Wasfl (WASP family member 1 like) - Rat Genome Database

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Gene: Wasfl (WASP family member 1 like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Wasfl
Name: WASP family member 1 like
RGD ID: 1561552
Description: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium; INTERACTS WITH trichloroethene.
Type: protein-coding
RefSeq Status: PREDICTED
Previously known as: hypothetical protein LOC302367; LOC302367; RGD1561552; similar to WASP family 1; uncharacterized protein LOC302367
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X77,113,760 - 77,116,492 (-)NCBIGRCr8
mRatBN7.2X73,040,984 - 73,043,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX73,040,902 - 73,043,716 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX74,530,999 - 74,533,731 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X78,051,043 - 78,053,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X75,617,954 - 75,620,686 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X79,064,200 - 79,066,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX79,064,204 - 79,066,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X79,250,643 - 79,253,375 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X96,194,109 - 96,196,841 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX74,321,556 - 74,324,288 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:31904090  


Genomics

Variants

.
Variants in Wasfl
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000057460
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
2 5 3 3 3 1 3 6 1 5 20

Sequence


Ensembl Acc Id: ENSRNOT00000057460   ⟹   ENSRNOP00000054268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX73,040,902 - 73,043,716 (-)Ensembl
Rnor_6.0 EnsemblX79,064,204 - 79,066,932 (-)Ensembl
RefSeq Acc Id: NM_001126271   ⟹   NP_001119743
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X77,113,760 - 77,116,492 (-)NCBI
mRatBN7.2X73,040,984 - 73,043,716 (-)NCBI
Rnor_6.0X79,064,200 - 79,066,932 (-)NCBI
Rnor_5.0X79,250,643 - 79,253,375 (-)NCBI
RGSC_v3.4X96,194,109 - 96,196,841 (-)RGD
CeleraX74,321,556 - 74,324,288 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001119743 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI62049 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054268.2
RefSeq Acc Id: NP_001119743   ⟸   NM_001126271
- UniProtKB: B1WC92 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054268   ⟸   ENSRNOT00000057460
Protein Domains
WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC92-F1-model_v2 AlphaFold B1WC92 1-634 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701908
Promoter ID:EPDNEW_R12432
Type:single initiation site
Name:RGD1561552_1
Description:similar to WASP family 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X79,066,914 - 79,066,974EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561552 AgrOrtholog
BioCyc Gene G2FUF-1885 BioCyc
Ensembl Genes ENSRNOG00000037827 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057460.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.340 UniProtKB/TrEMBL
  6.10.280.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111186 IMAGE-MGC_LOAD
InterPro WH2_actin_bd UniProtKB/TrEMBL
KEGG Report rno:302367 UniProtKB/TrEMBL
MGC_CLONE MGC:188026 IMAGE-MGC_LOAD
NCBI Gene 302367 ENTREZGENE
Pfam WH2 UniProtKB/TrEMBL
PhenoGen Wasfl PhenoGen
PROSITE WH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037827 RatGTEx
SMART WH2 UniProtKB/TrEMBL
UniProt B1WC92 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Wasfl  WASP family member 1 like  RGD1561552  similar to WASP family 1  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1561552  similar to WASP family 1   RGD1561552_predicted  similar to WASP family 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561552_predicted  similar to WASP family 1 (predicted)  LOC302367  similar to WASP family 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302367  similar to WASP family 1      Symbol and Name status set to provisional 70820 PROVISIONAL