Gzmbl1 (Granzyme B-like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gzmbl1 (Granzyme B-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gzmbl1
Name: Granzyme B-like 1 (Ensembl:Granszyme B-like 1)
RGD ID: 1561819
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis; INTERACTS WITH 3,7-dihydropurine-6-thione; mercaptopurine; purine-6-thiol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Granszyme B-like 1; granzyme B-like; LOC502004; RGD1561819; similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,056,878 - 34,060,691 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1534,057,366 - 34,060,273 (-)EnsemblGRCr8
mRatBN7.21530,086,674 - 30,090,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,087,130 - 30,090,037 (-)EnsemblmRatBN7.2
Rnor_6.0X123,015,024 - 123,023,509 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,015,480 - 123,018,444 (-)Ensemblrn6Rnor6.0
Rnor_5.0X123,165,135 - 123,173,038 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,770,698 - 34,773,425 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,656,567 - 29,659,294 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Gzmbl1
99 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
13 1 2 6 11 14 6 43 6 71 48 1 4 4 6 8

Sequence


Ensembl Acc Id: ENSRNOT00000032601   ⟹   ENSRNOP00000029828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1534,057,366 - 34,060,273 (-)Ensembl
mRatBN7.2 Ensembl1530,087,130 - 30,090,037 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071692   ⟹   ENSRNOP00000064418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,015,480 - 123,018,444 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099316   ⟹   ENSRNOP00000097712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,087,876 - 30,090,037 (-)Ensembl
RefSeq Acc Id: XM_039094069   ⟹   XP_038949997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81534,056,878 - 34,060,691 (-)NCBI
mRatBN7.21530,086,674 - 30,090,455 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038949997 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029828
  ENSRNOP00000097712.1
Ensembl Acc Id: ENSRNOP00000064418   ⟸   ENSRNOT00000071692
RefSeq Acc Id: XP_038949997   ⟸   XM_039094069
- UniProtKB: F1M7H8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097712   ⟸   ENSRNOT00000099316
Ensembl Acc Id: ENSRNOP00000029828   ⟸   ENSRNOT00000032601
Protein Domains
Peptidase S1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561819 AgrOrtholog
BioCyc Gene G2FUF-13653 BioCyc
Ensembl Genes ENSRNOG00000045973 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050198 Ensembl
Ensembl Transcript ENSRNOT00000032601 ENTREZGENE
  ENSRNOT00000099316.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
NCBI Gene 502004 ENTREZGENE
PANTHER GRANZYME B UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Gzmbl1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045973 RatGTEx
  ENSRNOG00000050198 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0A8I6ARP0_RAT UniProtKB/TrEMBL
  F1M7H8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-02-24 Gzmbl1  Granzyme B-like 1  Gzmbl1  Granszyme B-like 1  Name changed 629549 APPROVED
2012-08-22 Gzmbl1  Granszyme B-like 1  RGD1561819  similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561819  similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B)   RGD1561819_predicted  similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561819_predicted  similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B) (predicted)  LOC502004  similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502004  similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B)      Symbol and Name status set to provisional 70820 PROVISIONAL