Timm17b (translocase of inner mitochondrial membrane 17b) - Rat Genome Database

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Gene: Timm17b (translocase of inner mitochondrial membrane 17b) Rattus norvegicus
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Symbol: Timm17b
Name: translocase of inner mitochondrial membrane 17b
RGD ID: 1561744
Description: Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human TIMM17B (translocase of inner mitochondrial membrane 17B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911130; LOC317374; mitochondrial import inner membrane translocase subunit Tim17-B; mitochondrial import inner membrane translocase subunit Tim17-B-like; RGD1561744; similar to mitochondrial inner membrane translocase component Tim17b; translocase of inner mitochondrial membrane 17 homolog B; translocase of inner mitochondrial membrane 17 homolog B (yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,268,257 - 17,275,424 (-)NCBIGRCr8
mRatBN7.2X14,596,330 - 14,603,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,594,577 - 14,603,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,409,868 - 19,416,951 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,666,160 - 20,673,243 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,931,330 - 16,938,413 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,441,369 - 15,448,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,340,839 - 15,347,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,441,651 - 15,448,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,222,604 - 16,229,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,630,879 - 26,637,962 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,681,087 - 14,688,170 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10339406   PMID:12865426   PMID:18614015   PMID:20053669   PMID:34800366  


Genomics

Comparative Map Data
Timm17b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,268,257 - 17,275,424 (-)NCBIGRCr8
mRatBN7.2X14,596,330 - 14,603,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,594,577 - 14,603,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,409,868 - 19,416,951 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,666,160 - 20,673,243 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,931,330 - 16,938,413 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,441,369 - 15,448,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,340,839 - 15,347,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,441,651 - 15,448,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,222,604 - 16,229,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,630,879 - 26,637,962 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,681,087 - 14,688,170 (-)NCBICelera
Cytogenetic MapXq12NCBI
TIMM17B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,893,447 - 48,898,143 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,893,447 - 48,898,143 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,750,730 - 48,755,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,635,676 - 48,640,370 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,506,979 - 48,511,674NCBI
CeleraX52,908,104 - 52,912,800 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,406,865 - 46,411,455 (-)NCBIHuRef
CHM1_1X48,781,872 - 48,786,568 (-)NCBICHM1_1
T2T-CHM13v2.0X48,303,928 - 48,308,624 (-)NCBIT2T-CHM13v2.0
Timm17b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,765,575 - 7,773,891 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,765,596 - 7,776,168 (+)EnsemblGRCm39 Ensembl
GRCm38X7,899,336 - 7,907,652 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,899,357 - 7,908,351 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,476,524 - 7,484,778 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,056,357 - 7,064,611 (+)NCBIMGSCv36mm8
CeleraX3,561,893 - 3,570,179 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.56NCBI
Timm17b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543425,076 - 430,767 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543425,076 - 430,767 (-)NCBIChiLan1.0ChiLan1.0
TIMM17B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,382,580 - 50,386,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,385,952 - 50,390,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,191,130 - 41,195,561 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,049,175 - 49,053,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,049,175 - 49,053,452 (-)Ensemblpanpan1.1panPan2
TIMM17B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,052,592 - 42,056,601 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,052,781 - 42,071,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,428,033 - 16,432,051 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,188,824 - 42,192,839 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,186,311 - 42,207,558 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,175,028 - 42,179,046 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,163,309 - 42,167,327 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,257,520 - 42,261,535 (-)NCBIUU_Cfam_GSD_1.0
Timm17b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,566,902 - 34,584,732 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721818,608 - 826,042 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721817,738 - 824,074 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMM17B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,970,108 - 42,975,955 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,970,586 - 42,976,287 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,837,475 - 47,842,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIMM17B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,010,164 - 46,014,616 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX46,010,446 - 46,014,510 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,495,126 - 11,499,551 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timm17b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893675,859 - 680,889 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893675,859 - 680,974 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Timm17b
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:165
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000037066, ENSRNOT00000066373
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat

