Defb14 (defensin beta 14) - Rat Genome Database

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Gene: Defb14 (defensin beta 14) Rattus norvegicus
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Symbol: Defb14
Name: defensin beta 14
RGD ID: 1561378
Description: Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to other organism. Predicted to be active in extracellular space. Orthologous to several human genes including DEFB103A (defensin beta 103A); INTERACTS WITH furan; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-14; beta-defensin 14; defensin, beta 14
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,365,892 - 77,369,668 (-)NCBIGRCr8
mRatBN7.21670,663,443 - 70,668,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,663,333 - 70,666,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,940,391 - 75,941,249 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,403,557 - 79,404,415 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,652,995 - 74,653,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,647,523 - 75,650,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,647,680 - 75,648,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,247,809 - 75,250,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,455,087 - 75,455,945 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,531,179 - 68,532,037 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Experimental Data Annotations    Click to see Annotation Detail View

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Defb14Ratcoat/hair pigmentation trait  ISORGD:122626389068941Coat colour, dominant blackOMIAPMID:12692166|PMID:15649147|PMID:17483404|PMID:17947548|PMID:19197024|PMID:21321476|PMID:24098367|PMID:31658272|PMID:34751460|PMID:35037272|PMID:35510419|PMID:36427679|PMID:37582787

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Experimental Data Annotations     Click to see Annotation Detail View

Vertebrate Trait

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11085990   PMID:15625724   PMID:16033865   PMID:16436752   PMID:18167348   PMID:21115716  


Genomics

Comparative Map Data
Defb14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,365,892 - 77,369,668 (-)NCBIGRCr8
mRatBN7.21670,663,443 - 70,668,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,663,333 - 70,666,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,940,391 - 75,941,249 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,403,557 - 79,404,415 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,652,995 - 74,653,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,647,523 - 75,650,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,647,680 - 75,648,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,247,809 - 75,250,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,455,087 - 75,455,945 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,531,179 - 68,532,037 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
DEFB103A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,881,392 - 7,882,663 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,881,392 - 7,882,663 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl87,428,888 - 7,430,348 (-)EnsemblGRCh38hg38GRCh38
GRCh3787,738,914 - 7,740,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,776,136 - 7,777,596 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map8p23.1NCBI
HuRef86,934,690 - 6,936,069 (-)NCBIHuRef
CHM1_187,804,318 - 7,805,713 (+)NCBICHM1_1
T2T-CHM13v2.0812,027,390 - 12,028,661 (+)NCBIT2T-CHM13v2.0
Defb14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39819,213,172 - 19,245,342 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl819,244,373 - 19,245,228 (+)EnsemblGRCm39 Ensembl
GRCm38819,160,244 - 19,195,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl819,194,357 - 19,195,212 (+)EnsemblGRCm38mm10GRCm38
MGSCv37819,194,328 - 19,195,309 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36819,194,334 - 19,195,189 (+)NCBIMGSCv36mm8
Celera819,317,849 - 19,318,830 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.35NCBI
CBD103
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11658,965,216 - 58,966,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1658,965,216 - 58,967,712 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1654,487,571 - 54,489,128 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,081,626 - 57,083,181 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,070,481 - 57,083,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11659,123,440 - 59,124,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,093,003 - 55,094,561 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,467,668 - 55,469,226 (+)NCBIUU_Cfam_GSD_1.0
LOC404703
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1537,957,488 - 38,066,223 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11537,960,248 - 38,065,632 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Defb14
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000048414
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
UniSTS:492990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21670,663,555 - 70,664,414 (+)MAPPERmRatBN7.2
Rnor_6.01675,647,680 - 75,648,538NCBIRnor6.0
Rnor_5.01675,247,912 - 75,248,770UniSTSRnor5.0
RGSC_v3.41675,455,087 - 75,455,945UniSTSRGSC3.4
Celera1668,531,179 - 68,532,037UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 2 2 21 19 31 6 17 6 6 41 24 11 8 27 25

Sequence


Ensembl Acc Id: ENSRNOT00000048414   ⟹   ENSRNOP00000048330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,663,333 - 70,666,540 (-)Ensembl
Rnor_6.0 Ensembl1675,647,680 - 75,648,538 (-)Ensembl
RefSeq Acc Id: NM_001037504   ⟹   NP_001032593
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,365,892 - 77,366,880 (-)NCBI
mRatBN7.21670,663,453 - 70,664,441 (-)NCBI
Rnor_6.01675,647,680 - 75,648,538 (-)NCBI
Rnor_5.01675,247,809 - 75,250,820 (-)NCBI
RGSC_v3.41675,455,087 - 75,455,945 (-)RGD
Celera1668,531,179 - 68,532,037 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253372   ⟹   XP_006253434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,365,892 - 77,369,668 (-)NCBI
mRatBN7.21670,663,443 - 70,668,473 (-)NCBI
Rnor_6.01675,647,523 - 75,650,913 (-)NCBI
Rnor_5.01675,247,809 - 75,250,820 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600241   ⟹   XP_017455730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,365,892 - 77,368,084 (-)NCBI
mRatBN7.21670,663,443 - 70,666,271 (-)NCBI
Rnor_6.01675,647,523 - 75,649,720 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032593 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253434 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455730 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51885 (Get FASTA)   NCBI Sequence Viewer  
  EDM08968 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048330
  ENSRNOP00000048330.1
GenBank Protein Q32ZH7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032593   ⟸   NM_001037504
- Peptide Label: precursor
- UniProtKB: Q32ZH7 (UniProtKB/Swiss-Prot),   A6IWA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253434   ⟸   XM_006253372
- Peptide Label: isoform X1
- UniProtKB: Q32ZH7 (UniProtKB/Swiss-Prot),   A6IWA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455730   ⟸   XM_017600241
- Peptide Label: isoform X1
- UniProtKB: Q32ZH7 (UniProtKB/Swiss-Prot),   A6IWA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048330   ⟸   ENSRNOT00000048414
Protein Domains
Beta-defensin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZH7-F1-model_v2 AlphaFold Q32ZH7 1-67 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561378 AgrOrtholog
BioCyc Gene G2FUF-10819 BioCyc
Ensembl Genes ENSRNOG00000032304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048414 ENTREZGENE
  ENSRNOT00000048414.2 UniProtKB/Swiss-Prot
Gene3D-CATH Antimicrobial Peptide, Beta-defensin 2, Chain A UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot
KEGG Report rno:641627 UniProtKB/Swiss-Prot
NCBI Gene 641627 ENTREZGENE
PANTHER BETA-DEFENSIN UniProtKB/Swiss-Prot
  BETA-DEFENSIN 103 UniProtKB/Swiss-Prot
Pfam Defensin_beta UniProtKB/Swiss-Prot
PhenoGen Defb14 PhenoGen
RatGTEx ENSRNOG00000032304 RatGTEx
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot
UniProt A6IWA4 ENTREZGENE, UniProtKB/TrEMBL
  DFB14_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-07 Defb14  defensin beta 14    defensin, beta 14  Name updated 1299863 APPROVED
2006-02-09 Defb14  defensin, beta 14      Symbol and Name status set to provisional 70820 PROVISIONAL