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Gene: Myo15a (myosin XVA) Rattus norvegicus

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Symbol:

Myo15a

Name:

myosin XVA

RGD ID:

1561873

Description:

Predicted to enable actin filament binding activity and microfilament motor activity. Involved in response to light stimulus. Predicted to be located in stereocilium. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; actin-based cell projection; and cytoplasm. Used to study blindness. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH bisphenol A; methoxychlor; perfluorooctanoic acid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102549801; LOC501699; Myo15; myosin XV; myosin-XV; RGD1561873; similar to myosin XV; unconventional myosin-XV; unconventional myosin-XV-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MYO15A (myosin XVA)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Myo15a (myosin XVA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Myo15a (myosin XVA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100971960 (unconventional myosin-XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MYO15A (myosin XVA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Myo15a (myosin XVA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MYO15A (myosin XVA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MYO15A (myosin XVA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Myo15a (myosin XVA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	OR1F1 (olfactory receptor family 1 subfamily F member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MYO15A (myosin XVA)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Myo15a (myosin XVA)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	myo15ab (myosin XVAb)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	myo15aa (myosin XVAa)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	myo15aa (myosin XVAa)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hum-4	Alliance	DIOPT (OMA\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	hum-4	Alliance	DIOPT (OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Myo10A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Allele / Splice:

Myo15a^ci2

Genetic Models:

LEW-Myo15a^ci2/Ztm

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	45,776,907 - 45,835,473 (+)	NCBI		GRCr8
GRCr8 Ensembl	10	45,776,907 - 45,835,473 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	10	45,277,619 - 45,335,953 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,278,737 - 45,335,340 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	46,840,098 - 46,897,362 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,840,113 - 46,896,054 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	46,595,676 - 46,660,835 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,742,535 - 46,798,928 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	44,535,548 - 44,591,592 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alport syndrome (ISO)

autistic disorder (ISO)

autosomal recessive nonsyndromic deafness (ISO)

autosomal recessive nonsyndromic deafness 3 (ISO,ISS)

autosomal recessive nonsyndromic deafness 9 (ISO)

Birt-Hogg-Dube syndrome (ISO)

blindness (IAGP)

common variable immunodeficiency 2 (ISO)

Deafness, with Smith-Magenis Syndrome (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

Joubert syndrome 1 (ISO)

nonsyndromic deafness (ISO)

Potocki-Lupski syndrome (ISO)

sensorineural hearing loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

Dibutyl phosphate (ISO)

ethylparaben (ISO)

formaldehyde (ISO)

genistein (ISO)

Licochalcone B (ISO)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

ozone (ISO)

perfluorooctanoic acid (EXP)

potassium dichromate (ISO)

sotorasib (ISO)

titanium dioxide (ISO)

trametinib (ISO)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (IBA)

endocytosis (IBA)

inner ear morphogenesis (IEA,ISO)

locomotory behavior (IEA,ISO)

response to light stimulus (IDA)

sensory perception of sound (IEA,ISO)

Cellular Component

actin cytoskeleton (IBA)

actin-based cell projection (IBA)

cell projection (IEA)

cytoplasm (IBA,IEA)

cytoskeleton (IEA)

membrane (IBA)

myosin complex (IEA)

stereocilium (IEA,ISO)

stereocilium bundle (IEA,ISO)

Molecular Function

actin binding (IEA)

actin filament binding (IBA)

ATP binding (IEA)

cytoskeletal motor activity (IEA)

microfilament motor activity (IBA)

nucleotide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal a-wave implicit time (IAGP)

abnormal b-wave implicit time (IAGP)

abnormal vision (IAGP)

retina outer nuclear layer degeneration (IAGP)

retina photoreceptor degeneration (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Mechanotransduction by hair cells: models, molecules, and mechanisms.	Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
3.	A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats.	Held N, etal., PLoS One. 2011 Mar 29;6(3):e15669. doi: 10.1371/journal.pone.0015669.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3.	Wang A, etal., Science. 1998 May 29;280(5368):1447-51.

