Slc22a21 (solute carrier family 22 (organic cation transporter), member 21) - Rat Genome Database

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Gene: Slc22a21 (solute carrier family 22 (organic cation transporter), member 21) Rattus norvegicus
Analyze
Symbol: Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
RGD ID: 1561735
Description: Predicted to enable carnitine transmembrane transporter activity. Predicted to be involved in carnitine transmembrane transport and monoatomic ion transport. Predicted to act upstream of or within carnitine transport. Predicted to be located in peroxisomal membrane; INTERACTS WITH (R)-carnitine; bisphenol A; pirinixic acid.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cartregulin; LOC303140; Octn3; organic cation/carnitine transporter 2; solute carrier family 22 member 21; solute carrier family 22 member 5; up-regulator of carnitine transporter, OCTN2
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,605,665 - 38,633,376 (-)NCBIGRCr8
mRatBN7.21038,104,114 - 38,133,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,104,122 - 38,130,671 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01039,296,904 - 39,324,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01039,078,685 - 39,106,861 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,407,529 - 39,426,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1037,447,092 - 37,476,033 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15389639   PMID:16839516   PMID:19735737   PMID:23694905  


Genomics

Comparative Map Data
Slc22a21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,605,665 - 38,633,376 (-)NCBIGRCr8
mRatBN7.21038,104,114 - 38,133,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,104,122 - 38,130,671 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01039,296,904 - 39,324,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01039,078,685 - 39,106,861 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,407,529 - 39,426,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1037,447,092 - 37,476,033 (-)NCBICelera
Cytogenetic Map10q22NCBI
Slc22a21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,840,780 - 53,871,159 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,840,791 - 53,871,158 (-)EnsemblGRCm39 Ensembl
GRCm381153,949,954 - 53,980,333 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,949,965 - 53,980,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,764,326 - 53,793,529 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,794,247 - 53,823,450 (-)NCBIMGSCv36mm8
Celera1158,530,877 - 58,567,728 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.05NCBI

