Map3k20 (mitogen-activated protein kinase kinase kinase 20)

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Gene: Map3k20 (mitogen-activated protein kinase kinase kinase 20) Rattus norvegicus

Analyze

Symbol:

Map3k20

Name:

mitogen-activated protein kinase kinase kinase 20

RGD ID:

1561394

Description:

Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including cellular response to radiation; intracellular signal transduction; and regulation of intracellular signal transduction. Predicted to act upstream of with a positive effect on pyroptosis. Predicted to act upstream of or within MAPK cascade; cytoskeleton organization; and embryonic digit morphogenesis. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; aflatoxin B1.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC311743; mitogen-activated protein kinase kinase kinase MLT; MLTK; RGD1561394; similar to MLTK-beta; sterile alpha motif and leucine zipper containing kinase AZK; Zak

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	57,130,539 - 57,289,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	57,130,551 - 57,289,626 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	60,525,000 - 60,684,368 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	69,108,644 - 69,268,008 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	66,873,682 - 67,033,044 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	58,965,025 - 59,120,507 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	58,965,552 - 59,067,369 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	65,435,276 - 65,598,052 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	54,767,724 - 54,915,022 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	56,670,166 - 56,831,147 (+)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

centronuclear myopathy 6 with fiber-type disproportion (ISO)

genetic disease (ISO)

split hand-foot malformation (ISO,ISS)

split hand-foot malformation 1 (ISO)

split hand-foot malformation 5 (ISO)

Split-Foot Malformation with Mesoaxial Polydactyly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(-)-anisomycin (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-hydroxynon-2-enal (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (EXP,ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

caffeine (ISO)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

fenamidone (ISO)

fisetin (ISO)

fluoranthene (ISO)

fluorescein 5-isothiocyanate (ISO)

gentamycin (EXP)

indometacin (ISO)

ivermectin (ISO)

lead(0) (ISO)

methapyrilene (ISO)

methimazole (EXP)

myristicin (ISO)

nickel atom (ISO)

oxaliplatin (ISO)

ozone (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

protein kinase inhibitor (ISO)

quinoline (ISO)

rac-lactic acid (ISO)

raloxifene (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (ISO)

trichostatin A (ISO)

triclosan (ISO)

Triptolide (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to gamma radiation (ISO)

cellular response to UV-B (ISO,ISS)

cytoskeleton organization (ISO)

DNA damage checkpoint signaling (ISO)

embryonic digit morphogenesis (ISO)

GCN2-mediated signaling (ISO,ISS)

intracellular signal transduction (ISO)

JNK cascade (ISO,ISS)

limb development (ISO)

negative regulation of stress-activated protein kinase signaling cascade (ISO)

negative regulation of translation in response to endoplasmic reticulum stress (ISO)

p38MAPK cascade (ISO,ISS)

positive regulation of apoptotic process (ISO)

positive regulation of mitotic DNA damage checkpoint (ISO)

positive regulation of programmed cell death (ISO,ISS)

pyroptosis (ISO,ISS)

stress-activated MAPK cascade (ISO,ISS)

stress-activated protein kinase signaling cascade (ISO,ISS)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

nucleus (ISO)

Molecular Function

ATP binding (ISO)

JUN kinase kinase kinase activity (ISO,ISS)

magnesium ion binding (ISO)

MAP kinase kinase kinase activity (IBA,ISO,ISS)

protein binding (ISO)

protein kinase activator activity (ISO,ISS)

protein serine/threonine kinase activity (ISO,ISS)

ribosome binding (ISO,ISS)

small ribosomal subunit rRNA binding (ISO,ISS)

stalled ribosome sensor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

c-Jun N-terminal kinases MAPK signaling pathway (ISO)

mitogen activated protein kinase signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mechanisms and functions of p38 MAPK signalling.	Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7957077	PMID:10924358	PMID:11042189	PMID:11836244	PMID:15342622	PMID:19184368	PMID:22681889	PMID:25869677	PMID:26755636