Additional References at PubMed

PMID:11718241	PMID:14629112	PMID:14724386	PMID:16962269	PMID:19056867	PMID:20016102

Genomics

Comparative Map Data

Myo15a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	45,776,907 - 45,835,473 (+)	NCBI		GRCr8
GRCr8 Ensembl	10	45,776,907 - 45,835,473 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	10	45,277,619 - 45,335,953 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,278,737 - 45,335,340 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	46,840,098 - 46,897,362 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,840,113 - 46,896,054 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	46,595,676 - 46,660,835 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,742,535 - 46,798,928 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	44,535,548 - 44,591,592 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

MYO15A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	18,108,756 - 18,179,800 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	18,108,756 - 18,179,802 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	18,012,070 - 18,083,114 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	17,952,745 - 18,023,841 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	17,952,744 - 18,023,840	NCBI
Celera	17	18,953,160 - 19,024,251 (+)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	17,765,392 - 17,836,464 (+)	NCBI		HuRef
CHM1_1	17	18,020,789 - 18,091,861 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	18,055,569 - 18,126,619 (+)	NCBI		T2T-CHM13v2.0

Myo15a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	60,360,165 - 60,419,195 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	60,360,165 - 60,419,195 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	60,469,339 - 60,528,369 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	60,469,339 - 60,528,369 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	60,282,841 - 60,341,871 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	61,007,838 - 61,067,005 (+)	NCBI		MGSCv36	mm8
MGSCv36	11	60,285,534 - 60,344,564 (+)	NCBI		MGSCv36	mm8
Celera	11	64,710,231 - 64,711,213 (-)	NCBI		Celera
Cytogenetic Map	11	B2	NCBI
cM Map	11	37.81	NCBI

Myo15a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	11,132,719 - 11,186,378 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955478	11,131,908 - 11,186,465 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100971960
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	53,085,248 - 53,159,407 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	57,796,388 - 57,870,842 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	32,661,499 - 32,723,320 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	38,033,646 - 38,091,376 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

MYO15A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	41,369,484 - 41,421,303 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	41,370,509 - 41,392,881 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	41,507,455 - 41,559,211 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	41,474,709 - 41,526,462 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	41,442,539 - 41,494,282 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	41,389,966 - 41,441,709 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	41,581,821 - 41,633,567 (-)	NCBI		UU_Cfam_GSD_1.0

Myo15a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	61,142,863 - 61,197,568 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936741	1,669,680 - 1,723,891 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936741	1,669,680 - 1,724,929 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYO15A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	60,533,502 - 60,582,645 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MYO15A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	17,157,275 - 17,217,609 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	17,157,490 - 17,218,009 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	3,687,568 - 3,750,880 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Myo15a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	3,284,085 - 3,344,759 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624849	3,283,180 - 3,345,456 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Myo15a
384 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35893451	64140567	Rat
152025229	Scl83	Serum cholesterol level QTL 83	4.33		blood cholesterol amount (VT:0000180)		10	36211556	69161158	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31796281	76796281	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	35509383	91417879	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41831278	86831278	Rat
11528631	Bss117	Bone structure and strength QTL 117	6.41	4e-07	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	10	45446681	45933445	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44939359	89939359	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45529164	96099749	Rat
11528628	Bss116	Bone structure and strength QTL 116	6.46	4e-07	femur morphology trait (VT:0000559)	femur length (CMO:0000442)	10	44679312	46132467	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35893263	64653589	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42823274	87823274	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44939359	89939359	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42823274	87823274	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2298480	Eau7	Experimental allergic uveoretinitis QTL 7		0.0049	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	35509383	80509383	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35893263	52293000	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	43608793	88608793	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	29377046	52699134	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31129113	76129113	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44939359	89939359	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
12880050	Am10	Aortic mass QTL 10		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	39503487	84503487	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	35509383	88177745	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Genetic Models

This gene Myo15a is modified in the following models/strains:

LEW-Myo15a^ci2/Ztm

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	9	46	110	52	54	25	23	25	6	162	88	11	93	33	59	29	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001077498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000079133 ⟹ ENSRNOP00000068681

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	45,776,907 - 45,835,473 (+)	Ensembl
mRatBN7.2 Ensembl	10	45,278,737 - 45,335,340 (+)	Ensembl
Rnor_6.0 Ensembl	10	46,840,113 - 46,896,054 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086083 ⟹ ENSRNOP00000071821

