Ppp1r3a (protein phosphatase 1, regulatory subunit 3A) - Rat Genome Database

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Gene: Ppp1r3a (protein phosphatase 1, regulatory subunit 3A) Rattus norvegicus
Analyze
Symbol: Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
RGD ID: 1561312
Description: Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500036; protein phosphatase 1 regulatory subunit 3A; protein phosphatase 1, regulatory (inhibitor) subunit 3A; RGD1561312; similar to type 1 protein phosphatase targeting subunit RGL/GM
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8443,905,648 - 43,946,236 (-)NCBIGRCr8
mRatBN7.2442,937,353 - 42,980,195 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl442,939,599 - 42,980,638 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx447,935,810 - 47,976,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0443,856,823 - 43,897,416 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0442,265,462 - 42,306,053 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0441,171,486 - 41,212,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl441,171,486 - 41,212,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0440,763,443 - 40,804,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4440,195,325 - 40,235,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera438,272,622 - 38,313,215 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
2. Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus. Doney AS, etal., BMC Genet. 2003 Jun 28;4:11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity. Hansen L, etal., Diabetes. 2000 Feb;49(2):298-301.
5. A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hansen L, etal., Hum Mol Genet. 1995 Aug;4(8):1313-20.
6. Variation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians. Hegele RA, etal., J Clin Endocrinol Metab. 1998 Nov;83(11):3980-3.
7. The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population. Maegawa H, etal., Diabetes. 1999 Jul;48(7):1469-72.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Digenic inheritance of severe insulin resistance in a human pedigree. Savage DB, etal., Nat Genet. 2002 Aug;31(4):379-84. Epub 2002 Jul 15.
15. Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM. Shen GQ, etal., Diabetes Care. 1998 Jul;21(7):1086-9.
16. The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus. Wang G, etal., Chin Med J (Engl). 2001 Dec;114(12):1258-62.
17. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Xia J, etal., Diabetes. 1998 Sep;47(9):1519-24.
Additional References at PubMed
PMID:26593335   PMID:31235787  


Genomics

Comparative Map Data
Ppp1r3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8443,905,648 - 43,946,236 (-)NCBIGRCr8
mRatBN7.2442,937,353 - 42,980,195 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl442,939,599 - 42,980,638 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx447,935,810 - 47,976,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0443,856,823 - 43,897,416 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0442,265,462 - 42,306,053 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0441,171,486 - 41,212,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl441,171,486 - 41,212,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0440,763,443 - 40,804,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4440,195,325 - 40,235,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera438,272,622 - 38,313,215 (-)NCBICelera
Cytogenetic Map4q22NCBI
PPP1R3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387113,876,777 - 113,919,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7113,876,777 - 114,075,920 (-)EnsemblGRCh38hg38GRCh38
GRCh377113,516,832 - 113,559,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367113,301,622 - 113,346,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 347113,108,336 - 113,153,015NCBI
Celera7108,323,366 - 108,365,567 (-)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7107,880,214 - 107,922,483 (-)NCBIHuRef
CHM1_17113,450,259 - 113,492,463 (-)NCBICHM1_1
T2T-CHM13v2.07115,191,582 - 115,233,899 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27112,912,237 - 112,954,446 (-)NCBI
Ppp1r3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39614,713,821 - 14,755,273 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl614,713,976 - 14,755,273 (-)EnsemblGRCm39 Ensembl
GRCm38614,713,822 - 14,755,274 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl614,713,977 - 14,755,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv37614,663,822 - 14,705,274 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36614,663,582 - 14,705,246 (-)NCBIMGSCv36mm8
Celera614,805,199 - 14,846,652 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map66.31NCBI
Ppp1r3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543219,858,423 - 19,893,175 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543219,854,649 - 19,893,148 (-)NCBIChiLan1.0ChiLan1.0
PPP1R3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26150,689,220 - 150,887,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan172,699,476 - 2,898,173 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07105,831,567 - 105,873,793 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17118,529,362 - 118,571,591 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7118,529,362 - 118,571,770 (-)Ensemblpanpan1.1panPan2
PPP1R3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11453,169,836 - 53,216,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1453,170,954 - 53,217,169 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1452,629,027 - 52,654,678 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01453,207,268 - 53,254,477 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1453,207,282 - 53,254,421 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11453,239,468 - 53,286,626 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01452,925,489 - 52,972,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01453,298,675 - 53,345,641 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511841,864,856 - 41,900,319 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365894,789,570 - 4,826,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365894,789,547 - 4,827,727 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1831,997,713 - 32,039,852 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11831,997,667 - 32,039,949 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21834,430,740 - 34,471,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12182,596,714 - 82,635,779 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2182,595,511 - 82,635,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604221,132,063 - 21,169,665 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248275,543,420 - 5,581,847 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248275,543,497 - 5,581,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r3a
148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1046
Count of miRNA genes:345
Interacting mature miRNAs:483
Transcripts:ENSRNOT00000065919
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
2290374Gluco32Glucose level QTL 326.27blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43717795044463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

