Ifitm2-ps2 (interferon induced transmembrane protein 2, pseudogene 2) - Rat Genome Database

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Gene: Ifitm2-ps2 (interferon induced transmembrane protein 2, pseudogene 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ifitm2-ps2
Name: interferon induced transmembrane protein 2, pseudogene 2
RGD ID: 1561738
Description: Predicted to be involved in several processes, including defense response to other organism; negative regulation of viral genome replication; and response to interferon-alpha. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM3 (interferon induced transmembrane protein 3); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: MODEL
Previously known as: AABR07021463.1; LOC501858; RGD1561738; similar to interferon induced transmembrane protein 2 (1-8D)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,737,384 - 70,738,072 (+)NCBIGRCr8
mRatBN7.21368,187,131 - 68,187,808 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,187,366 - 68,187,854 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01373,661,005 - 73,661,699 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,661,131 - 73,661,553 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01378,586,150 - 78,586,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41371,032,741 - 71,033,424 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1368,050,936 - 68,051,630 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ifitm2-ps2
4 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000068548   ⟹   ENSRNOP00000059884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,187,366 - 68,187,854 (+)Ensembl
RefSeq Acc Id: XR_008822
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1368,050,821 - 68,051,504 (+)RGD
RefSeq Acc Id: XR_086002
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_5.01378,585,921 - 78,586,604 (+)NCBI
RGSC_v3.41371,032,741 - 71,033,424 (+)RGD
Protein Sequences
Ensembl Protein ENSRNOP00000059884.3
Ensembl Acc Id: ENSRNOP00000059884   ⟸   ENSRNOT00000068548

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A096-F1-model_v2 AlphaFold D4A096 1-141 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561738 AgrOrtholog
BioCyc Gene G2FUF-17827 BioCyc
Ensembl Genes ENSRNOG00000042995 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068548.3 UniProtKB/TrEMBL
InterPro CD225/Dispanin_fam UniProtKB/TrEMBL
  IFITM_antiviral_protein UniProtKB/TrEMBL
NCBI Gene 501858 ENTREZGENE
PANTHER INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN UniProtKB/TrEMBL
  INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 2 UniProtKB/TrEMBL
Pfam CD225 UniProtKB/TrEMBL
PhenoGen Ifitm2-ps2 PhenoGen
RatGTEx ENSRNOG00000042995 RatGTEx
UniProt D4A096_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-10 Ifitm2-ps2  interferon induced transmembrane protein 2, pseudogene 2  RGD1561738  similar to interferon induced transmembrane protein 2 (1-8D)  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1561738  similar to interferon induced transmembrane protein 2 (1-8D)  AABR07021463.1    Data merged from RGD:15004630 737654 PROVISIONAL
2019-11-08 AABR07021463.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1561738  similar to interferon induced transmembrane protein 2 (1-8D)   RGD1561738_predicted  similar to interferon induced transmembrane protein 2 (1-8D) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561738_predicted  similar to interferon induced transmembrane protein 2 (1-8D) (predicted)  LOC501858  similar to interferon induced transmembrane protein 2 (1-8D)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501858  similar to interferon induced transmembrane protein 2 (1-8D)      Symbol and Name status set to provisional 70820 PROVISIONAL