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	45,776,907 - 45,835,473 (+)	Ensembl
mRatBN7.2 Ensembl	10	45,278,737 - 45,335,340 (+)	Ensembl
Rnor_6.0 Ensembl	10	46,840,113 - 46,896,054 (+)	Ensembl

RefSeq Acc Id:

NM_001427826 ⟹ NP_001414755

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	45,776,907 - 45,835,473 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414755	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM04652	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068681.2
	ENSRNOP00000071821
	ENSRNOP00000071821.2

Ensembl Acc Id:

ENSRNOP00000068681 ⟸ ENSRNOT00000079133

Ensembl Acc Id:

ENSRNOP00000071821 ⟸ ENSRNOT00000086083

RefSeq Acc Id:	NP_001414755 ⟸ NM_001427826
- UniProtKB:	A0A0G2K1F7 (UniProtKB/TrEMBL), A6HF47 (UniProtKB/TrEMBL)

Protein Domains

FERM Myosin motor MyTH4 SH3

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561873	AgrOrtholog
BioCyc Gene	G2FUF-24855	BioCyc
Ensembl Genes	ENSRNOG00000059219	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000079133.2	UniProtKB/TrEMBL
	ENSRNOT00000086083	ENTREZGENE
	ENSRNOT00000086083.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.820	UniProtKB/TrEMBL
	1.20.5.190	UniProtKB/TrEMBL
	1.20.58.530	UniProtKB/TrEMBL
	1.25.40.530	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	3.40.850.10	UniProtKB/TrEMBL
	6.20.240.20	UniProtKB/TrEMBL
	Myosin VI head, motor domain, U50 subdomain	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	FERM_2	UniProtKB/TrEMBL
	FERM_central	UniProtKB/TrEMBL
	FERM_domain	UniProtKB/TrEMBL
	IQ_motif_EF-hand-BS	UniProtKB/TrEMBL
	Kinesin_motor_dom_sf	UniProtKB/TrEMBL
	Myosin_head_motor_dom	UniProtKB/TrEMBL
	MyoXV_FERM_C	UniProtKB/TrEMBL
	MYSc_Myo15	UniProtKB/TrEMBL
	MyTH4_dom	UniProtKB/TrEMBL
	MyTH4_dom_sf	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	PH/PTB_dom	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Unconventional_Myosin_ATPase	UniProtKB/TrEMBL
NCBI Gene	501699	ENTREZGENE
PANTHER	MYOSIN VII, XV	UniProtKB/TrEMBL
	PTHR22692:SF21	UniProtKB/TrEMBL
Pfam	FERM_M	UniProtKB/TrEMBL
	Myosin_head	UniProtKB/TrEMBL
	MyTH4	UniProtKB/TrEMBL
	PF00612	UniProtKB/TrEMBL
	SH3_2	UniProtKB/TrEMBL
PhenoGen	Myo15a	PhenoGen
PRINTS	MYOSINHEAVY	UniProtKB/TrEMBL
PROSITE	FERM_3	UniProtKB/TrEMBL
	MYOSIN_MOTOR	UniProtKB/TrEMBL
	MYTH4	UniProtKB/TrEMBL
	PS50096	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000059219	RatGTEx
SMART	MYSc	UniProtKB/TrEMBL
	MyTH4	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00015	UniProtKB/TrEMBL
Superfamily-SCOP	FERM_3-hlx	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0G2JTE7_RAT	UniProtKB/TrEMBL
	A0A0G2K1F7	ENTREZGENE, UniProtKB/TrEMBL
	A6HF47	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Myo15a	myosin XVA	LOC102549801	unconventional myosin-XV-like	Data merged from RGD:7705247	737654	PROVISIONAL
2013-12-18	LOC102549801	unconventional myosin-XV-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-01-22	Myo15a	myosin XVA	Myo15	myosin XV	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-29	Myo15	myosin XV	RGD1561873_predicted	similar to myosin XV (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561873_predicted	similar to myosin XV (predicted)	LOC501699	similar to myosin XV	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501699	similar to myosin XV			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Mammalian Phenotype

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Imported Disease Annotations - OMIM

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