Markers in Region
AW533988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2442,979,377 - 42,979,539 (+)MAPPERmRatBN7.2
Rnor_6.0441,211,261 - 41,211,422NCBIRnor6.0
Rnor_5.0440,803,218 - 40,803,379UniSTSRnor5.0
RGSC_v3.4440,235,102 - 40,235,263UniSTSRGSC3.4
Celera438,312,404 - 38,312,565UniSTS
RH 3.4 Map4259.0UniSTS
Cytogenetic Map4q21UniSTS
RH139844  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2442,941,283 - 42,941,489 (+)MAPPERmRatBN7.2
Rnor_6.0441,173,171 - 41,173,376NCBIRnor6.0
Rnor_5.0440,765,128 - 40,765,333UniSTSRnor5.0
RGSC_v3.4440,197,010 - 40,197,215UniSTSRGSC3.4
Celera438,274,307 - 38,274,512UniSTS
RH 3.4 Map4259.0UniSTS
Cytogenetic Map4q21UniSTS
AI170678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2442,940,411 - 42,940,508 (+)MAPPERmRatBN7.2
Rnor_6.0441,172,299 - 41,172,395NCBIRnor6.0
Rnor_5.0440,764,256 - 40,764,352UniSTSRnor5.0
RGSC_v3.4440,196,138 - 40,196,234UniSTSRGSC3.4
Celera438,273,435 - 38,273,531UniSTS
RH 3.4 Map4259.0UniSTS
Cytogenetic Map4q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 92 34 42 9 24
Low 49 27 15 15 15 3 12 30
Below cutoff 70 20 43 20 77 46 69 18

Sequence


Ensembl Acc Id: ENSRNOT00000085596   ⟹   ENSRNOP00000071537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl442,939,599 - 42,980,638 (-)Ensembl
Rnor_6.0 Ensembl441,171,486 - 41,212,072 (-)Ensembl
RefSeq Acc Id: NM_001109222   ⟹   NP_001102692
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8443,905,648 - 43,946,236 (-)NCBI
mRatBN7.2442,939,599 - 42,980,189 (-)NCBI
Rnor_6.0441,171,486 - 41,212,072 (-)NCBI
Rnor_5.0440,763,443 - 40,804,029 (-)NCBI
RGSC_v3.4440,195,325 - 40,235,913 (-)RGD
Celera438,272,622 - 38,313,215 (-)RGD
Sequence:
RefSeq Acc Id: XM_008762717   ⟹   XP_008760939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8443,905,981 - 43,946,236 (-)NCBI
mRatBN7.2442,937,353 - 42,980,195 (-)NCBI
Rnor_6.0441,171,822 - 41,212,116 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063286475   ⟹   XP_063142545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8443,905,981 - 43,944,123 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102692 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760939 (Get FASTA)   NCBI Sequence Viewer  
  XP_063142545 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15096 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071537.2
RefSeq Acc Id: NP_001102692   ⟸   NM_001109222
- UniProtKB: A6IE09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760939   ⟸   XM_008762717
- Peptide Label: isoform X1
- UniProtKB: D3ZM60 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071537   ⟸   ENSRNOT00000085596
RefSeq Acc Id: XP_063142545   ⟸   XM_063286475
- Peptide Label: isoform X2
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZM60-F1-model_v2 AlphaFold D3ZM60 1-1096 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692883
Promoter ID:EPDNEW_R3408
Type:multiple initiation site
Name:Ppp1r3a_1
Description:protein phosphatase 1, regulatory subunit 3A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0441,212,034 - 41,212,094EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561312 AgrOrtholog
BioCyc Gene G2FUF-45594 BioCyc
Ensembl Genes ENSRNOG00000059350 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085596.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2440 UniProtKB/TrEMBL
InterPro CBM21_dom_sf UniProtKB/TrEMBL
  CBM_21 UniProtKB/TrEMBL
  PP1_regulatory_subunit_3 UniProtKB/TrEMBL
KEGG Report rno:500036 UniProtKB/TrEMBL
NCBI Gene 500036 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3A UniProtKB/TrEMBL
Pfam CBM_21 UniProtKB/TrEMBL
PhenoGen Ppp1r3a PhenoGen
PROSITE CBM21 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059350 RatGTEx
UniProt A6IE09 ENTREZGENE, UniProtKB/TrEMBL
  D3ZM60 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r3a  protein phosphatase 1, regulatory subunit 3A  Ppp1r3a  protein phosphatase 1, regulatory (inhibitor) subunit 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Ppp1r3a  protein phosphatase 1, regulatory (inhibitor) subunit 3A  RGD1561312_predicted  similar to type 1 protein phosphatase targeting subunit RGL/GM (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561312_predicted  similar to type 1 protein phosphatase targeting subunit RGL/GM (predicted)  LOC500036  similar to type 1 protein phosphatase targeting subunit RGL/GM  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500036  similar to type 1 protein phosphatase targeting subunit RGL/GM      Symbol and Name status set to provisional 70820 PROVISIONAL