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Gene: Dock8 (dedicator of cytokinesis 8) Rattus norvegicus
Symbol: Dock8
Name: dedicator of cytokinesis 8
RGD ID: 1561588
Description: Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including immunological synapse formation; memory T cell proliferation; and positive regulation of establishment of T cell polarity. Predicted to localize to cytoplasm and leading edge membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 2 and hyper IgE recurrent infection syndrome 2. Orthologous to human DOCK8 (dedicator of cytokinesis 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dedicator of cytokinesis protein 8; LOC499337; MGC116414; similar to dedicator of cytokinesis 8
Homo sapiens (human) : DOCK8 (dedicator of cytokinesis 8)  HGNC  Alliance
Mus musculus (house mouse) : Dock8 (dedicator of cytokinesis 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock8 (dedicator of cytokinesis 8)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK8 (dedicator of cytokinesis 8)
Canis lupus familiaris (dog) : DOCK8 (dedicator of cytokinesis 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock8 (dedicator of cytokinesis 8)
Sus scrofa (pig) : DOCK8 (dedicator of cytokinesis 8)
Chlorocebus sabaeus (African green monkey) : DOCK8 (dedicator of cytokinesis 8)
Heterocephalus glaber (naked mole-rat) : Dock8 (dedicator of cytokinesis 8)
more info ...
Allele / Splice: Dock8m1Ztm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01242,934,685 - 243,153,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,959,488 - 243,153,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,200,507 - 250,417,771 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,441,384 - 228,634,717 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1219,852,410 - 220,042,463 (+)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Dock8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1561588
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.