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,609,460 - 52,634,490 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,344,739 - 193,370,949 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptges3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,360,041 - 11,395,390 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480211,360,056 - 11,392,911 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptges3
106 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:82
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000003787
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH127823  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27507,474 - 507,667 (+)MAPPERmRatBN7.2
Rnor_6.072,496,729 - 2,496,921NCBIRnor6.0
Rnor_5.072,476,116 - 2,476,308UniSTSRnor5.0
RGSC_v3.471,368,573 - 1,368,765UniSTSRGSC3.4
Celera7386,669 - 386,861UniSTS
Cytogenetic MapXq22UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:234880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23138,422,800 - 138,423,071 (-)MAPPERmRatBN7.2
mRatBN7.23138,422,800 - 138,423,071 (+)MAPPERmRatBN7.2
mRatBN7.23139,113,719 - 139,113,990 (-)MAPPERmRatBN7.2
mRatBN7.23139,113,719 - 139,113,990 (+)MAPPERmRatBN7.2
Rnor_6.03145,442,092 - 145,442,362NCBIRnor6.0
Rnor_6.03145,989,568 - 145,989,838NCBIRnor6.0
Rnor_5.03152,350,261 - 152,350,531UniSTSRnor5.0
Rnor_5.03151,809,970 - 151,810,240UniSTSRnor5.0
RGSC_v3.43140,062,377 - 140,062,647UniSTSRGSC3.4
Celera3137,871,890 - 137,872,160UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003787   ⟹   ENSRNOP00000003787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,075,227 - 1,092,357 (+)Ensembl
mRatBN7.2 Ensembl7490,656 - 507,752 (+)Ensembl
Rnor_6.0 Ensembl72,479,311 - 2,497,013 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094676   ⟹   ENSRNOP00000082352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,075,267 - 1,092,356 (+)Ensembl
mRatBN7.2 Ensembl7490,703 - 507,571 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097034   ⟹   ENSRNOP00000080703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7499,952 - 507,571 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097314   ⟹   ENSRNOP00000085230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7499,595 - 508,084 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097618   ⟹   ENSRNOP00000096830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7499,609 - 508,084 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101866   ⟹   ENSRNOP00000096607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,075,715 - 1,092,367 (+)Ensembl
mRatBN7.2 Ensembl7491,055 - 508,084 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104676   ⟹   ENSRNOP00000096677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,075,264 - 1,092,695 (+)Ensembl
mRatBN7.2 Ensembl7490,679 - 508,084 (+)Ensembl
RefSeq Acc Id: NM_001130989   ⟹   NP_001124461
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,075,309 - 1,092,363 (+)NCBI
mRatBN7.27490,698 - 507,759 (+)NCBI
Rnor_6.072,479,311 - 2,497,013 (+)NCBI
Rnor_5.072,459,082 - 2,476,400 (+)NCBI
RGSC_v3.471,351,206 - 1,368,857 (+)RGD
Celera7370,050 - 386,953 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263697   ⟹   XP_063119767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,075,261 - 1,092,357 (+)NCBI
RefSeq Acc Id: XM_063263698   ⟹   XP_063119768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,075,230 - 1,092,357 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001124461 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119767 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119768 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66579 (Get FASTA)   NCBI Sequence Viewer  
  EDL84891 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082352
  ENSRNOP00000096677
GenBank Protein P83868 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001124461   ⟸   NM_001130989
- UniProtKB: P83868 (UniProtKB/Swiss-Prot),   B2GV92 (UniProtKB/TrEMBL),   R9PXR7 (UniProtKB/TrEMBL),   A0A8I6AQE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003787   ⟸   ENSRNOT00000003787
Ensembl Acc Id: ENSRNOP00000082352   ⟸   ENSRNOT00000094676
Ensembl Acc Id: ENSRNOP00000096677   ⟸   ENSRNOT00000104676
Ensembl Acc Id: ENSRNOP00000085230   ⟸   ENSRNOT00000097314
Ensembl Acc Id: ENSRNOP00000096607   ⟸   ENSRNOT00000101866
Ensembl Acc Id: ENSRNOP00000096830   ⟸   ENSRNOT00000097618
Ensembl Acc Id: ENSRNOP00000080703   ⟸   ENSRNOT00000097034
RefSeq Acc Id: XP_063119768   ⟸   XM_063263698
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZTE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119767   ⟸   XM_063263697
- Peptide Label: isoform X1
Protein Domains
CS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83868-F1-model_v2 AlphaFold P83868 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694921
Promoter ID:EPDNEW_R5446
Type:initiation region
Name:Ptges3_1
Description:prostaglandin E synthase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,479,326 - 2,479,386EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561913 AgrOrtholog
BioCyc Gene G2FUF-35400 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000002642 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000094676 ENTREZGENE
  ENSRNOT00000104676 ENTREZGENE
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot
InterPro CS_dom UniProtKB/Swiss-Prot
  HSP20-like_chaperone UniProtKB/Swiss-Prot
  p23-like UniProtKB/Swiss-Prot
KEGG Report rno:362809 UniProtKB/Swiss-Prot
NCBI Gene 362809 ENTREZGENE
PANTHER PROSTAGLANDIN E SYNTHASE 3 UniProtKB/Swiss-Prot
  PTHR22932 UniProtKB/Swiss-Prot
Pfam PF04969 UniProtKB/Swiss-Prot
PhenoGen Ptges3 PhenoGen
PROSITE PS51203 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002642 RatGTEx
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot
UniProt A0A8I5ZQW8_RAT UniProtKB/TrEMBL
  A0A8I5ZTE4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZQ2_RAT UniProtKB/TrEMBL
  A0A8I6AQE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQZ3_RAT UniProtKB/TrEMBL
  A0A8I6ATR8_RAT UniProtKB/TrEMBL
  A0A8L2Q1B4_RAT UniProtKB/TrEMBL
  B2GV92 ENTREZGENE, UniProtKB/TrEMBL
  P83868 ENTREZGENE
  R9PXR7 ENTREZGENE
  TEBP_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Ptges3  prostaglandin E synthase 3  Ptges3  prostaglandin E synthase 3 (cytosolic)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ptges3  prostaglandin E synthase 3 (cytosolic)   Ptges3_predicted  prostaglandin E synthase 3 (cytosolic) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ptges3_predicted  prostaglandin E synthase 3 (cytosolic) (predicted)  RGD1561913_predicted  similar to Sid3177p (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1561913_predicted  similar to Sid3177p (predicted)  LOC362809  similar to Sid3177p  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362809  similar to Sid3177p      Symbol and Name status set to provisional 70820 PROVISIONAL