Markers in Region
RH140085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,596,010 - 14,596,194 (+)MAPPERmRatBN7.2
Rnor_6.0X15,441,050 - 15,441,233NCBIRnor6.0
Rnor_6.0X15,340,238 - 15,340,421NCBIRnor6.0
Rnor_5.0X16,222,285 - 16,222,468UniSTSRnor5.0
Rnor_5.0X16,120,479 - 16,120,662UniSTSRnor5.0
RGSC_v3.4X26,630,560 - 26,630,743UniSTSRGSC3.4
CeleraX14,680,768 - 14,680,951UniSTS
RH 3.4 MapX125.1UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000037066   ⟹   ENSRNOP00000038100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,594,577 - 14,602,502 (-)Ensembl
Rnor_6.0 EnsemblX15,340,839 - 15,347,591 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066373   ⟹   ENSRNOP00000059538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,594,577 - 14,603,416 (-)Ensembl
Rnor_6.0 EnsemblX15,441,651 - 15,448,403 (-)Ensembl
RefSeq Acc Id: NM_001108249   ⟹   NP_001101719
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,268,257 - 17,275,340 (-)NCBI
mRatBN7.2X14,596,330 - 14,603,413 (-)NCBI
Rnor_6.0X15,441,369 - 15,448,452 (-)NCBI
Rnor_5.0X16,222,604 - 16,229,687 (-)NCBI
RGSC_v3.4X26,630,879 - 26,637,962 (-)RGD
CeleraX14,681,087 - 14,688,170 (-)RGD
Sequence:
RefSeq Acc Id: XM_063280051   ⟹   XP_063136121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,268,257 - 17,275,424 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101719 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136121 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83812 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038100.5
  ENSRNOP00000059538.3
RefSeq Acc Id: NP_001101719   ⟸   NM_001108249
- UniProtKB: A6KP64 (UniProtKB/TrEMBL),   A0A8J8XD91 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038100   ⟸   ENSRNOT00000037066
Ensembl Acc Id: ENSRNOP00000059538   ⟸   ENSRNOT00000066373
RefSeq Acc Id: XP_063136121   ⟸   XM_063280051
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACA5-F1-model_v2 AlphaFold D4ACA5 1-172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701739
Promoter ID:EPDNEW_R12262
Type:initiation region
Name:Timm17b_1
Description:translocase of inner mitochondrial membrane 17b
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,448,438 - 15,448,498EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561744 AgrOrtholog
BioCyc Gene G2FUF-2929 BioCyc
Ensembl Genes ENSRNOG00000025156 Ensembl
  ENSRNOG00000048613 Ensembl
  ENSRNOG00000063664 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037066.7 UniProtKB/TrEMBL
  ENSRNOT00000066373.4 UniProtKB/TrEMBL
InterPro Tim17 UniProtKB/TrEMBL
KEGG Report rno:317374 UniProtKB/TrEMBL
NCBI Gene 317374 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17 UniProtKB/TrEMBL
  MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM17-B UniProtKB/TrEMBL
Pfam Tim17 UniProtKB/TrEMBL
PhenoGen Timm17b PhenoGen
RatGTEx ENSRNOG00000025156 RatGTEx
  ENSRNOG00000048613 RatGTEx
  ENSRNOG00000063664 RatGTEx
UniProt A0A8J8XD91 ENTREZGENE, UniProtKB/TrEMBL
  A6KP64 ENTREZGENE, UniProtKB/TrEMBL
  D4ACA5_RAT UniProtKB/TrEMBL
UniProt Secondary F1M3N4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Timm17b  translocase of inner mitochondrial membrane 17b  LOC100911130  mitochondrial import inner membrane translocase subunit Tim17-B-like  Data merged from RGD:6494590 737654 PROVISIONAL
2014-10-22 Timm17b  translocase of inner mitochondrial membrane 17b  Timm17b  translocase of inner mitochondrial membrane 17 homolog B (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911130  mitochondrial import inner membrane translocase subunit Tim17-B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-23 Timm17b  translocase of inner mitochondrial membrane 17 homolog B (yeast)  Timm17b  translocase of inner mitochondrial membrane 17b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Timm17b  translocase of inner mitochondrial membrane 17b  Timm17b_predicted  translocase of inner mitochondrial membrane 17 homolog B (yeast) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Timm17b_predicted  translocase of inner mitochondrial membrane 17 homolog B (yeast) (predicted)  RGD1561744_predicted  similar to mitochondrial inner membrane translocase component Tim17b (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1561744_predicted  similar to mitochondrial inner membrane translocase component Tim17b (predicted)  LOC317374  similar to mitochondrial inner membrane translocase component Tim17b  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317374  similar to mitochondrial inner membrane translocase component Tim17b      Symbol and Name status set to provisional 70820 PROVISIONAL