Il27 (interleukin 27) - Rat Genome Database

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Gene: Il27 (interleukin 27) Rattus norvegicus
Symbol: Il27
Name: interleukin 27
RGD ID: 1561420
Description: Predicted to enable interleukin-27 receptor binding activity. Involved in response to Gram-positive bacterium. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27); PARTICIPATES IN interleukin-27 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; benzo[a]pyrene; lipopolysaccharide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-27 subunit alpha; LOC365368; RGD1561420; similar to IL-27 p28 subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21181,173,108 - 181,178,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,173,372 - 181,178,582 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01198,003,615 - 198,010,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,003,683 - 198,008,893 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,981,789 - 204,987,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,730,394 - 185,735,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,831,320 - 178,837,817 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. IL-27 enhances Leishmania amazonensis infection via ds-RNA dependent kinase (PKR) and IL-10 signaling. Barreto-de-Souza V, etal., Immunobiology. 2015 Apr;220(4):437-44. doi: 10.1016/j.imbio.2014.11.006. Epub 2014 Nov 15.
2. Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. Cao J, etal., EMBO Mol Med. 2014 Jan;6(1):120-40. doi: 10.1002/emmm.201302890.
3. IL-27 controls sepsis-induced impairment of lung antibacterial host defence. Cao J, etal., Thorax. 2014 Oct;69(10):926-37. doi: 10.1136/thoraxjnl-2014-205777. Epub 2014 Jul 29.
4. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. Chae SC, etal., J Hum Genet. 2007;52(4):355-61. Epub 2007 Feb 22.
5. Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence. Clement M, etal., PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.
6. A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. Dibra D, etal., PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.
7. Association of Interleukin-27 rs 153109 Single Nucleotide Polymorphism with Spontaneous Resolution of Hepatitis C Virus - Genotype 4a Infection in Egyptian Patients. Fawzy MM, etal., Asian Pac J Cancer Prev. 2016;17(4):2093-7. doi: 10.7314/apjcp.2016.17.4.2093.
8. Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice. Fazalul Rahiman SS, etal., Trop Biomed. 2013 Dec;30(4):663-80.
9. Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model. Fujita H, etal., J Immunol. 2009 Jul 1;183(1):254-60.
10. Human Immunodeficiency Virus Type-1 Myeloid Derived Suppressor Cells Inhibit Cytomegalovirus Inflammation through Interleukin-27 and B7-H4. Garg A, etal., Sci Rep. 2017 Mar 24;7:44485. doi: 10.1038/srep44485.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Hall AO, etal.
13. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. Harker JA, etal., J Virol. 2018 May 29;92(12). pii: JVI.02196-17. doi: 10.1128/JVI.02196-17. Print 2018 Jun 15.
14. Relationship of IL27 gene polymorphisms with the risk of pulmonary tuberculosis in Chinese Han population. He C and Liu J, Int J Clin Exp Pathol. 2018 Aug 1;11(8):4147-4152. eCollection 2018.
15. The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis. He J, etal., Crit Care. 2018 Sep 30;22(1):248. doi: 10.1186/s13054-018-2180-0.
16. Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese. He L, etal., PLoS One. 2014 May 9;9(5):e96792. doi: 10.1371/journal.pone.0096792. eCollection 2014.
17. Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. Hirase T, etal., Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H420-9. doi: 10.1152/ajpheart.00198.2013. Epub 2013 May 31.
18. Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. Huang M, etal., Mediators Inflamm. 2016;2016:4025167. doi: 10.1155/2016/4025167. Epub 2016 Jun 15.
19. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. Huang N, etal., DNA Cell Biol. 2008 Sep;27(9):527-31.
20. Circulating interleukin-27 levels in Helicobacter pylori-infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin-associated gene A virulence factor. Jafarzadeh A, etal., J Dig Dis. 2011 Aug;12(4):302-7. doi: 10.1111/j.1751-2980.2011.00510.x.
21. Rather than interleukin-27, interleukin-6 expresses positive correlation with liver severity in naïve hepatitis B infection patients. Kao JT, etal., Liver Int. 2012 Jul;32(6):928-36. doi: 10.1111/j.1478-3231.2011.02742.x. Epub 2012 Jan 9.
