Afg1l (AFG1 like ATPase) - Rat Genome Database

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Gene: Afg1l (AFG1 like ATPase) Rattus norvegicus
Analyze
Symbol: Afg1l
Name: AFG1 like ATPase
RGD ID: 1561501
Description: Predicted to enable ATP hydrolysis activity. Predicted to be involved in mitochondrial protein catabolic process and mitochondrial protein quality control. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Orthologous to human AFG1L (AFG1 like ATPase); INTERACTS WITH 17beta-estradiol; acetamide; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AFG1-like ATPase; Lace1; lactation elevated 1; lactation elevated protein 1; LOC502479; MGC124994; similar to lactation elevated 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82047,380,582 - 47,550,307 (-)NCBIGRCr8
mRatBN7.22045,798,344 - 45,967,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2045,798,349 - 45,967,906 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2047,515,806 - 47,685,351 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02047,165,974 - 47,335,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02047,861,988 - 48,028,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02047,038,824 - 47,208,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02048,714,679 - 48,877,546 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,296,402 - 46,302,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2054,003,540 - 54,168,475 (+)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
membrane  (IEA)
mitochondrial membrane  (IEA,ISO,ISS)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:18614015   PMID:26759378   PMID:27323408  


Genomics

Comparative Map Data
Afg1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82047,380,582 - 47,550,307 (-)NCBIGRCr8
mRatBN7.22045,798,344 - 45,967,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2045,798,349 - 45,967,906 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2047,515,806 - 47,685,351 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02047,165,974 - 47,335,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02047,861,988 - 48,028,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02047,038,824 - 47,208,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02048,714,679 - 48,877,546 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,296,402 - 46,302,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2054,003,540 - 54,168,475 (+)NCBICelera
Cytogenetic Map20q13NCBI
AFG1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386108,295,054 - 108,526,001 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6108,294,991 - 108,526,796 (+)EnsemblGRCh38hg38GRCh38
GRCh376108,616,258 - 108,847,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,722,791 - 108,950,951 (+)NCBINCBI36Build 36hg18NCBI36
Build 346108,722,790 - 108,950,958NCBI
Celera6109,362,234 - 109,590,401 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6106,183,791 - 106,411,846 (+)NCBIHuRef
CHM1_16108,879,055 - 109,107,208 (+)NCBICHM1_1
T2T-CHM13v2.06109,472,456 - 109,703,353 (+)NCBIT2T-CHM13v2.0
Afg1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391042,188,577 - 42,354,561 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1042,188,581 - 42,354,561 (-)EnsemblGRCm39 Ensembl
GRCm381042,312,581 - 42,478,565 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1042,312,585 - 42,478,565 (-)EnsemblGRCm38mm10GRCm38
MGSCv371042,032,391 - 42,198,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361042,001,000 - 42,166,829 (-)NCBIMGSCv36mm8
Celera1043,184,771 - 43,345,934 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.88NCBI
Afg1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541133,386,098 - 33,617,721 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541133,386,568 - 33,617,721 (+)NCBIChiLan1.0ChiLan1.0
AFG1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25128,302,910 - 128,540,479 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16126,189,125 - 126,428,316 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06106,097,263 - 106,326,453 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16109,956,704 - 110,370,685 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6109,956,916 - 110,367,328 (+)Ensemblpanpan1.1panPan2
AFG1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,312,922 - 65,516,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,313,140 - 65,515,992 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,128,524 - 65,331,934 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01266,188,670 - 66,394,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1266,188,865 - 66,394,683 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11265,543,778 - 65,745,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01265,390,373 - 65,593,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01265,663,309 - 65,865,515 (+)NCBIUU_Cfam_GSD_1.0
Afg1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946100,278,885 - 100,479,172 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365644,553,732 - 4,757,616 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365644,553,758 - 4,755,126 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFG1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl174,367,617 - 74,591,853 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1174,367,421 - 74,590,766 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,635,078 - 83,849,079 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFG1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11365,341,306 - 65,559,829 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1365,331,879 - 65,531,108 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604037,659,385 - 37,885,317 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afg1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478013,771,341 - 14,038,146 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478013,769,419 - 14,031,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Afg1l