Genomics

Comparative Map Data

Map3k20
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	57,130,539 - 57,289,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	57,130,551 - 57,289,626 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	60,525,000 - 60,684,368 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	69,108,644 - 69,268,008 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	66,873,682 - 67,033,044 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	58,965,025 - 59,120,507 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	58,965,552 - 59,067,369 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	65,435,276 - 65,598,052 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	54,767,724 - 54,915,022 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	56,670,166 - 56,831,147 (+)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

MAP3K20
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	173,075,517 - 173,268,015 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	173,075,435 - 173,268,015 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	173,940,574 - 174,132,743 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	173,648,811 - 173,840,983 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	167,553,959 - 167,746,148 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	165,819,879 - 166,012,160 (+)	NCBI		HuRef
CHM1_1	2	173,947,661 - 174,139,938 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	173,561,966 - 173,754,582 (+)	NCBI		T2T-CHM13v2.0

Map3k20
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	72,115,970 - 72,272,954 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	72,115,981 - 72,272,954 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	72,285,637 - 72,442,610 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	72,285,637 - 72,442,610 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	72,123,694 - 72,280,667 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	72,086,616 - 72,243,449 (+)	NCBI		MGSCv36	mm8
Celera	2	73,970,184 - 74,127,061 (+)	NCBI		Celera
Cytogenetic Map	2	C3	NCBI
cM Map	2	43.11	NCBI

Map3k20
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955449	1,976,186 - 2,139,044 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAP3K20
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2B	75,763,197 - 75,957,208 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	60,362,635 - 60,555,445 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	177,817,875 - 178,010,556 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	177,818,344 - 178,010,556 (+)	Ensembl	panpan1.1		panPan2

MAP3K20
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	17,353,829 - 17,515,247 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	17,341,300 - 17,514,869 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	17,343,501 - 17,518,950 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	17,466,459 - 17,641,702 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	17,467,503 - 17,641,702 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	17,547,032 - 17,722,456 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	17,545,748 - 17,720,652 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	17,648,987 - 17,824,502 (+)	NCBI		UU_Cfam_GSD_1.0

Map3k20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	134,476,003 - 134,650,636 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	3,029,979 - 3,202,796 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	3,029,942 - 3,203,319 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP3K20
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	79,173,033 - 79,380,993 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	79,174,444 - 79,378,520 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	88,495,627 - 88,690,961 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP3K20
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	58,573,303 - 58,764,759 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	140,811,053 - 140,999,695 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Map3k20
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	10,405,701 - 10,565,943 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	10,392,738 - 10,566,563 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Map3k20
590 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	507
Count of miRNA genes:	257
Interacting mature miRNAs:	318
Transcripts:	ENSRNOT00000002067, ENSRNOT00000002068
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	16954708	61954708	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	27936919	72936919	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	28249687	73249687	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	28249687	73249687	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	28249687	73249687	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	28249687	73249687	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	28249687	73249687	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	28468571	73468571	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	28468571	73468571	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31426403	70668733	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31426403	70668733	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31426403	70668733	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31426403	70668733	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31426403	70668733	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31426403	70668733	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	33703347	61017857	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	62951183	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582249	Bw77	Body weight QTL 77	3.2	0.0025	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	64655484	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat

Markers in Region

RH80553

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	57,248,770 - 57,248,998 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	59,071,685 - 59,071,912	NCBI	Rnor6.0
Rnor_5.0	3	65,554,665 - 65,554,892	UniSTS	Rnor5.0
RGSC_v3.4	3	54,873,758 - 54,873,985	UniSTS	RGSC3.4
Celera	3	56,790,022 - 56,790,249	UniSTS
Cytogenetic Map	3	q22	UniSTS

RH134323

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	57,248,547 - 57,248,766 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	59,071,462 - 59,071,680	NCBI	Rnor6.0
Rnor_5.0	3	65,554,442 - 65,554,660	UniSTS	Rnor5.0
RGSC_v3.4	3	54,873,535 - 54,873,753	UniSTS	RGSC3.4
Celera	3	56,789,799 - 56,790,017	UniSTS
RH 3.4 Map	4	402.65	UniSTS
Cytogenetic Map	3	q22	UniSTS