22. Interleukin-27-Producing CD4(+) T Cells Regulate Protective Immunity during Malaria Parasite Infection. Kimura D, etal., Immunity. 2016 Mar 15;44(3):672-82. doi: 10.1016/j.immuni.2016.02.011. Epub 2016 Mar 8.
23. IL-27/IFN-gamma induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. Li JJ, etal., J Immunol. 2010 Oct 1;185(7):4401-9. Epub 2010 Sep 3.
24. Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis. Lin S, etal., Infect Drug Resist. 2019 Dec 2;12:3755-3763. doi: 10.2147/IDR.S231215. eCollection 2019.
25. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. Liu L, etal., J Biol Chem. 2012 Apr 6;287(15):11899-910. doi: 10.1074/jbc.M111.308064. Epub 2012 Feb 16.
26. Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome. Lucchesi D, etal., Arthritis Rheumatol. 2020 Sep;72(9):1559-1570. doi: 10.1002/art.41289. Epub 2020 Jul 21.
27. Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice. Mohammadnejad L, etal., Arch Razi Inst. 2021 Jan;75(4):491-500. doi: 10.22092/ari.2019.126151.1333. Epub 2021 Jan 1.
28. Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Moro K, etal., Nat Immunol. 2016 Jan;17(1):76-86. doi: 10.1038/ni.3309. Epub 2015 Nov 23.
29. Interleukin-27 expression following infection with the murine gammaherpesvirus 68. Nelson DA, etal., Cytokine. 2010 Aug;51(2):184-94. doi: 10.1016/j.cyto.2010.04.015. Epub 2010 May 20.
30. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. O'Dwyer MJ, etal., Intensive Care Med. 2008 Apr;34(4):683-91. doi: 10.1007/s00134-007-0968-5. Epub 2008 Jan 29.
31. Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27. Pan L, etal., Rheumatology (Oxford). 2020 Dec 6. pii: 6024785. doi: 10.1093/rheumatology/keaa752.
32. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Park J, etal., Infect Immun. 2019 Nov 18;87(12). pii: IAI.00455-19. doi: 10.1128/IAI.00455-19. Print 2019 Dec.
33. Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. Pinto MT, etal., AIDS Res Hum Retroviruses. 2014 Jun;30(6):610-22. doi: 10.1089/aid.2013.0109. Epub 2013 Oct 16.
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response. Quirino GFS, etal., Infect Immun. 2016 Jul 21;84(8):2289-2298. doi: 10.1128/IAI.00283-16. Print 2016 Aug.
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Comprehensive gene review and curation RGD comprehensive gene curation
39. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Rinchai D, etal., Eur J Immunol. 2012 Dec;42(12):3280-90. doi: 10.1002/eji.201242526. Epub 2012 Oct 25.
40. Interleukin-27 is abrogated in gastric cancer, but highly expressed in other Helicobacter pylori-associated gastroduodenal diseases. Rocha GA, etal., Helicobacter. 2020 Feb;25(1):e12667. doi: 10.1111/hel.12667. Epub 2019 Nov 8.
41. Role of IL-27-producing dendritic cells in Th1-immunity polarization in Lewis rats. Saito F, etal., Biochem Biophys Res Commun. 2005 Dec 30;338(4):1773-8. Epub 2005 Nov 2.
42. Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis. Seman BG, etal., Infect Immun. 2020 Feb 20;88(3). pii: IAI.00828-19. doi: 10.1128/IAI.00828-19. Print 2020 Feb 20.
43. Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. Skouras VS, etal., Infect Dis (Lond). 2015 Jul;47(7):477-83. doi: 10.3109/23744235.2015.1019919. Epub 2015 Mar 10.
44. [Diagnostic value of interleukin-27 in tuberculous pleural effusion]. Sun M, etal., Zhonghua Yi Xue Za Zhi. 2014 Sep 16;94(34):2641-4.
45. IL-27 Suppresses Antimicrobial Activity in Human Leprosy. Teles RMB, etal., J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.
46. Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. Tong X, etal., Parasitol Res. 2018 Jul;117(7):2255-2263. doi: 10.1007/s00436-018-5914-7. Epub 2018 May 19.