1027 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
RH132205  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22045,798,399 - 45,798,579 (+)MAPPERmRatBN7.2
Rnor_6.02047,038,876 - 47,039,055NCBIRnor6.0
Rnor_5.02048,714,731 - 48,714,910UniSTSRnor5.0
Celera2054,168,244 - 54,168,423UniSTS
RH 3.4 Map20487.32UniSTS
Cytogenetic Map20q13UniSTS
REN50740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22045,865,730 - 45,865,970 (+)MAPPERmRatBN7.2
Rnor_6.02047,109,875 - 47,110,114NCBIRnor6.0
Rnor_5.02048,781,679 - 48,781,918UniSTSRnor5.0
Celera2054,102,822 - 54,103,061UniSTS
Cytogenetic Map20q13UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000076620   ⟹   ENSRNOP00000082827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2045,798,349 - 45,967,906 (-)Ensembl
RefSeq Acc Id: NM_001037656   ⟹   NP_001032745
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,380,582 - 47,550,126 (-)NCBI
mRatBN7.22045,798,348 - 45,967,906 (-)NCBI
Rnor_6.02047,038,824 - 47,208,812 (-)NCBI
Rnor_5.02048,714,679 - 48,877,546 (-)NCBI
RGSC_v3.42046,296,402 - 46,302,522 (-)RGD
Celera2054,003,540 - 54,168,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099033   ⟹   XP_038954961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,380,582 - 47,543,978 (-)NCBI
mRatBN7.22045,798,344 - 45,961,645 (-)NCBI
RefSeq Acc Id: XM_039099037   ⟹   XP_038954965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,437,086 - 47,550,307 (-)NCBI
mRatBN7.22045,864,104 - 45,967,997 (-)NCBI
RefSeq Acc Id: XM_039099038   ⟹   XP_038954966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,453,209 - 47,550,307 (-)NCBI
mRatBN7.22045,870,986 - 45,967,997 (-)NCBI
RefSeq Acc Id: XM_063279475   ⟹   XP_063135545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,453,477 - 47,550,307 (-)NCBI
RefSeq Acc Id: XM_063279476   ⟹   XP_063135546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,453,477 - 47,513,825 (-)NCBI
RefSeq Acc Id: XM_063279477   ⟹   XP_063135547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,453,477 - 47,527,990 (-)NCBI
RefSeq Acc Id: XM_063279478   ⟹   XP_063135548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,453,477 - 47,510,401 (-)NCBI
RefSeq Acc Id: XM_063279479   ⟹   XP_063135549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,453,477 - 47,490,401 (-)NCBI
RefSeq Acc Id: XM_063279481   ⟹   XP_063135551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,380,582 - 47,485,420 (-)NCBI
RefSeq Acc Id: XR_005497332
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,386,536 - 47,550,307 (-)NCBI
mRatBN7.22045,804,311 - 45,967,996 (-)NCBI
RefSeq Acc Id: XR_005497334
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,411,753 - 47,550,307 (-)NCBI
mRatBN7.22045,829,523 - 45,967,996 (-)NCBI
RefSeq Acc Id: XR_010060756
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,411,753 - 47,550,307 (-)NCBI
RefSeq Acc Id: NP_001032745   ⟸   NM_001037656
- UniProtKB: Q32PX9 (UniProtKB/Swiss-Prot),   A0A8I5ZXV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038954961   ⟸   XM_039099033
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZXV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954965   ⟸   XM_039099037
- Peptide Label: isoform X6
- UniProtKB: A6K6Z0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954966   ⟸   XM_039099038
- Peptide Label: isoform X7
- UniProtKB: A6K6Z0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082827   ⟸   ENSRNOT00000076620
RefSeq Acc Id: XP_063135551   ⟸   XM_063279481
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063135545   ⟸   XM_063279475
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135547   ⟸   XM_063279477
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063135546   ⟸   XM_063279476
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063135548   ⟸   XM_063279478
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063135549   ⟸   XM_063279479
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32PX9-F1-model_v2 AlphaFold Q32PX9 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561501 AgrOrtholog
BioCyc Gene G2FUF-3360 BioCyc
Ensembl Genes ENSRNOG00000043033 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000076620 ENTREZGENE
  ENSRNOT00000155260 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7320504 IMAGE-MGC_LOAD
InterPro ATPase_AFG1-like UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:502479 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124994 IMAGE-MGC_LOAD
NCBI Gene 502479 ENTREZGENE
PANTHER AFG1-LIKE ATPASE UniProtKB/Swiss-Prot
  PTHR12169 UniProtKB/Swiss-Prot
Pfam AFG1_ATPase UniProtKB/Swiss-Prot
PhenoGen Afg1l PhenoGen
RatGTEx ENSRNOG00000043033 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZXV9 ENTREZGENE, UniProtKB/TrEMBL
  A6K6Z0 ENTREZGENE, UniProtKB/TrEMBL
  AFG1L_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-27 Afg1l  AFG1 like ATPase  Lace1  lactation elevated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Lace1  lactation elevated 1  LOC502479  similar to lactation elevated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC502479  similar to lactation elevated 1      Symbol and Name status set to provisional 70820 PROVISIONAL