BE097452

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	57,287,315 - 57,287,493 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	59,117,880 - 59,118,057	NCBI	Rnor6.0
Rnor_5.0	3	65,595,425 - 65,595,602	UniSTS	Rnor5.0
RGSC_v3.4	3	54,912,395 - 54,912,572	UniSTS	RGSC3.4
Celera	3	56,828,520 - 56,828,697	UniSTS
Cytogenetic Map	3	q22	UniSTS

BG374587

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	57,245,781 - 57,245,921 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	59,068,696 - 59,068,835	NCBI	Rnor6.0
Rnor_5.0	3	65,551,676 - 65,551,815	UniSTS	Rnor5.0
RGSC_v3.4	3	54,870,769 - 54,870,908	UniSTS	RGSC3.4
Celera	3	56,787,033 - 56,787,172	UniSTS
Cytogenetic Map	3	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	42	28	12	17	12	8	11	74	28	34	11	8
Low		1	29	29	2	29				7	7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001398993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001398994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001059755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006224483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592327	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	FQ209892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002068 ⟹ ENSRNOP00000002068

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	57,130,551 - 57,289,626 (+)	Ensembl
Rnor_6.0 Ensembl	3	58,965,552 - 59,067,369 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097727 ⟹ ENSRNOP00000087005

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	57,130,590 - 57,249,005 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112816 ⟹ ENSRNOP00000077905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	57,130,590 - 57,249,005 (+)	Ensembl

RefSeq Acc Id:

NM_001398993 ⟹ NP_001385922

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	57,130,539 - 57,289,943 (+)	NCBI

RefSeq Acc Id:

NM_001398994 ⟹ NP_001385923

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	57,130,539 - 57,249,019 (+)	NCBI

RefSeq Acc Id:

XM_039106372 ⟹ XP_038962300

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	57,142,254 - 57,289,943 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001385922	(Get FASTA)	NCBI Sequence Viewer
	NP_001385923	(Get FASTA)	NCBI Sequence Viewer
	XP_038962300	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002068
	ENSRNOP00000002068.3
	ENSRNOP00000077905
	ENSRNOP00000077905.1
	ENSRNOP00000087005.1

RefSeq Acc Id:

ENSRNOP00000002068 ⟸ ENSRNOT00000002068

RefSeq Acc Id:	XP_038962300 ⟸ XM_039106372
- Peptide Label:	isoform X1
- UniProtKB:	D4AE17 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000077905 ⟸ ENSRNOT00000112816

RefSeq Acc Id:

ENSRNOP00000087005 ⟸ ENSRNOT00000097727

RefSeq Acc Id:	NP_001385922 ⟸ NM_001398993
- Peptide Label:	isoform 1
- UniProtKB:	D4AE17 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001385923 ⟸ NM_001398994
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I5Y262 (UniProtKB/TrEMBL), A0A8I6A4W9 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AE17-F1-model_v2	AlphaFold	D4AE17	1-453	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561394	AgrOrtholog
BioCyc Gene	G2FUF-49438	BioCyc
Ensembl Genes	ENSRNOG00000001515	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002068	ENTREZGENE
	ENSRNOT00000002068.6	UniProtKB/TrEMBL
	ENSRNOT00000097727.1	UniProtKB/TrEMBL
	ENSRNOT00000112816	ENTREZGENE
	ENSRNOT00000112816.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	SAM	UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/TrEMBL
	Ser-Thr/Tyr-Pkinase	UniProtKB/TrEMBL
	Ser/Thr_prot_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	311743	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED	UniProtKB/TrEMBL
Pfam	Pkinase_Tyr	UniProtKB/TrEMBL
	SAM_1	UniProtKB/TrEMBL
PhenoGen	Map3k20	PhenoGen
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	SAM_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001515	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
	SAM	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	SSF47769	UniProtKB/TrEMBL
UniProt	A0A8I5Y262	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A4W9	ENTREZGENE, UniProtKB/TrEMBL
	D4AE17	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-10-28	Map3k20	mitogen-activated protein kinase kinase kinase 20	Zak	sterile alpha motif and leucine zipper containing kinase AZK	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1561394	similar to MLTK-beta	RGD1561394_predicted	similar to MLTK-beta (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1561394_predicted	similar to MLTK-beta (predicted)	LOC311743	similar to MLTK-beta	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC311743	similar to MLTK-beta			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)