47. Association between polymorphisms of cytokine genes and secretion of IL-12p70, IL-18, and IL-27 by dendritic cells in patients with pulmonary tuberculosis. Urazova OI, etal., Tuberculosis (Edinb). 2019 Mar;115:56-62. doi: 10.1016/ Epub 2019 Feb 6.
48. Interleukin 27 could be useful in the diagnosis of tuberculous pleural effusions. Valdés L, etal., Respir Care. 2014 Mar;59(3):399-405. doi: 10.4187/respcare.02749. Epub 2013 Aug 20.
49. Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. Vultaggio A, etal., J Immunol. 2009 Jan 15;182(2):880-9.
50. The correlation between hepatitis B virus infection and IL-27. Wang HL, etal., Biomed Mater Eng. 2012;22(1-3):187-93. doi: 10.3233/BME-2012-0706.
51. IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis. Wang L, etal., J Infect Dis. 2018 Jan 4;217(2):198-207. doi: 10.1093/infdis/jix581.
52. Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis. Wang W, etal., Thorax. 2018 Mar;73(3):240-247. doi: 10.1136/thoraxjnl-2016-209718. Epub 2017 Aug 26.
53. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. Wirtz S, etal., J Exp Med. 2006 Aug 7;203(8):1875-81. doi: 10.1084/jem.20060471. Epub 2006 Jul 31.
54. Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Yan J, etal., J Hepatol. 2016 May;64(5):1128-1136. doi: 10.1016/j.jhep.2015.12.020. Epub 2016 Jan 6.
55. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. Yoshimoto T, etal., J Immunol. 2007 Oct 1;179(7):4415-23.
56. Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. Yoshizaki A, etal., Ann Rheum Dis. 2011 Jan;70(1):194-200. Epub 2010 Aug 12.
57. Association of the Interleukin-27 Gene Expression and Hepatitis B Virus Infection in Liver Transplanted Patients. Zare A, etal., Exp Clin Transplant. 2017 Oct;15(5):554-560. doi: 10.6002/ect.2015.0243. Epub 2016 Feb 26.
58. Comparison of the interleukin 27 expression for the acute and chronic phase of mononucleosis in children. Zelazowska-Rutkowska B, etal., Cytokine. 2021 May;141:155395. doi: 10.1016/j.cyto.2020.155395. Epub 2021 Feb 8.
59. Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses. Zeng R, etal., J Virol. 2012 Apr;86(8):4505-17. doi: 10.1128/JVI.07091-11. Epub 2012 Feb 1.
60. Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. Zhang GL, etal., J Immunol Res. 2019 May 6;2019:1538439. doi: 10.1155/2019/1538439. eCollection 2019.
61. High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV. Zhang GL, etal., Liver Int. 2014 Feb;34(2):266-73. doi: 10.1111/liv.12268. Epub 2013 Jul 25.
62. Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. Zhang J, etal., J Biol Chem. 2010 Jul 9;285(28):21269-81. doi: 10.1074/jbc.M110.100818. Epub 2010 Apr 30.
63. Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Zhu C, etal., Clin Immunol. 2009 Apr;131(1):92-7. doi: 10.1016/j.clim.2008.10.011. Epub 2008 Dec 9.
64. Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells. Zhu H, etal., Virol J. 2015 Nov 14;12:189. doi: 10.1186/s12985-015-0418-x.