Variants

.
Variants in Slc22a21
150 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
D10Mco55  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41039,423,560 - 39,423,962RGDRGSC3.4
RGSC_v3.41039,423,561 - 39,423,963UniSTSRGSC3.4
RGSC_v3.11039,437,183 - 39,437,585RGD
Celera1037,461,987 - 37,462,389UniSTS
Cytogenetic Map10q22UniSTS
RH131079  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,009,158 - 38,009,353 (+)MAPPERmRatBN7.2
mRatBN7.21038,104,987 - 38,105,182 (+)MAPPERmRatBN7.2
Rnor_6.01039,297,778 - 39,297,972NCBIRnor6.0
Rnor_6.01039,201,955 - 39,202,149NCBIRnor6.0
Rnor_5.01039,079,559 - 39,079,753UniSTSRnor5.0
Rnor_5.01038,983,736 - 38,983,930UniSTSRnor5.0
RGSC_v3.41039,312,583 - 39,312,777UniSTSRGSC3.4
RGSC_v3.41039,408,406 - 39,408,600UniSTSRGSC3.4
Celera1037,447,966 - 37,448,160UniSTS
Celera1037,352,153 - 37,352,347UniSTS
RH 3.4 Map10406.1UniSTS
Cytogenetic Map10q22UniSTS
RH133914  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,128,889 - 38,129,081 (+)MAPPERmRatBN7.2
Rnor_6.01039,322,297 - 39,322,488NCBIRnor6.0
Rnor_5.01039,104,424 - 39,104,615UniSTSRnor5.0
Celera1037,471,867 - 37,472,058UniSTS
RH 3.4 Map10404.8UniSTS
Cytogenetic Map10q22UniSTS
AU047818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,021,835 - 38,022,054 (+)MAPPERmRatBN7.2
Rnor_6.01039,214,632 - 39,214,850NCBIRnor6.0
Rnor_5.01038,996,413 - 38,996,631UniSTSRnor5.0
RGSC_v3.41039,325,260 - 39,325,478UniSTSRGSC3.4
RGSC_v3.41039,421,587 - 39,421,789UniSTSRGSC3.4
Celera1037,459,707 - 37,459,909UniSTS
Cytogenetic Map10q22UniSTS
UniSTS:547023  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,130,097 - 38,130,384 (+)MAPPERmRatBN7.2
Rnor_6.01039,323,505 - 39,323,791NCBIRnor6.0
Rnor_5.01039,105,632 - 39,105,918UniSTSRnor5.0
Celera1037,473,075 - 37,473,361UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000041253   ⟹   ENSRNOP00000049867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,104,122 - 38,130,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081898   ⟹   ENSRNOP00000069462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,104,985 - 38,130,367 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102603   ⟹   ENSRNOP00000079086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,105,779 - 38,130,671 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116636   ⟹   ENSRNOP00000096599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,104,901 - 38,130,671 (-)Ensembl
RefSeq Acc Id: XM_008767743   ⟹   XP_008765965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,605,665 - 38,633,376 (-)NCBI
mRatBN7.21038,104,114 - 38,133,095 (-)NCBI
Rnor_6.01039,296,904 - 39,324,861 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087194   ⟹   XP_038943122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,605,665 - 38,633,376 (-)NCBI
mRatBN7.21038,104,114 - 38,130,125 (-)NCBI
RefSeq Acc Id: XM_039087195   ⟹   XP_038943123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,605,665 - 38,630,702 (-)NCBI
mRatBN7.21038,104,114 - 38,129,844 (-)NCBI
RefSeq Acc Id: XM_039087196   ⟹   XP_038943124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,607,933 - 38,633,376 (-)NCBI
mRatBN7.21038,107,169 - 38,133,104 (-)NCBI
RefSeq Acc Id: XM_039087197   ⟹   XP_038943125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,609,850 - 38,633,376 (-)NCBI
mRatBN7.21038,109,087 - 38,133,106 (-)NCBI
RefSeq Acc Id: XM_039087198   ⟹   XP_038943126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,607,892 - 38,633,376 (-)NCBI
mRatBN7.21038,107,130 - 38,133,106 (-)NCBI
RefSeq Acc Id: XP_008765965   ⟸   XM_008767743
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM55 (UniProtKB/TrEMBL),   A6HEF6 (UniProtKB/TrEMBL),   A6HEF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038943122   ⟸   XM_039087194
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943123   ⟸   XM_039087195
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038943126   ⟸   XM_039087198
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038943124   ⟸   XM_039087196
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943125   ⟸   XM_039087197
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000069462   ⟸   ENSRNOT00000081898
Ensembl Acc Id: ENSRNOP00000049867   ⟸   ENSRNOT00000041253
Ensembl Acc Id: ENSRNOP00000079086   ⟸   ENSRNOT00000102603
Ensembl Acc Id: ENSRNOP00000096599   ⟸   ENSRNOT00000116636
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-25123 BioCyc
Ensembl Genes ENSRNOG00000069239 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041253.5 UniProtKB/TrEMBL
  ENSRNOT00000081898.2 UniProtKB/TrEMBL
  ENSRNOT00000102603.1 UniProtKB/TrEMBL
  ENSRNOT00000116636.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
KEGG Report rno:303140 UniProtKB/TrEMBL
NCBI Gene 303140 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 5 UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/TrEMBL
PhenoGen Slc22a21 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000069239 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A0G2JVF2_RAT UniProtKB/TrEMBL
  A0A8I6G2T6_RAT UniProtKB/TrEMBL
  A0A8I6GM55 ENTREZGENE, UniProtKB/TrEMBL
  A6HEF6 ENTREZGENE, UniProtKB/TrEMBL
  A6HEF7 ENTREZGENE, UniProtKB/TrEMBL
  Q3I408_RAT UniProtKB/TrEMBL
UniProt Secondary F1LZE4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-27 Slc22a21  solute carrier family 22 (organic cation transporter), member 21  LOC303140  up-regulator of carnitine transporter, OCTN2  Name and Symbol changed 629549 APPROVED
2006-02-09 LOC303140  up-regulator of carnitine transporter, OCTN2      Symbol and Name status set to provisional 70820 PROVISIONAL