Additional References at PubMed
PMID:12121660   PMID:12734330   PMID:21123181   PMID:22790384   PMID:23725508   PMID:23731464   PMID:25268627   PMID:25820907   PMID:26994309   PMID:28928459   PMID:29549229   PMID:36602425  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21181,173,108 - 181,178,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,173,372 - 181,178,582 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01198,003,615 - 198,010,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,003,683 - 198,008,893 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,981,789 - 204,987,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,730,394 - 185,735,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,831,320 - 178,837,817 (-)NCBICelera
Cytogenetic Map1q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381628,499,362 - 28,506,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,499,362 - 28,512,051 (-)EnsemblGRCh38hg38GRCh38
GRCh371628,510,683 - 28,518,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,418,184 - 28,425,656 (-)NCBINCBI36Build 36hg18NCBI36
Build 341628,418,472 - 28,425,633NCBI
Celera1627,685,614 - 27,693,084 (+)NCBICelera
Cytogenetic Map16p12.1-p11.2NCBI
HuRef1626,536,601 - 26,544,073 (-)NCBIHuRef
CHM1_11629,522,293 - 29,529,765 (-)NCBICHM1_1
T2T-CHM13v2.01628,869,090 - 28,896,415 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397126,188,181 - 126,194,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)EnsemblGRCm39 Ensembl
GRCm387126,589,009 - 126,595,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,732,809 - 133,738,424 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,380,443 - 126,386,058 (-)NCBIMGSCv36mm8
Celera7126,438,423 - 126,444,039 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.18NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554936,712,005 - 6,717,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,712,005 - 6,717,417 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11634,982,084 - 34,989,328 (+)NCBINHGRI_mPanPan1
PanPan1.11628,979,717 - 28,984,655 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1618,243,988 - 18,248,369 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,244,040 - 18,247,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,822,685 - 19,827,046 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,380,027 - 18,384,391 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,380,086 - 18,384,093 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,179,035 - 18,183,396 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,094,139 - 18,098,496 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,410,212 - 18,414,571 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024409344123,875,494 - 123,879,941 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,973,385 - 11,976,583 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,972,715 - 11,978,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl318,421,981 - 18,427,915 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,421,962 - 18,427,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1526,348,559 - 26,358,028 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,348,848 - 26,356,360 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,217,584 - 3,222,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478213,009,564 - 13,015,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,009,450 - 13,015,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Il27
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:102
Interacting mature miRNAs:107
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,172,878 - 181,173,062 (+)MAPPERmRatBN7.2
Rnor_6.01198,003,190 - 198,003,373NCBIRnor6.0
Rnor_5.01204,981,950 - 204,982,133UniSTSRnor5.0
RGSC_v3.41185,729,901 - 185,730,084UniSTSRGSC3.4
Celera1178,830,895 - 178,831,078UniSTS
Cytogenetic Map1q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 1 7 18 1 7 10
Below cutoff 2 9 33 24 1 24 5 7 20 18 11 1 5


RefSeq Acc Id: ENSRNOT00000025950   ⟹   ENSRNOP00000025950
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,173,372 - 181,178,582 (-)Ensembl
Rnor_6.0 Ensembl1198,003,683 - 198,008,893 (-)Ensembl
RefSeq Acc Id: XM_039101198   ⟹   XP_038957126
Rat AssemblyChrPosition (strand)Source
mRatBN7.21181,173,108 - 181,178,720 (-)NCBI
RefSeq Acc Id: XM_344962   ⟹   XP_344963
Rat AssemblyChrPosition (strand)Source
mRatBN7.21181,173,108 - 181,178,717 (-)NCBI
Rnor_6.01198,003,615 - 198,010,112 (-)NCBI
Rnor_5.01204,981,789 - 204,987,782 (-)NCBI
RGSC_v3.41185,730,394 - 185,735,604 (-)RGD
Protein Sequences
Protein RefSeqs XP_038957126 (Get FASTA)   NCBI Sequence Viewer  
  XP_344963 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025950
RefSeq Acc Id: XP_344963   ⟸   XM_344962
- Peptide Label: isoform X2
- UniProtKB: D3ZPW3 (UniProtKB/TrEMBL),   A6I997 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025950   ⟸   ENSRNOT00000025950
RefSeq Acc Id: XP_038957126   ⟸   XM_039101198
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPW3-F1-model_v2 AlphaFold D3ZPW3 1-234 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561420 AgrOrtholog
BioCyc Gene G2FUF-57440 BioCyc
Ensembl Genes ENSRNOG00000019170 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025950 ENTREZGENE
  ENSRNOT00000025950.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-27_alpha UniProtKB/TrEMBL
  PTHR20879 UniProtKB/TrEMBL
PhenoGen Il27 PhenoGen
RatGTEx ENSRNOG00000019170 RatGTEx

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Il27  interleukin 27  RGD1561420_predicted  similar to IL-27 p28 subunit (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561420_predicted  similar to IL-27 p28 subunit (predicted)  LOC365368  similar to IL-27 p28 subunit  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365368  similar to IL-27 p28 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL